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        Measurement of Exhaled Nitric Oxide in Children: A Comparison Between NObreath® and NIOX VERO® Analyzers

        Yoko Inoue,Sakura Sato,Tetsuharu Manabe,Eishi Makita,Masako Chiyotanda,Kyohei Takahashi,Hitoshi Yamamoto,Noriyuki Yanagida,Motohiro Ebisawa 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.5

        Purpose: Few studies have compared fractional exhaled nitric oxide (FeNO) measurement by NIOX VERO® (NOV) and other devices in children. Moreover, there is no agreement between differences in FeNO values obtained using different devices in adults. Here, we compared FeNO values obtained using NOV and NObreath® (NOB) systems to derive a correction equation for children. Methods: Eighty-eight participants (age 7–15 years) who were diagnosed with atopic bronchial asthma and visited Sagamihara National Hospital as outpatients between January and April of 2017 were included. We measured FeNO values obtained using NOB and NOV, and analyzed them using Wilcoxon tests and Altman-Bland plots. Results: The median age of the participants was 11.5 years, and the scored Asthma Control Test (ACT) or Childhood ACT (C-ACT) was 25 (interquartile range, 24–25) or 26 (24–27). NOB and NOV values were significantly different (31 [14–52] versus 36 [20–59] ppb; P = 0.020) and strongly correlated (r = 0.92). An equation to convert NOB values into NOV values was derived using linear regression as follows: log NOV = 0.7329 × log NOB + 0.4704; NOB for 20, 40, 58, 80 and 100 ppb corresponded to NOV for 27, 44, 59, 73 and 86 ppb. Thus, NOB < 58 ppb suggested NOB < NOV, whereas NOB > 58 ppb suggested NOB > NOV. Conclusions: NOB and NOV values were strongly correlated. Participants whose FeNO values were relatively low represented NOB < NOV, whereas those whose FeNO values were relatively high represented NOB > NOV.

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        Alumina fi lm sputter deposition on mold steel by large-area electron beam irradiation

        Togo Shinonaga,Masashi Takata,Motohiro Inoue,Akira Okada 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.5

        During the large-area EB irradiation, plasma generation is confirmed by collision of electrons with vaporized workpiece materials above the substrate surface due to its high energy density. This phenomenon would cause the sputtering of target material when it is set near the substrate surface. Thus, there is a possibility for coating a target material on the substrate surface by the large-area EB irradiation. The simultaneous sputter deposition of target material with melting and resolidification of workpiece surface by the large-area EB would improve the adhesion strength between the coated fi lm and the workpiece surface. In this study, a new ceramics coating method with sputtering of target tube by large-area EB irradiation is proposed. Ceramic target tube made of alumina is put on the substrate surface of mold steel, and the large-area EB is irradiated to the substrate surface. The alumina fi lm with thickness of several micro meter can be formed on the substrate surface. Moreover, the fi lm formation mechanism is discussed by changing material property of a jig supporting the alumina target tube. The spectrum of plasma generated on the substrate surface during the EB irradiation is also analyzed. It is made clear that the magnetic property of jig greatly influences on the fi lm formation. Furthermore, main components of plasma generated on workpiece surface during the process are components of steel in the case of low number of EB irradiation, while much more alumina component as a fi lm is detected in the case of high number of EB irradiation.

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