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RISS 인기검색어
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- 저자 : Luo Xiangping (검색결과 3 건)
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Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis
Jing Luo,Huanhuan Guo,Zhuofu Liu,Tao Peng,Xianting Hu,Miaomiao Han,Xiangping Yang,Xuhong Zhou,Huabin Li 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.3
Purpose: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients. Methods: Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry. Moreover, the serum total immunoglobulin E (IgE) and IgE concentrations secreted into the cultured peripheral blood mononuclear cells (PBMCs) were measured by using enzyme-linked immunosorbent assay. Results: We found the peripheral blood of AR patients contained higher percentages of memory B cells, plasma cells, and CD19+CD24hiCD27+ regulatory B cells (Bregs) than those of age-matched healthy controls (P<0.05), while the percentages of naïve B cells and CD19+CD24hiCD38hi Bregs were significantly lower in AR patients than in healthy individuals (P<0.05). In addition, the serum total IgE and IgE concentrations secreted into the cultured PBMCs were elevated in AR patients than in the healthy controls (P<0.05). Conclusions: Our findings indicate that AR patients were characterized by increase in terminally differentiated memory B cells or plasma cells and decreases in CD19+CD24hiCD38hi Breg cells in the peripheral blood.
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Cheng Luo,Mingjing Fang,Shicong Zhai,Xiangping Ou,Yang Pu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11
The compaction of over-wet fluvioglacial deposits filler is difficult due to its high moisture content. This paper presents an easy but effective improvement method to treat over-wet fluvioglacial deposits using quicklime. Firstly, several tests are conducted to figure out the properties of the over-wet fluvioglacial deposits. Then, the relationship curves between the difference of natural-optimal moisture content and compaction degree are established. Finally, field test is carried out and the compaction degree of the subgrade soil is evaluated by sand cone method. The field test in the case study shows that the moisture content difference of filler is 10.9%, and the optimal quicklime content is 6% according to the curves. Results indicate that the average compaction degree of subgrade soil is 94.90% (>93%) and the value of CBR is much higher than required 3%, which proves that the method using quicklime works well to improve over-wet fluvioglacial deposits filler for rapid construction of highway embankment. Considering the inadequacy of stiffness of quicklime-treated filler, the rapid increase of stiffness for the upper roadbed using over-wet fluvioglacial deposits filler needs further research.
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Shen Qiaoqiao,Luo Xiangping,Feng Xiangang,Gao Yulin 한국간호과학회 2022 Asian Nursing Research Vol.16 No.3
Purpose: The aim of this paper is to develop a scale for measuring the perinatal bereavement care competence of midwives and assess its psychometric properties. Methods: The Perinatal Bereavement Care Competence Scale was developed in four phases. (1) Item generation: 75 items were formulated based on a literature review and interviews with midwives. (2) Delphi expert consultation: 15 experts evaluated whether the items were clear/appropriate/relevant to the questionnaire dimensions, and the items were optimized. (3) Pilot test: The comprehensibility, acceptability, and time required to complete the questionnaire by midwives were assessed. (4) Evaluation of reliability and validity: The scale was validated by initial item analysis, exploratory and confirmatory factor analyses, and internal consistency reliability and testeretest reliability. Results: The final scale consisted of six dimensions and 25 items: maintaining belief (three items), knowing (four items), being with (six items), preserving dignity (four items), enabling (five items), and self-adjustment (three items). Exploratory factor analysis yielded a six-factor structure that was consistent with the theoretical framework and explained 70.8% of the total variance. Confirmatory factor analysis indicated a good fit for the six-factor model. Cronbach's a for the scale was 0.931, and the test eretest reliability coefficient was 0.968. Conclusion: The Perinatal Bereavement Care Competence Scale is a valid and reliable instrument for measuring the competence of midwives in caring for bereaved parents who have experienced perinatal loss.
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