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      • KCI등재

        The Interaction Effects of Language Proficiency and Language Analytic Ability on Explicit Deductive and Inductive Grammar Instruction

        Miki Satori 아시아테플 2024 The Journal of Asia TEFL Vol.21 No.1

        This study explored which type of explicit instruction (explicit-deductive or explicit-inductive) was more effective for Japanese EFL learners across different proficiency levels and examined the role of language analytic ability (LAA) in L2 proficiency and learning outcomes. This study also investigated how individual differences in LAA mediated the effects of these two types of explicit instructional approaches. The participants were 82 late learners of English as a foreign language (EFL). They completed a subtest of an aptitude test and a form-focused sentence correction test to measure their resulting performance. The results indicated that explicit-deductive grammar instruction might be more beneficial than explicit-inductive instruction for Japanese EFL learners with low proficiency. LAA had a positive effect on L2 proficiency, but the effects of individual differences in LAA on instructional outcomes were neutralised by more structured explicit grammar instruction in the case of Japanese EFL learners. Follow-up analyses showed that the interaction effect of LAA with explicit-deductive instruction was significant in the low-LAA group. This study highlights the importance of considering the interaction among LAA, language proficiency, and instructional conditions in the design of the most effective learning activities in Japanese EFL classrooms.

      • KCI등재

        Modern Japanese Helenas in a Metropolitan Courtyard

        Miki Iwata 한국셰익스피어학회 2014 셰익스피어 비평 Vol.50 No.5

        Riku Onda’s An Incident in the Courtyard (2006) is a contemporary Japanese hybrid-genre novel partly based on William Shakespeare’s A Midsummer Night’s Dream. Though the novel has a complex narrative structure, it mainly deals with three actresses in their competition for the role of Helena in A Midsummer Night’s Dream, who are involved in the death of its director, Kamiya. Through their struggle to express themselves and a metafictional intervention of a Puck-like figure, Tomoe, with them, the work explores how a relatively minor character in the Bard’s comedy can reflect gender problems seen in the early-modern as well as the contemporary world. Tomoe is a commentator of an unfinished draught of a playwright, Akira (the three actresses are characters in his play). She is associated with the half-legendary Japanese Amazonian warrior, Tomoe Gozen, which adds a new twist to the shadow of the Amazonian subjugation to the marriage institution in A Midsummer Night’s Dream. Tomoe is an Amazon, but she is not a Hippolyta but a Puck in Onda’s work. As a cross-bordering trickster, she checks her male friend’s manuscript which attributes the cause of the murder to the three actresses’ stereotypically female passions, and helps the Helenas speak out that they perform what (male) audience would like them to do ? that they are creature of the male discourse. The change of the key number 4 (a symbol of concord and of marriage) in the original play to two odd numbers, 3 and 1, in the novel also contributes to undermine the heterosexual marriage imperatives which critics traditionally have connected with A Midsummer Night’s Dream. However, recent queer studies argue that heterosexual marriage in the play is achieved not by rectification but by distortion, highlighting its impossibility. Onda’s novel also seeks an alternative ending other than heterosexual matrimony. Akira’s play remains unfinished so that Tomoe speaks the epilogue of this open-ended work, demonstrating that a story in which a newly-married husband is killed can end happily without any excuse, and the attempt is not a refutation of the original, but an approval of the play’s potential subversion of the patriarchal marriage institution. An Incident in the Courtyard shows us, as all good adaptations do, how we can read A Midsummer Night’s Dream from the contemporary point of view.

      • KCI등재

        Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity

        Miki Okada-Iwabu,Masato Iwabu,Kohjiro Ueki,Toshimasa Yamauchi,Takashi Kadowaki 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.5

        Obesity associated with unhealthy diet and lack of exercise is shown to contribute to the onset and/or aggravation of the metabolic syndrome and diabetes, thus placing affected individuals at increased risk of cardiovascular disease and cancer. Plasma adiponectin levels are decreased in obesity, which causes insulin resistance and diabetes. Therefore, we identified adiponectin receptors (AdipoRs) as the therapeutic target. It was suggested that, similarly to caloric restriction and exercise, activation of the AdipoRs may have the potential not only to improve lifestyle-related diseases but to contribute to prolonged the shortened lifespan on a high caloric unhealthy diet. To this end, we have identified “AdipoRon” as an adiponectin receptor agonist. Indeed, AdipoRon ameliorated diabetes associated with obesity as well as to increase exercise endurance, thus prolonging shortened lifespan of obese mice fed on a high fat diet. Additionally, we have recently determined the crystal structures of the human AdipoRs. The seven-transmembrane helices of AdipoRs are structurally distinct from those of G-protein coupled receptors. It is expected that these findings will contribute not only to the elucidation of the AdipoR-related signal transduction but to the development and optimization of AdipoR-targeted therapeutics for obesity-related diseases such as diabetes.

      • KCI등재후보

        Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene

        Miki Fujimura,Shinya Sonobe,Yasuo Nishijima,Kuniyasu Niizuma,Hiroyuki Sakata,Shigeo Kure,Teiji Tominaga 대한뇌졸중학회 2014 Journal of stroke Vol.16 No.2

        Moyamoya disease is characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its etiology is still unknown, recent genome-wide and locus-specific association studies identified RNF213 as an important susceptibility gene of moyamoya disease among East Asian population. A polymorphism in c.14576G>A in RNF213 was identified in 95% of familial patients with moyamoya disease and 79% of sporadic cases, and patients having this polymorphism were found to have significantly earlier disease onset and a more severe form of moyamoya disease, such as the presentation of cerebral infarction and posterior cerebral artery stenosis. The exact mechanism by which the RNF213 abnormality relates to moyamoya disease remains unknown, while recent reports using genetically engineered mice lacking RNF213 by homologous recombination provide new insight for the pathogenesis of this rare entity. Regarding biomarkers of moyamoya disease, moyamoya disease is characterized by an increased expression of angiogenic factors and pro-inflammatory molecules such as vascular endothelial growth factors and matrix metalloproteinase-9, which may partly explain its clinical manifestations of the pathologic angiogenesis, spontaneous hemorrhage, and higher incidence of cerebral hyperperfusion after revascularization surgery. More recently, blockade of these pro-inflammatory molecules during perioperative period is attempted to reduce the potential risk of surgical complication including cerebral hyperperfusion syndrome. In this review article, we focus on the genetics and biomarkers of moyamoya disease, and sought to discuss their clinical implication.

      • KCI등재
      • Development of Technology for Determining Rice Amylose Content using Near-infrared Spectroscopy

        ( Miki Matsuo ),( Shuso Kawamura ),( Mizuki Kato ),( Edenio Olivares Diaz ),( Shigenobu Koseki ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        Rice is staple food for people in the large part of the world, especially in Asian countries. The major chemical constituent contents of rice are moisture, protein and starch (amylose and amylopectin). Those chemical constituents associate with eating quality of rice. Near-infrared (NIR) spectroscopy is one of the non-destructive methods for determining grain chemical contents. Moisture and protein contents can be measured with high accuracy using NIR spectrometer at rice grain elevator in Japan. However, the accuracy to measure amylose content is not sufficient. Thus, there is a strong need for the highly accurate measurement of rice amylose content using non-destructive method. The overall objective of this study was to develop non-destructive techniques to determine rice amylose content for practical use at rice grain elevator. Amylose content measurement was performed using an auto-analyzer for reference (chemical) analysis. Spectra data of rice were obtained using an NIR spectrometer with a wavelength range of 850 to 1048 nm. Calibration model to determine amylose content was developed using non-waxy Japonica-type rice samples (calibration set, n=974, including 14 cultivars) grown in Japan from 2008 to 2016. Partial least squares (PLS) regression analysis was used to develop calibration model. The accuracy of the model was validated using other rice samples (validation set, n=95, including 10 cultivars) grown in 2017. There are two cultivar groups of non-waxy Japonica-type rice produced in Japan. One is ordinary amylose content rice cultivar and the other is low amylose content rice cultivar. The accuracy of determination of rice amylose content was improved by increasing production years of calibration sample set. When one calibration model to determine amylose content was developed using all cultivars together, validation statistics were shown: coefficient of determination (r<sup>2</sup>) was 0.72, bias was -0.04%, standard error of prediction (SEP) was 0.92%, and ratio of SEP to standard deviation of reference data (RPD) was 1.90. To improve the accuracy of determination of rice amylose content, two calibration models were developed using ordinary amylose content rice cultivars or low amylose content rice cultivars, respectively. As a result, the accuracy of two calibration models was better than that of one calibration model. Validation statistics of the two calibration models were shown: coefficient of determination (r<sup>2</sup>) was 0.93, bias was 0.01%, standard error of prediction (SEP) was 0.64%, and ratio SEP to standard deviation of reference data (RPD) was 2.76. The production year of validation set (2017) was different from those of calibration set (2008 to 2016). This is the same condition as practical use of this non-destructive method at rice grain elevator. The result obtained in this study indicated that the two calibration models enables non-destructive determination of rice amylose content at rice grain elevator.

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