단삼(Salvia miltiorrhiza Bunge)으로 부터 Tanshinone IIA의 분리 및 함량분석

박미정,이승호,박정일,강신정,장승엽,이경순,손건호,Park, Mi-Jung,Lee, Seung-Ho,Park, Jeong-Hill,Kang, Shin-Jung,Chang, Seung-Yeup,Lee, Kyong-Soon,Son, Kun-Ho 한국생약학회 1999 생약학회지 Vol.30 No.2

The rhizomes of Salvia miltiorrhiza Bunge(Labiatae) has been used in Chinese traditional medicine for the treatment of coronary heart diseases and myocardial infarction. As a part of a research for standardization of crude oriental drugs, we have determined the content of tanshinone IIA in Salvia miltiorrhiza purchased from various regions of Korea. The HPLC method by which quantitative analysis was conducted, showed reproducible results and chromatographic isolation of tanshinone IIA was accomplished successively.

치과병원 치주과 내원환자와 일반인 간의 구강위생 상태와 탐침시 출혈에 대한 통계학적 비교 연구

박미정,조규성,채중규,김종관,Park, Mi-Jeong,Cho, Kyoo-Sung,Chai, Jung-Kui,Kim, Chong-Kwan 대한치주과학회 1989 Journal of Periodontal & Implant Science Vol.19 No.1

과민성 장 증후군의 특성과 병태생리 및 위험요인에 대한 고찰

박미정,최명애,김금순,홍해숙,이경숙,정재심,채영란,안경주,신기수,최정안,Park, Mi-Jung,Choe, Myung-Ae,Kim, Keum-Soon,Hong, Hae-Sook,Lee, Kyung-Sook,Jeong, Jae-Sim,Chae, Young-Ran,An, Gyeong-Ju,Shin, Ki-Soo,Choi, Jung-An 한국재활간호학회 2005 재활간호학회지 Vol.8 No.2

Purpose: Irritable bowel syndrome (IBS) is frequently yet little understood disease. Review was performed to promote understanding on the characteristics, pathophysiology, and risk factors of IBS. Content: IBS is characterized by abdominal discomfort associated with pain and altered bowel function; structural and biochemical abnormalities are absent. Generally IBS is more prevalent in women and people with higher educational and social background, but there are some controversies. IBS is diagnosed by the Rome II or Manning criteria after excluding organic gastrointestinal diseases. The pathophysioloy is explained by abnormal control mechanism of central and enteric nervous system. Mucosal immunity, secretions, and neurotransmitter are also associated with the hypersensitivity and motility change of bowel function. Stress is known as a major triggering factor and contributed to symptoms. Other risk factors are genetic elements, childhood experiences, inflammation, anxiety, depression, diet, and sleep disorders.

간질경련을 주소로 내원한 소아 환자의 복약순응도

박미정(Mi Jung Park),남유니(Yoo Nee Nam),최덕영(Deok Young Choi),선용한(Yong Han Sun),은병욱(Byung Wook Eun),심소연(So Yeon Sim),조강호(Kang Ho Cho),류 일(Eell Ryoo),손동우(Dong Woo Son),전인상(In Sang Jeon),차 한(Hann Tchah) 대한소아신경학회 2009 대한소아신경학회지 Vol.17 No.2

목적:간질환자의 대부분이 약물이 중요한 치료 수단으로 약물순응도가 치료의 성과에 영향을 줄 수 있을 것으로 생각 된다. 본 연구에서는 소아 간질 환자에서의 약물순응도와 이에 영향을 미치는 인자가 있는지 알아보고자 한다. 방법:가천의과학대학교 길병원 소아청소년과로 간질경련을 주소로 내원한 환자 327명을 대상으로 후향적인 방법으로 분석하였다. 다른 병원에서 이미 복약 중이던 환자나 30일 이상 입원한 환자, 뇌막염이나 뇌염 사고 등으로 인한 경련 환자는 제외하였다. 2년 이상 치료중이거나 완치된 환자를 대상으로 하였다. 결과:전체 327명 환자의 평균 복약률은 80.8%이고 평균 복약률이 50% 미만인 경우가 28명(8.6 %), 50%에서 80%까지가 96명, 80%를 넘는 경우가 203명(62.1%)이다. 성별, 나이, 1일 복약 회수, 뇌파 결과, 뇌영상검사 결과, 간질의 원인, 첫 경련의 지속시간에 따른 평균 복약률에는 유의한 차이를 보이지 않았다. 그러나 알약을 복용한 군에서 가루약을 복용한 군보다 복약률이 높았고, 2000년 이후에 복약을 시작한 군에서 2000년 이전에 복약을 시작한 군보다 복약률이 높았다. 좋은 순응도를 보인 군이 61.8%였지만 8.6%에서 낮은 순응도를 보였다. 결론:알약 복약군과 2000년 이후 복약 시작군의 순응도가 더 좋았다. 전체 환자의 복약 순응도는 대부분 좋았으나 50%이하의 복약 순응도를 보인 낮은순응군(8.6%)의 순응도를 높이기 위한 노력이 필요하겠다. Purpose:The sole available treatment for the majority of epilepsy patients is antiepileptic drug therapy. Drug compliance is an important factor for adequate treatment. This study is for investigating pediatric epilepsy patients' compliance to antiepileptic drug treatment at Gil hospital, in South Korea. Methods:From February 1997 to July 2005, retrospective studies were made on 327 patients with epilepsy in Gil hospital of Gachon medical school. The patients who were taking medication prescribed at other hospitals, were admitted to the hospital for over 30 days, had seizures due to meningitis, encephalitis or trauma were excluded. The participants included patients followed for two years or until the seizures were no longer present. Results:Of the total 327 patients, the mean drug compliance was 80.8%; over 80% for 203 patients(62.1%), 80-50% for 97, under 50% for 28(8.6%). Gender, the age of patients, dose frequency, results of the EEG, MRI abnormalities, etiology of epilepsy, and the duration of the first seizure did not significantly influence drug compliance. However, the patients taking tablets or capsules showed higher compliance than those treated with powder medication. In addition, the patients who started to take drugs after the year 2000 had higher compliance than those before 2000. Conclusion:The patients taking tablets or capsules and those who started after 2000 had higher compliance. Although most patients had satisfactory drug compliance, 8.6% had poor compliance(under 50% of compliance); this group requires further attention to improve their compliance.

아로니아를 첨가한 막걸리의 발효특성

박미정(Mi-Jung Park),김형국(Hyeong-Kook Kim),최경근(Kyong-Kun Choi),구본열(Bon-Yeol Koo),이시경(Si-Kyung Lee) 한국식품과학회 2016 한국식품과학회지 Vol.48 No.1

아로니아 첨가량을 0.3, 0.8, 1.3 및 1.9%로 제조한 막걸리의 발효 중 이화학적 특성과 관능적 특성을 조사하였다. pH는 발효과정 중 모든 실험군에서 감소하여 발효 6일에 현저히 낮아지는 경향을 보였으며, 최종 pH는 3.49-3.74였다. 당도는 담금 직후에는 1.31-2.75oBx로 대조구가 가장 낮았으며, 아로니아 첨가율이 증가할수록 높았다. 발효 2일째 7.96-8.53으로 최대값을 나타내었고, 그 이후부터 최종 발효일까지 서서히 감소하는 경향을 나타내었다. 총산도는 담금 직후 발효 6일까지 급격히 증가하였으며 대조군에 비해서 아로니아를 첨가함에 따라 총산도가 증가되었고 최종발효 14일에는 0.50-0.62%로 나타났다. 알코올 함량은 최종 발효 14일까지 완만히 증가하였고, 11.97-14.13의 분포를 나타내었으며 대조군에 비하여 아로니아 첨가군에서 알코올 함량이 높았다. 아미노산은 막걸리를 담금 직후에는 1.57-2.22%에서 최종발효 14일에는 5.86-6.92%로 나타났으며 아로니아 1.9% 첨가군에서 가장 높게 나타났다. 환원당은 발효 2일째까지 증가하다가 4일 후부터 감소되었으며, 최종발효시점에 1.67-1.97%로 나타내었다. 총균수와 효모수는 모든 시험구가 발효 4일째 최대값을 나타내었고 이후 급격히 감소하였다. 총 폴리페놀함량과 총 플라보노이드 함량은 담금 직후부터 최종 발효시까지 증가하였으며, 아로니아 첨가량이 증가할수록 증가하였다. 관능검사 평가결과에서 색은 아로니아 1.9% 첨가군에서, 단맛은 아로니아 1.3% 첨가군에서, 신맛과 쓴맛은 아로니아 1.9% 첨가군에서 높게 나왔으며. 목넘김(목에 넘어가는 느낌)과 종합적 기호도가 아로니아 1.3%첨가군에서 가장 우수하게 나타났고, 아로니아 막걸리의 개발 상품화 가능성이 높은 것으로 확인되었다. This study was conducted to investigate the quality characteristics of makgeolli containing aronia, (Aronia melanocarpa (0-1.9%)). After an initial decrease in the range of pH from 4.93-5.04 to 3.43-3.61 over a period of 6 days, it gradually increased until 14 days. As the fermentation proceeded, sugar contents and reducing sugar contents initially increased in majority of the samples, and subsequently decreased after 2 days. Total acidity contents increased until 6 days and then became higher as the content of aronia increased. Total acidity levels were within the range of 0.50-0.62%. After 14 days of fermentation, the alcohol contents ranged between 11.97 and 14.13%. Over the same time span, the amino acid content increased from a range of 1.57-2.22 to 5.86-6.92%. The microbial cell count and yeast colony count increased over the initial 4 days and then gradually decreased. Total polyphenol content and total flavonoid of aronia makgeolli were significantly higher than those of the control group. Based on the sensory evaluation, makgeolli with 1.3% aronia demonstrated the highest overall acceptance.

액세서리 조형성을 모티브로 한 업스타일

박미정 ( Mi-jung Park ),박은준 ( Eun-jun Park ) 한국미용예술경영학회 2011 미용예술경영연구 Vol.5 No.2

A purpose of this study is to understand concept of a design, to acquire an element of a design and a principle, and to create the best artistic side of Upstyle design that was fitted to modelling form for beauty. And is to rediscover creative design by mixing Upstyle that are combinded with motives from various design of accessories that have various designs which have roles to beutify people among a lot of elements that express beauty, so that cover disadvantages of shape of face and highlight merits of image by various molding principles with different and brilliant sense of trend from the former Upstyle. Generally, the purpose of design is, as a creative method, to satisfy human desire, to make human's life more convenient, beautiful, and anything that has a form has a purpose of art, creativity, convenience, efficiency. In fact, we define it is design that all the procedure of moldig about planning, and forming. The molding in design of Upstyle is made up of shape, color, feeling of hair. And the forms of hair are the bulk, size, volume that can be extendable to every direction. And hair can be affected by gravity. Hair has directivity according to its elasticity, hair stream and flow. The hair stream can be varied widely by visually-recognized texture, described as smooth, rough, soft and so on. Based on the features of hair, 4 different up-styles were conducted using accessory design principles as an inspiration. A hair style inspired by a well-balanced accessory brought a visual order and stability from its weight whic enables viewer to feel comfortable. Meanwhile, a unique and artistic design motivated by an accessory with a harmonious design left a strong impression, incurring creativity and splendor with three-dimensional effect and keeping its texture vividly at the same timhe. Also, a style inspired by a rhythmical accessory brought abundant volume as well as romantic and soft feeling. For the last, a style inspired by an accessory with a distinct point escaped from an elegant and romantic image, a typical image of up-style. Instead, it highlighted a specific part, subsequently dispersing attentions toward face itself and covering weak points of face shape. Considering these factors, accessory design elements can be useful sources for up-styles as widening its design range and elevating the completion level based on design principle.

인삼 단백분획물이 일차배양한 계배의 근육세포에 미치는 영향

박미정(Mi Jung Park),송진호(Jin Ho Song),이흔파(Heum Pa Lee),김영중(Young Choong Kim) 한국생약학회 1990 생약학회지 Vol.21 No.3

Effects of the protein fraction of Panax ginseng on chicken embryonic skeletal muscle cells cultured with a deficient medium were studied. The protein fraction was further fractionated into four groups according to the molecular weight; larger than 10,000 dalton(fraction A), between 5,000 and 10,000 dalton(fraction B), between 1,000 and 5,000 dalton(fraction C), between 500 and 1, 000 dalton(fraction D). According to the microscopic observation, all four protein fractions at the concentration of 10∼100 ㎍/㎖ showed the tendency to stimulate the growth and differentiation of the muscle cells. The activity of acetylcholinesterase in muscle cells was significantly elevated by the protein fraction A at the concentration of 100 ㎍/㎖. Protein fractions B,C and D significantly enhanced the synthesis of RNA in the muscle cells. The synthesis of DNA in muscle cells was significantly enhanced by protein fractions A,B and C.

한국의 이차전지 산업 생태계

박미정(Mi Jung Park),전두진(Doo Jin Jun),강석기(Seog Gi Kang) 한국전지학회 2021 한국전지학회지 Vol.1 No.2

리튬이차전지는 과거 소니의 최초 상용화를 시작으로 지금까지 한중일 중심으로 성장해왔다. 한국은 리튬이차전지 제조기술력을 기반으로 글로벌점유율을 차지해왔으나, 소재부품장비 해외의존도가 일본, 중국에 비해 높은 편이다. 본 논문에서는 한국과 일본, 중국의 이차전지 산업경쟁력을 비교 분석하고, 안정적인 공급망 확보의 중요성을 알아본다. Lithium secondary batteries have grown mainly in Korea, China and Japan, starting with Sony"s first commercialization in the past. Korea has been occupying a global market share based on its lithium secondary battery manufacturing technology, but it is highly dependent on overseas materials, parts and equipment. This paper compares the competitiveness of the secondary battery industry in Korea, Japan, and China, and introduces the importance of securing a supply chain.

지속성 외래 복막투석 환자에서 영양상태와 투석의 적절도

박미정(Mi Jung Park),이균상(Kyun Sang Lee),조민석(Min Seok Cho),김정기(Jeong Ki Kim),박병석(Byoung Seok Park),마성권(Seong Kwon Ma),고정희(Jung Hee Ko),나명윤(Myong Yun Nah),염충호(chung Ho Yeum),정권(Jung Gwon),김수완(Soo Wan Kim) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4

Purpose - Malnutrition is common in CAPD patients and depends on many factors such as dialysis-related and nondialysis-related factors. The present study aimed to assess nutritional status, dialysis adequacy and their relationships with overall mortality and morbidity. Methods - We studied 102 patients who had been receiving CAPD for at least 6 months. Dialysis adequacy was assessed by parameters derived from urea kinetic modeling(UKM) and nutritional status was assessed by serum biochemical measurement, normalized protein catabolic rate(nPCR), normalized protein equvalent of total nitrogen appearance(nPNA) and urea kinetic studies. Spearman's simple correlation and multiple linear stepwise regression analysis were used to assess correlation between dialysis adequacy and nutritional status in CAPD patients. We compared the differences between patients who suffered morbid events, defined as either an infectious complication or hospitalization, and patients who remained well. Results : The results showed that the total dialysis dose(total weekly Kt/Vurea ) has statistically significant correlation with nPCR(r=0.234, p=0.028), nPNA (r=0.246, p=0.021), total weekly creatinine clearance (WCC)(r=0.479, p=0.0001), serum albumin levels(r= 0.233, p=0.029), serum cholesterol(r=0.266, p=0.013), serum BUN(r=-0.290, p=0.006) and serum creatinine levels(r=-0408, p-0.0001). nPNA was positively correlated with serum cholesterol(r=0.217, p=0.045), serum transferrin(r=0.218, p=0.042) and serum ferritin levels(r=0.220, p=0.043). Patients who suffered morbid events had an old age(p=0.001), long duration of CAPD(p=0.0001), higher CRP(p=0.021), lower serum albumin level(p=0.020), lower hematocrit(p=0.049) and lower WCC(p=0.017). Conclusions: These results indicate that adequate dialysis is very important for the maintenance of adequant nutrition because nutritional status positively correlated with dialysis dose, which is best assessed by UKM. In addition, assessment of nutritional status and dialysis adequacy are important in predicting clinical outcomes in CAPD patients.

만성 신부전 환자에서 고호모시스틴혈증에 관한 연구

박미정(Mi Jung Park),이균상(Kyun Sang Lee),조민석(Min Seok Cho),김정기(Jeong Ki Kim),박병석(Byoung Seok Park),마성권(Seong Kwon Ma),고정희(Jung Hee Ko),나명윤(Myong Yun Nah),염충호(chung Ho Yeum),김수완(Soo Wan Kim),김남호(Nam Ho Kim 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.4

Objective : It has been reported that hyperhomocysteinemia is an independent risk factor for atherosclerotic complications, although the mechanisms re- main unclear. The major determinents of total fasting plasma homocysteine(tHcy) concentrations have been recently reported but there are still conflicting data on the influence of those in peritoneal and hemodialysis patients. Therefore, we evaluated the prevalence and association of vascular complications and the determinents of hyperhomocysteinemia in chronic renal failure patients receiving conservative treatment(predialysis), peritoneal dialysis(PD) and hemodia-lysis (HD) patients. Methods We measured the factors, including fasting plasma vitamine levels(folate, vitamin E4 and vitamin B12), serum creatinine concentration, dialysis adequacy-related varibles as well as associated risk factors for vascular diseases that might affect tHcy concentrations in 37 predilysis, 30 PD, 34 HD patients and 21 normal persons. Continuous variables were compared using independent sample t-test. Spearman's correlation was used to determine the strength of association between tHcy and other predictive varia41es. Percentages were compared using Pearson's chi-square test or Fisher's exact test, depending on the frequencies. Independent determinents of tHcy concentration and atherosclerotic vascular complications were identified using multiple regression analysis. Results : The prevalence of hyperhomocysteinemia was 83.8, 72, 88% among predialysis, PD and HD patients, respectively(Odds ratio was 103.33, 81.43, 150.0 vs. controls, respectively). tHcy values in pre- dialysis, PD and HD patients are significantly higher than those in controls(24.68±9.01, 21.04±8.82, 23.62± 9.46 vs. 8.80±2.07 ㎛oL/L, repectively, p<0.01). Pre- dialysis, PD and HD patients with atherosclerotic vascular complications had higher tHcy concentrations than did predialysis, PD and HD patients with- out vascular complications(21.93±8.71 vs. 32.09±4.71 ㎛oL/L, p<0.01, 17.57±5.85 vs. 28.74±9.70 ㎛oL/L, p<0.01, 19.00±4.29 vs. 33.28±10.13, p<0.01 respectively). We also observed increasing odds ratios of vascular events with increasing tHcy concentrations. For predialysis, PD and HD patients, fasting plasma folate level had negative correlation with tHcy concentrations by spearman's simple correlaltion. And using muliple regression analysis, we recognized hyperhomocysteinemia is an independent risk factor for atherosclerosis and fasting plasma folate is a major determinent of tHcy concentrations in predialysis, PD and HD patients. Conclusions: Hyperhomocysteinemia in predialysis, PD and HD patients was more prevalent than that in norrnal controls. Risk of atherosclerotic vascular complications increased with increasing tHcy concentrations. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and fasting plasma folate is a major determinent of tHcy concentrations in predialysis, PD and HD patients.