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Helix Beam Model of a Coil Spring Including Twisting Effect to Capture Lateral Deformation
김현우,장진석,유완석,Oleg Dmitrochenko,Aki Mikkola 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
A coil spring is a widely used mechanical component to store and release energy in mechanical systems. Although the potential energy of a coil spring is related mainly to longitudinal deformation, lateral deformation occurs frequently due to the eccentricity of the applied loads. Most studies focused on numerical modeling of a coil spring just for longitudinal deformation and compared the numerical results with experiments. In this paper, the twisting effect was newly included in the helix beam element to capture lateral deformation. The computational results obtained from the numerical derivation were compared with the experimental results, which were measured using a high speed camera. To calculate the deformation of a coil spring, 36 cases of static deformation were measured by loading 7 additional masses. The modeling of a coil spring was derived by adding a twisting effect term to a helix beam element formulation, and the contribution of the twisting effect was verified. The properties of a coil spring used in the numerical simulation were obtained from the experimental data.
Patient utilization survey of mirabegron prescribed for overactive bladder
Päivi Rahkola-Soisalo,Marcin Balcerzak,Jarno Ruotsalainen,Tomi S. Mikkola 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.2
Purpose: Mirabegron, a β3-adrenoreceptor agonist, is used to treat overactive bladder. The factors affecting persistence of mirabegron use or symptom improvement are not thoroughly known, but could be related to patient characteristics. Therefore, we evaluated persistence of medication use, symptom improvement, and quality of life among Finnish mirabegron users. In addition, we assessed possible predictors of change in these variables. Materials and Methods: Participants (52 men, 118 women) with an initial mirabegron prescription were recruited nationwide from 79 pharmacies. Volunteers were interviewed at baseline and after 6 months. Subject and clinical characteristics, symptom severity, and quality of life (EQ-5D-5L) were assessed using a visual analogue scale. Results: Of 170 participants, 144 (84.7%) were reached after 6 months. The rate of persistent mirabegron use was 50.7%. Experiencing adverse effects (29.6%) was the most common reason for discontinuation of medication. A primary health care unit as a prescription site (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.03–4.9) was associated with increased risk for discontinuation. Mirabegron relieved symptoms in 45.2% and enhanced quality of life in 41.7% of the participants. Age <64 years was associated with better probability of symptom improvement (OR, 2.7; 95% CI, 1.1–6.8), whereas none of the other parameters assessed predicted change in quality of life. Conclusions: In this Finnish population, 50.7% of the participants continued using mirabegron after 6 months. The prescription site seemed to be important for persistent use, which may be related to patient counseling. Younger patients were more likely to benefit from treatment with mirabegron.
Fink, Stephen P,Yang, Dong-Hoon,Barnholtz-Sloan, Jill S,Ryu, Yeon-Mi,Mikkola, Debra,Potter, John D,Lampe, Johanna W,Markowitz, Sanford D,Myung, Seung-Jae Plenum Pub. Corp.] 2013 Digestive diseases and sciences Vol.58 No.9
<P>15-Hydroxprostaglandin dehydrogenase (15-PGDH) mediates a colon neoplasia suppressor pathway, acting through metabolic antagonism of cyclooxygenase-mediated colon carcinogenesis. To determine whether the colon tumor prevention activity of 15-PGDH acts as a constant or variable effect among individuals, we determined whether 15-PGDH levels remain stable over subsite and time in the human colon, determined the extent of differences in 15-PGDH levels between different individuals, and determined whether 15-PGDH modulation mediates any part of the anti-colon tumor effect of aspirin.</P>