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생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구
민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.
생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구
김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.
( Seong Woo Go ),( Boo Kyeong Kim ),( Sung Hak Lee ),( Tae Jung Kim ),( Joo Yeon Huh ),( Jong Min Lee ),( Jick Hwan Hah ),( Dong Whi Kim ),( Min Jung Cho ),( Tae Wan Kim ),( Ji Young Kang ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6
Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.
Lee, Hak-Joo,Lee, Kyeong-Seok,Cho, Jung-Min,Lee, Taek-Sung,Kim, Inho,Jeong, Doo Seok,Lee, Wook-Seong American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.22
<P>Nanocrystalline diamond (NCD) thin film growth was systematically investigated for application for the thin film waveguide mode resonance sensor. The NCD thin film was grown on the Si wafer or on the SiO<SUB>2</SUB>-coated sapphire substrate using the hot filament chemical vapor deposition (HFCVD). The structural/optical properties of the samples were characterized by the high-resolution scanning electron microscopy (HRSEM), high-resolution transmission electron microscopy (HRTEM), energy dispersive X-ray spectroscopy (EDS), near edge X-ray absorption fine structure (NEXAFS), X-ray diffraction (XRD), and ultraviolet–visible (UV–vis) spectroscopy. The waveguide modes of the NCD layer were studied by prism coupler technique using laser (wavelength: 632.8 nm) with varying incident angle. A novel aspect was disclosed in the grain size dependence on the growth temperature at the relatively low methane concentration in the precursor gas, which was important for optical property: the grain size increased with decreasing growth temperature, which was contrary to the conventional knowledge prevailing in the microcrystalline diamond (MCD) domain. We have provided discussions to reconcile such observation. An optical waveguide mode resonance was demonstrated in the visible region using the microstructure-controlled transparent NCD thin film waveguide, which provided a strong potential for the waveguide mode resonance sensor applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-22/am403066k/production/images/medium/am-2013-03066k_0015.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am403066k'>ACS Electronic Supporting Info</A></P>
총각무와 옥수수 재배시 SCB액비 시용수준이 토양화학성과 생육에 미치는 영향
강성수(Seong-Soo Kang),김민경(Min-Kyeong Kim),권순익(Soon-Ik Kwon),김명숙(Myong-Suk Kim),윤성원(Sung-Won Yoon),하상건(Sang-Gun Ha),김유학(Yoo-Hak Kim) 한국토양비료학회 2011 한국토양비료학회지 Vol.44 No.6
비멀칭 노지 밭토양 조건에서 총각무와 옥수수 재배시 퇴비단여과액비 (SCB) 시용 후 표토 (0<SUP>-1</SUP>5 cm) 화학성의 경시적 변화와 작물생산성을 평가하였다. 밑거름으로 SCB액비의 처리수준은 총각무 재배시 질소시비량 6 kg 10a<SUP>-1</SUP>, 옥수 수 재배시 질소시비량 10 kg 10a<SUP>-1</SUP>을 기준으로 무비구 (NF), 1배구 (SCB<SUP>-1</SUP>), 2배구 (SCB-2), 3배구 (SCB-3), SCB<SUP>-1</SUP>+NK 처리구의 5수준으로 하여 3반복 난괴법으로 배치하였다. SCB 액비의 양분함량에 따라 토양 중 크게 증가한 항목은 전기 전도도, 질산태질소와 치환성칼륨과 나트륨 함량이었다. 토양유기물함량, 유효인산, 치환성칼슘과 마그네슘의 변화는 나타나지 않았다. 전기전도도와 질산태질소, 치환성나트륨 함량은 강우량과 비례하여 감소하였으며 2008년 옥수수 재배시 장마기를 지나면서 시험 전 수준으로 낮아졌다. 치환성 칼륨 함량은 장마기에 다소 낮아졌으나 시험 후인 8월에도 처리 수준별로 높은 상태로 유지되어 토양 중 상당량 집적되는 것으로 나타났다. 총각무의 경우에는 SCB액비 처리량에 따라 생체중과 질소흡수량이 높았으나 옥수수 재배시에는 처리량에 따라 수량과 건물중이 증가하는 경향을 나타내지 않았다. SCB액비를 밑거름으로 적정량 사용하고 웃거름 시비 방법을 개선하므로써 생산성을 높이고 환경부하도 줄일 수 있는 방법과 SCB액비를 장기간 연속하여 사용시 유기물함량 변화나 중금속 또는 미량원소 축적문제에 대해서 추가 검토가 필요할 것으로 생각된다. A liquid fertilizer treated with slurry composting and biofiltration (SCB) process has been applied increasingly on agricultural field but the effects on the soil properties and crop production has not been throughly evaluated. This study was conducted to investigate the effect of the SCB application on soil chemical properties and the growth of radish and corn. SCB liquid fertilizer as a basal fertilization was treated with five levels based on 6kg 10a<SUP>-1</SUP> for radish and 10 kg 10a<SUP>-1</SUP> for corn. The experimental design was the completely randomized block design with five levels and three replicates. Electrical conductivity (EC), NO₃-N, Exch. K and Exch. Na increased depending on the treatment levels of SCB. There were no changes in soil organic matter, Avail. P₂O5, Exch. Ca and Exch. Mg. EC, NO₃-N and Exch. Na content decreased as precipitation increased. Especially, they decreased up to the initial condition before the treatment after the heavy rainy season in 2008. Although Exch. K decreased at the rainy season, they remained relatively higher content after the experiment on August, 2008. Fresh weight and the amount of N uptake of radish increased due to the levels of SCB, but corn did not present any significant increase. It is recommended that we need to decide the proper amount of SCB as well as the application method on the field to increase the productivity and decrease environmental stress. Additional experiments also need to clarify the effect of the trace element and heavy metal accumulations due to long term application of SCB.
Park, Kyeong Seon,Kwak, SooHeon,Cho, Young Min,Park, Kyong Soo,Jang, Hak C,Kim, Seong Yeon,Jung, Hye Seung John Wiley and Sons Inc. 2017 Journal of diabetes investigation Vol.8 No.2
<P><B>Abstract</B></P><P><B>Aims/Introduction</B></P><P>Dipeptidyl peptidase‐4 inhibitors might have pleiotropic protective effects on cardiovascular disease (CVD), in contrast to sulfonylureas. Therefore, we compared various CVD risk factors between vildagliptin and glimepiride.</P><P><B>Materials and Methods</B></P><P>We carried out a randomized, prospective and crossover trial. A total of 16 patients with type 2 diabetes whose glycated hemoglobin was >7% were randomized to add vildagliptin or glimepiride. After 12‐week treatment, each drug was replaced with the other for another 12 weeks. Before and after each treatment, glucose homeostasis and CVD risk factors were assessed, and the continuous glucose monitoring system was applied to calculate glycemic variability.</P><P><B>Results</B></P><P>The mean age of the participants was 60 years, 31% were men, body mass index 25.5 kg/m<SUP>2</SUP> and HbA1c 8.41%. Both vildagliptin and glimepiride significantly decreased glycated hemoglobin and glycemic variability indices. Despite the improved glucose homeostasis, favorable change of CVD markers was not prominent in both the arms, along with significant weight gain. Only plasma stromal cell‐derived factor (SDF)‐1α decreased by 30% in the vildagliptin arm. According to regression analyses, the reduction of SDF‐1α was independently associated with vildagliptin usage and serum interleukin‐6 changes, but white blood cells were not related with the SDF‐1α changes.</P><P><B>Conclusion</B></P><P>Compared with glimepiride, vildagliptin arrestingly decreased plasma SDF‐1α, and its clinical implications should be further investigated.</P>
Go, Seong Woo,Kim, Boo Kyeong,Lee, Sung Hak,Kim, Tae-Jung,Huh, Joo Yeon,Lee, Jong Min,Hah, Jick Hwan,Kim, Dong Whi,Cho, Min Jung,Kim, Tae Wan,Kang, Ji Young The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.6
Imatinib mesylate is a targeted therapy that acts by inhibiting tyrosine kinase of the bcr-abl fusion oncoprotein, which is specific to chronic myeloid leukemia (CML), and the c-transmembrane receptor, which is specific to gastrointestinal stromal tumors. Interstitial pneumonitis is a rare adverse event of imatinib therapy. It is clinically difficult to distinguish from infectious pneumonia, which can frequently occur due to the underlying disease. The standard treatment for imatinib-induced pneumonitis is to discontinue the medication and optionally administer corticosteroids. However, there are a few cases of successful retrial with imatinib. We describe a case of successful rechallenge of imatinib in a patient with imatinib-induced interstitial pneumonitis and CML without a recurrence of the underlying disease after 3 months of follow-up.