Biolite: A Patented Ultra-Low-Level Laser-Therapy Device for Treating Musculoskeletal Pain and Associated Impairments

Michele Gallamini,Giovanni D’Angelo,Gabriele Belloni 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.4

After an excursus on state-of-the-art knowledge for low-level laser therapy (LLLT), Biolite, a patented ultra-low-level laser therapy device used to treat musculoskeletal pain and associated impairments, is presented. The application protocols include short stimulation of sequences of acupuncture points. The observed effects seem, however, to be far from those that might be expected after acupuncture. The primary effect seems more likely to be an extracellular soft-tissue matrix reaction. The development of the technique, the studies performed, and the evidence collected over > 10 years suggest that specifically modulated laser light can interact with human tissues at light fluences well under those previously considered as being capable of having any effect. Musculoskeletal pain very often becomes an autonomous dysfunction that is independent of the original injury and that can be effectively treated using specific peripheral acupuncture-like stimulation. Because such acupuncture is capable of reducing motor control “interferences” from noxious stimuli, it can improve motor control performance, thereby reducing the risk of falls in the elderly individuals. The proposal of acupuncture-derived protocols to be applied by Western physiotherapists using an ultra-low-level laser therapy device is a further “bridge” between two different, and sometimes very different, clinical worlds to better serve our patients.

Functional Outcome after Reimplantation in Patients Treated with and without an Antibiotic-Loaded Cement Spacers for Hip Prosthetic Joint Infections

Michele Fiore,Claudia Rondinella,Azzurra Paolucci,Lorenzo Morante,Massimiliano De Paolis,Andrea Sambri 대한고관절학회 2023 Hip and Pelvis Vol.35 No.1

Purpose: A staged revision with placement of a temporary antibiotic-loaded cement spacer after removal of the implant is the “gold standard” for treatment of chronic prosthetic joint infection (PJI). It enables local delivery of antibiotics, maintenance of limb-length and mobility, easier reimplantation. However, bacterial colonization of spacers and mechanical complications can also occur. The aim of this study is to evaluate functional results and infection control in two-stage treatment of total hip arthroplasty (THA) PJI with and without a spacer. Materials and Methods: A retrospective review of 64 consecutive patients was conducted: 34 underwent twostage revision using a cement spacer (group A), 30 underwent two-stage revision without a spacer (group B). At the final follow-up, functional evaluation of patients with a THA in site, without PJI recurrence, was performed using the Harris hip score (HHS). Measurement of limb-length and off-set discrepancies was performed using anteroposterior pelvic X-rays. Results: Most patients in group B were older with more comorbidities preoperatively. Thirty-three patients (97.1%) in group A underwent THA reimplantation versus 22 patients (73.3%) in group B (P<0.001). No significant differences in limb-length and off-set were observed. The results of functional evaluation performed during the final follow-up (mean, 41 months) showed better function in patients in group A (mean HHS, 76.3 vs. 55.9;P<0.001). Conclusion: The use of antibiotic-loaded cement spacer seems superior in terms of functional outcomes and reimplantation rate. Resection arthroplasty might be reserved as a first-stage procedure in patients who are unfit, who might benefit from a definitive procedure.

Immunostaining patterns reveal potential morphogenetic role of Toll-like receptors 4 and 7 in the development of mouse respiratory system, liver and pancreas

Michele Sommariva,Marco Busnelli,Elena Menegola,Francesca Di Renzo,Serena Indino,Alessandra Menon,Isabella Barajon,Francesca Arnaboldi 대한해부학회 2023 Anatomy & Cell Biology Vol.56 No.2

Toll-like receptors (TLRs) are the mammalian ortholog of Drosophila melanogaster protein Toll, originallyidentified for its involvement in embryonic development. In mammals, TLRs are mainly known for their ability to recognize pathogen- or damage-associated molecular patterns and, consequently, to initiate the immune response. However, it is becoming clear that TLRs can play a role also in mammal embryo development. We have previously described TLR4 and TLR7 expression in developing mouse peripheral nervous system and gastrointestinal tract. In the present study, we extended the investigation of TLR4 and TLR7 to the respiratory system and to the two main accessory organs of the digestive system, the liver and pancreas. TLR4 and TLR7 immunostaining was performed on mouse conceptuses collected at different stages, from E12 to E18. TLR4 and TLR7 immunoreactivity was evident in the embryo pancreas and liver at E12, while, in therespiratory apparatus, appeared at E14 and E17, respectively. Although further studies are required to elucidate the specific role of these TLRs in embryo development, the differential spatiotemporal TLR4 and TLR7 appearance may suggest that TLR expression in developing embryos is highly regulated for a possible their direct involvement in the formation of the organs and in the acquisition of immune-related features in preparation for the birth.

フランスの民話

Michele Simonsen,?口淳(번역자),?口仁枝(번역자) 비교민속학회 1989 비교민속학 Vol.4 No.-

Remembering How: Language, Memory, and the Salience of Manner

( Michele I Feist ),( Paula Cifuentes Ferez ) 서울대학교 인지과학연구소 2013 Journal of Cognitive Science Vol.14 No.4

Inspired by Talmy`s (1985, 2000) seminal work on the lexicalization of motion events, the linguistic encoding of elements of motion events has been an active area of research. Recently, Slobin (2003, 2004, 2006) refined Talmy`s typology, pointing out the differential salience of manner of motion across languages. Among the potential cognitive consequences of this differential salience of manner, Slobin (2003) postulates that manner might be more memorable for speakers of high-manner-salient languages than for speakers of low-manner-salient languages. In this paper, we take up this suggestion, asking whether English speakers and Spanish speakers will show different patterns of errors in a test of recognition for short video clips of motion events, consistent with the Linguistic Relativity Hypothesis. We observed that English speakers produced fewer errors overall, and fewer errors in responses to previously unseen items. Responses to previously viewed items revealed a more subtle effect, with the number of videos viewed at study playing a role in the language effect: English speakers made fewer errors on previously viewed items when they had seen fewer items at study, while Spanish speakers made fewer errors when they had seen more items at study. We discuss the implications of these findings for the Linguistic Relativity Hypothesis and for the role of manner salience in memory for motion events.

Chinese Classics in Matteo Ricci’s 天主实义 and its reception in Korea

Michele Ferrero 고려대학교 한자한문연구소 2010 동아한학연구 Vol.- No.6

Matteo Ricci’s (利?? 1552-1610) 天主?? (“The true meaning of the Lord of Heaven”) is “an unrivalled example of meeting between Chinese Classics and Christianity” but also marks the beginning of the acceptance of Christianity in Korea. Yi Su-gwang known as Jibong (1563-1628), one of the leading figures of the time, introduced in Korea both Western and Catholic knowledge, through the mediation of the Confucian Chinese books of Matteo Ricci and his friends. The 天主?? was explicitly written in dialogue with Confucianism and all the main topics of the treatise are presented in connection with the Chinese Classics: the existence of God; the human soul; the debate whether the soul is some energy or it is spirit; the issue of reincarnation; the cultivation of moral virtue; the connection between actions, intention and reward; the goodness of human nature.

Cyclic presentations of groups and cyclicbranched coverings of (1,1)-knots

Michele Mulazzani 대한수학회 2003 대한수학회보 Vol.40 No.1

In this paper we study the connections between cyclicpresentations of groups and cyclic branched coverings of (1,1)-knots. In particular, we prove that every n-oldstrongly-cyclic branched covering of a (1,1)-knot admits acyclic presentation for the fundamental group encoded by aHeegaard diagram of genus n.

Shifting from paper to Digital Records - Preservation?

Michele V,Cloonan 한국기록관리학회 2002 한국기록관리학회지 Vol.2 No.2

RANS simulation of secondary flows in a low pressure turbine cascade: Influence of inlet boundary layer profile

Michele, Errante,Andrea, Ferrero,Francesco, Larocca Techno-Press 2022 Advances in aircraft and spacecraft science Vol.9 No.5

Secondary flows have a huge impact on losses generation in modern low pressure gas turbines (LPTs). At design point, the interaction of the blade profile with the end-wall boundary layer is responsible for up to 40% of total losses. Therefore, predicting accurately the end-wall flow field in a LPT is extremely important in the industrial design phase. Since the inlet boundary layer profile is one of the factors which most affects the evolution of secondary flows, the first main objective of the present work is to investigate the impact of two different inlet conditions on the end-wall flow field of the T106A, a well known LPT cascade. The first condition, labeled in the paper as C1, is represented by uniform conditions at the inlet plane and the second, C2, by a flow characterized by a defined inlet boundary layer profile. The code used for the simulations is based on the Discontinuous Galerkin (DG) formulation and solves the Reynolds-averaged Navier-Stokes (RANS) equations coupled with the Spalart Allmaras turbulence model. Secondly, this work aims at estimating the influence of viscosity and turbulence on the T106A end-wall flow field. In order to do so, RANS results are compared with those obtained from an inviscid simulation with a prescribed inlet total pressure profile, which mimics a boundary layer. A comparison between C1 and C2 results highlights an influence of secondary flows on the flow field up to a significant distance from the end-wall. In particular, the C2 end-wall flow field appears to be characterized by greater over turning and under turning angles and higher total pressure losses. Furthermore, the C2 simulated flow field shows good agreement with experimental and numerical data available in literature. The C2 and inviscid Euler computed flow fields, although globally comparable, present evident differences. The cascade passage simulated with inviscid flow is mainly dominated by a single large and homogeneous vortex structure, less stretched in the spanwise direction and closer to the end-wall than vortical structures computed by compressible flow simulation. It is reasonable, then, asserting that for the chosen test case a great part of the secondary flows details is strongly dependent on viscous phenomena and turbulence.

Basel III in Reality

( Michele Fratianni ),( John C. Pattison ) 세종대학교 경제통합연구소 2015 Journal of Economic Integration Vol.30 No.1

Financial regulation has shifted from a system as an oligopoly dominated by the G2/G5 to expanded clubs like the Basel Committee for Banking Supervision. Expansive clubs have to agree to terms that are closer to the preferences of soft-regulation members. Yet, once a global agreement on minimum standards, such as Basel 3, is reached, the task is left to national or regional regulators. Deviations from the Basel 3 standards are bound to occur; the complexity of the agreement will facilitate an asymmetric implementation of national regulation and supervision. Countries like Australia, Canada, the United Kingdom, the United States, and some Scandinavian countries have chosen higher standards. On the other hand, we should expect deviations to take place in member countries of the Eurozone that are heterogeneous having different preferences and trade-off between regulatory stringency and economic activity. The requirements of both global clubs and regional club regarding transparency, monitoring, and a level playing field will also cause a collision. This paper reports examples of heterogenous applications of supervisions and reforms.