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( Man Mook Ha ),( Joon Mo Kim ),( Hyun Joong Kim ),( Ki Ho Park ),( Martha Kim ),( Chul Young Choi ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.3
Purpose: To determine the lowest limit of signal strength that is still effective for accurate analysis of optic coherence tomography (OCT) values, we investigated the reproducibility of OCT scans by signal strength (SS). Methods: A total of 668 subjects were scanned for measurements of retinal nerve fiber layer (RNFL) thickness using the Stratus OCT twice on the same day. The variability of overall RNFL thickness parameters obtained at different SS was analyzed and compared by repeated-measures of ANOVA and Spearman`s correlation coefficient. Values of the intraclass correlation coefficient (ICC) and variability (standard deviation) of RNFL thickness were obtained. The false positive ratio was analyzed. Results: When SS was 3, the variability of RNFL thickness was significantly different (low ICC, high variability) in comparison to when SS was 4 or greater. Significant negative correlations were observed between variability in RNFL thickness and signal strength. The difference of variability of average RNFL thickness between SS 4 (4.94 μm) and SS 6 (4.41 μm) was 0.53 μm. Conclusions: Clinically, the difference of variability of average RNFL thickness between SS 4 and SS 6 was quite small. High SS is important, however, when signal strength is low due to uncorrectable factors in patients in need of OCT for glaucoma and retinal disease. Our results suggest that SS 4 is the lowest acceptable limit of signal strength for obtaining reproducible scanning images.
Ha, Chang-Man,Kang, Hae-Mook,Lee, Byung-Ju The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.4
In the present study we determined if NELL2, a neural tissue-specific protein containing 6 epidermal growth factor (EGF)-like repeat domains, plays an important role in the regulation of puberty initiation in the rat hypothalamus. We origin811y found that NELL2 is a new estrogen-responsive gene in hypothalami derived from estrogen-sterilized and control rats using a PCR differential display. In the 40-day-old female rat hypothalamus, NELL2 was up-regulated by neonatal estrogen treatment. In situ hybridization histochemistry showed that NELL2 is very abundant in the ventromedial hypothalamic nucleus that is responsible for the control of sex behavior. NELL2 mRNA level in the medial basal hypothalamus showed a dramatic increase before female puberty onset, which suggests that NELL2 may be involved in the process regulating female puberty onset. We attemped to block NELL2 synthesis with intracerebroventricular injection of an antisense oligodeoxynucleotide (ODN) to the NELL2 mRNA, and examined its effect on the puberty onset of the female rat. The antisense ODN significantly delayed puberty initiation determined by vaginal opening. In summary, NELL2 may play an important role in the regulation of female puberty onset.
Purification and characterization of a cytosolic Ca2+-independent phospholipase A2 from bovine brain
Jeong, Eui Man,Ahn, Kyong Hoon,Jeon, Hyung Jin,Kim, Ha Dong,Lee, Ho Sup,Jung, Sung Yun,Jung, Kwang Mook,Kim, Seok Kyun,Bonventre, Joseph V.,Kim, Dae Kyong Springer-Verlag 2011 Molecules and cells Vol.32 No.5
황색포도알균 패혈증 환자에서 발생한 스트렙토콕쿠스미티스에 의한 내인성 안내염 1예
이용우,하만묵,한소영,배정훈,Yong Woo Lee,Man Mook Ha,So Young Han,Jeong Hun Bae 대한안과학회 2012 대한안과학회지 Vol.53 No.8
Purpose: To report a case of endogenous endophthalmitis due to Streptococcus mitis in a patient with Staphylococcus aureus sepsis. Case summary: A 77-year-old male complained of sudden visual loss and ocular pain in his right eye and was treated with intravenous antibiotics for Staphylococcus aureus sepsis. With a diagnosis of endogenous endophthalmitis, the patient received pars plana vitrectomy and intravitreal injection of antibiotics. Vitreous fluid was obtained before surgery, and the organism was identified as Streptococcus mitis. Twenty-one days after the surgery, intraocular inflammation was stabilized, and visual acuity was improved from light perception to 20/60. Conclusions: Appropriate sampling and culture of vitreous fluid are important for the diagnosis of endogenous endophthalmitis. The possibility that the causative organism of endogenous endophthalmitis may be different from the result of blood culture should be considered. J Korean Ophthalmol Soc 2012;53(8):1190-1193
Kook, Sun-Young,Hong, Hyun Seok,Moon, Minho,Ha, Chang Man,Chang, Sunghoe,Mook-Jung, Inhee The Society 2012 The Journal of neuroscience Vol.32 No.26
<P>The blood-brain barrier (BBB), which is formed by adherens and tight junctions (TJs) of endothelial cells, maintains homeostasis of the brain. Disrupted intracellular Ca2? homeostasis and breakdown of the BBB have been implicated in the pathogenesis of Alzheimer's disease (AD). The receptor for advanced glycation end products (RAGE) is known to interact with amyloid β-peptide (Aβ) and mediate Aβ transport across the BBB, contributing to the deposition of Aβ in the brain. However, molecular mechanisms underlying Aβ-RAGE interaction-induced alterations in the BBB have not been identified. We found that Aβ1?42 induces enhanced permeability, disruption of zonula occludin-1 (ZO-1) expression in the plasma membrane, and increased intracellular calcium and matrix metalloproteinase (MMP) secretion in cultured endothelial cells. Neutralizing antibodies against RAGE and inhibitors of calcineurin and MMPs prevented Aβ1?42-induced changes in ZO-1, suggesting that Aβ-RAGE interactions alter TJ proteins through the Ca2?-calcineurin pathway. Consistent with these in vitro findings, we found disrupted microvessels near Aβ plaque-deposited areas, elevated RAGE expression, and enhanced MMP secretion in microvessels of the brains of 5XFAD mice, an animal model for AD. We have identified a potential molecular pathway underlying Aβ-RAGE interaction-induced breakage of BBB integrity. This pathway might play an important role in the pathogenesis of AD.</P>
술폰산화 폴리에틸렌옥사이드로 표면개질한 생체동맥의 석회화 저항 효과
김형묵,백만종,선경,이승렬,이송암,김광택,이인성,이원규,박기동,김영하,Kim, Hyoung-Mook,Baek, Man-Jong,Sun, Kyung,Lee, Seung-Yeol,Lee, Song-Am,Kim, Kwang-Taik,Lee, In-Sung,Lee, Won-Kyu,Park, Ki-Dong,Kim, Young-Ha 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.11
Background: Calcific degeneration is the major cause of clinical failure of glutaraldehyde (GA) crosslinked bioprosthetic tissues implanted in the body and necessitates the reoperation or causes death. Surface modification of biologic tissues using sulfonated polyethyleneoixde (PEO-SO3) has been suggested to significantly enhance blood compatibility, biostability and calcification-resistance by means of the synergistic effect of highly mobile and hydrophilic PEO chains and electrical repulsion of negatively charged sulfonate groups. This study was designed to evaluate the anticalcification effect of surface-modification of biologic arteries by direct coupling of PEO-SO3 after GA fixation and changes of calcification according to the implantation period through the quantitative investigation of the deposited calcium and phosphorous contents of the biologic arterial tissues in the canine circulatory implantation model. Material and Method: Total of 16 fresh canine carotid arteries were harvested from eight adult dogs and divided in to GA group(n =8) and PEO-SO3 group(n=8). Sulfonation of diamino-terminated PEO was performed using propane sultone. Canine carotid arteries were only crosslinked with 0.65% GA solution in GA group and modified by direct coupling 5% PEO-SO3 solution after GA crosslinkage for 2 days and stabilized by NaBH4 solution for 16 hours in PEO-SO3 group. In both groups the resected segment of bilateral carotid arteries were reconstructed. Reconstructed segments of the two groups were analysed the quantities of calcium and phosphorous contents after 3(n=4) and 6(n=4) weeks in vivo. Result: After implantation of 3 seeks, PEO-SO3 group showed significantly less depositions.