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Bioactivity Guided Phytochemical Study of Clematis hirsuta Growing in Saudi Arabia
Abdel-Kader, Maged S.,Al-Taweel, Areej M.,El-Deeb, Kadriya S. The Korean Society of Pharmacognosy 2008 Natural Product Sciences Vol.14 No.1
Bioactivity guided phytochemical study of the petroleum ether and butanol extracts of Clematis hirsuta resulted in the isolation of 12 compounds. Rat paw edema as a model of acute inflammation was used to evaluate the anti-inflammatory activity of the extracts and the chromatographic fractions. Five known sterols and triterpenes namely: ${\beta}-amyrin$ (1), lupeol (2), ${\beta}-sitosterol$ (3), oleanolic acid (4) and stigmasterol glycoside (5) were isolated from the petroleum ether extract. The n-butanol extract afforded two compounds reported for the first time from natural source: (S)-(+)-dihydro-5-(hydroxymethyl)-2(3H)-furanone (7) and (s)-(-)-5-hydroxymethyl-2(5H)-furanone (8). In addition, anemonin (6), dihydro-4-hydroxy-5-(hydroxymethyl)-2(3H)-furanone (2-deoxy-D-ribono-1,4-lactone) (9), biophenol (cimidahurin) (10), glucose (11) and sucrose (12) were also identified. The structures were determined from spectroscopic data including 1D- and 2D-NMR experiments.
Rare 2-Phenoxychromones from Ononis serrata Growing in Egypt
Maged S. Abdel-Kader,Fahima F. Kassem,Masouda E. Amer 한국생약학회 2004 Natural Product Sciences Vol.10 No.1
Two 2-phenoxychromones; a rare group of natural products, were isolated from the combined ethyl acetate and chloroform fractions of the ethanolic extract of Ononis serrata frossk (Leguminosae) growing in Egypt. Structures were elucidated by chemical, spectroscopic methods as well as single X-ray diffraction analyses. The cytotoxic and antimicrobial effects of the two compounds were examined. It is worth to mention that this is the first report on the isolation of 2-phenoxychromones from the family Leguminosae.
Phytochemical Study of Lotus ornithopodioloides L.
Maged S. Abdel-Kader,Omer A. Basudan,Saleh I. Alqasoumi,Mohamed I. Abou-Shoer 한국생약학회 2007 Natural Product Sciences Vol.13 No.4
investigation of the aerial parts of L. resulted in the isolationof six known compounds. The structures were determined utilizing physical, chemical, spectral methods as wellas direct comparison with reference materials whenever possible. The compounds were identified as: β-sitosterol;the two triterpenes oleanolic and betulinic acids; the two cyanogenic glycosides lotaustralin and linamarin inaddition to the flavonol diglycoside kaempferitin.KeywordsLotus ornithopodioloides (Fabaceae), β-sitosterol, triterpene acids, cyanogenic glycosides, kaemferitin
Constituents of the Aerial Parts of Lonicera etrusca Growing in Saudi Arabia
Saleh I. Alqasoumi,Adnan J. Al-Rehaily,Maged S. Abdel-Kader 한국생약학회 2009 Natural Product Sciences Vol.15 No.3
Phytochemical investigation of the aerial parts of Lonicera etrusca resulted in the isolation of three iridoids including two aglycones, loganin aglycone (log-1) (1) and lonicerin (log-2) (2), and the known common glycoside loganin (4). The study also afforded a coumarin derivative, 7-hydroxycoumarin (3), and a flavonoid glycoside, luteolin-7-O- β-D-glucoside (5). The structures were determined utilizing physical, chemical and spectral methods.
Hoda M. Fathy,Mohamed I. Aboushoer,Azza Baraka,Maged S. Abdel-Kader,Abdallah A. Omar 한국생약학회 2009 Natural Product Sciences Vol.15 No.1
Phytochemical investigation of the roots of Echiochilon fruticosum resulted in the isolation of two naphthoquinone derivatives. Compound 1 was identified as anhydroalkanin while compound 2 was identified as a new derivative 5-hydroxy 8-methoxy 2-(4-methylpent-1,3-dienyl) naphthalene-1,4-dione named as echiochiloquinone. In addition, caffeic acid 3, caffeic acid methyl ester 4 were isolated. The structures were determined by physical, chemical and spectral methods. The anti-inflammatory activity of the root extracts and compound 2 was evaluated utilizing both cotton pellet-induced and carragenin-induced rat paw edema. The ulcerogenic effect was also studied.
Anthraquinones with Antibacterial Activities from Crucianella maritima L. Growing in Egypt
Abdalla M. El-Lakany,Maha A. Aboul-Ela,Maged S. Abdel-Kader,Jihan M. Badr,Nawal N. Sabri,Yousry Goher 한국생약학회 2004 Natural Product Sciences Vol.10 No.2
From the extracts of Crucianella maritima L. (Rubiaceae), five new anthraquinones namely; 1-hydroxy- 2-methyl-6-methoxy anthraquinone, 6-methoxy-2-methyl quinizarin, 6-methyl-anthragallol-2,3-dimethyl ether, 6-methyl-anthragallol-2-methyl ether, and 1-hydroxy-2-carbomethoxyanthraquinone were isolated and identified. In addition, deacetyl asperulosidic acid 6'-glucoside sodium salt, a new iridoid diglucoside, along with twelve known anthraquinones, three flavonols, three sterols, and one triterpene were also isolated and identified for the first time from this plant. Their chemical structures were established by physical, chemical and spectroscopic data, including UV, MS, ID- and 2D-NMR analyses. The antimicrobial, cytotoxic activities and a preliminary clinical trial of the crude extracts and some isolates are also presented. Chemotaxonomical aspects are briefly discussed.
Saleh I. Alqasoumi,Adnan J. Al-Rehaily,Abdulmalik M. AlSheikh,Maged S. Abdel-Kader 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
In a project to study the hepatroprotective effect of some plant extracts four plants Ephedra foliate Boiss, Alhagi maurorum Medikus, Capsella bursa-pastoris (L.) Medik. and Hibiscus sabdariffa L. were studied. The ethanol extract of the aerial part of the first three plants and the flowers of H. sabdariffa were subjected to hepatoprotective assays using Wistar albino rats. Liver injury induced in rats using carbon tetrachloride. The biochemical parameters; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflection of the liver condition. Based on the good results of the biochemical parameters measurements, histopathological study was performed on the liver of rats treated with E. foliate. The normal appearance of hepatocytes indicated a good protection of the extract from carbon tetrachloride hepatotoxicity. All the results were compared with silymarin, the reference hepatoprotective drug.
Constituents of Erythrina caffra Stem Bark Grown in Egypt
Sawsan El-Masry,Hala M. Hammoda,Hala H. Zaatout,Saleh I. Alqasoumi,Maged S. Abdel-Kader 한국생약학회 2010 Natural Product Sciences Vol.16 No.4
A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2'-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) erythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2'-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus. Keywords - Erythrina caffra, alkaloids, isoflavanoids, Staphylococcus aureus
Two New Flavonol Glycosides From The Aerial Parts of Lotus lalambensis Growing in Saudi Arabia
Hanan M. El-Youssef,Brian T. Murphy,Masouda E. Amer,Adnan J. Al-Rehaily,Maged S. Abdel-Kader,David G. I. Kingston 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
Phytochemical study of the aerial parts of Lotus lalambensis Schweinf resulted in the isolation and identification of two new flavonol glycosides; kaempferol 3-O-(5"-acetyl)-apioside-7-O-α-L-rhamnopyranoside (1) and kaempferol 3-O-α-[β-D-xylosyl-(1"" → 2")-L-rhamnopyranoside]-7-O-α-L-rhamnopyranoside (2). Structures were determined utilizing different physical, chemical, spectroscopic data including 2D-NMR experiments and HRFABMS.