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RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study
Jung, Kyuwhan,Koh, InSong,Kim, Jeong-Hyun,Cheong, Hyun Sub,Park, Taejin,Nam, So Hyun,Jung, Soo-Min,Sio, Cherry Ann,Kim, Su Yeong,Jung, Euiseok,Lee, Byoungkook,Kim, Hye-Rim,Shin, Eun,Jung, Sung-Eun,Cho The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.5
<P>Necrotizing enterocolitis (NEC) characterized by inflammatory intestinal necrosis is a major cause of mortality and morbidity in newborns. Deep RNA sequencing (RNA-Seq) has recently emerged as a powerful technology enabling better quantification of gene expression than microarrays with a lower background signal. A total of 10 transcriptomes from 5 pairs of NEC lesions and adjacent normal tissues obtained from preterm infants with NEC were analyzed. As a result, a total of 65 genes (57 down-regulated and 8 up-regulated) revealed significantly different expression levels in the NEC lesion compared to the adjacent normal region, based on a significance at fold change ≥ 1.5 and <I>P</I> ≤ 0.05. The most significant gene, <I>DPF3</I> (<I>P</I> < 0.001), has recently been reported to have differential expressions in colon segments. Our gene ontology analysis between NEC lesion and adjacent normal tissues showed that down-regulated genes were included in nervous system development with the most significance (<I>P</I> = 9.3 × 10<SUP>−7</SUP>; <I>P<SUB>corr</SUB></I> = 0.0003). In further pathway analysis using Pathway Express based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, genes involved in thyroid cancer and axon guidance were predicted to be associated with different expression (<I>P<SUB>corr</SUB></I> = 0.008 and 0.020, respectively). Although further replications using a larger sample size and functional evaluations are needed, our results suggest that altered gene expression and the genes' involved functional pathways and categories may provide insight into NEC development and aid in future research.</P>
Reliability and validity of Korean version of modified-Yale preoperative anxiety scale
Kyuwhan Jung,Mi-Hyang Im,Jeong-Min Hwang,Ah-Young Oh,Moon Seok Park,Woo-Jin Jeong,Seong-Chan Kim,Sun-Woo Jung,Hyejin Sohn,Mi-Ok Yoon,Mi-Suk Jang,Suk-Bae Moon 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.1
Purpose: The modified Yale Preoperative Anxiety Scale (mYPAS) was developed for evaluating the level of preoperative anxiety in children. The purpose of this study was to develop a Korean version of the mYPAS (K-mYPAS) and to establish its validity and reliability based on the Korean preoperative pediatric patients. Methods: K-mYPAS was made through stringent back-translation procedure. Total enrolled 102 patients answered questionnaires of Korean version of State-Trait Anxiety Inventory for Children (K-STAIC), and were videotaped for 2 to 5 minutes before induction of anesthesia. Three observers of experienced psychiatrist, surgeon, and nurse analyzed videotape with K-mYPAS comparing to K-STAIC. The inter- and intraobservers reliability, concurrent and construct validity, sensitivity, specificity, and predictive value were analyzed. Results: The value of Cronbach a for interobservers reliability was 0.939 and intraobserver reliability was statistically significant (P < 0.001). Concurrent and construct validity were also statistically significant (P < 0.001 and P < 0.001, respectively). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 81.3%, 91.4%, 81.3%, 91.4%, and 88.2%, respectively. Conclusion: The K-mYPAS had good psychometric properties and can be used as a reliable and valid instrument for the assessment of preoperative anxiety in children.
위성통신을 이용한 광역계통 시각동기 감시시스템 구현에 관한연구
오규환(Kyuwhan Oh),최효열(Hyoyul Choi),정광균(KwangKyoon Jung) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7
산업발달로 인한 전력산업 구조변화와 해마다 증가하는 전력소비는 전력계통의 복잡성을 증가시켜 전력품질의 신뢰성과 안정도 확보룰 위한 계통데이터의 실시간 수집 및 감시/제어의 중요성을 부각시키고 있다. 또한 최근 몇 년간 선진국에서 발생하는 대정전사고는 전체 계통의 유기적인 흐름과 변화를 감시할 수 있는 시스템의 필요성을 인식시켰으며, 이를 위해서 선진국에서는 광역계통감시시스템 (WAMS)의 개발에 집중을 하고 있는 실정이다. 본 논문에서는 한전전력연구원에서 연구중인 광역계통감시시스템과 전력계통에서 시각동기 데이터를 취득하는 sPMU의 구조와 전력계통에 최초로 적용한 위성시스템에 대하여 기술한다.
Association Analysis of SLC6A20 Polymorphisms With Hirschsprung Disease
Lee, Jin Sol,Oh, Jung-Tak,Kim, Jeong-Hyun,Seo, Jeong-Meen,Kim, Dae-Yeon,Park, Kwi-Won,Kim, Hyun-Young,Jung, Kyuwhan,Park, Byung Lae,Koh, InSong,Shin, Hyoung Doo by European Society for Pediatric Gastroenterology 2016 Journal of pediatric gastroenterology and nutritio Vol.62 No.1
<P>Purpose:Hirschsprung disease (HSCR) is a congenital and heterogeneous disorder, which is caused by no neuronal ganglion cells in part or all of distal gastrointestinal tract. Recently, our genome-wide association study has identified solute carrier family 6, proline IMINO transporter, member 20 (SLC6A20) as one of the potential risk factors for HSCR development. This study performed a replication study for the association of SLC6A20 polymorphisms with HSCR and an extended analysis to investigate further associations for subgroups and haplotypes.Methods:For the replication study, a total of 40 single nucleotide polymorphisms (SNPs) of SLC6A20 were genotyped in 187 HSCR subjects composed of 121 short-segment HSCR, 45 long-segment HSCR (L-HSCR), 21 total colonic aganglionosis, and 283 unaffected controls. Imputation was performed using genotype data from our genome-wide association study and this replication study.Results:Imputed meta-analysis revealed that 13 SLC6A20 SNPs (minimum P=0.0002 at rs6770261) were significantly associated with HSCR even after correction for multiple comparisons using false discovery rate (FDR) (minimum P-FDR=0.005). In further subgroup analysis, SLC6A20 polymorphisms appeared to have increased associations with L-HSCR. Moreover, haplotype analysis also showed significant associations between 2 haplotypes (BL3_ht2 and BL4_ht2) and HSCR susceptibility (P-FDR<0.05).Conclusions:Although further replications and functional evaluations are required, our results suggest that SLC6A20 may have roles in HSCR development and in the extent of aganglionic segment during enteric nervous system development.</P>
Kyeongyuk Min,Kwangkyoon Jung,Kyuwhan O,Jongwha Chong 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
In this paper, we propose a verification method for risk management system of the electric power grid (RMS-EPG) using satellite communication network. The RMS-EPG with satellite communication network should be verified with various contingencies for its design and maintenance. For the verification of RMS-PG, the proposed system composed of the satellite communication simulator and the Power flow emulator. Proposed simulator of satellite communication can evaluate not only the delay of communication with satellite but also the robustness of satellite communication according to the change of weather using simulation model for ITU-R 839. And the proposed emulator of Phase Measurement Unit for Satellite communication (sPMU) can realize its function that calculates the voltage stability by hardware implementation using FPGA. Using the proposed verification system, we verified its function of RMS-EPG for the power grid of Jeju Island in Korea
Ra-Yeong Song,Kyuwhan Jung 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.88 No.6
Purpose: Management of appendicitis in children has always been an issue in pediatric surgery. Both diagnostic methods and treatment vary significantly among medical centers, and little consensus exists in many aspects of the care for patients with appendicitis. Here, we assessed the value of drain insertion after appendectomy in children. Methods: This study is a retrospective review of pediatric patients who underwent appendectomy for perforated appendicitis at a tertiary medical center between 2003 and 2012. Patients who had a peritoneal drain inserted after appendectomy were compared with patients without drains regarding preoperative features and postoperative outcomes. Statistical analyses included a 2-tailed Student t-test and a chi-square or Fisher exact test. Results: In total, 958 patients were reviewed. Of 342 patients with perforated appendicitis, 108 (31.6%) had Jackson-Pratt (JP) drains inserted. The JP group had a longer hospital stay compared with the non-JP group (6.38 ± 3.59 days vs. 3.87 ± 2.38 days, P < 0.001). The JP group also had higher complication rates (22.2% vs. 6.8%, P = 0.003), including the formation of intra-abdominal abscesses. Conclusion: According to our results, there seems to be little evidence to support peritoneal drain insertion after appendectomy, even in perforated appendicitis cases.
김수배(Soobae Kim),오규환(Kyuwhan Oh),정광균(Kwangkyoon Jung),이범석(Beomseok Lee),현덕화(Duckhwa Hyun) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.10
There are several types of communication method which is used for the supply of electric power stably. But the communication methods used in KEPCO have weak points in the viewpoint of economy. technology and management. The Satellite communication systems have competitive power in price and technology for national wide utility owing to its wide area coverage and stability. This paper presents various adapted examples of the Power industry using he satellite communication systems.
김수배(Soobae Kim),오규환(Kyuwhan Oh),정광균(Kwangkyoon Jung),이범석(Beomseok Lee),현덕화(Duckhwa Hyun) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.10
There are several types of communication method which is used for the supply of electric power stably. But the communication methods used in KEPCO have weak points in the viewpoint of economy. technology and management. The Satellite communication systems have competitive power in price and technology for national wide utility owing to its wide area coverage and stability. For better practical use of satellite communication in power industry, we developed the portable satellite communication terminal. This paper presents various functions and composition of the portable terminal for power industry.
성인 수술환자에서 새롭게 개발된 경구용 고탄수화물음료의 수술 전 복용으로 인한 효과 및 안전성에 대한 예비연구
장원배 ( Won-bae Chang ),정규환 ( Kyuwhan Jung ),안상훈 ( Sang-hoon Ahn ),오흥권 ( Heung-gwon Oh ),윤미옥 ( Mi-ok Yoon ) 한국정맥경장영양학회 2016 한국정맥경장영양학회지 Vol.8 No.1
Purpose: In surgical procedures under general anesthesia, 6 to 8 hours of a nulla per os (NPO; nothing by mouth) has been regarded as essential for prevention of respiratory complication such as aspiration. However, recent studies have reported that oral intake of water and other clear fluids up to 2 hours before induction of anesthesia does not increase respiratory problems. The purpose of this pilot study is to investigate the safety and efficacy of a newly developed carbohydrate-rich solution in elective hernia repair surgery patients.Methods: A group of 30 adult patients scheduled for elective surgeries under general anesthesia were enrolled. The enrolled study group of patients was permitted to drink a carbohydrate-rich solution until two hours before the operation without volume limitation. Respiratory complication was investigated in the patients using the carbohydrate-rich solution until two hours before induction of general anesthesia. The feelings of thirst, hunger sense were measured pre- and post-operatively. In addition, hoarseness of voice, nausea and vomiting were investigated post-operatively. Satisfaction regarding the short time of fasting was measured. Visual analogue scale (VAS) was used for measurement of these six variables.Results: No patients showed serious respiratory complication such as dyspnea, desaturation. Eight of 30 study group patients complained of mild hoarseness. Most symptoms of hoarseness were mild, with VAS score less than 3 out of 10. Two patients complained 5 out of 10. Six patients felt nausea and 1 patient had vomiting. Pre/post-operative hunger sense and thirst feeling were 1.63/1.60 and 1.90/5.76, respectively. The satisfaction score was 3.00 out of 4. Conclusion: Allowing the administration of an oral carbohydrate-rich solution in elective surgery patients requiring general anesthesia is safe without serious respiratory complications and effective in providing satisfaction.