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Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.
Kim, Manbok,Hansen, Kristina K,Davis, Lesley,van Marle, Guido,Gill, Michael John,Fox, Julie D,Hollenberg, Morley D,Rancourt, Derrick E,Lee, Patrick W K,Yun, Chae-Ok,Johnston, Randal N International Medical Press 2010 ANTIVIRAL THERAPY Vol.15 No.6
<P>BACKGROUND: Respiratory enteric orphan (reo)virus is a promising oncolytic viral candidate. Reoviral anticancer therapy is currently undergoing multiple clinical trials targeting various human cancers; however, there is no effective reoviral inhibitor that can be used to block unwanted reovirus replication during reoviral anticancer therapy. METHODS: Studies were conducted with transformed or normal cells in vitro and in vivo to characterize viral replication in the presence or absence of chemical inhibitors. RESULTS: We have identified a protease inhibitor that is very effective in the inhibition of viral replication. The dipeptide benzyloxycarbonyl-Phe-Ala-fluoromethyl ketone (Z-FA-FMK) effectively inhibited reovirus replication in a susceptible host and cured cells of a persistent infection with reovirus in vitro. Electron microscopic analysis of Z-FA-FMK-treated cells revealed that internalized reovirus virions, retained in a perinuclear localization, no longer undergo further processing into viral factories following Z-FA-FMK treatment, suggesting that Z-FA-FMK specifically affects a reovirus virion maturation step. Animal studies showed that reovirus infection of Ras oncogenic tumours and host heart tissues is completely blocked by Z-FA-FMK treatment in severe combined immunodeficiency mice. CONCLUSIONS: Z-FA-FMK is a very effective viral inhibitor that can prevent reovirus replication in vitro and reovirus-mediated myocarditis, as well as reovirus-mediated oncolysis, in vivo. A potential application of this drug for inhibition of reovirus infection is suggested.</P>
Contributed Mini Review : Naturally occurring reoviruses for human cancer therapy
( Manbok Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.8
Naturally occurring reoviruses are live replication-proficient viruses that specifically infect human cancer cells while sparing their normal counterpart. Since the discovery of reoviruses in 1950s, they have shown various degrees of safety and efficacy in pre-clinical or clinical applications for human anti-cancer therapeutics. I have recently discovered that cellular tumor suppressor genes are also important in determining reoviral tropism. Carcinogenesis is a multi-step process involving the accumulation of both oncogene and tumor suppressor gene abnormalities. Reoviruses can exploit abnormal cellular tumor suppressor signaling for their oncolytic specificity and efficacy. Many tumor suppressor genes such as p53, ataxia telangiectasia mutated (ATM), and retinoblastoma associated (RB) are known to play important roles in genomic fidelity/maintenance. Thus, a tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to the accumulation of genetic defects which in turn could result in oncolytic reovirus susceptibility. This review outlines the discovery of oncolytic reovirus strains, recent progresses in elucidating the molecular connection between oncogene/tumor suppressor gene abnormalities and reoviral oncotropism, and their clinical implications. Future directions in the utility of reovirus virotherapy is also proposed in this review. [BMB Reports 2015; 48(8): 454-460]
소형풍력발전기 브레이크 패드 마모 및 디스크 온도 측정 센서 개발
김만복(Manbok Kim) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7
신재생 에너지에 대한 중요도가 증가와 동시에 풍력 발전 사업으로 인한 발전량도 증가하고 있는 추세이다. 하지만 풍력발전기의 유지보수에 대한 모니터링 시스템의 발전은 풍력산업의 발전에 비해 상대적으로 가야할 길이 멀다. 최근까지도 풍력발전기 내부에서 원인불명의 화재사고가 빈번하게 일어나고 있다. 풍력발전기의 유지보수에서 가장 중요한 것은 브레이크 시스템이다. 강풍이나 태풍으로 인해 블레이드 고속회전으로 풍력발전기의 손상을 예방할 수 있는 것이 바로 제동장치이다. 하지만 자동장치에서 브레이크 패드나 브레이크 디스크에 문제를 미리 모니터링하지 못했을 경우 심각한 사고를 야기할 수 있다. 따라서 본 논문에서는 풍력발전기의 브레이크 시스템 중 브레이크 패드의 마모량을 미리 파악할 수 있는 센서와 브레이크 디스크의 온도를 측정하는 센서를 개발하여 풍력발전기의 브레이크 시스템의 패도 마모량과 브레이크 디스크의 온도를 실시간으로 모니터링할 수 있는 설계를 구현하였다.
ALCA(Advanced Lane Change Assist)개발
김명훈(Myounghoon Kim),박만복(Manbok Park),김종철(Jongchul Kim) 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11
Driver Assist System such as BSD/LCA system help a driver to drive a car more comfort and safe. BSD(Blind Spot Detection)/LCA(Lane Change Assist) system gives warning information to driver when accident risk about adjacent lane vehicle is increased. But BSD/LCA system just gives warning to driver by using a HMI device as like led or buzzer. ALCA(Advanced Lane Change System) is developed from necessity of improved convenience and safety of lane change. ALCA system is based on BSD/LCA system and added a operation of an Brake system to occur a brake steer. If a risk of lane change is over a threshold, ALCA system controls a brake of one side of vehicle to change a vehicle heading direction. So driver can avoid a car accident for adjacent lane vehicle.