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( Kiyoto Mori ),( Makoto Naganuma ),( Shinta Mizuno ),( Hiroaki Suzuki ),( Mina T. Kitazume ),( Katsuyoshi Shimamura ),( Sayako Chiba ),( Akira Sugita ),( Katsuyoshi Matsuoka ),( Tadakazu Hisamatsu ) 대한장연구학회 2018 Intestinal Research Vol.16 No.3
Background/Aims: Recent research has highlighted the importance of interactions between commensal fungi and intestinal inflammation. However, there are few studies investigating whether commensal fungi contribute to inflammation in patients with Crohn’s disease (CD). The aim of this study is to investigate reveal interactions between commensal fungi and host immune cells in CD. Methods: CD14-positive monocytes were isolated from peripheral blood mononuclear cells from healthy human volunteers and then differentiated in the presence of macrophage colony-stimulating factor (M-CSF) (referred to as M-macrophages, M-Mφs) or M-CSF and interferon-γ (IFN-γ) (referred to as M-gamma macrophages, Mγ-Mφs). Cytokine production by these in vitro differentiated macrophages in response to β-(1,3)-glucan was analyzed by flow cytometry. Expression of Dectin-1 was examined using flow cytometry, western blotting, and quantitative reverse transcription-polymerase chain reaction. Cytokine production by in vitro differentiated macrophages in response to β-(1,3)-glucan was measured in the presence of an anti-Dectin-1 receptor antagonist, anti-Syr, or an anti-Fas-1 antibody. Cytokine production by lamina propria mononuclear cells (LPMCs) derived from CD patients in response to β-(1,3)-glucan was also analyzed. Results: Mγ-Mφs produced a large amount of tumor necrosis factor-α (TNF-α) and interleukin-6 in response to β-(1,3)-glucan. Dectin-1 expression was significantly higher in Mγ-Mφs than in M-Mφs. The increase in TNF-α production by Mγ-Mφs stimulated with glucan was reversed by blocking Dectin-1, Syr or Fas-1. LPMCs derived from CD patients stimulated with β-(1,3)-glucan produced significantly higher amount of TNF-α than LPMCs derived from UC patients. Conclusions: These results suggest that commensal fungal microbiota may contribute to the pathogenesis of CD by inducing macrophages-derived pro-inflammatory cytokines. (Intest Res 2018;16:384-392)
Hiroyuki Kaji,Akira Togayachi,Makoto Ochou,Maki Sogabe,Takashi Okura,Hirofumi Nozaki,Takashi Angata,Yasunori Chiba,Hidenori Ozaki,Atsushi Kuno,Yasuhito Tanaka,Yuzuru Ikehara,Masashi Mizokami,Hisashi N 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
We present here a high-throughput strategy to discover serological biomarkers for early-detection of hepatocellular carcinoma (HCC). Our strategy is also applicable to assess the progressed liver fibrosis that is associated with virus hepatitis. The glycan structure on glycoproteins derived from cancerous cells is known to be different from that derived from normal cells, specifically, the increased aberrant glycosylation appears in patient serum with virus hepatitis along with either or both the initiation and progression. Based on the above perceptions, in order to identify glycoproteins carrying aberrant glycosylation in serum of liver disease patients, we analyzed lectin-captured glycopeptides by the IGOT method. Many glycoproteins carrying altered glycans were successfully identified. The increased amount of these glycoproteins was clinically relevant to the progression of the liver diseases. We are now selecting appropriate molecules depending on the feasibility to detect an abnormality in the liver, such as the occurrence of liver cell neoplasm.
JENDL-4.0 Integral Testing for Fission Systems
R. D. McKnight,Kazuteru Sugino,Go Chiba,Yasunobu Nagaya,Kenji Yokoyama,Teruhiko Kugo,Makoto Ishikawa,Shigeaki Okajima 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Benchmark testing for the newly developed Japanese evaluated nuclear data library JENDL-4.0 is carried out by using a huge amount of the integral data. Benchmark calculations are performed with the continuous-energy Monte Carlo code with a large number of neutron histories or with the deterministic procedure which has been developed for fast reactor analyses in Japan. In the present paper, representative benchmark results are shown as a rapid report. They are the results for criticality of low enriched UO_2 or MOX fueled light water moderated systems, of uranium or plutonium fuelled solution systems, of various fast reactors, and results of PIE analyses for a PWR spent fuel and actinoide samples irradiated in fast reactors.
Operation and Maintenance of In-Situ CO₂ Measurement System Using Unmanned Aerial Vehicles
Kohei Nomura,Hirokazu Madokoro,Takashi Chiba,Makoto Inoue,Takeshi Nagayoshi,Osamu Kiguchi,Hanwool Woo,Kazuhito Sato 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
The aim of this study is to actualize an in-situ measurement system of greenhouse gases using a UAV. This paper presents vertical profiles of CO₂ concentration as a measurement result with operation and long-term maintenance for a periodic flight tests. For this study, a new joint part with a single structure for improving strength of the sensor mount is developed. Moreover, routine maintenance to replace a router and periodic regulation of the analyzer is provided. After updating flight altitude permission over 150 m, we conducted flight tests up to 500 m. We compare individual linear correction and liner regression applied for vertical profiles of CO₂ concentration. We address that correction using linear regression has advantage to reduce burden for in-situ measurement.