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Bioactivity Guided Phytochemical Study of Clematis hirsuta Growing in Saudi Arabia
Abdel-Kader, Maged S.,Al-Taweel, Areej M.,El-Deeb, Kadriya S. The Korean Society of Pharmacognosy 2008 Natural Product Sciences Vol.14 No.1
Bioactivity guided phytochemical study of the petroleum ether and butanol extracts of Clematis hirsuta resulted in the isolation of 12 compounds. Rat paw edema as a model of acute inflammation was used to evaluate the anti-inflammatory activity of the extracts and the chromatographic fractions. Five known sterols and triterpenes namely: ${\beta}-amyrin$ (1), lupeol (2), ${\beta}-sitosterol$ (3), oleanolic acid (4) and stigmasterol glycoside (5) were isolated from the petroleum ether extract. The n-butanol extract afforded two compounds reported for the first time from natural source: (S)-(+)-dihydro-5-(hydroxymethyl)-2(3H)-furanone (7) and (s)-(-)-5-hydroxymethyl-2(5H)-furanone (8). In addition, anemonin (6), dihydro-4-hydroxy-5-(hydroxymethyl)-2(3H)-furanone (2-deoxy-D-ribono-1,4-lactone) (9), biophenol (cimidahurin) (10), glucose (11) and sucrose (12) were also identified. The structures were determined from spectroscopic data including 1D- and 2D-NMR experiments.
Azim, Hamdy Abdel,Abdal-Kader, Yasser Salah el din,Mousa, Mohamed Mahmoud,Malek, Raafat Abdel,Abdalmassih, Michael Kheir,Ibrahim, Noha Yehia Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: To evaluate the impact of adding taxanes to anthracycline-based regimens in the adjuvant setting in localized young female breast cancer patients on the overall survival (OS) and the disease free survival (DFS). Materials and Methods: This retrospective study included all female breast cancer patients who were candidates for adjuvant chemotherapy presenting to Kasr Al Ainy centre of clinical oncology and Cairo oncology centre (Cairo Cure) in the period from January 2005 till December 2010. Results: Our study included 865 patients, 732 of whom received anthracycline based regimens and 133 taxane based regimens. The mean age of patients was 39 years. After a median follow up of 50 months the median DFS was 48.4 months. Survival analysis indicated that the tumor size (>5cm vs. <5cm) p=0.001), nodal involvement (Yes vs. No) p=0.0001) and pathology (invasive lobular vs. ductal) p=0.048) affected DFS. As regards hormonal status, ER, PR and HER 2neu positive patients had longer DFS (p=0.001, 0.003, 0.106). On multivariate analysis DFS was affected by tumor size and lymph node involvement (p=0.014, 0.007). Subgroup analysis showed improvement in arms treated with taxanes in terms of DFS with positive Her2neu, ER and PR, but this was not statistically significant. Conclusions: Adding adjuvant taxanes to anthracyclines is beneficial for treatment of localized breast cancer among all subgroups, especially higher risk groups. The type of adjuvant chemotherapy regimens and tumor characteristics have direct effects on DFS.
Phytochemical Study of Lotus ornithopodioloides L.
Maged S. Abdel-Kader,Omer A. Basudan,Saleh I. Alqasoumi,Mohamed I. Abou-Shoer 한국생약학회 2007 Natural Product Sciences Vol.13 No.4
investigation of the aerial parts of L. resulted in the isolationof six known compounds. The structures were determined utilizing physical, chemical, spectral methods as wellas direct comparison with reference materials whenever possible. The compounds were identified as: β-sitosterol;the two triterpenes oleanolic and betulinic acids; the two cyanogenic glycosides lotaustralin and linamarin inaddition to the flavonol diglycoside kaempferitin.KeywordsLotus ornithopodioloides (Fabaceae), β-sitosterol, triterpene acids, cyanogenic glycosides, kaemferitin
Rare 2-Phenoxychromones from Ononis serrata Growing in Egypt
Maged S. Abdel-Kader,Fahima F. Kassem,Masouda E. Amer 한국생약학회 2004 Natural Product Sciences Vol.10 No.1
Two 2-phenoxychromones; a rare group of natural products, were isolated from the combined ethyl acetate and chloroform fractions of the ethanolic extract of Ononis serrata frossk (Leguminosae) growing in Egypt. Structures were elucidated by chemical, spectroscopic methods as well as single X-ray diffraction analyses. The cytotoxic and antimicrobial effects of the two compounds were examined. It is worth to mention that this is the first report on the isolation of 2-phenoxychromones from the family Leguminosae.