Recommendations for the Management of Patients With Systemic Rheumatic Diseases During the Coronavirus Disease Pandemic

( Mi Ryoung Seo ),( Ji-won Kim ),( Eun-jung Park ),( Seung Min Jung ),( Yoon-kyoung Sung ),( Hyungjin Kim ),( Gunwoo Kim ),( Hyun-sook Kim ),( Myeung-su Lee ),( Jisoo Lee ),( Jian Hur ),( Bum Sik Chin 대한류마티스학회 2020 대한류마티스학회지 Vol.27 No.4

Patients with systemic rheumatic diseases (SRD) are vulnerable for coronavirus disease (COVID-19). The Korean College of Rheumatology recognized the urgent need to develop recommendations for rheumatologists and other physicians to manage patients with SRD during the COVID-19 pandemic. The working group was organized and was responsible for selecting key health questions, searching and reviewing the available literature, and formulating statements. The appropriateness of the statements was evaluated by voting panels using the modified Delphi method. Four general principles and thirteen individual recommendations were finalized through expert consensus based on the available evidence. The recommendations included preventive measures against COVID-19, medicinal treatment for stable or active SRD patients without COVID-19, medicinal treatment for SRD patients with COVID-19, and patient evaluation and monitoring. Medicinal treatments were categorized according to the status with respect to both COVID-19 and SRD. These recommendations should serve as a reference for individualized treatment for patients with SRD. As new evidence is emerging, an immediate update will be required. (J Rheum Dis 2020;27:218-232)

The experience of delirium care and clinical feasibility of the CAM-ICU in a Korean ICU.

Jung, Joo-Hee,Lim, Jung-Hye,Kim, Eun-Jung,An, Hyo-Chan,Kang, Min-Kyung,Lee, Jin,Min, Yu-Kyung,Park, Eun-Zoo,Song, Xiang-Hwa,Kim, Hye-Ryoung,Lee, Sun-Mi Sage Periodicals Press 2013 Clinical nursing research Vol.22 No.1

<P>This study aimed to assess intensive care unit (ICU) nurses' experiences caring for delirious patients and the empirical evaluation of the clinical feasibility of the confusion assessment method (CAM) for ICU (CAM-ICU). In Korea, neither regular assessment of early-stage delirium nor preventive interventions are carried out properly in the ICU. This study was conducted using a qualitative research design with focus group interviews. Nurses received training about the CAM-ICU, and used it to assess surgical ICU patients for the presence of delirium during a 5-month period. None of the nurses had heard of the CAM-ICU before the study, and many complained that it was very challenging to use. One positive outcome of the CAM-ICU trial was that the clinical interest in delirium increased. The CAM-ICU could be used to facilitate communication once the instrument becomes well-known among health care professionals.</P>

Case Reports : A Case of Enterocolic Lymphocytic Phlebitis Mimicking Surgical Abdomen

( Mi Ryoung Seo ),( Tae Eun Kim ),( Hee Jung Ryu ),( Han Joo Baek ),( Hyo Jin Choi ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.2

Vasculitis that involves the gastrointestinal (GI) tract often occurs as part of a systemic inflammatory process. It is a well-recognized manifestation of the small and medium sized vessel vasculitides. Vasculitis of the GI tract may occur in isolation; although it can progress to a systemic illness. It usually involves the arterioles, venules, and capillaries; however, it is very rare for only the venules to be affected. Enterocolic lymphocytic phlebitis is a localized vasculitis, typically affecting the small and medium-sized intramural and mesenteric veins of the intestines. We report a case of enterocolic lymphocytic phlebitis of the colon. A 38-year-old woman was presented with hematochezia and severe abdominal pain on the day of admission. She had no history of intestinal disease or systemic disease. Computed tomography showed an extremely thickened wall of the colon, along with several air bubbles in the colon with diffuse subcutaneous emphysema in the abdominal wall. An emergency exploration laparotomy and extended right hemicolectomy was performed. The patient recovered completely after surgery and remains well without further therapy.

Epigenetic regulation of <i>Kcna3</i>-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4⁺ T-cell activation

Kang, Jung-Ah,Park, Sang-Heon,Jeong, Sang Phil,Han, Min-Hee,Lee, Cho-Rong,Lee, Kwang Min,Kim, Namhee,Song, Mi-Ryoung,Choi, Murim,Ye, Michael,Jung, Guhung,Lee, Won-Woo,Eom, Soo Hyun,Park, Chul-Seung,Pa National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.31

<P>The role of cereblon (CRBN) in T cells is not well understood. We generated mice with a deletion in Crbn and found cereblon to be an important antagonist of T-cell activation. In mice lacking CRBN, CD4(+) T cells show increased activation and IL-2 production on T-cell receptor stimulation, ultimately resulting in increased potassium flux and calcium-mediated signaling. CRBN restricts T-cell activation via epigenetic modification of Kcna3, which encodes the Kv1.3 potassium channel required for robust calcium influx in T cells. CRBN binds directly to conserved DNA elements adjacent to Kcna3 via a previously uncharacterized DNA-binding motif. Consequently, in the absence of CRBN, the expression of Kv1.3 is derepressed, resulting in increased Kv1.3 expression, potassium flux, and CD4(+) T-cell hyperactivation. In addition, experimental autoimmune encephalomyelitis in T-cell-specific Crbn-deficient mice was exacerbated by increased T-cell activation via Kv1.3. Thus, CRBN limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 expression.</P>

Studies on Constituents of the Higher Fungi of Korea (XLVI) : Antitumor Components Extracted from the Cultured Mycelia of Lyophyllum decastes

Hye Ryoung Kim,Mi Ja Shim,Jung Woo Kim,Ha Won Kim,Chong Ock Lee,Eung Chil Choi,Byong Kak Kim 한국생약학회 1984 생약학회지 Vol.15 No.2

To investigate antitumor component of Lyophyllum decastes, the aqueous extract of its shake-cultured mycelia was subjected to antitumor test against sarcoma 180 cells implanted in ICR mice. The extract showed an inhibition ratio of 65.4% and was found to consist of a polysaccharide moiety and a protein moiety. After purification with DEAE-Sephadex A-50 ion exchange chromatography, Fraction D showed the highest inhibition ratio of 75.7%. The antitumor constituent was examined for immunoaccelerating activity and was found to increase macrophage accumulation in the peritoneal cavity and plaque forming cells of the spleen cells. It was named lyophyllan after the genus name.

Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

Ko, Ryoung-Eun,Moon, Seong Mi,Ahn, Soohyun,Jhun, Byung Woo,Jeon, Kyeongman,Kwon, O Jung,Huh, Hee Jae,Ki, Chang-Seok,Lee, Nam Yong,Koh, Won-Jung KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.8

<P>This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of <I>Mycobacterium avium</I> complex (MAC) lung disease (LD). Among MAC cases, the proportion of <I>M. avium</I> increased compared with <I>M. intracellulare</I>, whereas the incidence of <I>M. abscessus</I> complex and <I>M. kansasii</I> LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD.</P>

[P8-283] Antihyperglycemic of Gieditschiae Spina Extracts in Streptozotocin Nicotinamide-induced Diabetic Rats

Won-Mi Chu,Jae-Hee Park,Jung-Min Lee,Hae-Ryoung Park,Eunju Park 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

알코올로 인한 흰쥐의 백혈구 및 간 DNA 손상에 미치는 미더덕과 오만둥이 분말의 보충섭취 효과

김정미(Jung?Mi Kim),박해룡(Hae?Ryoung Park),이승철(Seung?Cheol Lee),박은주(Eunju Park) 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.10

미더덕과 오만둥이는 독특한 향과 맛이 있는 식품으로 널리 알려져 있으며 우리나라 전역에서 자생하나 경상남도 마산에서 가장 많이 생산되고 있는 해양생물이다. 한편, 과량의 에탄올 섭취는 microsomal ethanol oxidizing system(MEOS)에 의한 에탄올 산화를 증가시켜 superoxideion, hydrogen peroxide, hydroxyl radical, 1-hydroxyethyl radical과 같은 활성산소종을 생성하여 산화적 스트레스 상태를 유발하게 된다. 본 연구에서는 미더덕과 오만둥이의 보충투여가 과량의 에탄올 투여로 인해 유도되는 간기능 관련 지표와 간세포 및 백혈구 DNA 손상정도에 미치는 영향을 보고자 SD계 수컷 쥐를 세 군으로 나누어 6주간 25% 에탄올 용액을 자유로이 섭취하게 하면서 동결 건조하여 분말화한 미더덕과 오만둥이를 식이의 3%(w/w) 수준으로 보충투여하였다. 6주간의 미더덕과 오만둥이 투여는 체중증가량, 식이 및 에탄올 섭취량, 간을 비롯한 각종 장기무게에는 아무런 영향을 끼치지 않았다. 미더덕과 오만둥이 보충투여는 총 콜레스테롤을 비롯한 혈장 지질 수준에는 유의적인 영향이 없었지만, 혈장 ALT, ALP, LDH 활성 등 간기능 관련 지표들을 유의적으로 감소시켰다. 또한 미더덕과 오만둥이는 과량의 에탄올 섭취로 유도된 흰쥐의 백혈구, 간세포의 DNA 손상을 유의적으로 감소시킨 것으로 나타났으며, 간세포 DNA 손상도는 혈장 ALP와 LDH 활성과 유의적인양의 상관관계를 보여주었다. 결론적으로 미더덕과 오만둥이 분말의 보충투여는 알코올 섭취로 인해 유도된 간조직 손상에 대한 보호작용이 있는 것으로 사료된다. In this study, the ability of Styela clava or Styela plicata to reduce ethanol-induced hepatotoxicity and hepatic and leucocytic DNA damages was evaluated. Twenty four male SD rats were given 25% ethanol containing water (ad lib, p.o.) and divided into 3 groups; ethanol treated control group (EtOH), ethanol+3% S. clava (EtOH+SC), and ethanol+3% S. plicata (EtOH+SP). After 6 weeks, the supplementation of S. clava reduced the plasma ALT, ALP and LDH activities significantly (p<0.05), while S. plicata induced significant decrease in the plasma LDH activity only. The comet assay was employed to quantify the alcohol-induced DNA damage in rat hepatocytes and leucocytes. A significant protective effect on hepatic and leucocytic DNA damages was observed in S. clava or S. plicata supplemented groups compared to the EtOH control group. The hepatic DNA damage was correlated positively with plasma ALP and LDH activities. These results demonstrated that S. clava or S. plicata supplementation protected alcohol-induced hepatic and leucocytic DNA damage.

여대생의 월경전증후군에 영향을 미치는 요인

정금숙(Jung, Geum-Sook),오현미(Oh, Hyun-Mi),최인령(Choi, In-Ryoung) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.5

본 연구는 여대생의 월경전증후군에 영향을 미치는 요인을 파악하여,월경전증후군을 겪는 여대생에게 예방과 중재 를 위한 프로그램 개발과 적용의 기초 자료로 활용하기 위한 서술적 조사연구이다.G시의 여대생 330명에 대한 자료를 2012 년 4월 2일부터 4월 6일까지 수집하였다.연구 결과 여대생의 스트레스 전체 평균 평점은 2.50±.74,월경에 대한 태도 평균 평점은 3.07±.02,월경전증후군의 전체 평점 평균은 2.67±.60이었다.스트레스는 월경전증후군과 유의한 정적 상관관계가 있 는 것으로 나타났고(r=.36,p<.001),월경에 대한 태도와 월경전증후군도 유의한 정적 상관관계가 있는 것으로 나타났다(r=.34, p<.001).월경전증후군에 영향을 미치는 요인을 확인하기 위하여 다중회귀분석을 실시한 결과 월경에 대한 태도,스트레스 평점,흡연,월경통이 유의한 영향 요인이었으며,설명력은 27%이었다.가장 주요한 영향 요인은 월경에 대한 태도(β=.28, p<.001)이었고,그 다음으로는 스트레스 평점(β=.27,p<.001),흡연(β=.20,p<.001),월경통(β=.15,p<.001)이었다.이상의 연 구 결과를 토대로 심리사회적 요인을 고려한 새로운 간호 중재 방법을 모색하고,삶의 질 향상을 위한 내러티브적인 접근을 통한 질적 연구를 제언한다. This study was conducted to figure out the influential factors on premenstrual syndrome(PMS) of college female students which are to be utilized as the basic data to develop and apply programs for preventing and controlling such symptom. The subjects were 330 college female students. The data were collected from April 2, 2012 to April 6, 2012. From the results, There has been significant correlation between stress and PMS(r=.36, p<.001) and the attitude to menstruation has appeared to have significant positive correlation with PMS as well(r=.34, p<.001). Multiple regression analysis has been employed to identify the influential factors on PMS and the result has shown that menstrual attitude, grade point average for stress, smoking and dysmenorrhea have been the most significant influential factors with 27% of explanatory power. The level of significance has been high in menstrual attitude(β=.28, p<.001), grade point average for stress(β=.27, p<.001), smoking(β=.20, p<.001) and dysmenorrhea(β=.15, p<.001) respectively. In conclusion, it needs to find nursing interventions for PMS related to psychosocial factors and suggest a narrative study for improving quality of life of women with PMS.

Clinical phenotypes of Korean patients with Behcet disease according to gender, age at onset, and HLA-B₅₁

( Hee Jung Ryu ),( Mi Ryoung Seo ),( Hyo Jin Choi ),( Han Joo Baek ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.5

Background/Aims: The clinical manifestations of Behcet disease (BD) have been reported to differ according to country, region, and race. Gender, onset age, and human leukocyte antigen (HLA)-B₅₁ have also been known as the factors that influence the clinical features of BD. The aim of this study is to investigate the clinical phenotypes of Korean patients who visited the rheumatology clinic with BD with respect to gender, onset age, and HLA-B₅₁. Methods: Total 193 Korean patients (129 females and 64 males) fulfilling the international criteria for BD were retrospectively assessed. Results: The mean age at disease onset and disease duration of the BD patients were 32.2 ± 11.1 and 14.2 ± 9.3 years, retrospectively. Females suffered more frequently from genital ulcers (90.7% vs. 75.0%, p < 0.01), peripheral arthritis (67.4% vs. 43.8%, p < 0.01), and inf lammatory low back pain (38.8% vs. 23.4%, p = 0.03) than males, while skin involvement was more frequent in males than in females (90.6% vs. 75.2%, p = 0.01). The patients with late onset of BD ( > 40 years) suffered from neurologic involvement (15.9% vs. 4.2%, p = 0.007) more frequently than those with early onset of BD. The patients with HLA-B51 showed earlier onset of disease than without HLA-B51 (28.3 ± 11.4 years vs. 33.8±11.6 years, p = 0.02) and the neurologic and gastrointestinal involvements were more frequent in the patients without HLA-B₅₁ than with HLA-B51 (17.2% vs. 2.5%, p = 0.02 and 20.7% vs. 2.5%, p = 0.01, respectively). Conclusions: The clinical phenotypes in Korean patients with BD may be influenced by gender, onset age and HLA-B₅₁.