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        Health concerns regarding the effect of the COVID-19 pandemic on male fertility

        Hamidreza Mosleh,Fatemeh Moradi,Mehdi Mehdizadeh,Marziyeh Ajdary,Alaa Moeinzadeh,Ronak Shabani 대한생식의학회 2021 Clinical and Experimental Reproductive Medicine Vol.48 No.3

        Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus found in China in 2019. The disease caused by SARS-CoV-2, coronavirus disease 2019 (COVID-19), has been found to be closely related to the cells that secrete angiotensin-converting enzyme 2 (ACE2). ACE2 is involved in the renin-angiotensin system and is widely secreted in several tissues, including the testis, which has raised concerns because organs with high expression of the ACE2 receptor are susceptible to infection. Analyses have shown that in testicular cells, such as spermatogonia, seminiferous duct cells, Sertoli cells, and Leydig cells, there is a high expression level of ACE2. Therefore, SARS-CoV-2 may damage male reproductive tissues and cause infertility. Since male infertility is an important problem, scientists are evaluating whether COVID-19 may influence male infertility through the ACE2 receptor.

      • KCI등재

        The effect of diluted ropivacaine in distending fluid on cramping pain after hysteroscopic surgeries: a randomized clinical trial study

        Kobra Tahermanesh,Abolfazl Mehdizadeh Kashi,Marziyeh Ajdary,Samaneh Rokhgireh,Masood Mohseni,Shahla Chaichian,Maryam Ahmadi 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.6

        ObjectiveThe effect of ropivacaine on postoperative hysteroscopy has not yet been evaluated; this study investigated the effectof diluted ropivacaine in distending media during hysteroscopy on postoperative cramping pain. MethodsThis double-blind randomized clinical trial was conducted on 60 women who underwent hysteroscopy at a tertiaryhospital. Normal saline was used as the distending fluid in both groups. The intervention group received 10 mLof 2% ropivacaine in only one bottle of 1,000 mL normal saline as a distending fluid, while the control groupreceived 10 mL of normal saline in 1,000 mL normal saline during hysteroscopy. Patients’ pain scores wereevaluated before hysteroscopy and at 2, 6, 12, 24, and 48 hours after hysteroscopy. ResultsBased on the results, the pain measured by visual analog scale (VAS) score was significant at 6 and 12 hours after theintervention was significantly lower than that in the ropivacaine group (3.03±1.57 vs. 4±1.49, P=0.02 at 6 hours and1.28±1.36 vs. 2.4±1.43, P=0.003 at 12 hours). There were no significant differences in the VAS scores at 2, 24, and 48hours after the intervention between the two groups. ConclusionRopivacaine in the distending fluid during hysteroscopy is associated with a significant reduction in pain within a fewhours after hysteroscopy with no remarkable adverse effects.

      • KCI등재후보

        Does transcutaneous electrical nerve stimulation reduce the laparoscopic related shoulder pain?

        Abolfazl Mehdizadeh kashi,Sepideh Khodaverdi,Azam Govahi,Saeedeh Sarhadi,Mania Kaveh,Kambiz Sadegi,Roya Derakhshan,Marziyeh Ajdary,Shahla Chaichian 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.1

        Objective Although laparoscopic surgery is a good substitute for laparotomy in reducing postsurgical pain, many patients complain of shoulder pain after laparoscopic surgery and require pain-relief. Post-operative pain management leads to increased patient satisfaction. Transcutaneous Electrical Nerve Stimulation (TENS) is a non-pharmacological, noninvasive modality that reduces pain by activating the descending inhibitory systems in the central nervous system. Given the importance of decreasing shoulder pain after gynecological laparoscopy, the current study aimed to investigate the management of shoulder pain in these patients using TENS. Methods This was a retrospective case-control study. A total of 112 women aged 18-45 years who experienced shoulder pain due to gynecologic laparoscopic surgery were included in the study. Patients were divided into TENS and control groups. In the TENS group, TENS was used twice for 20 minutes each, but in the control group, the patients received regular treatment. Patients were evaluated at intervals of 2, 4, 8, 24, 48, and 72 hours after laparoscopy for shoulder pain score. Results The results showed a significant decrease in visual analog scale scores at 2, 4, and 8-hour in the TENS group compared with the control group. At 24 hours evaluation, although the pain was reduced, the difference was not significant. At 48- and 72-hour assessment, all patients in each group reported zero score for severity of pain. Conclusion The findings suggest that TENS significantly reduces postoperative shoulder pain.

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