http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Clinical Efficacy of Endocytoscopy for Gastrointestinal Endoscopy
Masashi Misawa,Shin-ei Kudo,Yuki Takashina,Yoshika Akimoto,Yasuharu Maeda,Yuichi Mori,Toyoki Kudo,Kunihiko Wakamura,Hideyuki Miyachi,Fumio Ishida,Haruhiro Inoue 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Endocytoscopy (EC) is a contact-type optical endoscope that allows in vivo cellular observation during gastrointestinal endoscopyand is now commercially available not only in Japan but also in Asian, European Union, and Middle Eastern countries. EC helpsconduct a highly accurate pathological prediction without biopsy. Initially, EC was reported to be effective for esophageal diseases. Subsequently, its efficacy for stomach and colorectal diseases has been reported. In this narrative review, we searched for clinicalstudies that investigated the efficacy of EC. EC seems to accurately diagnose gastrointestinal diseases without biopsy. Most of thestudies aimed to clarify the relationship between endocytoscopic findings of gastrointestinal neoplasia and pathological diagnosis. Some studies have investigated non-epithelial lesions or diseases, such as inflammatory bowel disease or infectious diseases. However, there are few high-level pieces of evidence, such as randomized trials; thus, further studies are needed.
Fujita Masashi,Kimura Hisamichi,Inoue Akihisa 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
New Al-based alloys with very high ultimate tensile strength were developed in high Al concentration range of 91-95 at.% for Al-Fe-Cr-Ti-M (M: Co and Mo) systems and Al-Fe-Cr-Mo-Ti-Co system by the dispersion of nanoscale quasicrystalline particles in Al phase. The effect of adding elements, M was discussed in the viewpoint of stability of super-cooled liquid state and formation ability of quasicrystalline phase. The P/M Al-Fe-Cr-Ti-M alloys with dispersed nanoscale quasicrystalline particles exhibited ultimate tensile strength of 350MPa at 573K and 200MPa at 673K.
정상귀유 ( Takahiro Inoue ),우전아사 ( Masashi Hada ),탕택돈자 ( Atsuko Yuzawa ),이세훈 ( Sei Hoon Lee ),권영대 ( Young Dae Kwon ) 한국병원경영학회 2008 병원경영학회지 Vol.13 No.4
Japanese national health expenditure was 8.0% of GDP in 2004, and it was lower than average of OECD countries. But it has increased rapidly in recent years. Japan has relatively many acute care beds and high-price medical equipments, and the average length of stay is long. Japanese government is trying healthcare reform to contain healthcare expenditure, increase the efficiency of management and improve the quality of healthcare. As healthcare policies for hospitals such as DPC (Diagnosis Procedure Combination) for acute care beds, reduction of long-term care beds, and functional differentiation and liaison among healthcare institutions are implemented, the number of hospitals in financial difficulties is increasing. The serious situation urges hospitals to adapt to changes and search new directions of management. They need to establish and implement appropriate positioning strategy, and increase management efficiencies. Korean healthcare system has similarities with Japanese in many aspects. The recent reform and changes in Japanese healthcare system and hospitals give suggestions to Korean hospitals as to how they can prepare for environmental changes and improve management.
Alumina fi lm sputter deposition on mold steel by large-area electron beam irradiation
Togo Shinonaga,Masashi Takata,Motohiro Inoue,Akira Okada 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.5
During the large-area EB irradiation, plasma generation is confirmed by collision of electrons with vaporized workpiece materials above the substrate surface due to its high energy density. This phenomenon would cause the sputtering of target material when it is set near the substrate surface. Thus, there is a possibility for coating a target material on the substrate surface by the large-area EB irradiation. The simultaneous sputter deposition of target material with melting and resolidification of workpiece surface by the large-area EB would improve the adhesion strength between the coated fi lm and the workpiece surface. In this study, a new ceramics coating method with sputtering of target tube by large-area EB irradiation is proposed. Ceramic target tube made of alumina is put on the substrate surface of mold steel, and the large-area EB is irradiated to the substrate surface. The alumina fi lm with thickness of several micro meter can be formed on the substrate surface. Moreover, the fi lm formation mechanism is discussed by changing material property of a jig supporting the alumina target tube. The spectrum of plasma generated on the substrate surface during the EB irradiation is also analyzed. It is made clear that the magnetic property of jig greatly influences on the fi lm formation. Furthermore, main components of plasma generated on workpiece surface during the process are components of steel in the case of low number of EB irradiation, while much more alumina component as a fi lm is detected in the case of high number of EB irradiation.
Seiji Ohtori,Takeshi Sainoh,Masashi Takaso,Gen Inoue,Sumihisa Orita,Yawara Eguchi,Junichi Nakamura,Yasuchika Aoki,Tetsuhiro Ishikawa,Masayuki Miyagi,Gen Arai,Hiroto Kamoda,Miyako Suzuki,Gou Kubota,Yos 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.2
Purpose: Sacroiliac fixation using iliac screws for highly unstable lumbar spine has been reported with an improved fusion rate and clinical results. On the other hand, there is a potential for clinical problems related to iliac fixation, including late sacroiliac joint arthritis and pain. Materials and Methods: Twenty patients were evaluated. Degenerative scoliosis was diagnosed in 7 patients, failed back syndrome in 6 patients, destructive spondyloarthropathy in 4 patients, and Charcot spine in 3 patients. All patients underwent posterolateral fusion surgery incorporating lumbar, S1 and iliac screws. We evaluated the pain scores, bone union, and degeneration of sacroiliac joints by X-ray imaging and computed tomography before and 3 years after surgery. For evaluation of low back and buttock pain from sacroiliac joints 3 years after surgery, lidocaine was administered in order to examine pain relief thereafter. Results: Pain scores significantly improved after surgery. All patients showed bone union at final follow-up. Degeneration of sacroiliac joints was not seen in the 20 patients 3 years after surgery. Patients showed slight low back and buttock pain 3 years after surgery. However, not all patients showed relief of the low back and buttock pain after injection of lidocaine into the sacroiliac joint, indicating that their pain did not originate from sacroiliac joints. Conclusion: The fusion rate and clinical results were excellent. Also, degeneration and pain from sacroiliac joints were not seen within 3 years after surgery. We recommend sacroiliac fixation using iliac screws for highly unstable lumbar spine.
Transdermal Fentanyl for Chronic Low Back Pain
Seiji Ohtori,Gen Inoue,Sumihisa Orita,Yawara Eguchi,Nobuyasu Ochiai,Shunji Kishida,Masashi Takaso,Yasuchika Aoki,Kazuki Kuniyoshi,Junichi Nakamura,Tetsuhiro Ishikawa,Gen Arai,Masayuki Miyagi,Hiroto Ka 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.4
Purpose: Chronic low back pain is a common clinical problem. As medication, non-steroidal anti-inflammatory drugs are generally used; however, they are sometimes non-effective. Recently, opioids have been used for the treatment of chronic low back pain, and since 2010, transdermal fentanyl has been used to treat chronic non-cancer pain in Japan. The purpose of the current study was to examine the efficacy of transdermal fentanyl in the treatment of chronic low back pain. Materials and Methods: This study included patients (n=62) that suffered from chronic low back pain and were non-responsive to non-steroidal anti-inflammatory drugs. Their conditions consisted of non-specific low back pain, multiple back operations, and specific low back pain awaiting surgery. Patients were given transdermal fentanyl for chronic low back pain. Scores of the visual analogue scale and the Oswestry Disability Index, as well as adverse events were evaluated before and after therapy. Results: Overall, visual analogue scale scores and Oswestry Disability Index scores improved significantly after treatment. Transdermal fentanyl (12.5 to 50 μg/h) was effective in reducing low back pain in 45 of 62 patients; however, it was not effective in 17 patients. Patients who experienced the most improvement were those with specific low back pain awaiting surgery. Adverse events were seen in 40% of patients (constipation, 29%; nausea, 24%; itching, 24%). Conclusion: Transdermal fentanyl significantly improved visual analog scale scores and Oswestry Disability Index scores in 73% of patients, especially those with specific low back pain awaiting surgery; however, it did not decrease pain in 27% of patients, including patients with non-specific low back pain or multiple back operations.
( Hiroyuki Kan ),( Yuji Arai ),( Masashi Kobayashi ),( Shuji Nakagawa ),( Hiroaki Inoue ),( Manabu Hino ),( Shintaro Komaki ),( Kazuya Ikoma ),( Keiichiro Ueshima ),( Hiroyoshi Fujiwara ),( Toshikazu 대한슬관절학회 2017 대한슬관절학회지 Vol.29 No.1
Purpose: The fixed flexion view (FFV) of the knee is considered useful for evaluating the joint space when assessing the severity of osteoarthritis (OA) of the knee. To clarify the usefulness of FFV for evaluation of the joint space and severity of knee OA, this study evaluated changes in the joint space on the FFV and standing extended view (SEV) in patients with knee OA. Materials and Methods: The SEV and FFV images were acquired in 567 patients (1,102 knees) who visited the hospital with a chief complaint of knee joint pain. Medial joint space width (MJSW) and Kellgren-Lawrence (K-L) classification assessed using the SEV and FFV images were compared. Results: Mean MJSW was significantly smaller when assessed on the FFV than on the SEV (3.02±1.55 mm vs. 4.31±1.30 mm; p<0.001). The K-L grade was the same or higher on the FFV than on the SEV. Conclusions: The FFV is more useful than the SEV for evaluating the joint space in OA knees. Treatment strategies in patients with knee OA should be determined based on routinely acquired FFV images.
Efficacy of Combination of Meloxicam and Pregabalin for Pain in Knee Osteoarthritis
Seiji Ohtori,Gen Inoue,Sumihisa Orita,Masashi Takaso,Yawara Eguchi,Nobuyasu Ochiai,Shunji Kishida,Kazuki Kuniyoshi,Yasuchika Aoki,Tetsuhiro Ishikawa,Masayuki Miyagi,Hiroto Kamoda,Miyako Suzkuki,Junich 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.5
Purpose: Osteoarthritic pain is largely considered to be inflammatory pain. Sensory nerve fibers innervating the knee have been shown to be significantly damaged in rat models of knee osteoarthritis (OA) in which the subchondral bone junction is destroyed, and this induces neuropathic pain (NP). Pregabalin was developed as a pain killer for NP; however, there are no reports on pregabalin use in OA patients. The purpose of this study was to investigate the efficacy of pregabalin for pain in OA patients. Materials and Methods: Eighty-nine knee OA patients were evaluated in this randomized prospective study. Patients were divided into meloxicam, pregabalin, and meloxicam+pregabalin groups. Pain scores were evaluated before and 4 weeks after drug application using a visual analogue scale (VAS), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pain scales among groups were compared using a Kruskal-Wallis test. Results: Before drug application, there was no significant difference in VAS and WOMAC scores among the three groups (p>0.05). Significant pain relief was seen in the meloxicam+pregabalin group in VAS at 1, 2, and 4 weeks, and WOMAC score at 4 weeks, compared with the other groups (p<0.05). No significant pain relief was seen in the meloxicam only group in VAS during 4 weeks and WOMAC score at 4 weeks compared with the pregabalin only group (p>0.05). Conclusion: Meloxicam+pregabalin was effective for pain in OA patients. This finding suggests that OA pain is a combination of inflammatory and NP.