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Miki, Daiki,Kubo, Michiaki,Takahashi, Atsushi,Yoon, Kyong-Ah,Kim, Jeongseon,Lee, Geon Kook,Zo, Jae Ill,Lee, Jin Soo,Hosono, Naoya,Morizono, Takashi,Tsunoda, Tatsuhiko,Kamatani, Naoyuki,Chayama, Kazuak Nature Publishing Group, a division of Macmillan P 2010 Nature genetics Vol.42 No.10
Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 ? 10<SUP>??11</SUP>, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 ? 10<SUP>??12</SUP>, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.
A Pilot Study Exploring the Effects of Reflexology on Cold Intolerance
Wenping Zhang,Shougo Takahashi,Takashi Miki,Hisayo Fujieda,Torao Ishida 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.1
Cold intolerance is an inability to tolerate cold temperatures and is accompanied by symptoms including headache, shoulder discomfort, dizziness and palpitations. The current study was performed to examine whether reflexology therapy affected cold intolerance in human subjects and whether the treatment was systemically effective. Ten female volunteer examinees with subjective feelings of cold were examined. After a 5-minute foot bath, 10 minutes of reflexology therapy was performed on their left foot. Skin temperature and blood flow were estimated before and after treatment, together with an interview concerning their feelings of cold and daily habits. In addition, how the recovery rate was affected by the application of a chilled-water load was also estimated. Along with significant increases in skin temperature and blood flow compared with pre-treatment at the bilateral points of KI-1, LR-3, and BL-60, a faster recovery after the application of the chilled-water load was also seen in the lower limbs on both sides. From these results, we conclude that reflexology has systemic effects and is an alternative method for treating cold intolerance.