한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

甘桔湯 및 甘桔湯 加味方의 解熱 , 消炎 , 祛痰 작용에 대한 연구

박만석,손영종,이영종 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

Objects : Gamgiltant, which is in common use of laryngopharyngeal disease, consists of Glycyrrhizae Radix and Placotycodi Radix. Author intended to find out the efficacy of Kami-gamgiltant(added Houttuyniae Herba, Schizandrae Fructus and Sterculliae lychnophorae Semen, which are good for respiratory disease, to Gamgiltant) for the purpose of developing a recipe effective for sphagitis or bronchitis. Methods : After oral administration of Gamgiltang or Kami-gamgiltant to rats, the efficacies of antipyretics, antiinflammation and discharge of phlegm are figured. After inducing the rats to be feverish by injecting LPS(10㎍ LPS/㎏ body weight) of Serratia marcescens into caudal vein of them, rectal temperatures were taken to prove antipyretic effect. After inducing the rats to be edematous by injecting 0.1% of carrageenin into hind paw, the volumes of hind paw were measured to prove antiinflammatory effect. To testify the effect on discharge of phlegm, after administrating the decoctions to rats, quantity of mucous in their throat are measured. Also by aspirating 250ppm of sulfur dioxide 2 and half hours a day during 12 days, rats were induced laryngopharyngeal infections. Then adminstrating the decoction since 5th day of aspiration, the numbers of leukocyte were figured with the object to identify microbial infections. Results : 1) Gamgiltang and Kami-gamgiltant have antipyretic effects on pyrexia induced by LPS injection. Also the latter recovered quickly than the former. 2) Gamgiltant and Kami-gamgiltang have antiedematous effects on edema induced by carrageenin injection. Also the latter shows a quick recovery than the former. 3) Gamgiltant and Kami-gamgiltang have no effect on normal mucous tissue in their throat. 4) The decoction of Gamgiltang has an effect on inflammation induced by exposure to sulfur dioxide, but the Kami-gamgiltant doesn't. Conclusion : Gamgiltang and Kami-gamgiltant could be effective for laryngopharyngeal disease.

산성강하물의 침착량과 동태 해명에 관한 연구 -춘천과 서울 강우의 화학조성 비교 : Comparison of Chemical Composition of Rain Water between Chunchon and Seoul

김만구,강미희,임양석,박기준,황훈,이보경,홍승희,이동수 江原大學校 附設 環境硏究所 1999 環境硏究 Vol.16 No.-

The rain water samples were collected at Chunchon and Seoul by using wet only automatic sampler from January 1996 through December 1997. The daily base rain water samples collected over than 95% rainy events during the whole period. The samples were measured both pH and conductivity, and were analysed major ionic components, SO₄^(2-), NO₃^(-), Cl^(-), NH₄^(+), Ca^(2+), Na^(+) and K ^(+), by ion chromatography. In 1996, about 77% sampled rain water showed below pH 5.6 and the 60% of rain water was lower than pH 5.0. The volume weighted average pH was 4.7 at all sites. In 1997, the volume weighted average pH was 4.6 and 4.9 at Seoul and Chunchon, respectively. Among the rain water samples, 87% and 55% of samples showed below than pH 5.6 and 5.0, respectively. The pH value of Chunchon was significantly (p<0.05) lower than Seoul at the rain samples for less than 20 ㎜ rainfall. However conductivity of the rain samples were 20.9 μS/㎝ for 1996 and 27.7 μS/㎝ for 1997 at Seoul, and 19.1 μS/㎝ for 1996 and 14.1 μS/㎝ for 1997 at Chunchon. H₂SO₄AND HNO₃CONTRIBUTED 65.9% and 29.6% of free acidity at Seoul, respectively. The ratio of [NO₃^(-)]/[nss-SO₄^(2-)] were 0.43 at Seoul and 0.51 at Chunchon for rain samples for less than 20 ㎜ rainfall. The annual wet deposition of Cl^(-), NO₃^(-), SO₄^(2-), H^(+), Na^(+), NH₄^(+), K ^(+), Mg^(2+) and Ca^(2+), respectively, 568.8 ㎏/㎢, 1489.3 ㎏/㎢, 3184.8 ㎏/㎢, 20.9 ㎏/㎢, 249.4 ㎏/㎢, 1091.2 ㎏/㎢, 189.8 ㎏/㎢, 90.2 ㎏/㎢, and 702.4 ㎏/㎢ at Seoul for 1996; 656.4 ㎏/㎢, 2029.7 ㎏/㎢, 3280.7 ㎏/㎢,27.2 ㎏/㎢, 229.4 ㎏/㎢, 1063.9 ㎏/㎢, 106.9 ㎏/㎢, 7802 ㎏/㎢, and 645.3 ㎏/㎢, at Seoul for 1997; 116.9 ㎏/㎢, 983.3 ㎏/㎢, 1797.0 ㎏/㎢, 21.4 ㎏/㎢, 83.2 ㎏/㎢, 648.1 ㎏/㎢, 78.0 ㎏/㎢, 22.2 ㎏/㎢ and 368.8 ㎏/㎢ at Chunchon for 1996; 100.2 ㎏/㎢, 1077.6 ㎏/㎢, 1754.0 ㎏/㎢, 13.4 ㎏/㎢, 146.0 ㎏/㎢, 602.3 ㎏/㎢, 88.8 ㎏/㎢, 16.2 ㎏/㎢ and 206.8 ㎏/㎢ at Chunchon for 1997.

Reliability and Data Integration of Duplicated Test Results Using Two Bioelectrical Impedence Analysis Machines in the Korean Genome and Epidemiology Study

Park, Bo-Young,Yang, Jae-Jeong,Yang, Ji-Hyun,Kim, Ji-Min,Cho, Lisa-Y.,Kang, Dae-Hee,Shin, Chol,Hong, Young-Seoub,Choi, Bo-Youl,Kim, Sung-Soo,Park, Man-Suck,Park, Sue-K. The Korean Society for Preventive Medicine 2010 Journal of Preventive Medicine and Public Health Vol.43 No.6

Objectives: The Korean Genome and Epidemiology Study (KoGES), a multicenter-based multi-cohort study, has collected information on body composition using two different bioelectrical impedence analysis (BIA) machines. The aim of the study was to evaluate the possibility of whether the test values measured from different BIA machines can be integrated through statistical adjustment algorithm under excellent inter-rater reliability. Methods: We selected two centers to measure inter-rater reliability of the two BIA machines. We set up the two machines side by side and measured subjects' body compositions between October and December 2007. Duplicated test values of 848 subjects were collected. Pearson and intra-class correlation coefficients for inter-rater reliability were estimated using results from the two machines. To detect the feasibility for data integration, we constructed statistical compensation models using linear regression models with residual analysis and R-square values. Results: All correlation coefficients indicated excellent reliability except mineral mass. However, models using only duplicated body composition values for data integration were not feasible due to relatively low $R^2$ values of 0.8 for mineral mass and target weight. To integrate body composition data, models adjusted for four empirical variables that were age, sex, weight and height were most ideal (all $R^2$ > 0.9). Conclusions: The test values measured with the two BIA machines in the KoGES have excellent reliability for the nine body composition values. Based on reliability, values can be integrated through algorithmic statistical adjustment using regression equations that includes age, sex, weight, and height.

A Study on Optimal Trajectory Planning for a Dual Arm Robot

Man Sik Park,Sang Ho Jin,Jung Il Park,Suck Gyu Lee 제어로봇시스템학회 1993 제어로봇시스템학회 국내학술대회 논문집 Vol.1993 No.10

효과적인 배전반 진단장치에 관한 연구

고만석(Man-Suck Ko),최홍규(Hong-Kyoo Choi),박준열(Joon-Yeol Park),박인철(In-Cheol Park),안진욱(Jin-Uk An) 한국조명·전기설비학회 2013 한국조명·전기설비학회 학술대회논문집 Vol.2013 No.11

원인불명 발열성 및 비정형성 폐렴 환자의 Coxiella burnetii 항체 분포 특성

박만석(Man Suck Park),박미연(Mi Yeoun Park),신영오(Yung Oh Shin) 대한미생물학회 2003 Journal of Bacteriology and Virology Vol.33 No.4

호산구성 근막염

박만규(Man Kyu Park),전성진(Sung Jin Jeon),서기석(Kee Suck Suh),김상태(Sang Tae Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6

We report a case of eosinophilic fasciitis occurring in a 48-year-old man who showed tender, edemstous, indurated, and tight skin on the left forearm and elbow joint. Laboratory findings showed peripheral blood eosinophilia and hypergammaglobulinemia. Other laboratory tests were negative or within normal limits including ANA and anti-DNA. Histopathological findings revealed sclerosis of dermis and thickening of fat and fascia with intense infiltrations of lymphocytes, histiocytes and eosinophils. He was treated successfully with oral prednisolone for 2 weeks.

국내 서식 살모사 독의 독력과 항독소 표준화

유천권,김영미,박미연,박만석,박영도,박경석 한국수의공중보건학회 1999 예방수의학회지 Vol.23 No.2

복강내 악성질환에 있어서의 복수 Carcinoembryonic Antigen 측정의 진단적 의의

박창영,이만호,김광조,이상종,전승준,유영석 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1

Ascites may be caused by various benign and malignant diseases but it is sometimes difficult to determine whether the ascites is caused by benign or malinant diseases. Various diagnostic methods such as ascitic level and ascites/serum ratio of protein and LDH, cytology and peritonioscopy have been used in differentiating between benign and malignant ascites. Carcinoembryonic antigen (CEA) level in pleural effusion is known to be useful bo make the diagnosis of malignant disease in thoracic cavity. Lowenstein et al. (1978) reported that CEA level in ascites was many-fold higher than in serum in patients with malignant disease and ascites. In order to determine whether ascites CEA is of help to make diagnosis of malignant diseases in abdominal cavity, both ascites CEA and serum CEA were measured and analyzed in 49 patients with ascites who were admitted to this hospital from June 1988 to December 1990. The results are as follows: 1) The mean value of CEA level in ascites and serum in benign ascites group was 1.47 ng/㎖, 2. 40 ng/㎖, respectively. The upper limit of ascites and serum CEA in benign ascites group was 3. 37 ng/㎖, 5.56 ng/㎖, respectively. 2) The CEA level of malignant ascites group was significantly higher than that of the benign ascites group in ascites (p$lt;0.05) and in serum (p$lt;0.05). 3) Ascites CEA level was higher than 3.37 ng/㎖ in 10 of 25 patients with malignant ascites (40%), and 1 of 24 patients with benign ascites. (4%) In 4 patients, ascites CEA level was higher than 100 ng/㎖, all of them have malignant diseases in abdominal cavity. 4) Serum CEA level was higher than 5.56 ㎎/㎖ in 10 of 25 patients with malignant ascites (40%), and 3 of 24 patients with benign ascites (12%). In 4 patients, serum CEA level was higher than 100 ng/㎖, all of them have malignant diseases in abdominal cavity. 5) The specificity of ascites CEA for malignant disease in abdominal cavity was 96.0% positive predictability 91.0%, sensitivity 40.0%, and negative predictability 60.0%. 6) The specificity of serum CEA for malignant disease in abdominal cavity was 88.0%, positive predictability 77%, sensitivity 40.0% and negative predictability 58.0% 7) The cases of which ascites CEA level was greater than 3.37 ng/㎖ was divided into hepatoma group (27%) and nonhepatoma group (73.0%), each mean value was 18.45 ng/㎖, and 33. 57 ng/㎖, respectively. In summary, the measurement of ascites CEA level is useful in differentiating the existence of malignant diseases in abdominal cavity.