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( Miju Cho ),( Hyeri Lee ),( Min Hee Hwang ),( Young-keun Cheong ),( Chon-sik Kang ),( Nam Taek Lee ),( Namhyun Chung ) 한국응용생명화학회 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.1
Although wheat is a common staple food in the world, some people suffer from a variety of wheat allergies. For example, wheat-dependent exercise-induced anaphylaxis is induced in the gastrointestinal tract by wheat proteins. Relatively high molecular weight proteins that are salt-insoluble induce many wheat allergies. In the present study, we investigated the induction of an allergy response using crude wheat proteins, which are relatively low molecular weight, salt-soluble proteins. The crude antigen used in this study was extracted using phosphate buffered saline. When the antigen extracts from various wheat cultivars were orally administered, differentiable degrees of allergy responses were observed as measured by serum IgE and histamine secretion compared to the control. Serum IgE levels increased following administration of three of the wheat extracts. This evidence suggests that a combination of salt-soluble wheat proteins could be antigens for the induction of various allergy responses.
Eye and skin irritation tests to assess the safety of Jeju saline groundwater
( Miju Cho ),( Yong Hoon Joo ),( Young Sig Park ),( Namhyun Chung ) 한국응용생명화학회(구 한국농화학회) 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.3
Saline groundwater was obtained from a 100-m deep basalt layer into which seawater had infiltrated. This groundwater is known to contain various minerals. Like deep seawater, saline groundwater is expected to have various applications due to the presence of biologically beneficial minerals. In Korea, saline groundwater is mainly obtained from the coastal area of Jeju. Before applying saline groundwater to various products, however, its biological safety needs to be examined. In the present study, skin and eye irritation tests were performed to assess the safety of saline groundwater according to the guidelines of the Korea Food and Drug Administration. When compared to control, Jeju saline groundwater showed no level of eye and skin irritation. These results suggest that Jeju saline groundwater induces no irritation, and is therefore sufficiently safe to be applied to the eye and skin of people.
Precessing Jet and Large Dust Grains in the V380 Ori NE Star-forming Region
Choi, Minho,Kang, Miju,Lee, Jeong-Eun,Tatematsu, Ken’ichi,Kang, Sung-Ju,Sayers, Jack,Evans II, Neal J.,Cho, Jungyeon,Kwon, Jungmi,Park, Geumsook,Ohashi, Satoshi,Yoo, Hyunju,Lee, Youngung American Astronomical Society 2017 The Astrophysical journal, Supplement series Vol.232 No.2
<P>The V380 Ori NE bipolar outflow was imaged in the SiO and CO J = 1 -> 0lines, and dense cores in L1641 were observed in the 2.0-0.89 mm continuum. The highly collimated SiO jet shows point-symmetric oscillation patterns in both position and velocity, which suggests that the jet axis is precessing and the driving source may belong to a non-coplanar binary system. By considering the position and velocity variabilities together, accurate jet parameters were derived. The protostellar system is viewed nearly edge-on, and the jet has a flow speed of similar to 35 km s(-1) and a precession period of similar to 1600 years. The CO outflow length gives a dynamical timescale of similar to 6300 years, and the protostar must be extremely young. The inferred binary separation of 6-70 au implies that this protobinary system may have been formed through the disk instability process. The continuum spectra of L1641 dense cores indicate that the emission comes from dust, and the fits with modified blackbody functions give emissivity power indices of beta= 0.3-2.2. The emissivity index shows a positive correlation with the molecular line width, but no strong correlation with bolometric luminosity or temperature. V380 Ori NE has a particularly low value of beta= 0.3, which tentatively suggests the presence of millimeter-sized dust grains. Because the dust growth takes millions of years, much longer than the protostellar age, this core may have produced large grains in the starless core stage. HH 34 MMS and HH 147 MMS also have low emissivity indices.</P>
Single- and repeated-dose oral toxicity tests of deep sea water mineral extracts in ICR mice
( Min Hee Hwang ),( Miju Cho ),( Dong Gun Lee ),( Eun Byeol Go ),( Young Sig Park ),( Namhyun Chung ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.3
Deep sea water (DSW) is located 100 to 500 m below the sea surface. DSW is widely used in various fields, and is an important source of minerals that can be used to treat mineral deficiency. In the present study, the oral toxicity of DSW-mineral extracts was determined using single-dose and 14-day repeated dose oral toxicity tests in ICR mice. For the single-dose oral toxicity tests, mineral extracts of magnesium (Mg) and calcium (Ca) at doses of 0, 6, 270, 810, and 1,350 mg/kg, respectively, were orally administered to mice once at the beginning of the experiment, and the mice were observed for 14 days. For the 14- day repeated dose oral toxicity tests, Mg and Ca mineral extracts at doses of 0, 3, 135, 405, 675 mg/kg, respectively, were orally administered to mice daily, and the mice were observed for 14 days. Various tests were performed including visual observation; analysis of relative organ weight, food intake, and organ weight; biochemical analysis, and histopathology. The results indicated that mortality and changes in appearance were not observed among differentially administered groups of male and female ICR mice during the experimental period. Differences in body weight gain, food intake, organ weight, and histopathology parameters were not significant between the control and mineral-administered groups. Some results of the biochemical analyses were significantly different, but showed no specific tendencies. Overall, no evidence of toxicity was observed from the oral administration of DSW extracts of Ca and Mg in ICR mice.
Eye and skin irritation tests using deep sea water-extracted minerals
( Yong Hoon Joo ),( Miju Cho ),( Do Hun Lee ),( Young Sig Park ),( Namhyun Chung ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.3
Deep sea water (DSW) contains many inorganic materials and minerals, which are extracted for use in diverse fields. However, before application, safety tests should be performed. In the present study, two DSW-extracted minerals were analyzed: calcium (Ca) and magnesium (Mg). Eye and skin irritation tests of DSW-extracted Ca and Mg were performed according to the guidelines of the Ministry of Food and Drug Safety of Korea. These two types of mineral extracts caused no symptoms of eye and skin irritation when compared to the control. These results suggest that DSW-extracted minerals caused no irritation in the eyes and on the skin, and could be safely applied to these areas.