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Chemical Constituents and Biological Activities of Cichorium intybus L.
Abdalla M. El-Lakany,Maha A. Aboul-Ela,Mohamed M. Abdul-Ghani,Hattem Mekky 한국생약학회 2004 Natural Product Sciences Vol.10 No.2
Continuation of a phytochemical study of Cichorium intybus L. (Astraceae) growing in Egypt, resulted in the isolation and identification of a new sesquiterpene lactone 3, 4-dihydrolactucin, in addition to the eight known compounds; kaempferol, isoscutellarin, cichoriin, umbelliferone, lupeol, lupeol acetate, β-sitosterol, and β-sitosterol-3-O-glucoside. Chemical structures of the isolated compounds were assigned based on different physical, chemical, and spectroscopic techniques including IR, UV, MS, 1D- and 2D-NMR spectra. Furthermore, the antimicrobial, and spasmogenic activities of some fractions and isolates were also assessed.
Anthraquinones with Antibacterial Activities from Crucianella maritima L. Growing in Egypt
Abdalla M. El-Lakany,Maha A. Aboul-Ela,Maged S. Abdel-Kader,Jihan M. Badr,Nawal N. Sabri,Yousry Goher 한국생약학회 2004 Natural Product Sciences Vol.10 No.2
From the extracts of Crucianella maritima L. (Rubiaceae), five new anthraquinones namely; 1-hydroxy- 2-methyl-6-methoxy anthraquinone, 6-methoxy-2-methyl quinizarin, 6-methyl-anthragallol-2,3-dimethyl ether, 6-methyl-anthragallol-2-methyl ether, and 1-hydroxy-2-carbomethoxyanthraquinone were isolated and identified. In addition, deacetyl asperulosidic acid 6'-glucoside sodium salt, a new iridoid diglucoside, along with twelve known anthraquinones, three flavonols, three sterols, and one triterpene were also isolated and identified for the first time from this plant. Their chemical structures were established by physical, chemical and spectroscopic data, including UV, MS, ID- and 2D-NMR analyses. The antimicrobial, cytotoxic activities and a preliminary clinical trial of the crude extracts and some isolates are also presented. Chemotaxonomical aspects are briefly discussed.