Application of Cox and Parametric Survival Models to Assess Social Determinants of Health Affecting Three-Year Survival of Breast Cancer Patients

Mohseny, Maryam,Amanpour, Farzaneh,Mosavi-Jarrahi, Alireza,Jafari, Hossein,Moradi-Joo, Mohammad,Monfared, Esmat Davoudi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Breast cancer is one of the most common causes of cancer mortality in Iran. Social determinants of health are among the key factors affecting the pathogenesis of diseases. This cross-sectional study aimed to determine the social determinants of breast cancer survival time with parametric and semi-parametric regression models. It was conducted on male and female patients diagnosed with breast cancer presenting to the Cancer Research Center of Shohada-E-Tajrish Hospital from 2006 to 2010. The Cox proportional hazard model and parametric models including the Weibull, log normal and log-logistic models were applied to determine the social determinants of survival time of breast cancer patients. The Akaike information criterion (AIC) was used to assess the best fit. Statistical analysis was performed with STATA (version 11) software. This study was performed on 797 breast cancer patients, aged 25-93 years with a mean age of 54.7 (${\pm}11.9$) years. In both semi-parametric and parametric models, the three-year survival was related to level of education and municipal district of residence (P<0.05). The AIC suggested that log normal distribution was the best fit for the three-year survival time of breast cancer patients. Social determinants of health such as level of education and municipal district of residence affect the survival of breast cancer cases. Future studies must focus on the effect of childhood social class on the survival times of cancers, which have hitherto only been paid limited attention.

EFFECTS OF PHOTOPERIOD MANIPULATION ON GROWTH PERFORMANCE AND STRESS RESPONSES OF JUVENILE BELUGA, Huso huso

Mahmoud Mohseni,Sungchul C. Bai,Erfan Shahkar,Fariba Ramzani,Maryam Khandaee 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5

Optimization of arsenite removal by adsorption onto organically modified montmorillonite clay: Experimental & theoretical approaches

Anoushiravan Mohseni Bandpei,Seyed Mohsen Mohseni,Amir Sheikhmohammadi,Mahdieh Sardar,Maryam Sarkhosh,Mohammad Almasian,Moayad Avazpour,Zahra Mosallanejad,Zahra Atafar,Shahram Nazari,SoheilaRezaei 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2

Arsenic is a critical contaminant for aqueous environments as it poses harmful health risks. To meet the stringent regulations regarding the presence of arsenic in aqueous solutions, the feasibility of montmorillonite clay modified with hexadecyltrimethyl ammonium chloride as the adsorbent was tested for the removal of arsenic ions from aqueous solutions. A scanning electron microscopy (SEM) study confirmed that the organically modified nanoclay (ONC) adsorbent had a porous structure with a vast adsorbent surface. The x-ray fluorescence (XRF) analysis proved the presence of carbon in the structure of the modified nanoclay that can be evidence for the creation of ONC. The x-ray diffraction (XRD) analysis results confirm the existence of four main groups of minerals, carbonate (Calcite), clay (Askmtyt and Kandyt), silicate (Quartz), and phyllosilicate (Kaolinite), in the ONC structure.The influence of various parameters such as solution pH, adsorbent dosage, initial arsenite concentration, and contact time on arsenic adsorption onto ONC was investigated. A 25 full factorial central composite experimental design was applied. A central composite design under response surface methodology (RSM) was employed to investigate the effects of independent variables on arsenite removal and to determine the optimum condition. The experimental values were in a good fit with the ones predicted by the model. The optimal operating points (adsorbent dosage: 3.7 g L−1, surfactant dosage: 3 g L−1 and the contact time: 37.2min) giving maximum arsenite removal (95.95%) were found using Solver “Add-ins” in Microsoft Excel 2010.

Assessment of flowing ability of self-compacting mortars containing recycled glass powder

Alipour, Pedram,Namnevis, Maryam,Tahmouresi, Behzad,Mohseni, Ehsan,Tang, Waiching Techno-Press 2019 Advances in concrete construction Vol.8 No.1

This paper investigates the effect of recycled glass powder (RGP) on flowing properties of self-compacting mortars (SCMs) containing different ratios of fillers and superplasticizer dosages. Fly ash (FA), nano-silica (NS), micro-silica (MS), metakaolin (MK) and rice husk ash (RHA) are used as fillers and their synergistic effect with RFP is studied. The effects of fillers and high-range water reducer (HRWR) on flowing ability of mortars are primarily determined by slump flow and V-funnel flow time tests. The results showed that for composites with a higher RGP content, the mortar flowing ability increased but tended to decrease when the composites containing 10% MK or 5% RHA. However, the flowing ability of samples incorporating 5% RGP and 10% SF or 25% FA showed an opposite result that their slump flow spread decreased and then increased with increasing RGP content. For specimens with 3% NS, the influence of RGP content on flowing properties was not significant. Except RHA and MS, the fillers studied in this paper could reduce the dosage of HRWR required for achieving the same followability. Also, the mixture parameters were determined and indicated that the flowability of mixtures was also affected by the content of sand and specific surface area of cement materials. It is believed that excess fine particles provided ball-bearing effect, which could facilitate the movement of coarse particles and alleviate the interlocking action among particles. Also, it can be concluded that using fillers in conjunction with RGP as cementitious materials can reduce the material costs of SCM significantly.

Effects of a curriculum integrating critical thinking on medical students’ critical thinking ability in Iran: a quasi-experimental study

Akbar Soltani,Mahboobeh Khabaz Mafinejad,Maryam Tajik,Hamideh Moosapour,Taha Bayat,Fatemeh Mohseni 한국보건의료인국가시험원 2021 보건의료교육평가 Vol.18 No.-

Purpose: Improving physicians’ critical thinking abilities could have meaningful impacts on various aspects of routine medical practice, such as choosing treatment plans, making an accurate diagnosis, and reducing medical errors. The present study aimed to measure the effects of a curriculum integrating critical thinking on medical students’ skills at Tehran University of Medical Sciences, Iran. Methods: A 1-group pre-test, post-test quasi-experimental design was used to assess medical students’ critical thinking abilities as they progressed from the first week of medical school to middle of the third year of the undergraduate medical curriculum. Fifty-six participants completed the California Critical Thinking Skills Test twice from 2016 to 2019. Results: Medical students were asked to complete the California Critical Thinking Skills Test the week before their first educational session. The post-test was conducted 6 weeks after the 2 and half-year program. Out of 91 medical students with a mean age of 20±2.8 years who initially participated in the study, 56 completed both the pre- and post-tests. The response rate of this study was 61.5%. The analysis subscale showed the largest change. Significant changes were found in the analysis (P=0.03), evaluation (P=0.04), and inductive reasoning (P<0.0001) subscales, but not in the inference (P=0.28), and deductive reasoning (P=0.42) subscales. There was no significant difference according to gender (P=0.77). Conclusion: The findings of this study show that a critical thinking program had a substantial effect on medical students’ analysis, inductive reasoning, and evaluation skills, but negligible effects on their inference and deductive reasoning scores.

Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach

Aliasghar Keramatinia,Alireza Ahadi,Mohammad Esmaeil Akbari,Maryam Mohseny,Alireza Mosavi Jarahi,Narjes Mehrvar,Neda Mansouri,S.A. Mortazavi Tabatabaei,Abolfazl Movafagh 대한암예방학회 2017 Journal of cancer prevention Vol.22 No.2

Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q34:q11). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.

The effect of diluted ropivacaine in distending fluid on cramping pain after hysteroscopic surgeries: a randomized clinical trial study

Kobra Tahermanesh,Abolfazl Mehdizadeh Kashi,Marziyeh Ajdary,Samaneh Rokhgireh,Masood Mohseni,Shahla Chaichian,Maryam Ahmadi 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.6

ObjectiveThe effect of ropivacaine on postoperative hysteroscopy has not yet been evaluated; this study investigated the effectof diluted ropivacaine in distending media during hysteroscopy on postoperative cramping pain. MethodsThis double-blind randomized clinical trial was conducted on 60 women who underwent hysteroscopy at a tertiaryhospital. Normal saline was used as the distending fluid in both groups. The intervention group received 10 mLof 2% ropivacaine in only one bottle of 1,000 mL normal saline as a distending fluid, while the control groupreceived 10 mL of normal saline in 1,000 mL normal saline during hysteroscopy. Patients’ pain scores wereevaluated before hysteroscopy and at 2, 6, 12, 24, and 48 hours after hysteroscopy. ResultsBased on the results, the pain measured by visual analog scale (VAS) score was significant at 6 and 12 hours after theintervention was significantly lower than that in the ropivacaine group (3.03±1.57 vs. 4±1.49, P=0.02 at 6 hours and1.28±1.36 vs. 2.4±1.43, P=0.003 at 12 hours). There were no significant differences in the VAS scores at 2, 24, and 48hours after the intervention between the two groups. ConclusionRopivacaine in the distending fluid during hysteroscopy is associated with a significant reduction in pain within a fewhours after hysteroscopy with no remarkable adverse effects.

Social Determinants of Health and 5-year Survival of Colorectal Cancer

Heidarnia, Mohammad Ali,Monfared, Esmat Davoudi,Akbari, Mohammad Esmail,Yavari, Parvin,Amanpour, Farzaneh,Mohseni, Maryam Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background: Early in the 21st century, cancers are the second cause of death worldwide. Colon cancer is third most common cancer and one of the few amenable to early diagnosis and treatment. Evaluation of factors affecting this cancer is important to increase survival time. Some of these factors affecting all diseases including cancer are social determinants of health. According to the importance of this disease and relation with these factors, this study was conducted to assess the relationship between social determinants of health and colon cancer survival. Materials and Methods: This was a cross-sectional, descriptive study for patients with colon cancer registered in the Cancer Research Center of Shahid Beheshti University of Medical Science, from April 2005 to November 2006, performed using questionnaires filled by telephone interview with patients (if patients had died, with family members). Data was analyzed with SPSS software (version 19) for descriptive analysis and STATA software for survival analysis including log rank test and three step Cox Proportional Hazard regression. Results: Five hundred fifty nine patients with ages ranging from 23 to 88 years with mean${\pm}$standard deviation of $63{\pm}11.8$ years were included in the study. The five year survival was 68.3%( 387 patients were alive and 172 patients were dead by the end of the study). The Cox proportional hazard regression showed 5-year survival was related to age (HR=0.53, p=0.042 for>50 years versus<50 years old) in first step, gender (HR=0.60, p=0.006 for female versus male) in second step, job (HR=1.7, p=0.001 for manual versus non manual jobs), region of residency (HR=3.49, p=0.018 for west versus south regions), parents in childhood (HR=2.87, p=0.012 for having both parents versus not having), anatomical cancer location (HR=2.16, p<0.033 for colon versus rectal cancer) and complete treatment (HR=5.96, p<0.001 for incomplete versus complete treatment). Conclusions: Social determinants of health such as job, city region residency and having parents during childhood have significant effects in 5-year survival of colon cancer and it may be better to consider these factors in addition to developing cancer treatment and to focus on these determinants of health in long-time planning.

Evaluation of sHLA-G levels in serum of patients with prostate cancer identify as a potential of tumor marker

Mohammad Hassan Heidari,Abolfazl Movafagh,Mohammad Amin Abdollahifar,Shabnam Abdi,Mohamadreza Mashhoudi Barez,Hadi Azimi,Afshin Moradi,Amin Bagheri,Matineh Heidari,Jafar Hessam Mohseni,Maryam Tadayon 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.1

Prostate cancer is the most common cancer type in men and is the second cause of death, due to cancer, in patients over 50, after lung cancer. Prostate specific antigen (PSA) is a widely used tumor marker for prostate cancer. Recently, PSA is discovered in non-prostatic cancer tissues in men and women raising doubts about its specificity for prostatic tissues. PSA exists in low serum level in healthy men and in higher levels in many prostate disorders, including prostatitis and prostate cancer. Thus, a supplementary tumor marker is needed to accurately diagnose the cancer and to observe the patient after treatment. Recently, soluble human leukocyte antigen-G (sHLA-G) has been introduced as a new tumor marker for different cancer types, including colorectal, breast, lung, and ovary. The present descriptive-experimental study was carried out including patients with malignant prostate tumor, patients with benign prostate tumor, and a group of health men as the control group, as judged by an oncologist as well as a pathologist. After sterile blood sampling, sHLA-G was measured by enzyme-linked immunosorbent assay in each group. The data was then analyzed using one-way ANOVA. P≤0.05 was considered as statistically significant. The results showed that the mean of sHLA-G level was high in patients. Also, it was found that there was a significant difference in sHLA serum level between the three groups. The data revealed that sHLA-G can be a novel upplementary tumor marker in addition to PSA to diagnose prostate cancer.