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杉山政則,白舜英,能美良作 한국산업미생물학회 1985 한국미생물·생명공학회지 Vol.13 No.1
Much of the progress in genetic engineering has been accomplished by employing Escherichia coli as the host organism. For many reasons, however, some other organisms have greater potential as alternatives to E. coli. In particular, streptomycetes are attractive organisms as hosts especially for the producation of various secondary metabolites such as antibiotics. In this article, therefore, we reviewed the techniques for development of vector system and expression of genes for antibiotic biosynthesis in streptomycete hosts.
항생물질생산균의 단백질합성계조해항생물질(蛋白質合成系阻害抗生物質)에 대한 자기내성기구와 생합성유전자
양한철,백순영,삼산정칙 한국농화학회 1988 Applied Biological Chemistry (Appl Biol Chem) Vol.31 No.4
Streptomycetes are attractive microorganisms for their production of various secondary metabolites such as antibiotics. Now, the development of gene manipulation in this microorganisms enables the cloning and analysis of the genes which coding for antibiotic biosynthesis and resistance to the drug. In this article, we reviewed the studies with respect to the mechanisms of self-protection and cloning of the genes cloning for antibiotic biosynthesis, particularly, in microorganisms which produce antibiotic inhibitors of protein synthesis.
Streptomyces lividasn 의 Blasticidin S 에 대한 내성 Mechanism
백순영,야촌정,미호이수하라,마사노리수기야마 생화학분자생물학회 1995 BMB Reports Vol.24 No.3
A mechanism of resistance to blasticidin S in Streptomyces lividans 66 was investigated. Although the microorganism was highly resistant to the drug in vivo, the in vitro protein-synthesizing system was significantly sensitive. The possible resistance mechanism was discussed and suggested.
New Prognostic Scoring System for Incurable Stage IV Colorectal Cancer
Kishiki, Tomokazu,Masaki, Tadahiko,Mastuoka, Hiroyoshi,Abe, Nobustugu,Mori, Toshiyuki,Sugiyama, Masanori Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Background: Components of the systemic inflammatory response, combined to form inflammation-based prognostic scores (mGPS, NLR, PLR, PI, PNI) have been associated with overall survival. The aim of the present study was to compare various prognostic factors including many previously established parameters and such systemic inflammation-based prognostic scores in a series of incurable stage IV colorectal cancer (CRC) patients. Materials and Methods: Patients (n=167) with stage IV CRC undergoing surgical procedures between 2005 and 2013 were enrolled. Preoperatively (7-30 days before surgery), routine laboratory examinations were performed on the same day. We calculated scores using these data and analyzed the association with cancer specific survival (CSS) statistically. Results: Univariate analysis revealed significant associations between CSS and WBC, albumin, CRP, CEA values, mGPS, PNI, and PI values among preoperative factors. On multivariate analysis, high mGPS and high CEA independently predicted shorter CSS (p=0.001 and p=0.018). A new scoring system was constructed using mGPS and CEA. When patients were separated into three categorized using this system, the new score accurately predicted CSS (p < 0.001). Conclusions: The present study indicates that a new scoring system, consisting of mGPS and CEA, is a simple and useful tool in predicting the survival of patients with incurable stage IV CRC, and should be included in the routine assessment of these patients for decision making of appropriate treatment.
Narandalai DANSHIITSOODOL,Hideyuki YAMASHITA,Masafumi NODA,Takanori KUMAGAI,Yasuyuki MATOBA,Masanori SUGIYAMA 대한바이러스학회 2014 Journal of Bacteriology and Virology Vol.44 No.2
Oral infection with Porphyromonas (P.) gingivalis causes periodontitis that is manifested by the destruction of gingival connective tissues. Although a few types of antibiotics are effective against the infection, its use induces the appearance of drug-resistant bacteria. The present study shows that the fermented product of Aspergillus (A.) oryzae S-03, cultivated on the fat-removed soybean, inhibits the cell growth of the P. gingivalis. Likewise, the fermented product of the S-03 strain cultured for 26~42 h displays an inhibitory activity to gingipain as a virulence factor of P. gingivalis. The activity is not lost even with heat treatment at 100℃ for 15 min. We also demonstrate that the S-03 strain exhibits high protease activity. In addition, the strain does not produce aflatoxin because of the loss of a regulatory gene, aflR, necessary for the toxin biosynthesis.