Expression and Clinical Significance of Osteopontin in Calcified Breast Tissue

Huan, Jin-Liang,Xing, Li,Qin, Xian-Ju,Gao, Zhi-Guang,Pan, Xiao-Feng,Zhao, Zhi-Dong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Osteopontin (OPN) is an integrin-binding protein, believed to be involved in a variety of physiological cellular functions. The physiology of OPN is best documented in the bone where this secreted adhesive glycoprotein appears to be involved in osteoblast differentiation and bone formation. In our study, we used semi-quantitative RT-PCR of osteopontin in calcification tissue of breast to detect breast cancer metastasis. The obtained data indicate that the expression of osteopontin is related to calcification tissue of breast, and possibly with the incidence of breast cancer. The expression strength of OPN by RT-PCR detection was related to the degree of malignancy of breast lesions, suggesting a close relationship between OPN and breast calcification tissue. The results revealed that expression of OPN mRNA is related to calcification of breast cancer tissue and to the development of breast cancer. Determination of OPN mRNA expression can be expected to be a guide to clinical therapy and prediction of the prognosis of breast cancer patients.

Microstructures and Fatigue Life of SnAgCu Solder Joints Bearing Nano-Al Particles in QFP Devices

Liang Zhang,Xi-ying Fan,Yong-huan Guo,Cheng-wen He 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.3

Microstructures and fatigue life of SnAgCu and SnAgCu bearing nano-Al particles in QFP (Quad flat package) devices were investigated, respectively. Results show that the addition of nano-Al particles into SnAgCu solder can refine the microstructures of matrix microstructure. Moreover, the nano-Al particles present in the solder matrix, act as obstacles which can create a back stress, resisting the motion of dislocations. In QFP device, it is found that the addition of nano-Al particles can increase the fatigue life by 32% compared with the SnAgCu solder joints during thermal cycling loading.

Highly heat-resistant NF membrane modified by quinoxaline diamines for Li+ extraction from the brine

Huan-Yin Xie,Run-Hua Tang,Gui-E Chen,Zhen-Liang Xu,Haifang Mao 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.112 No.-

The Functional layers with excellent heat-resistence nanofiltration (HRN) property were designed by fixingthermal stabilized quinoxaline diamines (QHDA) on poly (m-phenyleneisophthalamide) (PMIA) substratethrough interfacial polymerization. QHDA was used as aqueous monomer while cinnamoylchloride (CNC), isophthaloyl chloride (IPC) and trimesoyl chloride (TMC) were served as organic monomersto realize the immobilization of thermally stable N heterocycles. The experimental results statedclearly that the compact package reaction of QHDA with TMC lead a raise of thermal stability and saltsrejection at high temperature stream. With the optimal TMC and 0.5 wt.% QHDA, the as-developed membraneachieved the excellent NF performance and thermal stability. The rejection of MgSO4 reached to94.6 % at 30 C and hardly decrease at 90 C. The reduction in rejection was satisfactory at high temperatures. The functional layer still showed highly stability after 10 h long-term operation at 90 C with only2.8 % reduction in MgSO4 rejection. Besides, the excellent Mg2+ and poor Li+ rejection made this membranehave huge potential in the application of extracting Li+ from brine. The separation factor ofMg2+-Li+ at high temperature was satisfactory. Over all, this study offered a prospect technology toexploit heat-resistant membranes for extraction lithium at high temperature.

Aerodynamic properties of a streamlined bridge-girder under the interference of trains

Huan Li,Xu-hui He,Liang Hu,Xiaojun Wei 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.35 No.3

Trains emerging on a streamlined bridge-girder may have salient interference effects on the aerodynamic properties of the bridge. The present paper aims at investigating these interferences by wind tunnel measurements, covering surface pressure distributions, near wake profiles, and flow visualizations. Experimental results show that the above interferences can be categorized into two primary effects, i.e., an additional angle of attack (AoA) and an enhancement in flow separation. The additional AoA effect is demonstrated by the upward-moved stagnation point of the oncoming flow, the up-shifted global symmetrical axis of flow around the bridge-girder, and the clockwise-deflected orientation of flow approaching the bridgegirder. Due to this additional AoA effect, the two critical AoAs, where flow around the bridge-girder transits from trailing-edge vortex shedding (TEVS) to impinging leading-edge vortices (ILEV) and from ILEV to leading-edge vortex shedding (LEVS) of the bridge-girder are increased by 4° with respect to the same bridge-girder without trains. On the other hand, the underlying flow physics of the enhancement in flow separation is the large-scale vortices shedding from trains instead of TEVS, ILEV, and LEVS governed the upper half bridge-girder without trains in different ranges of AoA. Because of this enhancement, the mean lift and moment force coefficients, all the three fluctuating force coefficients (drag, lift, and moment), and the aerodynamic spanwise correlation of the bridge-girder are more significant than those without trains.

Effects of alkali- and alkaline-earth-metals on hydrogen generation during fluidized bed gasification of artificial waste

Tzu-Huan Peng,Chiou-Liang Lin,Hsien Chen 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.2

We evaluated the effects of Na, K, Ca, and the steam-to-biomass (S/B) ratio on gasification efficiency duringsyngas production. The results show that H2 production was positively correlated with the S/B ratio. However, increasesin the S/B ratio were limited because excessive steam decreased the reactor temperature and hampered the gasificationprocess. Regarding the effects of alkali metals on syngas composition, we found that the addition of either Na or Kincreased the molar percentages of H2 and CO, but decreased CH4 and CO2. The results also clearly show that the additionof Na or K improved the yield of syngas, the carbon conversion efficiency, and the cold gas efficiency. Improvementswere especially pronounced with K. Furthermore, Ca had different interactions with Na and K during gasification. WhenNa and Ca existed simultaneously, H2 production was enhanced.

PREPARATION, CHARACTERIZATION AND MAGNETIC PROPERTIES OF NANO-Fe3O4 AND COBALT-DOPED NANO-Fe3O4 BY CO-PRECIPITATION METHOD

XIAOJUAN LIANG,WEIWEI HUAN,XIANGCHEN JIA,HAIJUN DING,YUXIANG YANG,XIANGNONG LIU 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.4

Pure nano-Fe3O4 and cobalt-doped nano-Fe3O4 particles are successfully synthesized by co-precipitation method using tetramethylammonium hydroxide (TMAOH) as alkali. Several key factors that may affect preparation are carefully discussed such as alkali concentration, alkali dosage, reaction temperature, iron salt solution concentration and dispersant agents. Such nano-Fe3O4 particles prepared have good dispersibility and a very narrow size distribution with the average diameter about 38 nm, which are proved to be cubic spinel Fe3O4 crystal by XRD pattern. It is also found that the addition of PEG-4000 surfactant can improve the dispersibility of nanoparticles. In our work, effects of cobalt dopant concentration on magnetic properties of cobalt-doped nano-Fe3O4 are also discussed. The result shows that the coercivity of cobalt-doped nanoparticles changes greatly with the variation of cobalt dopant concentration. The maximum coercivity reaches as high as 1628 Oe, which is very meaningful for preparation of materials with high coercivity.

Multimodal Repair of Spinal Cord Injury With Mesenchymal Stem Cells

Yuan-huan Ma,Qing-yue Liang,Ying Ding,한인보,Xiang Zeng 대한척추신경외과학회 2022 Neurospine Vol.19 No.3

Spinal cord injury (SCI) is a result of a devastating injury to the central nervous system. Currently, there is no effective treatment available for these patients. The possible use of mesenchymal stem cell (MSC)-based treatment for SCI has been the focus of extensive investigations and is increasingly moving from the bench to bedside. Both experimental observations and clinical studies have shown the safety and efficacy of MSCs in managing SCI. However, the exact mechanism by which MSCs contribute to the repair of the injured spinal cord remains to be elucidated. In this review, we aim to summarize current research findings about the role of MSCs in improving complex pathology after SCI. MSCs exert a multimodal repair mechanism targeting multiple events in the secondary injury cascade. Our recent results showing the perineurium-like differentiation of surviving MSCs in the injured spinal cord may further the understanding of the fate of transplanted MSCs. These findings provide fundamental support for the clinical use of MSCs in SCI patients. Under experimental conditions, combining novel physical, chemical, and biological approaches led to significant improvements in the therapeutic efficacy of MSCs. These findings hold promise for the future of cell-based clinical treatment of SCI.

Evaluation of heavy metal distribution and biological toxicity in agglomeration bed material during artificial waste incineration in fluidized bed

Chiou-Liang Lin,Tzu-Huan Peng 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.5

This study discusses the impact of different operating parameters on the bed material particle size and heavy metal distribution, and evaluates the impact of bed material heavy metal on the environment through TCLP and Vibrio fischeri test. The experimental results show that the bed material particle size distribution inclines to smaller particle sizes as the operating temperature increases. When there is Na, the particle size increases due to the agglomeration of eutectic. As for the heavy metal distribution, the combination of the fine particle sizes (<0.59mm) with a large surface area and the large particle sizes with multiple eutectics has a higher heavy metal concentration. According to the results of leaching concentration of bed materials with different particle sizes, the heavy metals with large (>0.84 mm) and fine (<0.59 mm) particle sizes have the maximum leaching concentration. As for the biological toxicity, when the temperature is 700 oC or Na concentration is 0.3%, the biological toxicity is at its maximum, which may due to a high accumulation of heavy metals.

Simulation and Investigation of Humidity Sensor based on Fiber Grating Fabry-Perot

Xiong Yanling,Liang Huan,Ren Naikui,Han Junsheng,Wu Mingze 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.6

In this article we have discussed the relative humidity sensor based on fiber grating Fabry-Perot (FBG-FP) coated with polyimide (PI) as a moisture sensitive film in theory. The moisture expansion coefficient of PI film as moisture strain on the FBG-FP sensor, which will result the change of the fiber core effective refractive index, the length of the F-P cavity and the period and effective refractive index of FBG. For that reason, the interference fringes of the reflection spectrum will be changed also. The shift of peak wavelength of the spectrum is traced by the simulation of Matlab. We discuss three situations: the coating on the FBG, FP cavity and the both, and regardless of the temperature changes, the simulation results show that the RH sensitivity can reach to 3.77pm/%RH, 2.12 pm/%RH, 4.05 pm/%RH, respectively.

Novel space vector-based PWM strategy with minimal circulating current and line-current ripple for two parallel interleaved inverters

Jin, Xiao-Liang,Liu, Sheng-Fu,Shi, Wen,Yang, Huan,Zhao, Rong-Xiang The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.2

Existing PWM methods suffer from a trade off between zero-sequence circulating current (ZSCC) and line-current ripple, which are two major concerns of two parallel interleaved two-level (2L) voltage-source converters (VSCs). Thus, this paper introduces a novel space vector-based PWM strategy to reduce both line-current ripple and ZSCC. Given the redundancy of the vector combination of two parallel interleaved converters, this paper proposes eight optimal vector sequences, which simultaneously optimizes the ZSCC and the line-current ripple. Then, a carrier-based scheme is applied to yield optimal vector sequences, which simplifies the implementation procedure. Furthermore, this paper quantitatively compares both the ZSCC and the line-current ripple of the proposed method to those of existing PWM schemes. This comparison confirms that the proposed method is superior to existing PWM schemes in terms of current ripple and ZSCC. Finally, experimental results further verify the theoretical analysis and the effectiveness of the proposed strategy.