악성 림프종 환자에서 발생한 다형홍반

여운철,조광현,이유신,허대석,이승철 ( Un Cheol Yeo,Kwang Hyun Cho,Yoo Shin Lee,Dae Seog Heo,Seung Chul Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5

A Case of Erythema Multiforme A ssociated with Malignant Lymphoma Un Cheol Yeo, M.D., Kwang Hyun Cho, M.D., Yoo Shin Lee, M.D., Dae Seog Heo*, M.D., Seoung Chul Lee**, M.D Department of Dermatology and Internal Medicine*, College of Medicine, Seoul National University, Seoul, Korea, Department of Dermatology**, College of Medicine, Inha University, Kyung Gi Do, Korea We report a case of erythema multiforme associated with malignant lymphoma. Fifty-six-year-old male patient visited our clinic complaining generalized skin lesions which were compatible with erythema multiforme clinically and histopathologically. The skin lesions were treatment-resistant, recurrent and persistent for 3 years. In consideration of old age, atypical features of erythema multiforme and no other demonstrable etiology of erythema multiforme, we studied for internal malignancy. Malignant lymphoma at the duodenum was revealed by UGI series, abdominal CT, and endoscopic biopsy. After chemotherapy, the tumor mass and active skin lesions were cleared simultaneously. Erythema multiforme may be regarded as one of the paraneoplastic syndromes.

순·구개열 환자의 두부규격방사선사진상을 이용한 친자간의 유사성에 관한 연구

이언경,나승목,고광준,조수범 大韓口腔顎顔面 放射線學會 1994 Imaging Science in Dentistry Vol.24 No.2

The purpose of this study was to determine whether any similarity existed in craniofacial morphology between parents and offspring in cleft lip with or without cleft palate. Thirty three measurements of the various regions of cranium and face were obtained from lateral cephalometric radiograms in 28 families comprising 28 fathers, 28 mothers and 28 cleft patients. The measurements of cleft patients were compared with those of their fathers, mothers and midparents. The obtained results were as follows: 1. There were similar measurements between the cleft patients and their father; ramal height(Ar-Go), mandibular angle(∠MP-RP). 2. There were similar measurements between the cleft patients and their mothers; cranial base angle(∠NSBa), relation of maxilla to the cranial base(∠SNA), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), angle of inferior border of mandible(∠SNL-MP) and convexity of nose apex(soft tissue:N"PrnPog"). 3. There were similar measurements between the cleft patients and their mdparents; ramal height (Ar-Go), cranical base angle(∠NSBa), relation of maxilla to the cranial base(soft tissue:∠BaN"Sn), Y axis angle(∠NSGn) and mandibular angle(∠MP-RP). 4. There was no similar measurements between the cleft patients and their fathers and mothers simultaneously.

특정기업지원적 산업정책의 전개 : 성과와 문제점

이승훈,정운찬 서울대학교 사회과학연구소 1996 社會科學과政策硏究 Vol.18 No.2

졸 - 겔법에 의한 다공성 알루미나 미분체 제조에 관한 연구 : 2 . 물과 알콕시드의 비가 알루미나 미분체의 결정화 공정에 미치는 영향 2 . The Effect of [ H2O ] / [ Al - alkoxide ]on The Crystallization Mechanism of As - Prepared Particles

이성원,박형상,윤호성,황운연,구기갑,유승준,김용렬,이정운 한국화학공학회 2001 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.39 No.2

알루미늄 알콕시드의 반응속도를 제어하기 위한 혼합용매와 입자제조 과정에서의 응집을 방지하기 위한 분산제로 HPC를 첨가하는 방법에 의하여 구형의 다공성 알루미나 미분체를 제조하였으며, XRD, FT-IR 및 TG-DTA 분석을 통하여 공정변수로 선정한 물과 알루미늄 알콕시드의 비가 제조된 미분체의 결정화 공정에 미치는 영향에 대하여 고찰하였다. 축중합 반응에 첨가된 물과 Al-알콕시드의 비는 제조된 미분체 및 하소 공정을 거친 미분체의 결정구조에 영향을 미침을 알 수 있었다. [H₂O]/[ASB]의 비가 증가할수록 제조된 미분체는 비정질의 Al(OH)₃로부터 점진적으로 AlO(OH)의 화학조성을 갖는 의사-보헤마이트로 결정성이 바뀌었다. 그리고 건조 공정을 거친 미분체의 결정성이 좋을수록 δ와 θ-Al₂O₃는 저온에서 생성되었으나, α-Al₂O₃는 고온에서 생성되었다. 이와 같은 결과는 Al^(3+)이온의 결정 내에서의 배위체 변화와 관계됨을 알 수 있었다. 그리고 [H₂O]/[ASB]=2의 조건에서 제조된 입자는 다른 시료와 달리 600℃에서 η-Al₂O₃로 1,100℃에서 α-Al₂O₃2로 상전이 되었다. Spherical porous alumina particles were prepared by mixed solvent to control the reaction rate of Al-alkoxide and the particle shape with hydroxy-propyl cellulose(HPC). HPC was used as a dispersant to prevent aggregation during the formation of particles. The effect of [H₂O]/[ASB] ratio on the crystallization reactions of as-prepared particles was studied by XRD, FT-IR, and TG-DTA analysis. The mole ratio of water and Al-alkoxide added in the condensation reaction had an important effect on the crystal structure of as-prepared particles and the calcined particles. As the [H₂O]/[ASB] ratio increase, the crystal structure of as-prepared particles was continuously varied from amorphous Al(OH)₃ to pseudo-boehmite with chemical composition of AIO(OH). The samples which have higher crystallinite after drying process were transformed into the δ- and θ-Al₂O₃ at lower calcination temperature, but these sample were transformed into α-Al₂O₃ at higher calcination temperature. This result was thought to be the transformation of the coordination number of Al^(3+) ion in the crystal structure. The particles prepared by [H₂O]/[ASB]=2 condition crystallized to α-Al₂O₃at 600℃ and converted to η-Al₂O₃at 1,100℃ without intermediate phases.

스포츠에 의한 경수손상(頸髓損傷)에 관한 분석

이승훈,이신언,임정일 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

This study have focuses on 21 cases of spine-neck broken at S hospital in seoul. Breaking spine-bone neck have occurred frequently at young ages. There are 6 cases of smashed fracture, 8 cases of both-side joint dislocation, 2 cases of one-side joint dislocation. And there are eight cases of entire broken, three cases of intermediate broken, 1 case of brown-sequard, three cases of middle part broken, 6 cases of knot broken. There are 0 or 2 cases occurred annually, and it doesn't mean sudden decreasing of fractures. Most of cases are able to prevent, but the wounds didn't take any preventive actions. If preventive curing methods are make, it will decrease effectively. We must make several preventive plans to reduce fatal spine-neck fracture.

유포르비아속 식물로부터 단리한 가수분해형 탄닌의 인체고형암 세포에 대한 세포독성효과

이승호,박지수,김소영,정시련,최상운 영남대학교 약품개발연구소 1997 영남대학교 약품개발연구소 연구업적집 Vol.7 No.-

Seventy three hydrolysable tannins and related compounds were isolated from seven Euphorbia plants. Among therm, 28 compounds including nine gallotannins, eleven ellagitannins and eight related compounds were selected according to the structural similarity. Cytotoxicity of them on the human tumor cell lines including A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 were evealuated by the SRB Method in vitro, 3,4,6-Tri-O-galloyl-D-glucose was shown to exhibit most potent cytotoxic effect(4.4μg/ml〈ED_(50)〈10.3μg/ml)

유기산 첨가가 닭뼈(대퇴골) 스톡(stock)에 용출되는 무기질량에 미치는 영향

이승언,南出隆久,大谷貴美子,최석현,한재숙 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.5

The focus of this study was the influence of organic acids such as acetic, citric and malic acid on the dissolution of calcium (Ca), magnesium (Mg), and phosphorus (P) on chicken thigh bone. As the concentration (0, 0.5, 1, 2, 4%) of acetic, citric, and malic acid increased, the resultant contents of calcium, magnesium, and phosphorus were higher than that of the control. When the boiling time (2, 4, 6, 8, 12 hours) was increased, dissolved amounts of several minerals from the chicken thigh bone increased- Calcium dissolved the most when chicken stock was boiled for 12 hours with 4% of malic acid added. In addition to minerals, amino acids and proteins were further extracted by adding organic acids. The soup stock, which contains minerals such as calcium, can be obtained by boiling the chicken thigh bone for 12 hours with an organic acid.

지모(知母)의 항암활성성분에 관한 연구

이승호,유시용,최상운,노재성,김성기,이정옥,안종웅 영남대학교 약품개발연구소 1995 영남대학교 약품개발연구소 연구업적집 Vol.5 No.-

EtOAc soluble part of MeOH extract of Anemarrbena asphodeloides rhizome was evaluated for the cytotoxicity against the five kinds of human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15) in vitro. Bioassay-guided fractionation of EtOAc soluble part led to the isolation of active compound which was identified as timosaponin A-Ⅲ1 showed potent cytotoxic activity, but its genin, sarsasapogenin, did not show cell growth inhibition.

중추신경계에서의 효모 가수분해물이 음식섭취조절기전에 미치는 영향

이승언,정경희,김미자,배윤정,장은재 동덕여자대학교 2004 생활과학연구 Vol.9 No.-

Saccharomyces cerevisiea, which has been known as antistress compounds, was hydrolyzed by proteinase producing SCP-20. The addition effects of SCP-20 on the food intake regulation mechanism were studied measuring the expression amount of neurotransmitters, such as NPY and NOS, which can increase food intake in hypothalamus, and CCK, which can decrease food intake by using immunohistochemistry method. The 0, 2, and 5 g/kg SCP-20 was orally administrated to the experimental animals for one week. The expression of NPY and NOS was increased in the group of 5 g/kg administrated animals while that of CCK was increased in the group of 2 g/kg administrated animals. The results of this study suggested that SCP-20 may influence the control mechanism of oral dose-dependently. Further studies are needed to elucidate the roles of SCP-20 on the changes of food intake regulation controlling neurotransmitters.

Benztropine Mesylate가 Haloperidol 타액농도에 미치는 영향에 대한 연구

이승탁,사승언,양병환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3

Nineteen patients with schizophrenia by the DSM-III-R were administrated with only haloperidol in the first period. And the second period began after extrapyramidal symptoms developed, in this period they were administrated with haloperidol and benztropine concomittantly. At the third period, after withdrawal of benztropine, they were administrated with only haloperidol. For the purpose of evaluating the effect of benztropine mesylate on the haloperidol saliva level, the authors measured the haloperidol saliva level, the reduced haloperidol saliva level and the ratio of the reduced haloperidol saliva level/the haloperidol saliva level at the seperated administration period. The results are as follows : 1) Though the haloperidol saliva level of the single administration period of haloperidol was higher than that of other two periods, there was no statistically significant change. 2) The reduced haloperidol saliva level had no statistically significant change among three periods. 3) The reduced haloperidol saliva level/the haloperidol saliva level ratio had no statistically signifiant change among three periods. The authors concluded that the benztropine mesylate had no significant effect on the haloperidol saliva level in this study.