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A NEURAL NETWORK EXPERT SYSTEM FOR AERONAUTIC MAINTENANCE QUALITY EVALUATION
Li, Jiang Wen,Jun, Li Ting,He, Liu Long 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
It is a new way for AI to apply ANNs (Artificial Neural Networks) to expert system. ANNs provide an effective solution to the provlems encountered in building systems that emulate a management expert. In this artical, taking the advantage of learning algorithms of ANNs to simulate management experts experience, we build an expert system for aeronautic maintenance quality evaluation. Results showed that it is practicable and reliable.
Li-he Jiang,Xuan Luo,Wen ai He,Xiu-xiang Huang,Ting-ting Cheng 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.12
In this study, the mechanism of H_2S protection in the hippocampus of heroin-treated rats was investigated. Male Sprague-Dawley rats were randomly divided into three groups: a saline group, a heroin and saline group, and a heroin and sodium hydrosulfide group. According to the principle of increasing heroin dosage daily, heroin withdrawal was precipitated on day 9with an injection of naloxone (5 mg/kg, i.p.), and withdrawal symptoms were scored. The levels of cystathionine-β-synthase, H_2S, reduced glutathione and malondialdehyde, as well as the levels of cleaved caspase-3, Bax, and Bcl-2 proteins and the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the hippocampus. The results showed that exogenous H_2S alleviated heroin withdrawal symptoms. Moreover, exogenous H_2S not only increased cellular H_2S and the cystathionine-β-synthase protein level activity but also significantly improved heroin-induced oxidative stress. Protein expression of cleaved caspase-3 and Bax decreased, whereas Bcl-2 protein levels in hippocampus increased with exogenous H_2S. Exogenous H_2S alleviated heroin-induced rat hippocampal damage through antioxidant and antiapoptosis effects.
Static and free vibration analysis of shallow sagging inclined cables
Li, Zhi-Jiang,Li, Peng,He, Zeng,Cao, Ping Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.2
Based on link-model, we conducted a static analysis and computation of a three-span suspended cable structure in the present paper, and obtained the static configuration and tension distribution of the cable. Using the link and beam model based on finite element method, we analyzed the vibration modal of three-span suspended cable structure, and compared with the results obtained from ANSYS using link and beam element. The vibration modals of shallow sagging inclined cables calculated from proposed method agrees well with ANSYS results, which validates the proposed method. As a result, the influence of bend stiffness on in-plane natural frequencies is much greater than that on out-of-plane natural frequencies of inclined cables.
The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study
Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2
This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
Li, Shihao,Jiang, Jie,Yan, Yinan,Wang, Ping,Huang, Gang,Kim, Nam hoon,Lee, Joong Hee,He, Dannong Elsevier 2018 Materials science & engineering. C, Materials for Vol.93 No.-
<P><B>Abstract</B></P> <P>Folate receptor targeted photo-luminescent quantum carbon dots (Fr-CDs) were successfully prepared from folic acid and phenylenediamine isomers through hydrothermal approaches. Fr-CDs were spherical particles smaller than 10 nm, and emit stable green, blue and red luminescence under ultraviolet region excitation (λex = 365 nm) with maximum emissive lengths at 530, 429, and 612 nm. And the corresponding photoluminescence quantum yield as 15.4%, 12.6% and 16.2% respectively. Up-converted photoluminescent properties in near infrared 800 nm spectral region located in green, blue and yellow region. In-vitro studies showed Fr-CDs had almost none cytotoxicity (cell viability over 80%) and high affinitive to the Hela celline highly-expressed-folate-receptor membranes, and lighted on cytoplasm as the fluorescent marker. It displayed long luminescent-stability with PL intensity above 90% in ultraviolet illuminant exposure over 24 h. In in-vivo studies, Fr-CDs were internalized and accumulated in targeted cancer tissues of cervical carcinoma and the emitting fluorescence maintains over 30 min.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Multicolor carbon dots was prepared from folic acid and phenylenediamin isomers. </LI> <LI> These carbon dots exhibit targeting abilities with high affinity to ovarian cancer cells and tissues. </LI> <LI> Ultra-violet and near-infrared light excited photo-luminescent spectrums were investigated, and related quantum yield was calculated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>FA-doped CDs can effectively target ovarian cancer cells and aggregate in ovarian tumor tissue in a short 15 min.</P> <P>[DISPLAY OMISSION]</P>
Li-Li Zhao,Jiang Pan,Jian-He Xu 한국생물공학회 2010 Biotechnology and Bioprocess Engineering Vol.15 No.2
The lipase from Serratia marcescence ECU1010(Sml) was capable of enantioselectively catalyzing the synthesis of many chiral drug precursors. This paper investigated the immobilization of Sml on appropriate supporting materials and its performance in bioreactor. Chitosan, Celite 545, and DEAE-cellulose were found to be the ideal supports among 8 carriers tested with respect to enzyme load and activity recovery of lipase. When Sml was immobilized, significant improvements of stability against pH, thermal, and operational deactivation were observed with all the 3 better supports, and the best stability was observed when the lipase was immobilized on glutaraldehyde activated chitosan. As for the effect of organic solvent in the biphasic reaction system, the hydrolytic activity of the immobilized lipase on trans-3-(4'-methoxyphenyl)glycidic acid methyl ester ((±)-MPGM)observed in isopropyl ether was 6 and 3 times higher than those in toluene and methyl tert-butyl ether. The lipasecatalyzed production of (−)-MPGM by enzymatic resolution of (±)-MPGM with chitosan-Sml in isopropyl etherwater biphasic system was carried out in a 2 L stirred-tank reactor. The batch operation was more efficient operation mode for the enantioselective hydrolysis of (±)-MPGM,affording enantiopure (−)-MPGM in 44.3% overall yield,in contrast to 29.3% in a continuous reactor.
Static and free vibration analysis of shallow sagging inclined cables
Zhi-Jiang Li,Peng Li,Zeng He,Ping Cao 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.2
Based on link-model, we conducted a static analysis and computation of a three-span suspended cable structure in the present paper, and obtained the static configuration and tension distribution of the cable. Using the link and beam model based on finite element method, we analyzed the vibration modal of three-span suspended cable structure, and compared with the results obtained from ANSYS using link and beam element. The vibration modals of shallow sagging inclined cables calculated from proposed method agrees well with ANSYS results, which validates the proposed method. As a result, the influence of bend stiffness on in-plane natural frequencies is much greater than that on out-of-plane natural frequencies of inclined cables.
Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.
( Jiang Li ),( Yu Jie Sha ),( Dewi Seswita Zilda ),( Qiu Shi Hu ),( Pei Qing He ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.1
An extracellular agarase was purified from Bacillus sp. BI-3, a thermophilic agar-degrading bacterium isolated from a hot spring in Indonesia. The purified agarase revealed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, with an apparent molecular mass of 58 kDa. The optimum pH and temperature of the agarase were 6.4 and 70oC, respectively. The activity of the agarase was stable at high temperatures, and more than 50% activity was retained at 80oC for 15 min. Furthermore, the enzyme was stable in the pH range of 5.8?8.0, and more than 60% of the residual activity was retained. Significant activation of the agarase was observed in the presence of K+, Na+, Ca2+, Mg2+, and Sr2+; on the other hand, Ba2+, Zn2+, Cu2+, Mn2+, Co2+, Fe2+, and EDTA inhibited or inactivated the enzyme activity. The components of the hydrolytic product analyzed by thin-layer chromatography showed that the agarase mainly produced neoagarobiose. This study is the first to present evidence of agarolytic activity in aerobic thermophilic bacteria.