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Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant
Kyoungah Kang 기초간호학회 2015 Journal of korean biological nursing science Vol.17 No.4
Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and100 μg/mL). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-1β, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-1β, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of PGE2 expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.
Anti-Inflammatory Effects of Chrysanthemum indicum Water Extract in RAW 264.7 Cell as a Whole Plant
Kang, Kyoungah Korean society of Biological Nursing Science 2015 Journal of korean biological nursing science Vol.17 No.4
Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and $100{\mu}g/mL$). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-$1{\beta}$, cyclooxygenase (COX)-2 and prostaglandin $E_2$ ($PGE_2$) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-$1{\beta}$, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of $PGE_2$ expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.
강정인(Kang, Jeongin),최경아(Choi, Kyoungah),이임평(Lee, Impyeong) 한국측량학회 2014 한국측량학회 학술대회자료집 Vol.2014 No.4
In this study, we perform 3D modeling of Seoul fortress walls using a micro UAV as a means of data acquisition. Before acquiring the data, we have performed camera-calibration using a photogrammetric commercial SW, Photomodeler. Next, we acquire images using a commercial micro UAV, AR.Drone and construct 3D models of Seoul fortress walls, world heritage designated by UNESKO. Through this study, we verified the possibilities that we produce 3D models of cultural heritage using such a low-cost micro UAV.
6-Hydroxydopamine로 유도된 In Vitro 파킨슨병 모델에서 토란추출물의 Brain Resilience에 미치는 영향
조혜영(Cho Hyeyoung),강경아(Kang Kyoungah) 한국기초간호학회 2020 Journal of korean biological nursing science Vol.22 No.4
Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce a neuroinflammatory reaction and the in vitro Parkinson’s disease model, SH-SY5Y cells were stimulated with lipopolysaccharide (LPS) and 6-OHDA, respectively. After that, cells were treated with at various concentrations (1, 5, and 10 mg/mL) of taro extract. Then nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), interleukin (IL)-6, synaptophysin (SYP) and growth associated protein (GAP)-43 messenger ribonucleic acid (mRNA) expression level were measured. Results: Taro extract significantly suppressed LPS-induced NO production. Meanwhile, iNOS and IL-6 mRNA expression decreased in a dose-dependent manner. In addition, taro increased the mRNA expression of SYP and GAP-43 mRNA. Conclusion: These findings indicate that taro played an important role in brain resilience by inhibiting neuronal cell death and promoting neurite outgrowth, synaptogenesis, and neural plasticity. The results of this study suggest that taro may contribute to the prevention of neurodegenerative disease and become a new and safe therapeutic strategy for Parkinson’s disease.
정맥주사 투여 시 대상자가 인지하는 통증, 우울 및 불안과의 관계
김희정(Kim Heejeong),정승교(Chaung Seung Kyo),김경희(Kim Kyunghee),강경아(Kang Kyoungah) 기본간호학회 2007 기본간호학회지 Vol.14 No.3
Purpose: The purpose of this study was to identify factors that have an influence on the pain which patients recognize when receiving an intravenous injection. Method: Participants were 111 patients who were admitting to C University Hospital. The collected data were analyzed using the SPSS 11.0 program. Results: For the participants, factors related to administration of medication were the following: Phlebitis scale, who administers the Ⅳ injection, failure to complete the Ⅳ injection, explaination of the Ⅳ injection and rate of injection. Level of pain, depression and anxiety in the participants was as follows: Pain (4.86±2.09), depression (35.76±9.91), anxiety (32.34±8.87). There were positive correlations between pain and depression (r=.437, p<.000), between pain and anxiety (r=.478, p<.000), and between depression and anxiety (r=.544, p<.000). Conclusion: Such findings provide new insights into the dynamic relationships between depression, anxiety and pain which patients recognize when having an intravenous injection. Further studies should be conducted to establish the causal relation between depression, anxiety and pain and to determine appropriate nursing interventions.