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Cotton xanthate-Mg(Ⅱ)-homosulfamin complex의 생성 및 성상
김영미,하능진,정연진,이정수 釜山大學校 新藥開發硏究所 1999 藥學硏究誌 Vol.33 No.1
Formation of Cotton xanthate-Mg(Ⅱ)-Homosulfamine complex was investigated varying reaction conditions. Release of homosulfamin from cotton xanthate-Mg(Ⅱ)-homosulfamin complex was studied by batch- and flow-method. Antimicrobial activities were tested against Staphylococcus aureus ATCC 12228, Bacillus subtillis TG-1 Pseudomonas aeruginosa ATCC 9027 and Escherichia coli (NA-1) by employing ditch plate method and compared to that of free Hs.
숙명박물관 브랜드 프로모션을 위한 통합적 브랜드 개발 -2D, 3D, 4D 디자인 프로세스를 중심으로-
길혜경,김보현,오정은,이서연,이지원,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 여성생활사 중심의 유물 박물관인 숙명박물관의 인지도와 브랜딩의 문제를 해결하기 위해 브랜드·스페이스·마케팅을 활용한 통합 브랜드 개발 프로세스를 제안하는데 목적이 있다. 아울러 본 연구는 박물관의 브랜드를 프로모션하고 그래픽, 제품, 공간의 통합 브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구의 시간적 범위는 2017년 3월부터 6월까지 총 15주간 숙명여대 환경디자인학과 <브랜드·스페이스·마케팅>수업에서 진행된 수업의 결과물로서 4개 팀 중, 1개 팀의 작업물로 한다. 본 연구의 대상적 범위는 ‘숙명여자대학교 숙명박물관'의 2D~4D까지의 전반으로 설정한다. 그 결과, 제품부터 공간까지 숙명박물관의 통합된 브랜딩은 일 관성과 객관성, 스토리성을 얻을 수 있었다. ’숙명박물관'은 학교의 박물관이라는 장점을 극대화시켜 가치와 스토리를 부여하고 하나의 브랜드로 리뉴얼했다는 점에서 의의가 있다. 또한 향후 보편적인 박물관들의 차별화된 브랜드 개발의 참고자료로 활용될 수 있을 것으로 기대하며 브랜드 개발에 있어서 G·I, P·I, S·I의 통합 브랜드 메뉴의 기초 자료로 활용될 것으로 사료된다.
간경변 환자에서 Oro-cecal Transit Time의 측정
원경준,이준,변유미,조민근,조주연,서정균,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background: Neurotransmitter like substances in the gut have been proposed to contribute to the overall portal systemic encephalopathy (PSE). The source of the ammonia in patients with PSE is mainly the small bowel, as a result of the conversion of glutamine in the diet to glutamate and ammonia. PSE is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides such as lactulose. This study was performed to evaluate the relationship between PSE and oro-cecal transit time. In addition, performed to evaluate the effect of severity, cause, complications of liver cirrhosis on oro-cecal transit time. Methods: Between August 2006 and February 2007, 48 cirrhotic patients consecutively was enrolled in study their oro-cecal transit time after informed consent was obtained. A non-invasive hydrogen breath test was used to study oro-cecal transit time (OCTT). Result: The OCTT were delayed in cirrhotic patients with PSE compared without PSE (123.3 ± 42.7 min vs 170.0 ± 58.3 min, p<0.05). OCTT tended to prolongate further as the damage in the liver got worse, nevertheless the result was statistically meaningless (p<0.111). Neither presence of ascites or cause of PSE had any influence on gastrointestinal transit. Conclusions: Cirrhotic patients with PSE have more delayed OCTT than without PSE. Further research is needed to find out the relationship between OCTT and severity of liver cirrhosis.
프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성
최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1
Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.
Kim, Wan-Sung,Lee, Kwang-Soon,Kim, Ji-Hee,Kim, Chun-Ki,Lee, Gwangsoo,Choe, Jongseon,Won, Moo-Ho,Kim, Tae-Hyoung,Jeoung, Dooil,Lee, Hansoo,Kim, Ji-Yoon,Ae Jeong, Mi,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Y PERGAMON PRESS 2017 FREE RADICAL BIOLOGY AND MEDICINE Vol.112 No.-
<P><B>Abstract</B></P> <P>Ligation of the death receptors for TNF-α, FasL, and TRAIL triggers two common pathways, caspase-dependent intrinsic apoptosis and intracellular reactive oxygen species (ROS) generation. The apoptotic pathway is well characterized; however, a signaling linker between the death receptor and ROS production has not been clearly elucidated. Here, we found that death receptor-induced ROS generation was strongly inhibited by mitochondrial complex I and II inhibitors, but not by inhibitors of NADPH oxidase, lipoxygenase, cyclooxygenase or xanthine oxidase, indicating that ROS are mostly generated by the impairment of the mitochondrial respiratory chain. ROS generation was accompanied by caspase-8 activation, Bid cleavage, and cytochrome <I>c</I> release; it was blocked in FADD- and caspase-8-deficient cells, as well as by caspase-8 knockdown and inhibitor. Moreover, Bid knockdown abrogated TNF-α- or TRAIL-induced ROS generation, whereas overexpression of truncated Bid (tBid) or knockdown of cytochrome <I>c</I> spontaneously elevated ROS production. In addition, p53-overexpressing cells accumulated intracellular ROS via cytochrome <I>c</I> release mediated by the BH3-only protein Noxa induction. In a cell-free reconstitution system, caspase-8-mediated Bid cleavage and recombinant tBid induced mitochondrial cytochrome <I>c</I> release and ROS generation, which were blocked by Bcl-xL and antioxidant enzymes. These data suggest that anti-apoptotic Bcl-2 proteins play an important role in mitochondrial ROS generation by preventing cytochrome <I>c</I> release. These data provide evidence that the FADD/caspase-8/Bid/cytochrome <I>c</I> axis is a crucial linker between death receptors and mitochondria, where they play a role in ROS generation and apoptosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Death receptor ligands produce mitochondrial ROS (mROS) in a caspase-8-dependent manner. </LI> <LI> mROS production requires tBid formation and cytochrome <I>c</I> release. </LI> <LI> The caspase-8/Bid/cytochrome <I>c</I> axis plays a key role in death receptor-mediated mROS generation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
김혜정 ( Hye Jeoung Kim ),김민우 ( Min Woo Kim ),임영미 ( Young Mi Lim ),김향미 ( Hyang Mi Kim ),이경술 ( Kyung Sool Lee ),신미경 ( Mi Kyung Shin ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.12
Cornual pregnancy is a rare form of ectopic pregnancy and its diagnosis is difficult. Its incidence is 2-4% of all tubal pregnancies. Because greater vascularity and distensibility of implantation site lead to rupture at a later gestational age and cause the rapid intraperitoneal hemorrhage, cornual pregnancy causes serious maternal mortality and morbidity. Cornual pregnancy is relatively rare in the woman who has the history of ipsilateral salpingectomy. We have experienced a case of ipsilateral cornual pregnancy after previous salpingectomy in a 31-year-old woman and report this case with brief review of literature.
Perspective of entomopathogenic fungi as biological control agents
Jae Su Kim,Se Jin Lee,Jong Chul Kim,Sihyeon Kim,Jeoung Seon Yu,Min Ho Song,Mi Long Lee,Yi-Ting Yang,Yu-Shin Nai,Jeoung Jun Kim,Yeon Ho Je 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
The present issue of insect resistance and environmental toxicity of pesticides is triggering deep discussion about the pest management tactics, in which pest monitoring and control activity are mainly involved. Novel control agents, hopefully overcoming the present issues and problems, should be researched and commercially applied to the farm fields. With the monitoring-based research, additionally we have to focus on the control-based, particularly control agent-based research and application. Entomo- pathogenic fungi can used as one of the possible novel control agents once considerations are given to the control of soil- or water-dwelling pests. In our research group, the entomopathogenic fungal library has been constructed using the mealworm-based isolation system, which showed a variety of opportunities of their use in pest control. Important key production technologies including granular formulation have been developed to increase their industrialization. Some entomopathogenic fungal isolates showed high biological performance in the control of rice weevils, western flower thrips and Japanese bettles in field stands. To elucidate the fungal mode of action, a fungal transformation system using AtMT and gene identification tools were established. Recently a more deep study about the relationship between insect and entomopathogenic fungi is be investigated using RNA seq. We suggest that to make the entomopathogenic fungal products be applied to agricultural farm field, R&D of down-stream process should be seriously considered as the key step.