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Hyunseok Lee(Hyunseok Lee),Dongryul Oh(Dongryul Oh),Yong Chan Ahn(Yong Chan Ahn),Hongryull Pyo(Hongryull Pyo),Kyungmi Yang(Kyungmi Yang),Jae Myoung Noh(Jae Myoung Noh) 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: This retrospective study aimed to compare clinical outcomes and dosimetric parameters between radiation therapy (RT) techniques in patients with thymic epithelial tumor (TET). Materials and Methods: From January 2016 to December 2020, 101 patients with TET received adjuvant RT (median, 52.8 Gy; range, 48.4 to 66.0). Three different RT techniques were compared: three-dimensional conformal RT (3D-CRT; n = 59, 58.4%), intensity-modulated RT (IMRT; n = 23, 22.8%), and proton beam therapy (PBT; n = 19, 18.8%). Results: The median age of the patients and the follow-up period were 55 years (range, 28 to 79) and 43.4 months (range, 7.7 to 77.2). Patients in the PBT group were of the youngest age (mean age, 45.4 years), while those in IMRT group had the largest clinical target volume (mean volume, 149.6 mL). Patients in the PBT group had a lower mean lung dose (4.4 Gy vs. 7.6 Gy vs. 10.9 Gy, respectively; p < 0.001), lower mean heart dose (5.4 Gy vs. 10.0 Gy vs. 13.1 Gy, respectively; p = 0.003), and lower mean esophageal dose than patients in the 3D-CRT and IMRT groups (6.3 Gy vs. 9.8 Gy vs. 13.5 Gy, respectively; p = 0.011). Twenty patients (19.8%) showed disease recurrence, and seven patients (6.9%) died. The differences in the survival rates between RT groups were not statistically significant. Conclusion: In patients with TET who underwent adjuvant RT, PBT resulted in a lower dose of exposure to adjacent organs at risk. Survival outcomes for patients in PBT group were not significantly different from those in other groups.
Lee, Heeyoung,Kim, Kyungmi,Lee, Soomin,Yoon, Yohan Cambridge University press 2015 The Journal of dairy research Vol.82 No.1
<P>This study developed mathematical models in order to evaluate the effect of Aw (Water activity) and growth temperature on Staphylococcus aureus kinetic behaviour. The Aw levels (0·970, 0·975, 0·983, and 0·991) of cheese were adjusted by NaCl; then, Staph. aureus was inoculated on the cheese, followed by storage at 7-30 °C for 72-720 h. Total bacterial and Staph. aureus cell counts were enumerated on tryptic soy agar and mannitol salt agar, respectively. The Baranyi model was fitted to the Staph. aureus growth data in order to calculate the maximum specific growth rate (관max; log CFU/g/h), lag phase duration (관; h), lower asymptote (N0; log CFU/g) and upper asymptote (Nmax; log CFU/g). The effects of storage temperature and Aw on the kinetic parameters (관max and 관) were then further analysed with the Ratkowsky-type model and a polynomial equation, respectively. The root mean square error (RMSE) and relative error (RE) were calculated in order to estimate the model performance. No significant effect of Aw on Staph. aureus growth was observed at 7 °C; thus, the Baranyi model was fitted to the growth data from 15, 25 and 30 °C. The 관max values (0·011-0·303 log CFU/g/h) increased (P<0·05) as the storage temperature and Aw increased. In addition, 관 values (2·42-63·48 h) decreased (P<0·05) as storage temperature and Aw increased; yet, the effect of Aw on 관 was observed only at 15 °C. The theoretical minimum storage temperature and Aw were 10·15 °C and 0·882, respectively. RMSE (0·010-1·544) and RE values (-0·131 to 0·187) from validation indicated that model performance was appropriate. Hence, these results suggest that the developed models in this study should be useful in describing the effect of temperature and Aw on the growth kinetic behaviour of Staph. aureus in cheese along with the exposure assessment of Staph. aureus in cheese as well.</P>
Lee, Kyungmi,Kang, Dong Hyeon,Choe, Ju Eun,Yun, Mira,You, Jung-Min,Go, Min Jeong,Lee, Junseong,Jeon, Seungwon Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A potentiometric sensor based on the 1-benzyl-3-(4-nitrophenyl) thio-urea was synthesized and tested as an ionophore in PVC based membrane sensor towards $SCN^-$ ions. This membrane exhibits a linear stable response over a wide concentration range ($1.0{\times}10^{-5}$ to $1.0{\times}10^{-2}M$) with a slope of -59.2 mV/dec., a detection limit of ${\log}[SCN^-]=-5.05$, and a selectivity coefficient for thiocyanate against perchlorate anion of ${\log}K^{pot}_{SCN^-j}=-0.133$. The selectivity series of the membrane is as follows: $SCN^-$ > $ClO_4{^-}$ > $I^-$ > $NO_3{^-}$ > $HSO_3{^-}$ > $Cl^-$ > $HSO_4{^-}$ > $F^-$ > $CH_3COO^-$ > $HCO_3{^-}$ > $Br^-$ > $H_2PO_4{^-}$ > $SO{_3}^{2-}$ > $SO{_4}^{2-}$ > $CO{_3}^{2-}$. The proposed electrode showed good selectivity and a good response for the $SCN^-$ ion over a wide variety of other anions in pH 6.0 buffer solutions and has a fast response time of about < 5s. The influences of the membrane by pH, ionophore, and plasticizer were studied.
Magnetic Field Dependence of Energy Barrier of Perpendicular Nanomagnet
Kyungmi Song,Sung Chul Lee,Kyung-Jin Lee IEEE 2014 IEEE transactions on magnetics Vol.50 No.11
<P>Based on the nudged elastic band model, we investigate the thermal energy barrier and its field dependence of a circular-shaped perpendicular nanomagnet for various exchange constants and cell sizes. We find that the energy barrier depends not only on the cell size but also on the exchange stiffness constant when the switching is governed by the domain-wall nucleation and propagation. We show that analyzing the switching probability curve based on the field-dependent energy barrier equation for the single-domain switching can underestimate the energy barrier so that one has to use the correct field dependence of energy barrier, which can be obtained numerically.</P>
Fatigue-Alleviating Effect on Mice of an Ethanolic Extract from <i>Rubus coreanus</i>
LEE, Somi,YOU, Yanghee,YOON, Ho-Geun,KIM, Kyungmi,PARK, Jeongjin,KIM, Sunoh,HO, Jin-Nyoung,LEE, Jeongmin,SHIM, Sangin,JUN, Woojin Japan Society for Bioscience, Biotechnology, and A 2011 Bioscience, biotechnology, and biochemistry Vol.75 No.2
<P>The fatigue-alleviating effects on mice of <I>Rubus coreanus</I> were investigated by using an adjustable-current water pool. The mice were exhaustively exercised for 2 consecutive days, and those administered with the 80% ethanol extract (RCE) of <I>R. coreanus</I> displayed a lower reduction (20%) in swimming time on day 2 than the control group (41% reduction). RCE significantly prevented the depletion of hepatic antioxidants during exercise-induced fatigue. These results suggest that RCE alleviated fatigue by elevating the antioxidative potential.</P>