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Genomic copy number alterations as predictive markers of systemic recurrence in breast cancer
Hwang, Ki-Tae,Han, Wonshik,Cho, Jihyoung,Lee, Jong Won,Ko, Eunyoung,Kim, Eun Kyu,Jung, So-Youn,Jeong, Eun-Mi,Bae, Ji-Yeon,Kang, Jason J.,Yang, Song-Ju,Kim, Sung-Won,Noh, Dong-Young Wiley Subscription Services, Inc., A Wiley Company 2008 International journal of cancer: Journal internati Vol.123 No.8
<P>We tried to establish models that predict systemic recurrence in breast cancer by selecting marker clones with DNA copy number alterations (CNAs) using an array comparative genomic hybridization (CGH). Array CGH containing 4,044 human bacterial artificial chromosome clones was used to assess CNAs in 62 primary breast cancer tissues from 31 patients with systemic recurrence within 5 years after surgery and clinicopathologically well matched 31 patients who had no evidence of disease for at least 5years. Fourteen significant clones (11 clones showing gain and 3 showing loss) were identified by systemic recurrence-free survival (SRFS) analysis and 23 significant clones (17 clones showing gain and 6 showing loss) identified by χ<SUP>2</SUP> test and FDR test were selected as predictive markers of systemic breast cancer recurrence. The significant CNAs were found in the chromosomal regions of 5p15.33, 11q13.3, 15q26.3, 17q25.3, 18q23 and 21q22.3 with gain and 9p12, 11q24.1 and 14q32.33 with loss. We devised 2 prediction models for the systemic recurrence of breast cancer based on the 14 clones and the 23 clones, respectively. The survivals of the patients were significantly separated according to the scores from each model at the optimal cut off values in SRFS and overall survival analysis. We found candidate clones and genes of which CNAs were significantly associated with systemic recurrence of breast cancer. The devised prediction models with these clones were effective at differentiating the recurrence and nonrecurrence. © 2008 Wiley-Liss, Inc.</P>
Hwang, Kyu-Suk,Son, Young-Sik,Park, Sang-Wook,Park, Dae-Won,Oh, Kwang Joong Elsevier 2009 Journal of industrial and engineering chemistry Vol.15 No.6
<P><B>Abstract</B></P><P>An ionic liquid (THA-CP-MS41), trihexylamine-immobilized on chloropropyl-functionalized MCM41, was synthesized by a grafting technique through a co-condensation method and used as a catalyst in the reaction of carbon dioxide with glycidyl methacrylate (GMA). CO<SUB>2</SUB> was absorbed into the heterogeneous system of the GMA solution and dispersed with solid particles of the catalyst in a batch stirred tank with a plane gas–liquid interface at 101.3kPa. The absorption of CO<SUB>2</SUB> was analyzed using the mass transfer mechanism accompanied by chemical reactions based on the film theory. The proposed model fits the measured data of the enhancement factor to obtain the reaction rate constants.</P><P>Solvents such as <I>N</I>,<I>N</I>-dimethylacetamide, <I>N</I>-methyl-2-pyrrolidinone, and dimethyl sulfoxide influenced reaction rate constants.</P>
Hwang, Hye Jeon,Kim, Kyoung Won,Jeong, Woo Kyoung,Song, Gi-Won,Ko, Gi-Young,Sung, Kyu Bo,Shin, Yong Moon,Kim, Pyo Nyun,Ha, Tae-Yong,Moon, Deok-Bog,Kim, Ki-Hun,Ahn, Chul-Soo,Hwang, Shin,Lee, Sung-Gyu Radiological Society of North America 2009 Radiology Vol.253 No.2
<P>PURPOSE: To establish optimal Doppler ultrasonographic (US) venous pulsatility index and computed tomographic (CT) criteria for right hepatic vein (RHV) stenosis after living donor liver transplantation (LDLT) and to compare accuracies of these methods by using receiver operating characteristic (ROC) analysis. MATERIALS AND METHODS: This retrospective study was approved by an institutional review board; informed consent was waived. Eighty patients (48 men, 32 women; mean age, 51.5 years +/- 9.2 [standard deviation]) underwent Doppler US and CT within 8 days of hepatic venography following right lobe LDLT between October 2006 and September 2008. At venography, RHVs were classified into a stenosis or nonstenosis group. At Doppler US, venous pulsatility index was defined as the difference between maximum and minimum frequency shifts divided by maximum frequency shift. At CT, diameters of anastomosis and RHV were measured; percentage of stenosis was calculated. Mean Doppler US and CT parameters in the two groups were compared; ROC analysis was performed. RESULTS: There were 30 stenotic and 50 nonstenotic RHVs. Mean venous pulsatility index and mean anastomosis diameter were significantly lower and mean percentage of stenosis was significantly higher in the stenosis than the nonstenosis group (P < .001 each). Optimal cutoffs for venous pulsatility index, anastomosis diameter, and percentage of stenosis were 0.16, 3.7 mm, and 47%, respectively. Sensitivity and specificity were 86.7% and 68.0% for venous pulsatility index, 96.7% and 88.0% for anastomosis diameter, and 96.7% and 86.0% for percentage of stenosis, respectively. At ROC analysis, anastomosis diameter (P = .002) and percentage of stenosis (P = .003) were significantly more accurate than venous pulsatility index. CONCLUSION: CT is more accurate than Doppler US for RHV stenosis after LDLT, with venous pulsatility index as the sole sonographic criterion. Patients suspected of having RHV stenosis at Doppler US may benefit from CT to reduce unnecessary venography.</P>
Won, Jong Kook,Hwang, Chahwan,Ahn, Kyunghan,Choi, Seong-Young,Lee, Yongkyu,Kim, Jaehyun,Lee, Yangjin,Park, Sung Kyu,Chung, In,Kim, Choongik,Kim, Kwanpyo,Ahn, Sang Hyun,Lee, Min Hyung,Kim, Myung-Gil Elsevier 2019 Journal of solid state chemistry Vol.278 No.-
<P><B>Abstract</B></P> <P>Two-dimensional (2D) metal dichalcogenide nanomaterials have been receiving enormous research interest for electronic, optoelectronic, and catalytic applications. However, the facile tunability of alloying and doping, as well as the successful formation of ideal defect-free nanoplate morphology have been hardly achieved for 2D nanomaterials. Herein, we successfully synthesized a series of 2D solid-solution SnS<SUB>x</SUB>Se<SUB>2−x</SUB> particles of 0.20–2.00 μm width and 30–68 nm thickness with morphological defect-free nanoplate via a solvothermal reaction. With controlled reactivities of elemental chalcogen precursors, a co-surfactant hexylamine together with a structure-directing agent polyvinylpyrrolidone was found to be essential for realizing ideal defect-free nanoplate morphology of SnS<SUB>x</SUB>Se<SUB>2−x</SUB> particles without either cabbage-like or twinned structure. The successful synthesis of morphologically defect-free SnS<SUB>x</SUB>Se<SUB>2−x</SUB> nanoplates with rationally controlled energy band gaps ranging from 1.36 eV for SnSe<SUB>2</SUB> to 1.96 eV for SnS<SUB>2</SUB> could provide promising materials for electronics, optoelectronics, and electrocatalytic applications.</P> <P><B>Graphical abstract</B></P> <P>With chalcogen source control and surfactant/co-surfactant usage, morphologically defect free SnS<SUB>x</SUB>Se<SUB>2−x</SUB> nanoplates alloys were synthesized by facile solvothermal reaction.</P> <P>[DISPLAY OMISSION]</P>
Hwang, Min-Kyu,Lee, Hwa-Sung,Jang, Yun-Seok,Cho, Jeong-Ho,Lee, Shic-Hoon,Kim, Do-Hwan,Cho, Kil-Won The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.6
We improved the performance of pentacene-based thin film transistors by changing the curing environment of poly(4-vinylphenol) (PVP) gate dielectrics, while keeping the dielectric constant the same. The field-effect mobility of the pentacene TFTs constructed using the vacuum cured PVP was higher than that of the device based on the Ar flow cured gate dielectric, possibly due to the higher crystalline perfection of the pentacene films. The present results demonstrated that the curing conditions used can markedly affect the surface energy of polymer gate dielectrics, thereby affecting the field-effect mobility of TFTs based on those dielectrics.