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Adnan J. Al Rehaily,Kamal E. H. El Tahir,Jaber S. Mossa,Syed Rafatullah 한국생약학회 2001 Natural Product Sciences Vol.7 No.3
The pharmacological activities of the acetonitrile (MeCN), hexane extracts and isolated pure terpenoidal compound Lupeol from the leaves of Teclea nobilis, Delile (TN), on inflammation induced by carrageenan and implantation of cotton pellets in rats; the nociceptive response using writhing and tail flick tests and the antipyretic activity in yeast-induced fever were examined in mice. Oral administration of TN extracts at doses of 150 and 300 ㎎/㎏ and lupeol 5 and 10 ㎎/㎏ showed a significant anti-inflammatory activity in rats. The extracts of TN and lupeol significantly decreased the number of contractions and stretchings induced by acetic acid and heat-induced pain in mice. The antipyretic effect of extracts and lupeol was also found to be significant. The behavioral observation of animals showed that the hexane extract and lupeol caused CNS depressant activity and did not produce any toxic or lethal effects in animals at various dose levels. The results suggest that the Teclea nobilis extracts and lupeol possesses anti-inflammatory, analgesic and antipyretic activities.
Saleh I. Alqasoumi,Adnan J. Al-Rehaily,Abdulmalik M. AlSheikh,Maged S. Abdel-Kader 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
In a project to study the hepatroprotective effect of some plant extracts four plants Ephedra foliate Boiss, Alhagi maurorum Medikus, Capsella bursa-pastoris (L.) Medik. and Hibiscus sabdariffa L. were studied. The ethanol extract of the aerial part of the first three plants and the flowers of H. sabdariffa were subjected to hepatoprotective assays using Wistar albino rats. Liver injury induced in rats using carbon tetrachloride. The biochemical parameters; serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflection of the liver condition. Based on the good results of the biochemical parameters measurements, histopathological study was performed on the liver of rats treated with E. foliate. The normal appearance of hepatocytes indicated a good protection of the extract from carbon tetrachloride hepatotoxicity. All the results were compared with silymarin, the reference hepatoprotective drug.
Constituents of the Aerial Parts of Lonicera etrusca Growing in Saudi Arabia
Saleh I. Alqasoumi,Adnan J. Al-Rehaily,Maged S. Abdel-Kader 한국생약학회 2009 Natural Product Sciences Vol.15 No.3
Phytochemical investigation of the aerial parts of Lonicera etrusca resulted in the isolation of three iridoids including two aglycones, loganin aglycone (log-1) (1) and lonicerin (log-2) (2), and the known common glycoside loganin (4). The study also afforded a coumarin derivative, 7-hydroxycoumarin (3), and a flavonoid glycoside, luteolin-7-O- β-D-glucoside (5). The structures were determined utilizing physical, chemical and spectral methods.
Analgesic and Antipyretic Activity of Stachys schimperi Vatke
Mosa M. Qasheesh,Adnan J. Al-Rehaily 한국생약학회 2006 Natural Product Sciences Vol.12 No.1
analgesic and the antipyretic activity of the methanol, chloroform, hexane and acetonitrile extractsof the aerial parts of Stachys schimperi Vatke were investigated in mice. The nociceptive response was testedinduced fever test. The chloroform extract at 50 mg and hexane and acetonitrile extracts at 250 mg producedsignificant analgesic and antipyretic activity. KeywordsStachys schimperi, analgesia, hypothermia
Two New Flavonol Glycosides From The Aerial Parts of Lotus lalambensis Growing in Saudi Arabia
Hanan M. El-Youssef,Brian T. Murphy,Masouda E. Amer,Adnan J. Al-Rehaily,Maged S. Abdel-Kader,David G. I. Kingston 한국생약학회 2008 Natural Product Sciences Vol.14 No.2
Phytochemical study of the aerial parts of Lotus lalambensis Schweinf resulted in the isolation and identification of two new flavonol glycosides; kaempferol 3-O-(5"-acetyl)-apioside-7-O-α-L-rhamnopyranoside (1) and kaempferol 3-O-α-[β-D-xylosyl-(1"" → 2")-L-rhamnopyranoside]-7-O-α-L-rhamnopyranoside (2). Structures were determined utilizing different physical, chemical, spectroscopic data including 2D-NMR experiments and HRFABMS.