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Das Problem der Motivation im DaF-Unterricht in Korea
Michael Menke 인천대학교 인문학연구소 2015 인문학연구 Vol.24 No.-
Motivation is one of the key points in successful learning of a foreign language. There are two key types; intrinsic motivation as well as extrinsic motivation. Intrinsic motivation is the self-desire to learn a subject or hear a language, extrinsic motivation refers to positive motivation and progressive results from other people, especially the teacher. The main goal of this study is to determine the relationship between intrinsic motivation and how it provides more learning-influence which, in turn, provides a better level of language learning for students. Contrary to these findings, the Korean educations system places greater emphasis on grading, tests and the hierarchy of universities and subjects; all of which have a large extrinsic impact on students. Within the field of foreign language education, more emphasis needs to be placed on better quality teaching curriculum rather than on verifiable results. It is, for example, for foreign companies more important to hire people with strong communication skills and motivation than with diffuse excellent test scores.
Videoprojekte im DaF-Unterricht
Michael Menke 인천대학교 인문학연구소 2014 인문학연구 Vol.21 No.-
The use of video technology in German language classes is a necessary complement to other teaching parts such as reading, speaking, listening comprehension and oral expression. Video can convey very simply, because it contents all the important factors of non-verbal communication, gestures, facial expressions, backgrounds. The use of video-chat can help students to find interlocutors in the target language, because in Korea there are not so many native German speaking persons. The partners in internet can both be German-speaking individuals who are in Germany or elsewhere, but also students of German language in other countries or neighboring countries that have the same learning experiences. In the case of Korea, it has been shown in several video chat projects with Japan and China that interest and motivation of the learners of German were thereby greatly increased.
Successful Trastuzumab-Deruxtecan Rechallenge After Interstitial Lung Disease: A Case Report
Vincent A. de Weger,Tim Schutte,Inge R.H.M. Konings,Catharina Willemien Menke-van der Houven van Oordt 한국유방암학회 2023 Journal of breast cancer Vol.26 No.5
Trastuzumab deruxtecan (T-DXd) is used to treat human epidermal growth factor receptor 2-positive advanced breast cancer. Interstitial lung disease (ILD) is a severe adverse event associated with T-DXd. Current guidelines recommend permanent discontinuation of T-DXd after Common Terminology Criteria for Adverse Events (CTCAE) grade ≥ 2 ILD. Here, we describe a case of successful rechallenge with T-DXd after CTCAE grade 2 treatment-induced ILD. After discontinuation of T-DXd, ILD was treated with steroids until complete resolution. Given the initial beneficial antitumor response, retreatment was discussed during disease progression. In a shared decision with the patient, T-DXd was restarted at the lowest registered dose, along with low-dose steroids. ILD did not reoccur. Importantly, both clinical and radiological responses to the treatment were observed, with an improvement in the patient’s quality of life. This case demonstrates that retreatment with T-DXd after a grade 2 ILD event is feasible and yields clinical benefit.
A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors
Sarris, Panagiotis F.,Duxbury, Z.,Huh, S.,Ma, Y.,Segonzac, C.,Sklenar, J.,Derbyshire, P.,Cevik, V.,Rallapalli, G.,Saucet, Simon B.,Wirthmueller, L.,Menke, Frank L.H.,Sohn, K.,Jones, Jonathan D.G. Cell Press ; MIT Press 2015 Cell Vol.161 No.5
Defense against pathogens in multicellular eukaryotes depends on intracellular immune receptors, yet surveillance by these receptors is poorly understood. Several plant nucleotide-binding, leucine-rich repeat (NB-LRR) immune receptors carry fusions with other protein domains. The Arabidopsis RRS1-R NB-LRR protein carries a C-terminal WRKY DNA binding domain and forms a receptor complex with RPS4, another NB-LRR protein. This complex detects the bacterial effectors AvrRps4 or PopP2 and then activates defense. Both bacterial proteins interact with the RRS1 WRKY domain, and PopP2 acetylates lysines to block DNA binding. PopP2 and AvrRps4 interact with other WRKY domain-containing proteins, suggesting these effectors interfere with WRKY transcription factor-dependent defense, and RPS4/RRS1 has integrated a ''decoy'' domain that enables detection of effectors that target WRKY proteins. We propose that NB-LRR receptor pairs, one member of which carries an additional protein domain, enable perception of pathogen effectors whose function is to target that domain.
Menk, Florian,Shin, Suyong,Kim, Kyung-Oh,Scherer, Martin,Gehrig, Dominik,Laquai, Fré,dé,ric,Choi, Tae-Lim,Zentel, Rudolf American Chemical Society 2016 Macromolecules Vol.49 No.6
<P>Block copolymers composed of a MEH-PPV block and a nonconjugated functional block (molecular weights between 5 and 90 kg/mol) were synthesized in a facile one-pot procedure via ROMP. This one-pot procedure permits the synthesis of numerous block copolymers with little effort. Amphiphilic block copolymers were obtained via incorporation of oxanorbornene carrying, a PEG side chain as well as via postpolymerization modification of a reactive ester carrying norbornene derivative with methoxypoly(ethylene glycol)amine. These amphiphilic block copolymers can be self-assembled into micelles exhibiting different sizes (60-95 nm), morphologies (micelles or fused, caterpillar-like micelles), and optical properties depending on the polymer composition and the micellization procedure. Furthermore, the reactive ester carrying block copolymers enabled the introduction of anchor groups which facilitated the preparation of nanocomposites with CdSe/CdZnS core shell QDs. The obtained composites were studied using time-resolved photoluminescence measurements. The results revealed an increased interaction based on an accelerated decay of the QD emission for composites as compared to the mixture of the QDs with unfunctionalized polymers.</P>
Menk, Florian,Mondeshki, Mihail,Dudenko, Dmytro,Shin, Suyong,Schollmeyer, Dieter,Ceyhun, Oliver,Choi, Tae-Lim,Zentel, Rudolf American Chemical Society 2015 Macromolecules Vol.48 No.20
<P>The polymerization of alkoxy-substituted [2.2]paracyclophane-1,9-dienes via ring-opening metathesis polymerization (ROMP) to obtain soluble poly(<I>p</I>-phenylenevinylene)s is a versatile method due to its living nature which enables the possibility of block copolymerization and end group modification. However, detailed studies on the reactivity behavior and the polymerization process of alkoxy-substituted [2.2]paracyclophane-1,9-dienes have not been reported so far. Herein we present a detailed study on the varying tendencies of the four isomers of dimethoxy-(2-ethylhexyloxy)-[2.2]paracyclophane-1,9-diene to undergo ROMP. Therefore, we carried out polymerization combining all individual isomers with five different metathesis catalysts and collected initiation and propagation kinetics for various combinations. Furthermore, we revealed a specific coordination of the monomer repeating unit to the catalyst during the polymerization process and succeeded to polymerize not only the pseudogeminal isomers but also one of the pseudo-<I>ortho</I> isomers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mamobx/2015/mamobx.2015.48.issue-20/acs.macromol.5b01737/production/images/medium/ma-2015-017375_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ma5b01737'>ACS Electronic Supporting Info</A></P>