Astrochemical Properties of Planck Cold Clumps

Tatematsu, Ken’ichi,Liu, Tie,Ohashi, Satoshi,Sanhueza, Patricio,Nguyê,̃,n Lu’o’, Quang,Hirota, Tomoya,Liu, Sheng-Yuan,Hirano, Naomi,Choi, Minho,Kang, Miju,A.Thompson, Mark,Fuller, Gary,Wu, Y Published by the University of Chicago Press for t 2017 The Astrophysical journal Supplement series Vol.228 No.2

<P>We observed 13 Planck cold clumps with the James Clerk Maxwell Telescope/SCUBA-2 and with the Nobeyama 45 m radio telescope. The N2H+ distribution obtained with the Nobeyama telescope is quite similar to SCUBA-2 dust distribution. The 82 GHz HC3N, 82 GHz CCS, and 94 GHz CCS emission are often distributed differently with respect to the N2H+ emission. The CCS emission, which is known to be abundant in starless molecular cloud cores, is often very clumpy in the observed targets. We made deep single-pointing observations in DNC, (HNC)-C-13, N2D+, and cyclic-C3H2 toward nine clumps. The detection rate of N2D+ is 50%. Furthermore, we observed the NH3 emission toward 15 Planck cold clumps to estimate the kinetic temperature, and confirmed that most targets are cold (less than or similar to 20 K). In two of the starless clumps we observed, the CCS emission is distributed as it surrounds the N2H+ core (chemically evolved gas), which resembles the case of L1544, a prestellar core showing collapse. In addition, we detected both DNC and N2D+. These two clumps are most likely on the verge of star formation. We introduce the chemical evolution factor (CEF) for starless cores to describe the chemical evolutionary stage, and analyze the observed Planck cold clumps.</P>

Characterization of Solanum tuberosum multicystatin and its structural comparison with other cystatins.

Nissen, Mark S,Kumar, G N Mohan,Youn, Buhyun,Knowles, D Benjamin,Lam, Ka Sum,Ballinger, W Jordan,Knowles, N Richard,Kang, Chulhee American Society of Plant Physiologists 2009 The Plant cell Vol.21 No.3

<P>Potato (Solanum tuberosum) multicystatin (PMC) is a crystalline Cys protease inhibitor present in the subphellogen layer of potato tubers. It consists of eight tandem domains of similar size and sequence. Our in vitro results showed that the pH/PO(4)(-)-dependent oligomeric behavior of PMC was due to its multidomain nature and was not a characteristic of the individual domains. Using a single domain of PMC, which still maintains inhibitor activity, we identified a target protein of PMC, a putative Cys protease. In addition, our crystal structure of a representative repeating unit of PMC, PMC-2, showed structural similarity to both type I and type II cystatins. The N-terminal trunk, alpha-helix, and L2 region of PMC-2 were most similar to those of type I cystatins, while the conformation of L1 more closely resembled that of type II cystatins. The structure of PMC-2 was most similar to the intensely sweet protein monellin from Dioscorephyllum cumminisii (serendipity berry), despite a low level of sequence similarity. We present a model for the possible molecular organization of the eight inhibitory domains in crystalline PMC. The unique molecular properties of the oligomeric PMC crystal are discussed in relation to its potential function in regulating the activity of proteases in potato tubers.</P>

한국 중년기 남녀의 건강상태 및 건강 관리 행동 : 성별, 연령집단별 차이를 중심으로 Focused on Gender and Age-group Differences

한경혜,이정화,Ryff. C.,Marks. N.,옥선화,차승은 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.1

The purpose of this study is to examine the health status and health behavior of middle-aged Korean men and women. Even though there has been increased concern about extremely high mortality rate of Korean middle-aged men and mental health problems of middle aged women, there is a dearth of empirical studies which examine the health status and health behavior of middle-aged men and women in Korea. This study atternpts to frll these gaps. Data gathered from 1,667 men and women aged between 30-59 are analyzed to examine the level of physical health, mental health, perceived health and health behavior and to explore the gender and age group differences in these aspects. The results show that there exist gender difference and age group difference in health status: Women are less healthy than men and as age increased health status declined. Women at their 50s are least healthy and most unhappy suggesting age and gender interaction in health status. There exist a gender difference in health behavior: Mne have regular check-ups more frequently than women and exercise more. These results are discussed in terms of the gender difference in the experiences, social roles and life styles over the life course.

Supersonically sprayed gas- and water-sensing MIL-100(Fe) films

Lee, Jong-Gun,Joshi, Bhavana N.,Samuel, Edmund,An, Seongpil,Swihart, Mark T.,Lee, Ji Sun,Hwang, Young Kyu,Chang, Jong-San,Yoon, Sam S. ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.722 No.-

<P><B>Abstract</B></P> <P>Highly uniform, mechanically stable, dense, and water-adsorbing MIL-100(Fe) films were fabricated via supersonic spraying, a rapid, high-throughput, and scalable method compatible with roll-to-roll processing. The film surface area (1667 m<SUP>2</SUP> g<SUP>−1</SUP>) was comparable to that of the nanoparticles from which it was prepared (2009 m<SUP>2</SUP> g<SUP>−1</SUP>), and was higher than previously reported values for MIL-100(Fe) films. The gas and water adsorption abilities of the film were tested by nitrogen physisorption and water adsorption at 30 °C. The supersonically sprayed film was mechanically resistant up to a critical scratching load of 1.84 N, higher than the critical scratchability loads of dip-coated or spin-coated films. In humidity-sensing applications, films that incorporated conductive Ag nanowires were highly responsive to environmental humidity, demonstrating applicability as water vapor sensors. The fabricated films were characterized by X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly uniform, mechanically stable, dense, and water-adsorbing MIL-100(Fe) films were fabricated via supersonic spraying. </LI> <LI> The film surface area was the highest value reported in the literature. </LI> <LI> The supersonically sprayed film was mechanically resistant up to a critical scratching load of 1.84 N. </LI> <LI> The fabricated films were highly responsive to environmental humidity, demonstrating applicability as water vapor sensors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren’s surgery

Benjamin H Miranda,Charlotte Elliott,Christopher C Kearsey,David N Haughton,Mark R Webb,Ian Harvey,Fahmy S Fahmy 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.6

Background Numerous Dupuytren’s fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren’s disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren’s disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3−5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer (5.0±0 years vs. 4.0±0.2 years; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease- free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren’s flexion deformity.

3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren's surgery

Miranda, Benjamin H,Elliott, Charlotte,Kearsey, Christopher C,Haughton, David N,Webb, Mark R,Harvey, Ian,Fahmy, Fahmy S Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.6

Background Numerous Dupuytren's fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren's disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren's disease and unite current limited fasciectomy practice that varies considerably between surgeons. Methods We describe the 3DF principles; raising thin skin flaps (addressing dermal involvement), excising diseased palmar fascia with a 3-5 mm clearance margin (treating highly locally recurrent conditions) and excising the vertical septae of Legueu and Juvara (providing deep clearance, hence addressing all potentially involved pathological tissue). The surgical outcomes between traditional limited fasciectomy (LF) and 3DF are compared. Results From the 786 operations included (n=585), postoperative recurrence rates were significantly lower for the 3DF group (2/145, 1.4%) than the LF group (72/641, 11.2%) (P= 0.001), and the time to recurrence was significantly longer ($5.0{\pm}0years$ vs. $4.0{\pm}0.2years$; P<0.0001). With recurrence excluded, there were no differences between the postoperative complication rates for 3DF (5/145, 3.5%) and LF (41/641, 6.4%) (P=0.4). Conclusions Our results suggest that 3DF leads to lower recurrence rates and a longer disease-free period for patients, without increasing complications. 3DF provides a safe, efficacious, common ground surgical approach in the treatment of Dupuytren's flexion deformity.

Fault-Tolerant Tasking and Guidance of an Airborne Location Sensor Network

N. Eva Wu,Yan Guo,Kun Huang,Matthew C. Ruschmann,Mark L. Fowler 대한전기학회 2008 International Journal of Control, Automation, and Vol.6 No.3

This paper is concerned with tasking and guidance of networked airborne sensors to achieve fault-tolerant sensing. The sensors are coordinated to locate hostile transmitters by intercepting and processing their signals. Faults occur when some sensor-carrying vehicles engaged in target location missions are lost. Faults effectively change the network architecture and therefore degrade the network performance. The first objective of the paper is to optimally allocate a finite number of sensors to targets to maximize the network life and availability. To that end allocation policies are solved from relevant Markov decision problems. The sensors allocated to a target must continue to adjust their trajectories until the estimate of the target location reaches a prescribed accuracy. The second objective of the paper is to establish a criterion for vehicle guidance for which fault-tolerant sensing is achieved by incorporating the knowledge of vehicle loss probability, and by allowing network reconfiguration in the event of loss of vehicles. Superior sensing performance in terms of location accuracy is demonstrated under the established criterion.

Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting

Mark Steven Miller,Peter J. Allen,Powel H. Brown,Andrew T. Chan,Margie L. Clapper,Roderick H. Dashwood,Shadmehr Demehri,Mary L. Disis,Raymond N. DuBois,Robert J. Glynn,Thomas W. Kensler,Seema A. Khan 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1

The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored the Translational Advances in Cancer Prevention Agent Development Meeting on August 27 to 28, 2020. The goals of this meeting were to foster the exchange of ideas and stimulate new collaborative interactions among leading cancer prevention researchers from basic and clinical research; highlight new and emerging trends in immunoprevention and chemoprevention as well as new information from clinical trials; and provide information to the extramural research community on the significant resources available from the NCI to promote prevention agent development and rapid translation to clinical trials. The meeting included two plenary talks and five sessions covering the range from pre-clinical studies with chemo/immunopreventive agents to ongoing cancer prevention clinical trials. In addition, two NCI informational sessions describing contract resources for the preclinical agent development and cooperative grants for the Cancer Prevention Clinical Trials Network were also presented.

Chemotherapy and patient co-morbidity in ventral site hernia development

Mark A. Rettenmaier,Lisa N. Abaid,John V. Brown III,John P. Micha,Bram H. Goldstein 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.4

Objective: The risk factors associated with early ventral site hernia development following cancer surgery are ill defined and associated with an undetermined incidence. Methods: We analyzed 1,391 gynecologic cancer patient charts to identify the number of post-operative ventral site hernias over a nearly 6 year period. The following study variables were noted for evaluation: patient demographics, disease co-morbidity (hypertension, cardiovascular disease, diabetes), body mass index (BMI), treatment (e.g., chemotherapy regimen), intra-operative (e.g., bleeding) and postoperative (e.g., infection) complications, time to hernia development and length of hospital stay. Results: Twenty-six gynecologic cancer patients who developed a post-operative ventral hernia and subsequently underwent herniorrhaphy by our gynecologic oncology service were identified. The patient group’s overall time to initial hernia development was 11.23 months. Following a multiple regression analysis, we found that treatment (e.g., bevacizumab, liposomal doxorubicin or radiotherapy associated with compromised wound healing [p=0.0186] and disease co-morbidity [0.0432]) were significant prognostic indicators for an accelerated time to hernia development. Moreover, five patients underwent treatment associated with compromised wound healing and also had disease co-morbidity. In this sub-group, post-operative hernia development occurred more rapidly (3.8 months) than the overall group of patients. BMI and age did not impact time to hernia development (p>0.05). Conclusion: In the present gynecologic cancer patient series, a tendency for early post-operative hernia development appeared to coincide with treatment associated with compromised wound healing and disease co-morbidity. Gynecologic cancer surgeons should anticipate this potential complication and consider employing prophylactic intra-operative mesh to potentially prevent this condition. Objective: The risk factors associated with early ventral site hernia development following cancer surgery are ill defined and associated with an undetermined incidence. Methods: We analyzed 1,391 gynecologic cancer patient charts to identify the number of post-operative ventral site hernias over a nearly 6 year period. The following study variables were noted for evaluation: patient demographics, disease co-morbidity (hypertension, cardiovascular disease, diabetes), body mass index (BMI), treatment (e.g., chemotherapy regimen), intra-operative (e.g., bleeding) and postoperative (e.g., infection) complications, time to hernia development and length of hospital stay. Results: Twenty-six gynecologic cancer patients who developed a post-operative ventral hernia and subsequently underwent herniorrhaphy by our gynecologic oncology service were identified. The patient group’s overall time to initial hernia development was 11.23 months. Following a multiple regression analysis, we found that treatment (e.g., bevacizumab, liposomal doxorubicin or radiotherapy associated with compromised wound healing [p=0.0186] and disease co-morbidity [0.0432]) were significant prognostic indicators for an accelerated time to hernia development. Moreover, five patients underwent treatment associated with compromised wound healing and also had disease co-morbidity. In this sub-group, post-operative hernia development occurred more rapidly (3.8 months) than the overall group of patients. BMI and age did not impact time to hernia development (p>0.05). Conclusion: In the present gynecologic cancer patient series, a tendency for early post-operative hernia development appeared to coincide with treatment associated with compromised wound healing and disease co-morbidity. Gynecologic cancer surgeons should anticipate this potential complication and consider employing prophylactic intra-operative mesh to potentially prevent this condition.

Current Therapy in Peptic Ulcer

Marks, I.N. Medical Publications Korea 1976 Medical Progress Vol.3 No.8