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Spectral type and geometric albedo of (98943) 2001 CC21, the Hayabusa2# mission target
Jooyeon Geem,Masateru Ishiguro,Mikae,Granvik,Hiroyuki Naito,Hiroshi Akitaya,Tomohiko Sekiguchi,Sunao Hasegawa,Daisuke Kuroda,Tatsuharu Oono,Yoonsoo P. Bach,Sunho Jin,Rio Imazawa,Kaji S. Kawabata,Seiko 한국천문학회 2023 天文學會報 Vol.48 No.2
Han, Mi-Ryung,Zheng, Wei,Cai, Qiuyin,Gao, Yu-Tang,Zheng, Ying,Bolla, Manjeet K.,Michailidou, Kyriaki,Dennis, Joe,Wang, Qin,Dunning, Alison M.,Brennan, Paul,Chen, Shou-Tung,Choi, Ji-Yeob,Hartman, Mikae Oxford University Press 2017 Carcinogenesis Vol.38 No.5
<P>Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK11 and CDH1 and moderate-penetrance mutations in genes CHEK2, ATM, BRIP1, PALB2, RAD51C, RAD50 and NBN have been identified for breast cancer. In this study, we investigated whether there are additional variants in these 13 genes associated with breast cancer among women of Asian ancestry. We analyzed up to 654 single nucleotide polymorphisms (SNPs) from 6269 cases and 6624 controls of Asian descent included in the Breast Cancer Association Consortium (BCAC), and up to 236 SNPs from 5794 cases and 5529 controls included in the Shanghai Breast Cancer Genetics Study (SBCGS). We found three missense variants with minor allele frequency (MAF) < 0.05: rs80358978 (Gly2508Ser), rs80359065 (Lys2729Asn) and rs11571653 (Met784Val) in the BRCA2 gene, showing statistically significant associations with breast cancer risk, with P-values of 1.2 x 10(-4), 1.0 x 10(-3) and 5.0 x 10(-3), respectively. In addition, we found four low-frequency variants (rs8176085, rs799923, rs8176173 and rs8176258) in the BRCA1 gene, one common variant in the CHEK2 gene (rs9620817), and one common variant in the PALB2 gene (rs13330119) associated with breast cancer risk at P < 0.01. Our study identified several new risk variants in BRCA1, BRCA2, CHEK2, and PALB2 genes in relation to breast cancer risk in Asian women. These results provide further insights that, in addition to the high/moderate penetrance mutations, other low-penetrance variants in these genes may also contribute to breast cancer risk.</P>
Charlyne Brakta,Alain Stépanian,Peggy Reiner,Maxime Delrue,Mikaël Mazighi,Emmanuel Curis,Virginie Siguret 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1
Background and Purpose In patients with acute ischemic stroke (AIS) using a direct oral factor-Xa anticoagulant (DOAC) during the last 48 hours, a fixed plasma heparin-calibrated anti-Xa activity (0.5 IU/mL) was proposed as a threshold below which patients could be eligible for thrombolysis and/or thrombectomy. Besides, specific DOAC-calibrated anti-Xa thresholds up to 50 ng/mL have been proposed. However, specific DOAC assays are not widely available contrarily to low-molecularweight heparin (LMWH) anti-Xa activity. We developed and validated a nomogram for predicting apixaban and rivaroxaban concentrations based on LMWH anti-Xa assay. Methods Our prospective study included apixaban (n=325) and rivaroxaban (n=276) patients. On the same sample, we systematically measured specific DOAC concentration and LMWH anti-Xa activity, using STA®-Liquid-Anti-Xa (Stago) and specific DOAC- or LMWH-calibrators, respectively. The nomogram was built using quantifiable values for both assays on the derivation cohorts with a log-linear regression model. Model performances including sensitivity, specificity, and true positive rate for different thresholds were checked on the validation cohorts. Results The models built from the derivation cohorts predicted that values <30 ng/mL and <50 ng/ mL DOAC thresholds corresponded to LMWH-anti-Xa values <0.10 IU/mL and <0.64 IU/mL for apixaban; <0.10 IU/mL and <0.71 IU/mL for rivaroxaban. The model accurately predicted apixaban/ rivaroxaban concentrations in the validation cohort. Conclusions This easy-to-use nomogram, developed with our reagent, allowed accurately predicting DOAC concentrations based on LMWH-anti-Xa results in emergency situations such as AIS when drug-specific assessments are not rapidly available. Using DOAC <50 ng/mL equivalent threshold, instead of the fixed LMWH <0.5 IU/mL one, would allow proposing thrombolysis to more patients.
Mika Okura 한국간호과학회 2019 Asian Nursing Research Vol.13 No.4
Purpose: It is extremely difficult to apply the model learned in basic education for public health nurses (PHNs) to conduct community health assessments. The purpose of this study was to clarify the process by which community health needs can be structured through PHNs’ daily practice. Methods: Semistructured interviews were conducted in 29 PHNs, and continuous comparative analysis using a qualitative study was performed with a modified grounded theory approach. Results: The participants “used their five senses to understand the relationship between the health and life of people” and “considered those who do not attend” by “learning from stakeholders.” To verify such subjective feelings sourced from vague phenomena within the communities, subjective phenomena were converted into qualitative data. Conclusion: The application of the findings to organizational continuous education systems may not only help appropriately improve community health assessment methods but can also help improve the evaluation of daily practice and contribute to professional human-resource development.
Mika Liukkonen,Clas-Håkan Nygård,Raija Laukkanen 한국산업안전보건공단 산업안전보건연구원 2017 Safety and health at work Vol.8 No.4
It has been suggested that engaging technology can empower individuals to be more proactive about their health and reduce their health risks. The aim of the present intervention was to study the effects of technology-aided testing and feedback on physical activity and biological age of employees in a middle-sized enterprise. In all, 121 employees (mean age 42?±?10 years) participated in the 12-month three-arm cluster randomized trial. The fitness measurement process (Body Age) determined the participants’ biological age in years. Physical activity was measured with the International Physical Activity Questionnaire Short Form. Physical activity did not change during the intervention. Biological age (better fitness) improved in all groups statistically significantly (p?<?0.001), but with no interaction effects. The mean changes (years) in the groups were??2.20 for the controls, ?2.83 for the group receiving their biological age and feedback, and??2.31 for the group receiving their biological age, feedback, and a training computer. Technology-aided testing with feedback does not seem to change the amount of physical activity but may enhance physical fitness measured by biological age.
( Mika Aotake ) 아세아여성법학연구소 2010 아세아여성법학 Vol.13 No.-
This paper examines the reason why we can succeed to a deceased person`s estate according to the law of succession. According to Japanese theory, there are four reasons of succession- a deceased persons` will, maintenance of surviving family, substantial share of estate, and equality among members of the family . Each reason has been criticized , for example , maintenance of surviving family is not the role of succession but of social security system. In conclusion, maintenance of surviving family and substantial share of estate are the most persuasive reasons of succesion in present society. Maintenance of surviving family by succession means supplement of inadequate social security system, and getting substantial share of estate by succession means to secure the property of the member of family.