중·장거리 선수들의 점증적 트레드밀 운동부하후 혈장의 젖산탈수소효소 및 젖산탈수소 동위효소의 변화

이규성,김학렬,최용어 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1

고도로 훈련된 중, 장거리 런너(n=10)를 대상으로 단시간내에 최대상태(Exhaustion)에도달하도록 하는 점증적 트레드밀 운동을 실시 하였을때 혈장의 젖산탈수소효소(LDH)및 젖산탈수소 동위효소(LDH isozyme)를 분석함으로서 운동의 형태에 따른 조직의 상해 및 근섬유동원양상을 평가하고자 안정시와 운동직후 및 회복 30,60분에 주저정맥에서 약 5ml의 혈액을 채혈하였다. LDH활성도는 Beckman paragon법을 이용하여 측정 하였으며, LDH isozyme을 전기영동분리하고 scanning desitometer를 이용하여 상대적 %를 산출 하였다. 중, 장거리 런너들에서 점증적 트레드밀 운동부하후 혈장의 LDH활성도는 안정시에 비해 다소 증가 되었으나 통계적 유의차(p>0.05)는 없는것으로 나타났으며, 회복 30분과 60분에서도 안정시 및 운동직후 수준과 유의한차(p>0.05)는 없는것으로 나타났다. LDH isozyme은 운동직후 H-type(LDH1+2)에서 감소되는 경향을, M-type(LDH3+4+5)에서 증가되는 경향을 나타내였으나 통계적 유의차(p>0.05)는 없는 것으로 나타났으며, 회복의 시간경과에 따라서도 유의한차(p>0.05)는 없는 것으로 나타났다. 이러한 연구결과가 시사하는 바는 혈장의 젖산탈수소효소 및 젖산탈수소 동위효소의 변화는 운동의 형태에 따라 차이를 나타낸다는 것과, 현재에 이용된 트레드밀의 강도와 기간이 이들의 변화를 유발 시키기에는 불충분 하였다는 것으로 결론 지을수 있을 것이다. The pupose of this study was to estimate a damage of tissues and a recruitment patterns of muscle fibers followed exercise types by analyzing the plasma lactate dehydrogenase (LDH) and distribution of lactate dehydrogenase isozymes. The subjects for this study consisted of 10 middle and long distance runners. Venous blood samples of 5ml were collected before and after 2min incremental treadmill exercise, also in the 30,60min of recovery. Total LDH aetivity was examinated by using a Beckman paragon techniques. Also, LDH isozymes was determined to electrophoresis separation by using agarose gel buffered in paragon LD isoenzymes kit. This distribution of LDH isoenzymes was calculated from a relative percentage by scanning densitometer. Plasma total LDH activity after treadmill exercise did not statistically significant. difference(P>.05), and did not differ 30,60 minutes of recovery compared with treadmill exercise before. Distribution of LDH isozymes resulted in decreased of LDH H-type (LDHl+2), whereas LDH M-type(LDH3+4+5) increased, but did not statistically significant difference(P>.05) compared with exercise before. We conclude that Changes of plasma lactate dehydrogenase and lactate dehydrogenase isoenzymes differ as exercise types. And exercise intensity and duration of treadmill used to this research is not suitable to inducing a changes of these enzymes.

일 대학병원에 입원한 주요우울장애의 증상 특성

이진,김상훈,김학렬,박상학,황걸,장혁진 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

Objectives: The purpose of this study was to investigate the frequency and kinds of symptoms and the profile of depressive symptoms and somatic symptoms of admitted patients with major depressive disorder in a university hospital. Methods: The study was cross-sectional study in Chosun university hospital. A total of 299 patients who met the diagnostic criteria of major depressive disorder according to DSM-IV were participated in this study. Forty four item questionnaires were developed to check symptoms and the questionnaires checked from patient's medical record. Results: Common depressive symptoms were the following order: depressive mood (55.2%), initial insomnia (52.8%), anxious/tense (47.8%), tired/no energy (35.1%), suicidal ideation (28.8%). Common somatic symptoms were the following order: decreased appetite (33.1%), headache (22.1%). gastric discomfort (16.7%), palpitation (15.4%), chest discomfort (11.4%). Comparing depressive symptoms and somatic symptoms in terms of gender, anxious/tense, emotional/cry a lot, decreased appetite, gastric discomfort, palpitation, were more frequent in female patients (p<0.05), On the other hand, interpersonal sensitivity, pessimism were more frequent in male patients (p<0.05). Elderly depressed patients showed hypochondriasis symptom more frequently than younger patients (p<0.05). Conclusion: These results suggested that the depressive symptoms showed dissimilar in character according to the gender and age. Therefore proper diagnostic and therapeutic approaches will be needed for each patient's symptom characteristics.

알코올중독과 감각추구 성향

이병회,박상학,김상훈 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.1

저자들은 알코올중독환자의 감각추구경향을 알아보고자 알코올중독환자 45명과, 정상대조군 45명에게 인구통계학적 질문과 감각추구척도, 그리고 음주관련 설문지를 실시하여 다음과 같은 결과를 얻었다. 1) 알코올중독 환자집단이 대조군보다 평균음주량과 최대음주량, 월평균 음주빈도, 법적 제재 경험 유무, 가족력의 여부에서의 유의한 차이를 보였고 음주문제를 더 많이 경험하였다. 2) 감각추구 성향에 있어 통계적으로 유의미할 정도로 스릴과 모험을 추구하는 것으로 나타났으며 경험추구척도(ES 척도)에서 알코올중독군이 소량음주자보다 유의하게 더 높은 점수를 보였는데 이는 알코올중독군이 비관습적이고 비동조적인 생활방식과 마음과 감각을 통해 새로운 경험을 추구하는 것으로 나타났다. 권태감과 무료감에 대한 취약성 척도(BS scale)에서는 통계적으로 유의미할 정도로 권태감 및 무료감에 더 많이 취약한 것으로 나타났으며 전체 감각추구 척도에서 통계적으로 유의미할 정도로 더 높은 것으로 나타났으나 탈억제 추구척도(DIS scale)에서는 차이를 보이지 않았다. 3) 두 집단 모두가 평소 음주량과 최대 음주량이 DIS scale과 유의한 상관관계를 보였고 권태감과 무료감에 대한 취약성 척도(BS scale)는 평균 음주량과 긍정적인 상관관계가 있었으며 경험 추구 척도는 평균 음주량 및 음주빈도와 긍정적인 상관관계가 있었다. 4) 탈억제 추구 성향을 포함한 감각추구 성향이 개인의 음주행동과 관련된 중요한 변인이라는 점을 밝힘으로써 앞으로 알코올중독 및 일반 성인의 음주행동을 이해하고 예방하며 치료하는데 많은 시사점을 주고 있다고 하겠다. Objects : To investigate the sensation seeking tendency of alcohol dependency, the authors have examined 45 alcoholics, and 45 nonalcoholic persons as a normal control group with demographic questions, sensation seeking and questionnaire on alcohol related problems. Method : In sampling, they confined the subjects to same age, sex and education in the alcoholics and normal control group. That was to remove the possibility that the above three variations could affect the results. Result : 1) The alcoholics showed a higher frequency of drinking, average and maximum volume of alcohol than normal control group. And there was a significant difference of legal punishment as well as the high incidence of family members with alcoholic problem. 2) In sensation seeking tendency, the alcoholics showed significant scores for thrill and adventures. BS, ES & Total scales were in significant tendency in the alcoholics compared with normal drinking groups. There was no significant correlation with DIS scale among groups. 3) Both of the two groups showed significant correlation with DIS scale in average and maximum volume of drinking. The tendency of boredom and weariness was positively correlated with average volume of drinking and so was the tendency of experience seeking with average volume and frequency of drinking. Conclusion : It is suggested that is desirable for the deal with the tendency of boredom and weariness and to develop tendency to seek new sensational experiences through unusual and unconventional life style and mental attitudes using other methods than alcohol. and all of the three groups seem to drink in order to avoid the social restraints.

물 및 디메틸포름아마이드中에서 4-(2-Pyridylazo)-resorcinol의 分光電氣化學的 環元

李興洛,裵俊雄,李在鶴,吳相協 慶北大學校 1988 論文集 Vol.45 No.-

Spectroelectrochemistry involve the combination of an electrochemical technique with a spectroscopic techinque so that the two measurements may be performed simultaneously in an electrochemical cell. One of the most generally useful spectroelectrochemical technique involves spectral observation of a thin layer of solution. Thin-layer spectroelectrochemistry at the optically transparent thin-layer electrode(OTTLE) takes advantage of the rapid electrolysis (30∼60 sec.) and small volume features of thin-layer electrochemistry. This study has used controlled potential as the excitation signal. Potential control provides a facile means of presicely adjusting the redox potential of the thin solution layer as determined by the Nernst equation for reversible systems: E_applied=E^0'+0.059/n log (O)/(R) In experiment, the slopes of Nernstian plot were 28.3mV in aqeous solution and 53mV in N, N-dimethylformamide(DMF) solution. The results of this study showed that the reduction mechanisms of 4-(2-pyridylazo)-resorcinol(PAR) were one two-electron step in aqueous solution and two one-electrons steps in DMF solution. The formal reduction potentials(E^0') of the PAR were -0.574 volts vs. S.C.E. in aqueous soltion and -0.74 volts vs. Ag/AgClO_4 in DMF solution. These results were generally similar to the reduction mechanism of the other cyclic hydrocarbons in the aprotic solvent. In aprotic solvent, the product of the first electron transfer is expected to be a relatively stable anion radical. In this experiment tetraethylammonium perchlorate was used as a supporting electrolyte of the DMF solution.

강박장애와 감각추구 성향

이민규,박상학 中央醫學社 1991 中央醫學 Vol.56 No.5

The purpose of this study is to investigate the relationship between obsessive-compulsive symptoms and sensation-seeking tendency. The subjects were administered the Korean version of Leyton Obsessional Inventory and Sensation Seeking Scale in group. In correlation analysis, the symptom subscale score in Leyton Obsessional Inventory was correlated negatively with unconventional sensation seeking tendency. And then, Using the Leyton Obsessional Inventory, two groups were identified: obsessional group and nonobsessional control group. The author used discriminant function analysis to seek the discriminant sensation seeking behavior between the obsession group and nonobsessional control group. The results of the correlation analysis and discriminant function analysis were as follow. 1. Degree of obsessive symptom was negatively correlated with unconventional sensation seeking tendency. 2. In discriminant function analysis, there was no significant difference of general sensation seeking tendency between the obsessional group and nonobsessional control group.. 3. Specific sensation seeking behaviors, significantly discriminate two groups are as follow. 1) gambling for money 2) using four-letter-words 3) preplaned trip 4) respect for lawful authority 5) parachute jumping 6) good night of rest 7) sexual experience before marriage 8) enjoy discussions insulting others 9) uncontrollable emotional experience

중·장거리 선수들의 강력한 스프린트성 반복운동후 혈장 젖산, 젖산탈수소효소 및 젖산탈수소 동위효소의 변화

이규성,김학렬,최용어 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1

훈련된 중, 장거리 런너를 대상으로 강력한 스프린트성 운동(400m)을 반복적으로 수행하였을때 유발되는 형중 젖산농도, 젖산탈수소효소 및 젖산탈수소 동위효소의 변화를 평가함으로서 무산소성 운동에 대한 LDH 활성도의 특성을 재검토하고 이러한 무산소성 운동을 반복적으로 실시함으로서 유발되는 생체의 스트레스 및 근섬유 동원양상을 평가하고자 400m 트랙을 이용하여 강력한 스프린트 운동을 10회 동안 반복적으로 수행 하였다. 혈중 젖산농도, 젖산탈수소효소 및 젖산탈수소 동위효소를 분석하기 위한 혈액샘플은 400m 질주후 5분의 유식을 취하는 중 3분 경과시에 약 5ml의 혈액을 채혈 하였으며 혈액쌤플의 일부는 혈중 젖산농도를 분석하기 위하여 0.3M Perchloric acid 1000ul에 전혈 200ul를 첨가하고 30초간 진탕한후 원심분리하여 제단백 하였으며 상충액을 냉동보관하였다. 상충액은 1120ul Regent를 혼합하고 실온에서 60분간 방치한후 파장 340nm에서 time scan법으로 측정 하였다. 남은 혈액샘플은 혈장을 분하 하였으면 Beckmann Paragon 법을 이용하여 tltal LDH 활성도를 측정 하였다. 또한 LDH isozyme은 전기영동법으로서 Agarose gel을 사용하여 5개의 동위효소를 분리야였으며 scanning densitometer를 이용하여 상대적 %를 산출하였다. 스프린트성 반복운동에 따른 혈중 젖산농도는 안정시에 비해 1회 400m 질주 후 크게 증가된 수준(p<0.00001)을 나타내었으나 10회 질주가 반복될때가지 더이상의 유의한 증가 없이 전체적으로 일정한 수준을 유지 하였다. 그러나 total LDH 활성도는 혈중 전산농도와는 달리 안정시에 비해 400m 반복힛수에 따라 점차적으로 증가되는 경향을 나타내었으며 9회 400m 반복질주까지 안정시 수준과는 유의한차가 없었으나 10회 400m 질주후 증가수준은 안정시 수준보다 유의하게 높은 수준(p<0.01)을 나타내었다. 또한 total LDH 활성도의 상대적 %로 나나탠 LDH isozyme은 H-type(LDH1+2)의 경우 안정시에 비해 400m의 반복운동에 따라 감소되는 경향을 나타내였으며, 특히 LDH2에서 반복질주간에 통계적 유의차(p<0.01)를 나타내었다. 반면에 M-type(LDH3+4+5)은 반복 운동의 빈도에 따라 점차적으로 증가되는 경향을 나타내었으며, 특히 LDH4와 LDH5에서 현저하게 큰 증가경향을 나타내었다(p<0.001). 이러한 변화양상에 따라 M/H Subunit ratio가 점차적으로감소되는 경향을 나타내었으나 유의한차(p>0.05)는 없는 것으로 나나났다. 결과적으로 본 연구에서의 400m 반복적 질주에 따른 혈중젖산, total LDH 활성도 및 M-type LDH isozyme은 크게 증가를 나타내었다. 이러한 연구결과가 시사하는 바는 400m 반복적 질주에 따른 높은 혈중젖산의 축적이 증가된 totlal LDH 활성도와 M-LDH isozyme분포와 밀접한 관련성을 나나탠다는 것을 시사하는 바이다. The Purpose of this study was to-examine the profile of Lactate dehydrogenase activity during exercise by evaluating a changes of blood lactate concentration, LDH and LDH isozymes induced as a strenuously performed repetitive exercise(400m). Also, it was estimated from a physiological stress and recruitment patterns of muscle fibers indueced as an anaerobi exercise performed. Ten elite middle and long distance runers were employed for this study. Exercise protocol utilized a 10th 400m sprint run. Blood sample for analyzing the blood lactate concetration, lactate dehydrogenase, lactate dehydrogenase isozymes was collected at 3min out of rest period of 5min after 400m maximal run. One portion of the blood sample for analyzing a lactate concentration was deprotenized from 0.3M perchlioric regent to analyze a blood lactate cocnetration was measured by time scan methods in 340nm wave length after 60min ambient temperature. The reminder of the blood sample was stored in refrigerator after centrifuge. Total LDH activity of plasma was examined by using Beckman Paragon tchniques. Also, LDH isozymes was determined to electrophoresis separation by using agarose gel buffered by paragon LD isoenzymes kit. These distribution of LDH isozymes was calculated from a relative percentage by scanning densitometer. Blood lactate concentration followed strenuous repetitive exercise(400m) was shown significantly increased levels (p<0.0001) from 1th to 10th 400m maximal run in comparison with levels of rest. However, it was sustained a const.ant levels without more significant increase from 1th maximal run to 10th run. Total LDH activity showed a progressivly shift, trend as 400m run went on repetitively but, there was not significant difference(p>0.05) from rest levels to 9th maximal run. However, total LDH activity after the 10th 400m maximal run showed significantly increased levels(p <0.01), compared with rest levels. Also, distribution of LDH isozymes determine as relative percent.age of total LDH activity was displayed a decreased levels in case of H- specific type(LDH1+2) by increasing of 400m repetitive frequency. Especially, there displayed a significant difference(p<O.O1) in the LDH4 between 400m repetitive run. Wheareas, M- specific type(LDH3+4+5) was shown a increased levels by increasing of 400m repetitive frequency. Especially, there was significant difference (p <0.001) in the LDH 4 and LDH5. H/M subunit ratio followed changes of LDH isozymes distribution was shown a decreased levels, but there was not significant difference(p >0.05). In Conclusion, The results of this study showed a increase in blood lactate concentration, total LDH activity and M -type LDH isozymes. It was suggested that increase levels of blood lactate accumulation followed 400m repetitive maximal run was a close relation with the increase levels of total LDH activity, and M-LDH isozymes distribution.

양측 주관절 골관절염 후에 발생한 양측 척골신경 지연마비 1례 보고

이성태,안의환,이상학 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Tardy ulnar nerve palsy typically results from lateral condylar fracture of the humerus during periods of growth. There are many other causes inculding osteoarthritis of the elbow joint, medial epicondylar fracture of the humerus, recurrent dislocation of the ulnar nerve, and ganglion. We report a case of bilateral tardy ulnar nerve palsy resulting from osteoarthritis of both elbow joints in a 54-year-old male driver, who underwent anterior transposition of the ulnar nerve at the elbow joints.

의학 영상 저장 전송 시스템에 대한 연구 : 요구사항 및 사례연구를 중심으로 Requirements and Case Studies

이상학,전용희 대구효성가톨릭대학교 1998 연구논문집 Vol.57 No.2

The concept of Picture Archiving and Communication System(PACS) was originatted in radiology. The PACS is a medical imaging storage and dilivery system. The goal of PACS is to develop computer hardware and software which would enable electronic access, storage, transmission, and display of patient data and images. Installation of PACS in an existing hospital involves many technical and budget problems. Therefore, we need to study technical requirements which are necessary to implement PACS. According to the development of both computer and communication technologies, the introduction of PACS in domestic hospitals is becoming a reality and even appears as a vital component for the hospital information system. Therefore, the discussion and consideration on PACS before the installation inan existing hospital will be a real matter in the near future. Accordingly, we have defined general technical requirements for PACS in terms of hardware components required, imaging acquisition, media storage, compression/decompression, user interface, communication networks etc. Recent technology trends and case studies are also included. This basic study will be used for further study of PACS especially in terms of technical requirements for multimedia medical imaging storage, retrieval, and transmission on ATM networks.

조선대학교 의과대학 의학과 학사편입제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 朝鮮大學校 附設 醫學硏究所 1998 The Medical Journal of Chosun University Vol.23 No.1

There are many advantages and disadvantages under the limited bachelor's admission system. To diminish the demerits and to increase the merits of this system, the authors posed questions to the faculties and students of the Department of Medicine. Chosun University College of Medicine and other colleges in Korea. The questionnaire was made according to trends and feelings in this system. We received a lot of information and suggestions as to how to improve the system, in the following paper we discuss and report the prospective aspects of the bachelor's admission system.

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1