Clinical Significance of Serum Vascular Endothelial Growth Factor and Complement 3a Levels in Patients with Colorectal Cancer in Southern Iran

Mehrabani, Davood,Shamsdin, Seyedeh Azra,Dehghan, Alireza,Safarpour, Alireza Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: Colon cancer (CRC) is perhaps the second most common cause of cancer mortality. This study determined the clinical significance of serum vascular endothelial growth factor (VEGF) and serum complement 3a (C3a) levels in patients with CRC in Fars province, southern Iran. Materials and Methods: Between June 2010 and June 2012, 110 patients with CRC of both genders and different age groups were divided into 3 groups. Group A included patients who had just undergone surgery; Group B had undergone chemotherapy after surgery; and Group C had undergone chemotherapy and radiotherapy after surgery. Twenty one healthy subjects with normal colonoscopy were considered as a control group. ELISA was undertaken to determine VEGF and C3a levels before and after treatment measures. Results: The mean age of patients was $53.9{\pm}14.1$ years. Considering VEGF level, a significant decrease was visible after treatment measures in groups A and B, but not Group C. For VEGF level, the difference was not statistically significant between two genders and various age groups before and after treatment. No significant difference was found for VEGF level between patients and normal group before any treatment. Regarding C3a levels in 101 subjects, they significantly decreased after treatment measures. Before and after treatment, the difference was statistically significant between two genders, but was not statistically significant among various age groups. Conclusions: As VEGF and C3a levels were significantly lower in patients after treatment, these may be beneficial markers in assessment of CRC therapy especially in early stages.

Scoring of Tenders in Construction Projects Using Group Method of Data Handling

Masoud Nouri Mehrabani,Emadaldin Mohammadi Golafshani,Mehdi Ravanshadnia 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.7

In a competitive construction environment, contractors are often faced with a large number of tenders that compel them to make the best decision in a limited time. In this paper, a decision support system (DSS) based on group method of data handling model (GMDH) was developed for the scoring of tenders (STs). Based on a comprehensive study of the existing literature and experts’ opinions, seven criteria were extracted, namely client, contract, company, consulting engineers, project status/situation, risk, and economic criteria as the inputs of the system. To develop the DSS, the data from 135 tenders were collected from the previous tenders of a private construction contractor. The results illustrate that the proposed model, with a negligible error, is reliable in ST. Moreover, the proposed model specifies the score of new tenders, and decision-makers (DMs) can easily make their decisions in prioritizing and evaluating new tenders. Furthermore, a sensitivity analysis was performed to address the importance of the criteria, and it was concluded that the contract related criterion is the most important principle to the contractor. Eventually, a graphical user interface was designed in a user-friendly environment which allows the decision-makers to visualize the ST.

Multidisciplinary optimization of a stiffened shell by genetic algorithm

Mahdi Maghsoudi Mehrabani,Ali Asghar Jafari,Mohammad Azadi 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.2

Vibration analysis of simply supported rotating cross-ply laminated stiffened cylindrical shell is performed using an energy approach which includes variational and averaging method. The stiffeners include rings and stringers. The equations are obtained by Rayleigh-Ritz method and Sander’s relations. To validate the present method, the results are compared to the results available in other literatures. A good adoption is observed in different type of results including isotropic shells, rotating laminated shells, stiffened isotropic shells and stiffened laminated shells. Then, the optimization of parameters due to shell and stiffeners is conducted by genetic algorithm (GA) method under weight and frequency constraints. Stiffener shape, material properties and dimensions are also optimized.

Data reconciliation: Development of an object-oriented software tool

Ali Farzi,Arjomand Mehrabani-Zeinabad,Ramin Bozorgmehry Boozarjomehry 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.5

Object-oriented modeling methodology is used for encapsulating different methods and attributes of data reconciliation (DR) in classes. Classes which are defined for DR, cover steady-state, dynamic, linear and nonlinear DR problems. Two main classes are Constraints and DR and defined for manipulating constraints and general DR problem. The remaining classes are derived from these two classes. A class namely DDRMethod is developed for encapsulating all common attributes and methods needed for any DDR method. Developed DR software and the method of performing dynamic DR are discussed in this paper. Two illustrative examples of Extended Kalman Filtering and artificial neural networks are used for DDR and two classes of DDRByKalman and NetDDRMethod developed by inheritance from DDRMethod class for these two methods. Performance of the proposed method is investigated by DDR of temperature measurements of a distillation column.

Laminate composites behavior under quasi-static and high velocity perforation

M.H. Pol,E. Mehrabani Yeganeh,G. H. Liaghat 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.22 No.4

In this paper, the behavior of woven E-glass fabric composite laminate was experimentally investigated under quasi-static indentation and high velocity impact by flat-ended, hemispherical, conical (cone angle of 37° and 90°) and ogival (CRH of 1.5 and 2.5) cylindrical perforators. Moreover, the results are compared in order to explore the possibility of extending quasi-static indentation test results to high velocity impact test results in different characteristics such as perforation mechanisms, performance of perforators, energy absorption, friction force, etc. The effects of perforator nose shape, nose length and nose-shank connection shapes were investigated. The results showed that the quasi-static indentation test has a great ability to predict the high velocity impact behavior of the composite laminates especially in several characteristics such as perforation mechanisms, perforator performance. In both experiments, the highest performance occurs for 2.5 CRH projectile and the lowest is related to blunt projectiles. The results show that sharp perforators indicate lower values of dynamic enhancement factor and the flat-ended perforator represents the maximum dynamic enhancement factor among other perforators. Moreover, damage propagation far more occurred in high velocity impact tests then quasi-static tests. The highest damage area is mostly observed in ballistic limit of each projectile which projectile deviation strongly increases this area.

Disorders of Liver : Prevalence of Hepatitis D In Patients With Chronic Active Hepatitis B, And Comparison of Liver Enzymes And Histopathology In The Positive And Negative Group

( Seyed Alineza Taghavi ),( Davood Mehrabani ),( Farnaz Khademolhosseini ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The term viral hepatitis is used to describe viral infections that primarily involve the liver. Six main viruses have been recognized, as agents responsible for viral hepatitis, including hepatitis A, B, C, D, E and G viruses. The aim of this study was to determine the prevalence and histopathological characteristics of hepatitis D in patients with chronic active hepatitis B. Methods: In this study, anti-HDV antibody was checked by ELISA (Enzyme linked immunosorbent assay) method in 93 patients with chronic active hepatitis B (HBsAg +ve with>1.5 times normal aminotransferases and active liver pathology). Patients were selected from referrals to Mothahari Clinic in Shiraz in two consecutive years (1381-1382). Results: Among 93 Patients, 9 (9.7%) were seropositive for anti HDV antibody. Overall, 76.3% of our patients were males, and the positive group were all males. Comparison of liver enzymes (AST and ALT) and liver histology (grade and stage of liver disease) in the positive and negative group revealed a significantly higher AST (P value: 0.016) in the positive group. Mean ALT levels were also higher in positive group, but the difference was not statistically significant (P value: 0.162). Grade and stage of liver disease was also significantly more advanced in the positive group. (P value of: 0.004 and 0.009 respectively). Among the positive group, the most common mode of transmission was intravenous drug use (44.4%). Overall the most common mode of transmission (40.9%) was unknown (most patients were detected during screening for blood donation). There is a clear male predominance in the HDV positive group, that could be due to the higher rate of high risk behavior, including IV drug abuse. Conclusions: On the basis of findings, we suggest that the anti-HDV status in any patient with positive HBsAg should be checked. Confirmation of the results of anti-HDV Ab tests with more accurate tests showing recent HDV infection seems to be essential.

Influence of Superabsorbent Polymer Rates on Growth of Saffron Replacement Corms

Hamid-Reza Fallahi,Gholamreza Zamani,Mokhadereh Mehrabani,Mahsa Aghhavani-Shajari,Alireza Samadzadeh 한국작물학회 2016 Journal of crop science and biotechnology Vol.19 No.1

Mother corm size is the most important factor for production of replacement corms, flower, and stigma yield in saffron. In semi-arid regions, water shortage is a deterrent agent for appropriate corm growth of saffron. Therefore, in this experiment the effects of six levels of superabsorbent polymer (SAP) including 0, 10, 20, 30, 40, and 50 kg ha-1 was investigated on growth indices of replacement corms of saffron. For this purpose, an experiment was evaluated at the research farm of the Saffron Research Group, Sarayan Faculty of Agriculture, University of Birjand, Iran, during 2013-2015. Results showed that SAP application did not considerable effect on corm growth indices in the first life cycle of saffron. Nevertheless, consumption of 30-40 kg ha-1 SAP somewhat improved the number and total weight of replacement corms per clone. In the second life cycle of saffron, the positive impact of SAP was clearly observed on the growth of replacement corms. The application of 40 kg ha-1 SAP increased the amount of number of replacement corms per clone by 13%, total weight of replacement corms per clone by 36%, and scale weight of corms per clone by 50% compared with control. In addition, the amount of mean weight of replacement corms and mean number of buds per corm in treatment of application of 40 kg ha-1 SAP were 29 and 27% higher than the control treatment, respectively. SAP application decreased the amount of non-standard (< 8 g) corm production while significantly increased the percentage of corms with standard weight. Overall, the increasing effect of SAP application on corm weight, bud number, and standard corm yield was higher than the number of produced corms per clone. In addition, water-use efficiency in SAP application treatments (6.1 kg standard corm m-3) was more than the control (4.34 kg m-3) treatment. In total, SAP application is an appropriate strategy for production of standard saffron corms in semi-arid regions.

Fatty Acid and Carotenoid Production by Sporobolomyces ruberrimus when Using Technical Glycerol and Ammonium Sulfate

( Razavi Seyed Hadi ),( Seyed Mohammad Mousavi ),( Hassan Mehrabani Yeganeh ),( Ivan Marc ) 한국미생물생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.10

MGMT-B Gene Promoter Hypermethylation in Patients with Inflammatory Bowel Disease - A Novel Finding

Mokarram, Pooneh,Kavousipour, Soudabeh,Sarabi, Mostafa Moradi,Mehrabani, Golnosh,Fahmidehkar, Mohammad Ali,Shamsdin, Seyedeh Azra,Alipour, Abbas,Naini, Mahvash Alizade Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Inflammatory bowel disease (IBD) is a disease strongly associated with colorectal cancer (CRC) as a well-known precancerous condition. Alterations in DNA methylation and mutation in K-ras are believed to play an early etiopathogenic role in CRC and may also an initiating event through deregulation of molecular signaling. Epigenetic silencing of APC and SFRP2 in the WNT signaling pathway may also be involved in IBD-CRC. The role of aberrant DNA methylation in precancerous state of colorectal cancer (CRC) is under intensive investigation worldwide. The aim of this study was to investigate the status of promoter methylation of MGMT-B, APC1A and SFRP2 genes, in inflamed and normal colon tissues of patients with IBD compared with control normal tissues. A total of 52 IBD tissues as well as corresponding normal tissues and 30 samples from healthy participants were obtained. We determined promoter methylation status of MGMT-B, SFRP2 and APC1A genes by chemical treatment with sodium bisulfite and subsequent MSP. The most frequently methylated locus was MGMT-B (71%; 34 of 48), followed by SFRP2 (66.6 %; 32 of 48), and APC1A (43.7%; 21 of 48). Our study demonstrated for the first time that hypermethylation of the MGMT-B and the SFRP2 gene promoter regions might be involved in IBD development. Methylation of MGMT-B and SFRP2 in IBD patients may provide a method for early detection of IBD-associated neoplasia.

Evaluation of Coloring Potential of Dietzia natronolimnaea Biomass as Source of Canthaxanthin for Egg Yolk Pigmentation

Esfahani-Mashhour, M.,Moravej, H.,Mehrabani-Yeganeh, H.,Razavi, S.H. Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.2

An experiment was conducted to evaluate the effect of different levels of extracted pigment from Dietzia natronolimnaea biomass as a source of canthaxanthin in comparison with synthetic canthaxanthin on egg yolk pigmentation. The experiment used a completely randomized design (CRD). A total of 63 laying hens, 68 weeks old, were used and the birds were allotted to 7 dietary treatments with each treatment replicated three times with three hens per replicate. Treatments consisted of 3 levels of synthetic canthaxanthin (4, 8 and 16 ppm), 3 levels of extracted pigment from D. natronolimnaea biomass (4, 8 and 16 ppm) and control. Changes in yolk color were determined in 2 eggs taken at random, during the four week experimental period from each replicate. Supplementation of extracted pigment from D. natronolimnaea biomass had a significant effect on the color of egg yolks (p<0.05). Yolk color score of the control group was 6.83 in BASF color fan and the yolk color score of different extracted pigment levels was 11.00, 12.50 and 14.50, respectively. The yolk colors of different levels of synthetic canthaxanthin were 12.00, 14.00 and 15.00, respectively. The effect of pigment supplementation on egg yolk color was better explained by polynomial response curves. The $R_{2}$ indicated that for 3 supplementation levels of each pigment studied, over 90% of the color variation could be explained by the pigment concentration. The egg yolk color after 15 and 30 days of storage was not significantly different, but boiling reduced egg yolk color significantly (p<0.05).