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Neonatal Generalized Lymphatic Anomaly with Skin Involvement
( Gordana Markovic-sovtic ),( Slavisa Djuricic ),( Aleksandar Sovtic ),( Predrag Minic ),( Zorica Rakonjac ),( Isabel Colmenero ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.6
Generalized lymphatic anomaly (GLA) is a rare congenital disorder of lymphatic development, presenting with multiple lymphatic malformations in different organs and tissues. Here, we present a case of a female neonate prenatally diagnosed with foetal hydrops and a mediastinal cystic lymphatic malformation that showed postnatal expansive and infiltrative growth into the major airways, compromising mechanical ventilation and further management of the neonate. Complications that arose during surgical treatment of mediastinal structures led to the patient’s death. Lymphatic malformations were also noted in the skin at birth. Furthermore, a skin biopsy performed immediately after birth and the autopsy revealed an extremely rare diagnosis of combined macrocystic and microcystic forms of GLA with skin involvement.
Numerical investigation of glass windows under near-field blast
Chiara Bedon,Damijan Markovic,Vasilis Karlos,Martin Larcher Techno-Press 2023 Coupled systems mechanics Vol.12 No.2
The determination of the blast protection level and the corresponding minimum load-bearing capacity for a laminated glass (LG) window is of crucial importance for safety and security design purposes. In this paper, the focus is given to the window response under near-field blast loading, i.e., where relatively small explosives would be activated close to the target, representative of attack scenarios using small commercial drones. In general, the assessment of the load-bearing capacity of a window is based on complex and expensive experiments, which can be conducted for a small number of configurations. On the other hand, nowadays, validated numerical simulations tools based on the Finite Element Method (FEM) are available to partially substitute the physical tests for the assessment of the performance of various LG systems, especially for the far-field blast loading. However, very little literature is available on the LG window performance under near-field blast loads, which differs from far-field situations in two points: i) the duration of the load is very short, since the blast wavelength tends to increase with the distance and ii) the load distribution is not uniform over the window surface, as opposed to the almost plane wave configuration for far-field configurations. Therefore, the current study focuses on the performance assessment and structural behaviour of LG windows under near-field blasts. Typical behavioural trends are investigated, by taking into account possible relevant damage mechanisms in the LG window components, while size effects for target LG windows are also addressed under a multitude of blast loading configurations.
Kim, J.-G.,Markovic, D. AMERICAN INST OF AERONAUTICS AND ASTRONAUTICS 2016 AIAA journal Vol.54 No.11
<P>The partitioned structural equations of motion via the method of localized Lagrange multipliers (PALM) consist of internal and interface variables. The model reduction achieved based on PALM is called flexibility-based component mode synthesis (F-CMS), and it thus far has concentrated on reducing the internal degrees of freedom (DOFs) or reducing the internal and interface DOFs at once. In this work, well-defined three-level reduction formulations of the F-CMS method are proposed for better precision: internal DOFs, the localized Lagrange multipliers, and the interface boundary displacement. The proposed formulations include three different reduction techniques for the interface boundary displacement for better computational efficiency. Numerical experiments indicate that the proposed formulations can substantially reduce the overall reduced-order models further without compromising the accuracy, thus achieving a substantial additional reduction of computational cost compared with the previous works. In addition, the performance of a novel error estimator in the overall reduction levels is tested.</P>
TNF, IL12B, and IFNG Gene Polymorphisms in Serbian Patients with Psoriasis
( Svetlana Popadic ),( Emina Savic ),( Milos Markovic ),( Zorica Ramic ),( Ljiljana Medenica ),( Vera Pravica ),( Zorica Spuran ),( Vladimir Trajkovic ),( Dusan Popadic ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: Psoriasis is a common chronic inflammatory skin disease with a strong genetic basis. Cytokines such as tumor necrosis factor alpha (TNF-α), interleukins (ILs) such are IL-12 and IL-23, and interferon gamma (IFN-γ) are released from various inflammatory and resident cells, and have been implicated in the initiation/maintenance of inflammation. Certain alleles of the aforementioned cytokines may be associated with disease susceptibility/severity. Objective: To investigate the association of three common functional gene polymorphisms, namely TNF -308 G/A (rs1800629), IL12B (encoding the p40 subunit of IL-12/23) +1188 A/C (rs3212227), and IFNG +874 T/A (rs2430561) with psoriasis development and severity in Serbian patients. Methods: We genotyped 130 patients with psoriasis (26 of whom also had psoriatic arthritis) and 259 controls; rs1800629 and rs3212227, and rs2430561, by real-time PCR assay. Results: The TNF GG genotype was detected at a higher frequency in patients with psoriasis compared to control subjects (OR, 1.420; 95% CI, 0.870∼2.403) without statistical significance (p= 0.191). Lack of the TNF G allele was associated with lower psoriasis severity (p=0.007). The IL12B AC genotype was underrepresented in the patients with psoriatic arthritis compared to healthy subjects (OR, 0.308; 95% CI, 0.090∼ 1.057; p=0.049). The distribution of the rs2430561 allele and genotype frequencies was similar between patients with psoriasis and controls. Conclusion: Our study demonstrates an effect of the rs1800629 on psoriasis severity, and a marginal impact of the rs3212227 on susceptibility to psoriatic arthritis. Collectively, our results obtained in a Serbian cohort expand current knowledge regarding individual predisposition to psoriatic disease. (Ann Dermatol 27(2) 128∼132, 2015)
ED-FEM multi-scale computation procedure for localized failure
Rukavina, Ivan,Ibrahimbegovic, Adnan,Do, Xuan Nam,Markovic, Damijan Techno-Press 2019 Coupled systems mechanics Vol.8 No.2
In this paper, we present a 2D multi-scale coupling computation procedure for localized failure. When modeling the behavior of a structure by a multi-scale method, the macro-scale is used to describe the homogenized response of the structure, and the micro-scale to describe the details of the behavior on the smaller scale of the material where some inelastic mechanisms, like damage or plasticity, can be defined. The micro-scale mesh is defined for each multi-scale element in a way to fit entirely inside it. The two scales are coupled by imposing the constraint on the displacement field over their interface. An embedded discontinuity is implemented in the macro-scale element to capture the softening behavior happening on the micro-scale. The computation is performed using the operator split solution procedure on both scales.
Governmental or Social Support of Bariatric Surgery in the Asia-Pacific Region
임지선,조영혜,Hiroshi Yamamoto,Alvin Eng,Tania Markovic,김경곤 대한비만학회 2017 The Korean journal of obesity Vol.26 No.1
Herein we review the management status of governmental financial support of bariatric surgeries in several Asia-Pacific areas of Japan, Singapore, and Australia, which were discussed in the 2016 International Congress on Obesity and Metabolic Syndrome (ICOMES). Patient’s body mass index criteria of bariatric surgery for public support are different one another in the three countries. Whereas laparoscopic sleeve gastrectomy (LSG), Roux-en Y gastric bypass (RYGB), and laparoscopic adjustable gastric banding (LAGB) are applicable in both Singapore and Australia, the coverage of insurance is limited to LSG in Japan. In addition, the surgical fees and equipment costs are not fully covered by public health insurance for performing sleeve gastrectomy in Japan, but patients with morbid obesity can still use public health insurance. In Singapore, the waiting time for surgery in public hospitals is longer on average than for private hospitals. However, patients can obtain subsidies of up to 80% of the costs of surgery in public hospitals, while particularly needy patients may even be able to obtain completely free bariatric surgery through Medifund. In Australia, bariatric surgeries in public sectors are publicly funded, but most bariatric surgeries occur in the private sector and Medicare only reimburses surgical costs in the private sector. Although certain characteristics need to be improved, the access to bariatric surgery has shown steady progress through public support in each of these countries.