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Manning, A.,Highland, H. M.,Gasser, J.,Sim, X.,Tukiainen, T.,Fontanillas, P. AMERICAN DIABETES ASSOCIATION INC 2017 Diabetes Vol.66 No.7
<P>To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting plasma insulin (FI), a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in FI levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-h insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio 1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.</P>
Settlement and Resettlement in Asia: Migration vs. Empire in History
MANNING, Patrick The Asian Association of World Historians 2015 The Asian review of world histories Vol.3 No.2
At its simplest, this essay provides a narrative of migration in Asia since the arrival of Homo sapiens some 70,000 years ago. More fully, it presents the case for conducting long-term, world-historical interpretation for Asia with attention to multiple perspectives, which has become increasingly central to global historical analysis. Following an introductory articulation of the benefits of long-term interpretation, the second section presents a balance of three perspectives-empire, exchange, and migration-as frameworks for interpreting the Asian past. The third section presents further detail on migration in long-term Asian history. The concluding section identifies four changes in patterns of migration during the past two centuries and emphasizes the underlying importance of cross-community migration in long-term human biological and social evolution.
Misrepresentation of the IPCC CO2 emission scenarios
Manning, M. R.,Edmonds, J.,Emori, S.,Grubler, A.,Hibbard, K.,Joos, F.,Kainuma, M.,Keeling, R. F.,Kram, T.,Manning, A. C.,Meinshausen, M.,Moss, R.,Nakicenovic, N.,Riahi, K.,Rose, S. K.,Smith, S.,Swart, Springer Science and Business Media LLC 2010 Nature geoscience Vol.3 No.6
Informing direct neutron capture on tin isotopes near the N=82 shell closure
Manning, B.,Arbanas, G.,Cizewski, J. A.,Kozub, R. L.,Ahn, S.,Allmond, J. M.,Bardayan, D. W.,Chae, K. Y.,Chipps, K. A.,Howard, M. E.,Jones, K. L.,Liang, J. F.,Matos, M.,Nesaraja, C. D.,Nunes, F. M.,O'M American Physical Society 2019 Physical Review C Vol.99 No.4
Attracting Domestic Students to Study Abroad Programs at Universities
( Michael Manning ),( Chad Anderson ) 인천대학교 사회과학연구원 2016 사회과학연구 Vol.8 No.-
Korea provides one of the largest populations of international students studying in the United States but has fewer international students studying in Korea than domestic students studying abroad. In contrast, higher education in the United States has become more of a priority for international students in recent years. However, as the number of international students studying in the United States has risen, domestic university students have not followed the same pace with roughly 1-2% of domestic students studying abroad in recent years. Recent literature shows that lack of interest is not the main deterrent for domestic students with financial concerns and postponement of graduation being reported as the main issues. The purpose of this study is to: 1) identify what administrators at universities in America and Korea are doing to recruit domestic students for study abroad programs, and 2) determine if the administrative policies of Korean universities are being or should be implemented by American universities to balance the ratio of incoming and outgoing study abroad program students. The administrative differences were analyzed through a series of interviews with International Studies and Program Coordinators from four American and four Korean universities. The interviews focused on the areas of professional training and experience, method of recruitment of domestic students for study abroad programs, and challenges involved in student recruitment. The results from the interviews generated a number of promising suggestions for how American and Korean universities can modify their programs. The discussion and conclusion include specific policy suggestions with implications.
Analyzing Communication Methods between Korean Managers and Western Workers
( Michael Manning ) 인천대학교 사회과학연구원 2015 사회과학연구 Vol.6 No.-
The purpose of this paper is to provide a description of the strengths and weaknesses of managerial and communicative styles present in Korea through the eyes of Western workers. An identification of common managerial practices within Korea is analyzed in comparison to those that are present in Western countries. Using the research of Geert Hofstede and others, a comparison of national work cultures helps identify the underlying cultural factors that cause the differing expectations and behaviors of both managers and employees. By using this research to aid the framework of the study, a survey was constructed to (1) identify the role that gender of managers and workers plays in the employee’s level of happiness, (2) examine the impact that the level of English ability of Korean managers has in relation to the amount of workplace conflict with Western employees, and (3) identify the mode of communication being used by Korean managers with Western workers. The overarching goal of the study is to provide a guideline of communication methods that can be used to ensure cohesiveness for both Western workers and Korean management in the workplace.