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New Prognostic Scoring System for Incurable Stage IV Colorectal Cancer
Kishiki, Tomokazu,Masaki, Tadahiko,Mastuoka, Hiroyoshi,Abe, Nobustugu,Mori, Toshiyuki,Sugiyama, Masanori Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Background: Components of the systemic inflammatory response, combined to form inflammation-based prognostic scores (mGPS, NLR, PLR, PI, PNI) have been associated with overall survival. The aim of the present study was to compare various prognostic factors including many previously established parameters and such systemic inflammation-based prognostic scores in a series of incurable stage IV colorectal cancer (CRC) patients. Materials and Methods: Patients (n=167) with stage IV CRC undergoing surgical procedures between 2005 and 2013 were enrolled. Preoperatively (7-30 days before surgery), routine laboratory examinations were performed on the same day. We calculated scores using these data and analyzed the association with cancer specific survival (CSS) statistically. Results: Univariate analysis revealed significant associations between CSS and WBC, albumin, CRP, CEA values, mGPS, PNI, and PI values among preoperative factors. On multivariate analysis, high mGPS and high CEA independently predicted shorter CSS (p=0.001 and p=0.018). A new scoring system was constructed using mGPS and CEA. When patients were separated into three categorized using this system, the new score accurately predicted CSS (p < 0.001). Conclusions: The present study indicates that a new scoring system, consisting of mGPS and CEA, is a simple and useful tool in predicting the survival of patients with incurable stage IV CRC, and should be included in the routine assessment of these patients for decision making of appropriate treatment.
Investigation of Ferroelectric Transition in SrTi18O3 under Hydrostatic Pressure
Masaaki Kurita,Alain Moreac,Jean-Claude Ameline,Masaki Takesada,Mitsuru Itoh,Shinya Koshihara,Tadahiko Ishikawa 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1
SrTi18O3 shows a ferroelectric transition at 19.7 K at ambient pressure, and the appearance of new Raman peaks associated with this ferroelectric transition has been reported. This is the rst report of the observation of the change in the Raman spectra under high pressure. The ferroelectric-transition temperature probed by dielectric-property measurements decreases with increasing pressure (P), and the ferroelectric order seems to disappear for the P > 500 bar. Quite parallel behavior has been conrmed for the P dependence of the intensity of the Raman band characteristic of the ferroelectric state.