Oral Administration of Novel Oriental Medicine, KIOM-C, Protect against Influenza Virus

Jin Yeul Ma, Eun Ha Kim, Jun Han Lee, Min-Suk Song, Yun Hee Baek, Young Ki Choi 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

The influenza virus is an important respiratory risk affecting humans, and effective treatments are needed. Some oriental medicines are currently applied for treatment of common colds as well as influenza infection. Previous studies have reported that the therapeutic properties of MA-128 are effective for treatment of psoriasis antiasthmatic and atopic dermatitis. In this study, we investigated the therapeutic properties of the novel herbal medicine, MA-128, for treatment of influenza virus infection by oral administration. MA-128 is an active natural biological compound from herbal-marine origin. The results showed that oral administration of MA-128 in mice could confer a survival benefit against Type A influenza virus infection. Daily oral administration of MA- 128 resulted in delayed death in infected mice for three days against mouse adapted H3N2 (A/Philippines/2/82). However, it protected more than 60% of mice from lethal infection of 2009 pandemic H1N1 (A/Korea/CJ01/2009) influenza virus. In addition, lung viral titers were significantly reduced at seven days post infection (~100 times) compared with mock-treated mice and viruses were cleared at 9 dpi only in the MA-128 treated groups. This study demonstrated the potential of the novel herbal medicine, MA-128, as an herbal remedy against influenza A viruses.

Significant enhancement of bromate removal in drinking water: Implications for the mechanism of sonocatalytic reduction

Cui, Mingcan,Choi, Jongbok,Lee, Yonghyun,Ma, Junjun,Kim, Dukmin,Choi, Jaeyoung,Jang, Min,Khim, Jeehyeong Elsevier 2017 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.317 No.-

<P><B>Abstract</B></P> <P>Bromate (BrO<SUB>3</SUB> <SUP>−</SUP>) is a potential carcinogenic compound that can form during the disinfection of drinking water. For the first time, the sonocatalytic reduction of BrO<SUB>3</SUB> <SUP>−</SUP> were studied through examining the effect of the important operational parameters such as ultrasound (US) frequency, TiO<SUB>2</SUB> loading, pH, temperature and other anions. By observing sonoluminescence (SL) at various frequencies and measuring H<SUB>2</SUB> production rates, a new reduction mechanism for BrO<SUB>3</SUB> <SUP>−</SUP> is also proposed. The kinetic results presented that the BrO<SUB>3</SUB> <SUP>−</SUP> reduction rates enlarged as the measured H<SUB>2</SUB> production rate increased for all parameters, and the slopes between the BrO<SUB>3</SUB> <SUP>−</SUP> reduction and H<SUB>2</SUB> production rates for sonocatalysis were much higher than those for sonolysis. Interestingly, sonolysis could be limited by the amount of H<SUB>2</SUB> production, but sonocatalysis could increase the BrO<SUB>3</SUB> <SUP>−</SUP> reduction rate because of additional electrons (e<SUP>−</SUP>) from the surface of TiO<SUB>2</SUB> via SL. The highest SL intensities for H<SUB>2</SUB> production and BrO<SUB>3</SUB> <SUP>−</SUP> reduction rates occurred at an ultrasound frequency of 500kHz, implying that an increase in SL intensity caused by ultrasound cavitation enhanced H<SUB>2</SUB> production and increased the e<SUP>-</SUP> released to the conduction band of TiO<SUB>2</SUB>. At 500kHz, BrO<SUB>3</SUB> <SUP>−</SUP> reduction rate (6.84×10<SUP>−2</SUP> min<SUP>−1</SUP>) by sonophotocatalysis was 5.2 times higher than that (1.32×10<SUP>−2</SUP> min<SUP>−1</SUP>) of sonolysis. Investigation into the effect of anion species showed that BrO<SUB>3</SUB> <SUP>−</SUP> reduction was inhibited or enhanced depending on the type of anions present. In real application, sonocatalytic reduction of BrO<SUB>3</SUB> <SUP>−</SUP> could be advantageous, as it has higher reduction rates than those reported for photocatalysis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sonocatalytic BrO<SUB>3</SUB> <SUP>−</SUP> reduction was studied at various parameters and H<SUB>2</SUB> production. </LI> <LI> A new reduction mechanism is proposed by interpreting experimental results. </LI> <LI> Sonocatalytic reduction rates of BrO<SUB>3</SUB> <SUP>−</SUP> is much higher than sonolysis or photocatalysis. </LI> <LI> Other anions do not affect the sonocatalytic removal of BrO<SUB>3</SUB> <SUP>−</SUP>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

주야 교대 근무가 편두통에 미치는 영향 : 한림대학교 의료원 간호사 연구 Hallym Medical Center Nurse Study

주민경,유경호,마효일,김윤중,김주용,송흥기,이병철 대한두통연구회 2004 두통 Vol.5 No.1

센서 네트워크용 초소형 OS

송준근,마평수,박승민,Song, Jun-Geun,Ma, Pyeong-Su,Park, Seung-Min 한국통신학회 2007 정보와 통신 Vol.24 No.7

최근 몇 년간 유비쿼터스 서비스를 구현하기 위한 핵심 기술 중 하나인 무선 센서 네트워크에 대한 관심이 높아지고 있다. 무선 센서 네트워크 기술은 물류, 유통, 환경 감시, 홈오토메이션, 군사 분야 등 다양한 분야에 적용 될 수 있기 때문에 앞으로 관련 분야의 시장 또한 커질 것으로 예상되고 있다 [1]. 무선 센서 네트워크는 기존 유선 센서 네트워크나 무선 네트워크 환경과는 많은 차이를 가진다. 우선 극도로 제한된 시스템 자원만을 가질 수 있으며, 열악한 환경 속에서 무선매체를 통해 유기적으로 동작하여야 하는 특징을 가지고 있다. 적게는 수십 개에서 많게는 수백, 수천 개의 자율적인 하드웨어 노드들로 구성되는 무선 센서 네트워크에서 제한된 자원을 효과적으로 활용하기 위해서는 센서 노드에 적합한 운영체제가 필수적으로 요구된다. 지난 몇 년간 센서 노드하드웨어의 발달과 더불어 많은 센서 네트워크용 초소형 운영체제가 개발되어왔다. 현재 많이 알려져 있는 센서 네트워크용 OS로는, 가장 활발한 참여를 보이고 있는 TinyOS[3]부터 SOS[4], MANTIS[5], Contiki[6], T-kernel[7] 등이 있으며, 국내 기술로 개발된 Nano-Qplus[8] 등이 존재한다. 본고에서는 우선 센서 네트워크에 대한 배경 지식과 플랫폼 등에 대한 내용을 간단히 다루고, 본론에서 센서 네트워크용 운영체제가 가져야 할 조건과 현재 개발되어 있는 센서 네트워크 OS들의 특징에 대해 간략히 살펴보도록 하겠다. 또한 센서 네트워크 OS와 밀접한 연관성을 가지는 분야에 대해 간단히 살펴보고, 마지막으로 앞으로의 방향에 대해 알아본다.고려해 볼 때 atlas의 장축의 시계방향 회전은 액티베이터의 사용 효과로 생각되며, 이는 차후 II급 부정교합자에서 액티베이터 치료 효과를 판단하는 또 하나의 지표가 될 수 있다고 생각한다.인해 한반도를 포함한 동아시아 대륙이 태평양판 쪽으로 밀려감으로써 섭입하던 태평양판의 각도가 급해져 동아시아 연변에 강력한 흡입력이 발생하였으며, 이 때문에 태평양판의 운동 방향이 북북서에서 서북서방향으로 회전되었을 가능성이 있다. 따라서 약 51 Ma부터 한반도 동남부에는 지판 경계의 강력한 흡입력으로 동서 내지 서북서-동남동의 인장력이 작동되어 B그룹 암맥군이 관입한 것으로 해석된다.Ledge는 세 군 모두에서 나타나지 않았다. 4. 파일 binding 횟수는 MC군이 가장 적고 PT군이 가장 많았다 (p < 0.05). 이상의 결과를 볼 때, Mtwo 전동 파일을 crown-down technique으로 사용하는 것이 single length technique과 유사한 성형 효율을 보이면서도 더 안전할 것으로 추정된다.고 1명(3%)에서 원격전이를 보였다. 치료 중 급성 합병증으로 11명(37%)에서 RTOG grade 1-2의 장염을 보였으며 1명은 대장의 천공이 발생하여 수술로 치유되었다. 12명(40%)에서 RTOG grade 1-2의 급성 방광염을 보였다. 3명(10%)에서 RTOG grade 1-2의 백혈구 감소증이 보였으며 1명에서 심한 백혈구 감소증(RTOG grade 4)이 나타났으나 회복되어 치료를 완료하였다. 만성 합병증으로 5명(15%)에서 RTOG grade 1-2의 만성 장염을 보였으며 별다른 치료 없이 지내고 있으며

Sulphonated Reduced Graphene Oxide: A High Performance Anode Material for Lithium Ion Battery

Haibo Li,Rui Niu,Sen Liang,Yulong Ma,Min Luo,Jin Li,Lijun He 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.4

In this work, the sulfonated reduced graphene oxide (SRGO) was synthesized and proposed as an enhanced anode material for lithium ion battery (LIB). The result shows that the SRGO has an improved battery performance (i.e., ~341.7 mAh/g and ~190.6 mAh/g corresponds to SRGO and RGO at the 100th cycle with a current density of 200 mA/g) and superior cycling stability compared with pristine reduced graphene oxide (RGO). These are attributed to the improved specific surface area (448.35 m2 /g) and conductivity (2.5 x 10-4 S/m). Further, the SRGO exhibits good rate capability and excellent energy density at various current densities ranging from 50 mAh/g to 2000 mAh/g, suggesting that SRGO could be a promising anode material for high capacity LIB.

A chemically regenerative redox fuel cell using (2,2,6,6-tetramethylpiperidin-1-yl)oxyl redox reaction in acid medium

Han, Sang-Beom,Kwak, Da-Hee,Park, Hyun Suk,Park, Jin-Young,Ma, Kyeng-Bae,Won, Ji-Eun,Kim, Do-Hyoung,Kim, Min-Cheol,Park, Kyung-Won Elsevier 2018 Journal of Power Sources Vol.393 No.-

<P><B>Abstract</B></P> <P>(2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) with no free radical and non-volatile characteristic can be utilized as a liquid catalyst instead of O<SUB>2</SUB> at the cathode in a chemical regenerative redox fuel cell with H<SUB>2</SUB> as a fuel at the anode. In this study, the electrochemical properties and performance of TEMPO dissolved in sulfuric acid solution are investigated using half and unit cells. In the half-cell, TEMPO shows an activation energy of 1.27 kcal mol<SUP>−1</SUP> K<SUP>−1</SUP> for the reduction. A chemical regenerative redox fuel cell (CRRFC) using TEMPO as the liquid catalyst exhibits an open circuit voltage of 0.7 V and a maximum power density of 90 mW cm<SUP>−2</SUP> at 30 °C with a low activation loss. The regeneration cycling test of the CRRFC is performed at a constant voltage of 0.4 V under a flow rate of the oxygen-bubbled TEMPO solution. The performance of the CRRFC deteriorates, i.e., a power density of zero measured at >200 min. Thus, a highly efficient regeneration system needs to be developed for a high-performance CRRFC using TEMPO used as a liquid-type oxidant. Furthermore, stable liquid oxidants with relatively high standard reduction potentials can be proposed through various organic compounds.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CRRFC was proposed using TEMPO instead of O<SUB>2</SUB> at the cathode. </LI> <LI> TEMPO showed fairly fast transport and low activation energy for the reduction. </LI> <LI> CRRFC exhibited an open circuit voltage of ∼0.7 V at 30 °C. </LI> <LI> CRRFC exhibited a maximum power density of ∼90 mW cm<SUP>−2</SUP> at 30 °C. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

신기능과 혈색소의 관계

우학 ( Hak Woo ),신민호 ( Min Ho Shin ),김옥기 ( Ok Ki Kim ),배우균 ( Woo Kyun Bae ),조영욱 ( Young Wook Cho ),이연경 ( Youn Kyoung Lee ),마성권 ( Seong Kwon Ma ),김수완 ( Soo Wan Kim ),김남호 ( Nam Ho Kim ),최기철 ( Ki Chul Choi 대한내과학회 2007 대한내과학회지 Vol.72 No.2

목적: 빈혈은 만성신질환 환자들에서 좌심실비대 등 건강에 여러 가지 악영향을 미치는 중요한 합병증 중의 하나이다. 기저질환에 관계없이 신기능의 악화에 따른 빈혈의 발생빈도, 혈색소 농도와 적혈구용적률의 변화 및 성별에 따른 차이를 알아보기 위해 이 연구를 시행하였다. 방법: 전남대학교병원 내과에서 치료하고 있는 환자들 중 남성 157명, 여성 132명의 의무기록을 후향적으로 분석하였다. MDRD 등식에 따라 추정 사구체여과율을 측정하고, 사구체여과율(GFR)이 90 mL/min/1.73 m2 이상을 기준(정상)으로 하여, 추정 사구체여과율이 10 mL/min/1.73 m2씩 감소함에 따라 9개 군으로 분류하여 기준과 비교하여 평균 혈색소 농도와 적혈구용적률이 통계학적으로 유의하게 감소하는 신기능의 범위를 찾아서 남성과 여성을 각각 비교하였다. 결과: 모든 대상 환자들은 기준치(추정 사구체여과율≥90 mL/min/1.73 m2)에 비해 추정 사구체여과율 50≤GFR<60 mL/min/1.73 m2에서 평균 혈색소 농도는 0.8 g/dL(p=0.021), 적혈구용적률은 2.6%(p=0.011)가 감소하였고, 신기능이 감소함에 따라 평균 혈색소 농도와 적혈구용적률은 더욱 유의하게 감소하였다(Hgb.: r=0.635, Hct.: r=0.640, p<0.001). 남성은 기준치에 비해 추정 사구체여과율 40≤GFR<50 mL/min/1.73 m2에서 평균 혈색소 농도는 1.7 g/dL(p<0.01), 적혈구용적률은 4.4%(p<0.01)가 감소하였고, 신기능이 감소함에 따라 평균 혈색소 농도와 적혈구용적률은 더욱 유의하게 감소하였다(Hgb.: r=0.69 8, Hct.: r=0.689, p<0.001). 여성은 기준치에 비해 추정 사구체여과율 60≤GFR<70 mL/min/1.73 m2에서 평균 혈색소 농도는 0.9 g/dL(p<0.01), 적혈구용적률은 2.8%(p<0.01)가 감소하였고, 신기능이 감소함에 따라 평균 혈색소 농도와 적혈구용적률은 더욱 유의하게 감소하였다(Hgb.: r=0.672, Hct.: r=0.687, p<0.001). 결론: 만성신질환 환자들에서 혈색소 농도와 적혈구용적률은 신기능이 감소함에 따라 점차 감소하였고 이것은 경증 내지 중등도 신기능 감소부터 관찰되었다. Background: The goal of this study is to define the relationship between the decreased renal function and anemia, and also to determine whether this relationship is different in male and female patients. Methods: We conducted a retrospective study of 289 patients (male:female=157:132) who were followed at the department of internal medicine at Chonnam National University Hospital. General linear models were used to analyze the relationship between the hemoglobin concentration and Modification of Diet in the Renal Disease formula estimated Glomerular Filtration Rate (mL/min/1.73 m2). Results: Among all patients, the mean hemoglobin concentration and hematocrit of the men with a Glomerular Filtration Rate of 50~59 mL/min/1.73 m2 was an absolute change of 0.8 g/dL (p=0.021) and it was 2.6% (p=0.011) lower than those of the patients with a Glomerular Filtration Rate≥90 mL/min/1.73 m2 and continued to decrease further as the Glomerular Filtration Rate decreased, respectively (Hgb.: r=0.635, Hct.: r=0.640, all p<0.001). Among the male patients, the mean hemoglobin concentration and the hematocrit of men with a Glomerular Filtration Rate of 40~49 mL/min/1.73 m2 was an absolute change of 1.7 g/dL (p<0.01) and it was 4.4% (p<0.01) lower than those of the male patients with a Glomerular Filtration Rate≥90 mL/min/1.73 m2 and continued decrease as the Glomerular Filtration Rate decreased, respectively (Hgb.: r=0.698, Hct.: r=0.689, all p<0.001). Among the female patients, the mean hemoglobin concentration with a Glomerular Filtration Rate of 60~69 mL/min/1.73 m2 was an absolute change of 0.9 g/dL (p<0.01) and the mean hematocrit was 2.8% (p<0.01) lower than those of the female patients with a Glomerular Filtration Rate ≥90 mL/min/1.73 m2 and continued to decrease further as the Glomerular Filtration Rate decreased, respectively (Hgb.: r=0.672, Hct.: r=0.687, all p<0.001). Conclusions: A decrease in the hemoglobin concentration was statistically significant in the patients of both genders, along with a moderately decreased Glomerular Filtration Rate (≤60 mL/min/1.73 m2). (Korean J Med 72:191-199, 2007)

Prevalence and associations for abnormal bleeding times in patients with renal insufficiency

Kim, Ha Yeon,Oak, Chan Young,Kim, Min Jee,Kim, Chang Seong,Choi, Joon Seok,Bae, Eun Hui,Ma, Seong Kwon,Kim, Soo Wan Informa UK, Ltd. 2013 Platelets Vol.24 No.3

<P>Platelet dysfunction and associated hemorrhagic complications are often encountered in patients with chronic kidney disease. This study aimed to evaluate the prevalence and associations for abnormal bleeding time (BT) in patients with renal dysfunction. Hemoglobin, hematocrit, platelet, blood urea nitrogen, creatinine, and parathyroid hormone levels were determined in 1716 patients (55.18 ± 17.19 years, men 50.8%). For these patients, BTs were estimated using a platelet function analyzer-100. Glomerular filtration rates (GFRs) were estimated using the Chronic Kidney Disease Epidemiology Collaboration equation. The study population was divided into six groups according to the estimated GFR (eGRF): group I, eGFR ≥ 90 ml/min/1.73 m<SUP>2</SUP>; group II, 60 ≤ eGFR < 90 ml/min/1.73 m<SUP>2</SUP>; group III, 30 ≤ eGFR < 60 ml/min/1.73 m<SUP>2</SUP>; group IV, 15 ≤ eGFR < 30 ml/min/1.73 m<SUP>2</SUP>; group V, eGFR < 15 ml/min/1.73 m<SUP>2</SUP>; and group VI, undergoing regular hemodialysis. Renal insufficiency was defined as eGFR < 60 ml/min/1.73 m<SUP>2</SUP>. To further investigate the role of inflammatory cytokines, nitric oxide (NO) and tumor necrosis factor alpha (TNF-&agr;) were measured in a 327-patient subset of the total patient population (52.82 ± 18.3 years, men 60.9%). Abnormal BT occurred in 11.8% of group I, 15.3% of group II, 29.1% of group III, 37.5% of group IV, 35.0% of group V, and 32.1% of group VI. By Pearson correlation coefficient, eGFR (<I>r</I> = −0.089), hemoglobin (<I>r</I> = −0.127), platelet (<I>r</I> = −0.054) were correlated with BT. Multivariate analysis revealed that age [odds ratio (OR), 1.013; 95% CI, 1.004-1.022], renal insufficiency (eGFR < 60 ml/min/1.73 m<SUP>2</SUP>; OR, 2.271; 95% CI, 1.672-3.083), anemia (hemoglobin < 120 g/l; OR, 1.486; 95% CI, 1.089-2.027), and thrombocytopenia (platelet < 150 × 10<SUP>9</SUP>/l; OR, 1.445; 95% CI, 1.089-1.918) were independently associated with prolonged BT. Plasma levels of NO and TNF-&agr; were increased in patients with renal insufficiency (eGFR < 60 ml/min/1.73 m<SUP>2</SUP>). Plasma levels of NO in renal insufficiency group were higher in prolonged BT than those in normal BT. A significant positive correlation was noted between BTs and NO levels (<I>r</I> = 0.152, <I>p</I> = 0.009) but not with TNF-&agr; levels. The prevalence of abnormal BTs was higher as eGFR declined. Old age, renal insufficiency, anemia, and thrombocytopenia were independent associations for abnormal BT.</P>

Covalent Immobilization of Penicillin G Acylase onto Fe₃O₄@Chitosan Magnetic Nanoparticles

( Xiao Min Ling ),( Xiang Yu Wang ),( Ping Ma ),( Yi Yang ),( Jie Mei Qin ),( Xue Jun Zhang ),( Ye Wang Zhang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.5

Penicillin G acylase (PGA) was immobilized on magnetic Fe₃O₄@chitosan nanoparticles through the Schiff base reaction. The immobilization conditions were optimized as follows: enzyme/support 8.8 mg/g, pH 6.0, time 40 min, and temperature 25℃. Under these conditions, a high immobilization efficiency of 75% and a protein loading of 6.2 mg/g-support were obtained. Broader working pH and higher thermostability were achieved by the immobilization. In addition, the immobilized PGA retained 75% initial activity after ten cycles. Kinetic parameters Vmax and Km of the free and immobilized PGAs were determined as 0.113 mmol/min/mg-protein and 0.059 mmol/min/mg-protein, and 0.68 mM and 1.19 mM, respectively. Synthesis of amoxicillin with the immobilized PGA was carried out in 40% ethylene glycol at 25℃ and a conversion of 72% was obtained. These results showed that the immobilization of PGA onto magnetic chitosan nanoparticles is an efficient and simple way for preparation of stable PGA.

Electromagnetically-induced transparency and slow light in GaAs/AlGaAs multiple quantum wells in a transient regime.

Ma, Seong-Min,Xu, Hua,Ham, Byoung Seung Optical Society of America 2009 Optics express Vol.17 No.17

<P>Electromagnetically-induced transparency (EIT) is observed and analyzed for the group velocity of a femtosecond light pulse interacting with GaAs/AlGaAs multiple quantum wells (MQWs) in a transient regime. The calculated slowdown factor of the group velocity inside the medium due to the dynamic refractive index change is approximately 2.10 x 10(3). We discuss the potential of EIT-induced slow light in GaAs/AlGaAs MQWs for ultrafast (approximately 210 GHz) all-optical information processing such as photon routing.</P>