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        Constituents of Erythrina caffra Stem Bark Grown in Egypt

        Sawsan El-Masry,Hala M. Hammoda,Hala H. Zaatout,Saleh I. Alqasoumi,Maged S. Abdel-Kader 한국생약학회 2010 Natural Product Sciences Vol.16 No.4

        A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2'-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) erythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2'-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus. Keywords - Erythrina caffra, alkaloids, isoflavanoids, Staphylococcus aureus

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        C-Flavonoidal Glycosides from Erythrina caffra Flowers

        Sawsan El Masry,Hala M. Hammoda,Mohamed M. Radwan,Samir A. Ross,Hala H. Zaatout 한국생약학회 2010 Natural Product Sciences Vol.16 No.4

        A phytochemical investigation of the ethanolic extract of Erythrina caffra flowers from an Egyptian origin yielded three C-flavonoidal glycosides; 5,7,4`-trihydroxyflavone-8-C-β-D-glucopyranoside (vitexin) (1), 5,7,4`-trihydroxyflavone-6-C-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (isovitexin-2``-β-D-glucopyranoside) (2), 5, 7, 4`-trihydroxyflavone-6, 8-di-C-β-D-glucopyranoside (vicenin-2) (3) and one O-flavonoidal glycoside; kaempferol-3-O-β-D-glucopyranosyl) (1→2)-β-D-glucopyranoside (4). The structures of the isolated compounds (1 - 4) were elucidated using different spectral techniques (UV, 1D and 2D NMR and HRESIMS). This is the first report for the isolation of flavonoidal glycosides from Erythrina caffra. The antibacterial, antifungal, antimalarial, and antileishmanial activities of the isolates were evaluated. In addition, the cytotoxic activity of the ethanolic extract and the main fractions were tested using brine shrimp bioassay.

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