http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : MEIJING PIAO (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Extract of Seaweed Dictyota coriacea Scavenges Superoxide Anion and Hydroxyl Radical
MEIJING PIAO,Kyoung Ah Kang,Herath Mudiyanselage Udari Lakmini Herath,Pincha Devage Sameera Madushan Fernando,Nam Ho Lee,Jin Won Hyun 건강기능식품미래포럼 2023 건강기능식품미래포럼 학술지 Vol.3 No.2
In this study, we prepared the ethanol extract of Dictyota coriacea (DCEE) and investigated its ability, along with epiloliolide and 1,9-dihydroxycrenulide compounds derived from this seaweed, to eliminate superoxide anion (·O2 − ) and hydroxyl radical (·OH) through electron spin resonance spectrometry. The findings indicate that DCEE effectively scavenges both ·O2 − and ·OH, while the 2 compounds target ·OH only. These results support the ·OH scavenging properties of DCEE and imply the presence of substances within DCEE that can also eliminate ·O2 − . Furthermore, in order to identify ingredients with antioxidant properties and ensure their safety, we fractionated DCEE into 5 fractions using solvents of varying polarities (hexane, dichloromethane, ethyl acetate, butanol, and water) and examined these fractions for 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and cytotoxicity. Among the 5 fractions, the ethyl acetate fraction exhibited the highest activity, followed by the water and dichloromethane fractions, while the hexane and butanol fractions displayed the lowest activities. With regards to cytotoxicity, all fractions except for the water fraction exhibited varying degrees of cytotoxic effects, which correlated inversely with the polarity of the solvents used. The ethyl acetate and dichloromethane fractions demonstrated superior scavenging activity but also higher cytotoxicity, whereas the butanol fraction exhibited lower cytotoxicity but the least scavenging activity. These findings suggest that D. coriacea possesses the ability to eliminate ·O2 − and ·OH and propose that fractionating DCEE using water may yield antioxidant ingredients with minimal cytotoxicity
-
A New Direction of Cancer Classification: Positive Effect of Low-Ranking MicroRNAs
Feifei Li,Minghao Piao,Yongjun Piao,Meijing Li,류근호 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.5
Objectives: Many studies based on microRNA (miRNA) expression profiles showed a new aspect of cancer classification. Because one characteristic of miRNA expression data is the high dimensionality, feature selection methods have been used to facilitate dimensionality reduction. The feature selection methods have one shortcoming thus far: they just consider the problem of where feature to class is 1:1 or n:1. However, because one miRNA may influence more than one type of cancer, human miRNA is considered to be ranked low in traditional feature selection methods and are removed most of the time. In view of the limitation of the miRNA number, low-ranking miRNAs are also important to cancer classification. Methods: We considered both high- and low-ranking features to cover all problems (1:1, n:1, 1:n, and m:n) in cancer classification. First, we used the correlation-based feature selection method to select the high-ranking miRNAs, and chose the support vector machine, Bayes network, decision tree, k-nearestneighbor, and logistic classifier to construct cancer classification. Then, we chose Chi-square test, information gain, gain ratio, and Pearson’s correlation feature selection methods to build the m:n feature subset, and used the selected miRNAs to determine cancer classification. Results: The low-ranking miRNA expression profiles achieved higher classification accuracy compared with just using high-ranking miRNAs in traditional feature selection methods. Conclusion: Our results demonstrate that the m:n feature subset made a positive impression of low-ranking miRNAs in cancer classification.
-
-
Jin Won Hyun,Kyoung Ah Kang,장예,MEIJING PIAO,Ao Xuan Zhen,Herath Mudiyanselage Udari Lakmini Herath,Pincha Devage Sameera Madushan Fernando 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.4
Luteolin has been reported to possess apoptotic and antitumor properties. Apoptosis induced by endoplasmic reticulum (ER) stress becomes a potential target for chemotherapeutic strategies since drug resistance develops less if anticancer action is attributed to this apoptosis. In the present study, we raised a possibility that luteolin may induce apoptosis via inducing the ER stress and attempted to test this possibility using HT-29 human colon cancer cells. When HT-29 cells were treated with luteolin, decrease of cell viability, DNA fragmentation and the increase of sub-G1 population were observed, confirming that this compound induced apoptosis. Simultaneously, the cells showed typical signs observed in the response of ER stress, which were Ca2+ overloading in cytosol and mitochondria, phosphorylation of PKR-like ER kinase (PERK) and its downstream proteins: eukaryotic initiation factor-2α and inositol requiring protein1(IRE1), splicing of ER stress-specific X-box transcription factor-1 (XBP-1), cleavage of activating transcription factor 6 (ATF6) as well as up-regulation of glucose-regulated protein-78 (GRP78) and CCAAT/enhancer-binding protein-homologous protein (CHOP). However, when HT-29 cells transfected with siCHOP RNA were treated with luteolin, its effects on decrease of cell viability, DNA fragmentation and sub-G1 population were significantly reduced, suggesting that the luteolin-induced apoptosis is mediated by inducing ER stress. These results support that luteolin has the potential as an agent for cancer prevention or treatment.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
