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        Two-Dimensional Shear Wave Elastography Predicts Liver Fibrosis in Jaundiced Infants with Suspected Biliary Atresia: A Prospective Study

        Chen Huadong,Zhou Luyao,Liao Bing,Cao Qinghua,Jiang Hong,Zhou Wenying,Wang Guotao,Xie Xiaoyan 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6

        Objective: This study aimed to evaluate the role of preoperative two-dimensional (2D) shear wave elastography (SWE) in assessing the stages of liver fibrosis in patients with suspected biliary atresia (BA) and compared its diagnostic performance with those of serum fibrosis biomarkers. Materials and Methods: This study was approved by the ethical committee, and written informed parental consent was obtained. Two hundred and sixteen patients were prospectively enrolled between January 2012 and October 2018. The 2D SWE measurements of 69 patients have been previously reported. 2D SWE measurements, serum fibrosis biomarkers, including fibrotic markers and biochemical test results, and liver histology parameters were obtained. 2D SWE values, serum biomarkers including, aspartate aminotransferase to platelet ratio index (APRi), and other serum fibrotic markers were correlated with the stages of liver fibrosis by METAVIR. Receiver operating characteristic (ROC) curves and area under the ROC (AUROC) curve analyses were used. Results: The correlation coefficient of 2D SWE value in correlation with the stages of liver fibrosis was 0.789 (p < 0.001). The cut-off values of 2D SWE were calculated as 9.1 kPa for F1, 11.6 kPa for F2, 13.0 kPa for F3, and 15.7 kPa for F4. The AUROCs of 2D SWE in the determination of the stages of liver fibrosis ranged from 0.869 to 0.941. The sensitivity and negative predictive value of 2D SWE in the diagnosis of ≥ F3 was 93.4% and 96.0%, respectively. The diagnostic performance of 2D SWE was superior to that of APRi and other serum fibrotic markers in predicting severe fibrosis and cirrhosis (all p < 0.005) and other serum biomarkers. Multivariate analysis showed that the 2D SWE value was the only statistically significant parameter for predicting liver fibrosis. Conclusion: 2D SWE is a more effective non-invasive tool for predicting the stage of liver fibrosis in patients with suspected BA, compared with serum fibrosis biomarkers.

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        Development of Grain Boundary Character Distribution in Medium‑Strained 316L Stainless Steel During Annealing

        Weijiu Huang,Shanshan Yuan,Linjiang Chai,Luyao Jiang,Haiding Liu,Fangjun Wang,Dongzhe Wang,Junjun Wang 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.2

        A medium-strained (13% cold-drawing) 316L austenitic stainless steel rod was subjected to annealing between 750 and1100 °C. Electron backscatter diffraction and electron channeling contrast imaging techniques were jointly employed toinvestigate the development of microstructures and grain boundary character distribution during the annealing treatments. Results show that annealing at temperatures below 900 °C does not evidently change microstructures of the as-drawn specimen. Full recrystallization is observed after the temperature reaches 1000 °C and the deformation microstructures are replacedby fine and uniform recrystallized grains. A large number of annealing twins (with Σ3 misorientation) are produced by therecrystallization, leading to markedly increased fractions of special boundaries (fSB). The maximum fSB is found to be 67.3%in the present study. In addition, for the recrystallized grains, rapid growth is noticed at relatively high temperatures due toeasy migration of grain boundaries.

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