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Assessment of Parenting Attitudes by Children and Adolescents with Migraine
Kyeong Mi Lee(Kyeong Mi Lee),Min Suk Koh(Min Suk Koh),Ho-chan Lim(Ho-chan Lim),Soorack Ryu(Soorack Ryu),Yong Joo Kim(Yong Joo Kim),Jin-Hwa Moon(Jin-Hwa Moon) 대한소아신경학회 2022 대한소아신경학회지 Vol.30 No.4
Purpose: We aimed to investigate the parenting attitudes reported by patients and their relationships with the characteristics of headaches in children and adolescents with migraine. Methods: We conducted a retrospective review of medical records of children and adolescents with migrainous headaches (n=115; 59.1% female; mean age, 11.89±2.00 years). Children evaluated parental attitudes using the Parenting Attitude Test-Youth (PAT-Y), which comprises eight subscales and four newly devised secondary subscales. Headache severity was calculated by the visual analog scale (VAS), monthly frequency (MF), and VAS×MF/4 (VF). The scores of PAT-Y subscales and the correlations between PAT-Y scores and headache severity were analyzed by age group and sex. Scores for children’s depression inventory, childhood behavior checklists, and an attention deficit hyperactivity disorder scale were also analyzed. Results: In the elementary school age group, VAS was weakly negatively correlated with the “achievement press” (r=-0.28, P<0.05) and “high expectation” (r=-0.25, P<0.05) attitudes, and VF was weakly negatively correlated with “achievement press” (r=-0.32, P<0.05), “punishment” (r=-0.27, P<0.05), and “high expectation” (r=-0.29, P<0.05). In the middle-school age group, MF and VF were moderately positively correlated with the “achievement press” attitude (r=0.48, P<0.01 and r=0.48, P<0.01, respectively), VF was weakly positively correlated with the “neglectful” attitude(r=0.31, P<0.05), and MF was weakly positively correlated with scores for depression (r=0.29, P<0.05) and internalized problems (r=0.31, P<0.05). Conclusion: Parenting attitudes perceived by children and adolescents with migrainous headaches varied by age, and some parenting attitudes were related to headache severity. Education on age-appropriate parenting attitudes may help cope with migrainous headaches.
Potential Anti-inflammatory Effects of the Fruits of <i>Paulownia tomentosa</i>
Ryu, Hyung Won,Park, Yhun Jung,Lee, Su Ui,Lee, Seoghyun,Yuk, Heung Joo,Seo, Kyeong-Hwa,Kim, Yeah-Un,Hwang, Bang Yeon,Oh, Sei-Ryang American Chemical Society and American Society of 2017 Journal of natural products Vol.80 No.10
<P>As part of an ongoing search for new natural products from medicinal plants to treat respiratory disease, six new compounds, a dihydroflavonol (1) and five C-geranylated flavanones (3, 6, 8, 13, and 14), and 13 known compounds were isolated from mature fruits of Paulownia tomentosa. The structures of the new compounds were determined via interpretation of their spectroscopic data (1D and 2D NMR, UV, IR, ECD, and MS). In biological activity assays with human alveolar basal epithelial cells, the expression of TNF-alpha-induced proinflammatory cytokines (IL-8 and IL-6) was reduced significantly by the EtOAc fraction of a P. tomentosa extract as well as by the new compounds isolated from this fraction. Furthermore, the majority of the isolates (1-19 except 5-7) were found to inhibit human neutrophil elastase (HNE) activity, with IC50 values ranging from 2.4 +/- 1.0 to 74.7 +/- 8.5 mu M. In kinetic enzymatic assays with the HNE substrate MeOSuc-AAPV-pNA, compound 17 exhibited the highest inhibitory activity (K-i = 3.2 mu M) via noncompetitive inhibition. These findings suggest that the flavanone constituents of P. tomentosa fruits may be valuable for the development of new drug candidates to treat airway inflammation.</P>