Management of Premaxilla in Patient with Bilateral Complete Cleft Lip and Palate

Ui-Lyong Lee,Pill-Hoon Choung 대한구순구개열학회 2009 대한구순구개열학회지 Vol.12 No.2

전방으로 심하게 돌출된 전상악골로 인하여 구순성형술 및 비성형술의 결과가 악화 될 수 있다. 따라서 변위된 전상악골의 이상적인 위치로 재위치 시키려는 다양한 노력이 시도되어 왔다. 에디오피아와 같은 개발도상국에서는 어른이 되어서도 수술을 받지 못하는 구순구개열 환자가 많이 있다. 성인이 될 때까지 수술받지 못한 양측성 완전 구순구개열 환자에서는 근육, 골, 피부, 점막의 연속성이 없어서 전상악골이 심하게 전방으로 혹은 하방, 좌우측으로 변위된 경우가 대부분이다. 이 경우 구순성형술이 거의 불가능하며, 시도된다 할지라도 돌출된 전상악골 때문에 양쪽 구륜근을 봉합하여 주기가 대단히 어렵다. 따라서 이상적인 결과를 얻기 위해서는 구순성형술 전 혹은 동시에 전상악골의 재위치 술식이 필수적이다. 저자는 한국국제협력단에서 국제협력의사로 선발되어 에디오피아에서 30 개월간 근무하였다. 그 동안 다양한 양측성 완전 구순구개열 환자에서 전상악골의 재위치 술식을 경험하였다. 저자가 경험한 전상악골의 재위치 술식(전상악골의 재위치와 골이식술 동시 시행, 전상악골의 재위치와 구개열 성형술 동시시행)에 대하여 문헌고찰과 함께 보고하고자 한다.

High Dose Rate Brachytherapy in Primary and Recurrent Tongue Cancer

( Ui Lyong Lee ),( Jong Ho Lee ),( Pill Hoon Choung ),( Myung Jin Kim ),( Joo Yong Park ),( Sung Weon Choi ),( Kwan Ho Cho ) 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.S1

Effect of platelet-rich plasma on dental stem cells derived from human impacted third molars.

Lee, Ui-Lyong,Jeon, Soung Hoo,Park, Joo-Young,Choung, Pill-Hoon Future Medicine 2011 Regenerative medicine Vol.6 No.1

<P>Platelet-rich plasma (PRP) is fabricated from autologous blood and extensively used to promote soft and hard tissue healing. In the dental field, autologous PRP is widely used combined with dental implant installation and bone graft. This study will evaluate the biologic effect of PRP on the proliferation and the differentiation of human dental stem cells, and find the key cytokines inducing these effects to estimate the clinical feasibility of PRP for dental tissue engineering.</P>

폐쇄성 수면 무호흡증의 외과적 접근

이의룡(Ui-Lyong Lee) 대한치과의사협회 2021 대한치과의사협회지 Vol.59 No.12

Obstructive sleep apnea (OSA) is a chronic disease that requires long-term, continuous treatment. Considering the prevalence of sleep apnea and serious health-related sequelae, various medical and surgical treatments have been developed to achieve various therapeutic goals according to individual anatomy and patient compliance. Although CPAP treatment should be the preferred treatment, many patients cannot continue this treatment and alternative treatment is needed. Surgical treatment should be aimed at resolving the obstruction of the nose, palatal, retrolingual, and hypopharynx, or should be performed in the direction of increasing adherence to positive pressure therapy. In this review, the author will introduce various surgical approaches currently used when non-surgical treatment for sleep apnea did not yield positive results, and present research on the treatment results.

양막과 콜라겐을 이용한 생체 적합 드레싱 소재 개발 및 백서 창상치유 실험

안강민(Kang-Min Ahn),이지호(Ji-Ho Lee),이의룡(Ui-Lyong Lee),이종호(Jong-Ho Lee),이종원(Jong-Won Lee),김성포(Sung-Po Kim),양은경(Eun-Kyung Yang),김기호(Ki-Ho Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3

Purpose of study: Partial thickness skin graft is the golden standard regimen for full-thickness skin defect caused by burn or trauma. However, in case of extensive burns of more than 50% of total body surface area, the donor site is not sufficient to cover all defects. As a second choice, allograft, xenograft and synthetic materials have been used to treat skin defect. Among them the amniotic membrane(AM) was used as a biological dressing for centuries because of its potential for wound healing. In this study, quantification of EGF in AM and effect of AM-collagen complex on full thickness skin defects was examined. Materials & Methods: The concentration of EGF in fresh, deep frozen and freeze-dried AM was evaluated by ELISA. EGF-R immunostaining was performed in freeze-dried AM. SD rats weighing 250~300g was used for wound healing experiment. Three full thickness skin defects(28mm diameter) were made on dorsal surface of SD rat. The control group was covered by Vaselin gauze and AM-collagen complex and Terudermis was grafted in two other defects. Healing area, Cinamon’s score were evaluated before biopsy. Grafted sites were retrieved at 3 days, 1 week, 2 weeks and 4 weeks after operation. H & E and Factor VIII immunohistochemical stain was performed to evaluate the microscopic adhesion and structural integrity and microvessel formation. Results: 1. EGF concentration of fresh, deep frozen and freeze-dried AM showed similar level and EGF-R was stained in epithelial layer of freeze-dried AM. 2. At 4 weeks after grafting, the healing area of AM-collagen and Terudermis group was 99.29±0.71% and 99.19±0.77 of original size. However, that of control group was 24.88±2.90. 3. The Cinamon’s score of AM-Collagen and Terudermis group at 4 weeks was 15.6±1.26 and 14.6±3.13 and that of control group was 3.7±0.95. Significant difference was observed among control and experimental groups(p〈0.05). 4. Histologic examination revealed that AM protected leukocyte infiltration and epithelial migration was nearly completed at 4 weeks. Terudermis group showed mild neutrophil infiltration until 2 weeks and completion of epithelization at 4 weeks. Control group showed massive leukocyte infiltration until 4 weeks. 5. Microvessels were increased sharply at 1 week and control group at 1 and 4 week showed significant differences with Terudermis group of same interval(p〈0.05) but no differences were found with AM group(p〈0.05). Conclusion: EGF and EGF-R were well preserved in freeze-dried AM. AM attached to collagen acted as excellent biologic dressing which had similar effect with Terudermis. AM showed anti-inflammatory action and healing was completed at 4 weeks after full-thickness skin defect.

Cleft Alveolus Reconstruction Using a Three-Dimensional Printed Bioresorbable Scaffold With Human Bone Marrow Cells

Ahn, Geunseon,Lee, Jeong-Seok,Yun, Won-Soo,Shim, Jin-Hyung,Lee, Ui-Lyong by Mutaz B. Habal, MD. 2018 JOURNAL OF CRANIOFACIAL SURGERY - Vol.29 No.7

ABSTRACT: Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.

Management of Premaxilla in Patient with Bilateral Complete Cleft Lip and Palate

이의룡,정필훈,Lee, Ui-Lyong,Choung, Pill-Hoon Korean Cleft Lip and Plate Association 2009 대한구순구개열학회지 Vol.12 No.2

전방으로 심하게 돌출된 전상악골로 인하여 구순성형술 및 비성형술의 결과가 악화 될 수 있다. 따라서 변위된 전상악골의 이상적인 위치로 재위치 시키려는 다양한 노력이 시도되어 왔다. 에디오피아와 같은 개발도상국에서는 어른이 되어서도 수술을 받지 못하는 구순구개열 환자가 많이 있다. 성인이 될 때까지 수술받지 못한 양측성 완전 구순구개열 환자에서는 근육, 골, 피부, 점막의 연속성이 없어서 전상악골이 심하게 전방으로 혹은 하방, 좌우측으로 변위된 경우가 대부분이다. 이 경우 구순성형술이 거의 불가능하며, 시도된다 할지라도 돌출된 전상악골 때문에 양쪽 구륜근을 봉합하여 주기가 대단히 어렵다. 따라서 이상적인 결과를 얻기 위해서는 구순성형술 전 혹은 동시에 전상악골의 재위치 술식이 필수적이다. 저자는 한국국제협력단에서 국제협력의사로 선발되어 에디오피아에서 30 개월간 근무하였다. 그 동안 다양한 양측성 완전 구순구개열 환자에서 전상악골의 재위치 술식을 경험하였다. 저자가 경험한 전상악골의 재위치 술식(전상악골의 재위치와 골이식술 동시 시행, 전상악골의 재위치와 구개열 성형술 동시시행)에 대하여 문헌고찰과 함께 보고하고자 한다.

Anatomic Study on the Lacriimal Duct using Computerized Tomograph

Pill-Hoon Choung,Ui-Lyong Lee,Jong-Rak Hong 대한구순구개열학회 2002 대한구순구개열학회지 Vol.5 No.2

구순 구개열 환자의 악교정 성형수술로 구강내 Le Fort II 골절단술이나 비중격 성형술이 많이 이용되는에, 이 때 비골의 외측골절단술을요하며, 이에 대한술후합병중으로비루관의 폐쇄나비골의 분쇄골절둥이 발생할수 있어, 악안면기형환자를 다루는 구강악안면외과의사에게 비루관의 용용해부학적 연구는 중요하다. 본 연구의 목적은 교합면을 기준으로 촬영된 컴퓨터 단층 촬영에서 비루관의 위치와 크기를 조사하는데 있다. 2000년 7월부터 2003년 2월까지 서울대학교병원 구강악안면방시선과에서 컴퓨터 단충촬영을 시행한 환자 62명을 대상으로 비상악봉합선에서 비루관까지의 최단거리와 비루관의 최대반경과 최소반경을 측정하였다. 우측비상악봉합선에서 비루관까지의 거리는 5.68mm이고, 좌측은 5.67mm 였다. 좌우 및 성별간의 차이는 없었다. 이의 해부학적 지견은 악기형 수술시의 비루관폐쇄라는 합병증의 예방책으로 기여하리라 생각된다.

갑상선침생검으로 확인된 아급성 갑상선염 26예의 임상적 고찰

장필식 ( Jang Pil Sig ),김의현 ( Kim Ui Hyeon ),배경태 ( Bae Gyeong Tae ),권규돈 ( Kwon Gyu Don ),이종곤 ( Lee Jong Gon ),정의룡 ( Jeong Ui Lyong ),오용구 ( O Yong Gu ),박형근 ( Park Hyeong Geun ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6

N/A The clinical features and laboratory findings of 26 patients with histologically-proven subacute thyroiditis were examined from March 1984 to December 1988 at the Masan Koryo Hospital. The results were as follows: 1) All 26 patients with subacute thyroiditis were women, and the age distribution showed the peak incidence to be between the third and fourth decades(average age : 40 years). 2) The seasonal distribution showed the peak incidence to be between summer(34.6%) and autumn(30.8%). 3) The chief complaints were frequent anterior neck pain(69.2%), anterior neck swelling(23.1%) and fever(7.7%). The peak time from onset was 1-2weeks(50.0%). 4) On physical examination, 15 cases were nodular goiter(57.7%), and 11 cases were diffuse goiter(42.3%). All cases except one had moderate or severe tenderness. All 26 cases had a firm or hard consistency. 5) The mean value of ESR was elevated to 40.9 mm/ hr, and 12 cases(46.2%) were of mild or moderate hyperthyroid status. The serum thyroglobulin level was checked in 19 patients, and the mean value was elevated to 169.1 ng/ml. The positive rates for antithyroglobulin and antimicrosomal antibody were 1/24 and 3/24, respectively. 6) The thyroid scans were classified into the follwing groups: 15 cases(57.7%) showed both lobes nearly nonvisualized, 10 cases(38.5%) showed one lobe nearly nonvisualized, and one case(3.8%) showed both lobes slightly diffuse and enlarged. 7) Among the 26 cases, four were checked with radioactive iodine uptake(RAIU). The value was markedly depressed from 1-4% in all cases except one. 8) With aspirin or prednisolone therapy, the pain subsided and the goiters were reduced within several days.

고선량율 근접 방사선치료법을 이용한 원발성 및 재발된 설암의 치료

이의룡,이종호,정필훈,김명진,박주용,최성원,조관호,Lee, Ui-Lyong,Lee, Jong-Ho,Choung, Pill-Hoon,Kim, Myung-Jin,Park, Joo-Yong,Choi, Sung-Weon,Cho, Kwan-Ho 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.5

Low-dose rate brachytherapy(LDR) has been effective modality for treatment of oral cancer. But the disadvantage of LDR is radioexposure of medical staff. To overcome this problem, high dose rate(HDR) brachytherapy has been developed. Our study evaluates the outcomes of patients with tongue cancer as treated by HDR brachytherapy. Between 2002 and 2005, eight patients with carcinoma of the tongue were treated with HDR brachytherapy. Five patients had AJCC stage I or II disease and the remaining three patients had AJCC stage III or IV. The male-to-female ratio was 2:6 and the mean age was 60.1 years (range: 21-80 years).The median follow-up time was 23.8 months (range: 7-55 months). There was no local failure until now. Three patients showed some complications. Two patients showed soft tissue necrosis. There was no bone sequela in all cases. Our experience in treating tongue cancer with HDR brachytherapy is encouraging, because it gave a satisfactory local control. Prospective studies are necessary to delineate the optimum indication for this treatment modality and long-term outcome.