신경섬유종증 환자에게서 발생한 특발성 혈소판 감소증 1예

권세훈,김형호,강지인,장재혁,원경준,장재현,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Idiopathic thrombocytopenic purpura is a disease characterized by thrombocytopenia in peripheral blood with positive anti-platelet antibody titer, no splenomegaly, the presence of megakarocyte. The causes of idiopathic thrombocytopenic purpura were usually related to autoimmune disease, infection and drugs. A 46-years-old man was admitted for evaluation of abdominal mass. He has many cafe-au-lait spots and nodules in almost skin for 30 years. Several years ago, he palpated mass in Lt. inguinal area. hIe has known the abdominal mass after checking abdomen CT in local clinic and visited our hospital for evaluation of abdominal mass. At admission, laboratory tests showed hemoglobin 12.5 g/dL, hematocrit 38.4 %, WBC 5,460 /㎣ (neutrophil 64.5%, lymphocyte 21.7%, monocyte 4.1%, eosinophil 5.4%), reticulocyte 0.7%, Platelet 52,000 /㎣, total protein 6.51 g/dL, albumin 3.80 g/dL, alkaline pohsphatase 161 IU/L, AST 110.7 IU/L, ALT 64.9 IU/L, total bilirubin 0.44 ㎎/dL, BUN 18.4 ㎎/dL, creatinine 0.79 ㎎/dL. Peripheral blood smear showed normocytic normochromic anemia, thrombocytopenia. Bone marrow aspiration smear showed normoplastic myeloid and erythroid precursor. The bone marrow biopsy section shows normocellular marrow (35%) for his age and mildly increasing myeloid cell lineage. We have experienced a case of idiopathic thrombocytopenic purpura in a patient being in neurofibromatosis and therefore reporting it with documentary records. 저자들은 신경섬유종증 환자에서 특별한 원인을 발견할 수 없었음에도 특발성 혈소판 감소증이 발생한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

공정설계를 위한 객체지향 데이터 모델링

권성훈,이경휘 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.2

Process Planning may be defined as the systematic determination of the methods by which a product is to be manufactured economically and competitively. In it's generic nature, process planning is a non-standardized decision process based on intensive data, knowledge, and heterogeneous functions such as process selection, process sequencing, machine selection, and tool selection etc. How to semantically build data and knowledge bases about features, machine, tools, cutting parameter is a key problem in developing data models that support the entire semantics about manufacturing features, processes, machines, tools, etc. for process planning. Object oriented data models have a modeling power of rich semantics on a real world. In this paper, an object oriented data model for process planning is proposed on hole feature machining. The proposed data model includes submodels of feature, processes, machines, tools, cutting parameters, and a relation model among them, the data model may be used for performing process selection, machine selection, tool selection, and cutting parameter determination. In DB implementation, the object oriented data model is transformed into a relational data base(Sybase) which is prevalent in the related market. An illustrative example is given for validating the proposed data model and DB implementation.

신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구

權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.

성과 에이즈에 관한 보건교육 방법별 효과 측정

권관우,이경무,김훈수,김정순,정경균 韓國保健敎育.健康增進學會 2000 보건교육건강증진학회지 Vol.17 No.2

The objective of this study is to find the most effective educational method on Sex and AIDS/HIV among young people in Korea. The number of people with HIV amounts to 1,224 as of Sep. 2000, and is increasing continuously, especially among young people(National Institute of Health, 2000). In setting up the policy of health education on Sex and AIDS, the criteria should be the effectiveness. By two-stage cluster sampling, 4,713 students were selected from among the 19,093 students from 44 middle and high schools and divided into three groups and taken the education with three different methods(〈lecture with slides show〉, 〈lecture without any material〉 and 〈lecture through broadcasting system〉) by the same lecturer with the same contents for about 50 minutes. To compare the effects of education by methods, the tests on the AIDS knowledge, AIDS attitude on AIDS and Sexuality attitudes with self-administered questionnaire were implemented three times, that is, 'before', 'right after' and '2 weeks later' of the education. As to the decrees of change of AIDS knowledge, AIDS attitudes, Sexuality attitudes and subjective evaluation of the education, 〈lecture with slides show〉 was the most effective, 〈lecture without any material〉 was the second and 〈lecture through broadcasting system〉 was the least effective, respectively. In the cost-effectiveness analysis using the results of this study, 〈lecture with slides show〉 turned out to be the most effective, and 〈lecture through broadcasting system〉 was the second and 〈lecture without any material〉 was least effective. From these results, it is suggested that 〈lecture with slides show〉 is more effective health educational methods on Sex and AIDS than 〈lecture without any material〉 or 〈lecture through broadcasting system〉.

심혈관계질환으로 사망한 성인형다낭신 3예 보고

양경무,권일훈,조갑래,서중석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.1

Adult polycystic kidney disease is a genetic disease characterized by bilateral multiple renal cysts and is transmitted as an autosomal dominant traits. The disease usually manifests in the fourth decade of life. The affected patients usually die with end stage renal failure, cardiovascular assaults and infection etc. Cardiovascular assaults include ruptured berry aneurysm, spontaneous intracranial hemorrhage, acute myocardial infarction, dissecting aortic aneurysm and hypertensive heart failure. Fatal intracranial hemorrhage and hypertensive heart failure occur in 15% and 2% of patients, respectively. Genetically-dater-mined structural weakness in the arterial wall have been suggested as a possible factor in the genesis of berry aneurysm. We have experienced three autopsy cases with cardiovascular causes of sudden death. Two cases have intracranial hemorrahage (1 berry aneurysm and 1 intracerebral hemorrhage) and the remaining one is dead with hypertensive cardiomyopathy. All of them are aged over 40 years and associated with polycystic liver disease. Histologically, myriad cysts of enlarged bilateral kidney are lined by single layer of cuboidal cells with focal hyperplastic epithelial configuration. Diffusely scattered liver cysts are also lined by flat to cuboidal epithelium and often associated with portal fibrosis.

WIND ENERGY POTENTIAL ASSESMENT and SITING a WIND FARM in CHEJU ISLAND

김건훈,조경호,고장권,허종철,고경남 濟州大學校 工科大學 産業技術硏究所 1997 尖端技術硏究所論文集 Vol.8 No.2

본 연구는 제주도내 풍력발전기 보급 및 적지선정을 검토하는데 그 목적을 두었다. 이를 위하여 제주도내 다풍지역으로 예상되는 3개지역을 선정하여 1년간 풍력자원조사를 행하였고, 계측된 자료는 통계분석으로 풍력자원을 정량화하였으며 또한 세계적으로 경제성이 인증된 600kW 풍력발전기를 모델로하여 가상 출력을 산출함으로서 최적 풍력단지를 제시하였다. The possibility in the practical use and supply of the wind turbine in Cheju island was investigated. The wind data measured in three regions which have a plenty wind energy potential were utilized to quantify the wind power resources by statistical analysis. Power output was calculated for 600 kW wind turbine. The coastal area of Guja was superior to Daejung and Hoichun in wind power energy densities. The calculated capacity factor of 600 kW wind turbine in this site was high as much as 30%. Hoichun site, the intermediate region between the Halla mountain and the sea, was rich in wind power energy resources in winter. Hourly ideal energy density at three regions increased at sunrise, reached the maximum at 13-16 O'clock, decreased steadily, and finally remained constant at sunset.

임플란트 보철물에서 임시 접착용 시멘트의 인장결합강도 비교

서경숙,권태엽,권용훈,김교한 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.4

The major disadvantage of cement-retained implant-supported superstructure is difficulty of retrievability. Sometimes, it is recommended that proetheses be provisionally cemented to implant abutment in order to ebaluate occlusion, screw loosening and tissue reaction. The retention of the provisional luting cementedusually employed in this case is considered to be important. This study compared tensile bond strength of gold crowns cemented to machined titanium implant abutments with three provisional luting cements. Also the effect of petrolatum and thermocycling on tensile bond stength were evaluated. Tensile bond strength of provisional luting cement were as follows with the decreasing order of Eugenol (13.06±1.544 kgf), Temp-Bond (9.41±0.737 kgf), Cavex (8.04±0.974 kgf), and Temp-bond with petrolatum (5.28±0.800 kgf). The addition of petrolatum in Temp-bond decreased tensile bond strength significantly (p<0.01). After thermocycling of 1,500 cycles, the tensile bond strengths of the cements were decreased with the order of Nogenol (10.87±3.031 kgf), Temp-Bond (8.1±0.667 kgf), Cavex (7.33±1.103 kgf), Temp-bond with petrolatum (4.88±1.348 kgf). The mocycling decreased the bond strength of Temp-Bond significantly, with no effects no other cements (p<0.01).

WIND ENERGY POTENTIAL ASSESMENT and SITING a WIND FARM in CHEJU ISLAND

고경남,김건훈,조경호,고장권,허종철 濟州大學校 産業技術硏究所 1997 산업기술연구소논문집 Vol.8 No.2

The possibility in the practical use and supply of the wind turbine in Cheju island was investigated. The wind data measured in three regions which have a plenty wind energy potential were utilized to quantify the wind power resources by statistical analysis. Power output was calculated for 600 kW wind turbine. The coastal area of Guja was superior to Daejung and Hoichun in wind power energy densities. The calculated capacity factor of 600 kW wind turbine in this site was high as much as 30%. Hoichun site. the intermediate region between the Halla mountain and the sea. was rich in wind power energy resources in winter. Hourly ideal energy density at three regions increased at sunrise, reached the maximum a t 13-16 O'clock, decreased steadily, and finally remained constant at sunset.

통근교통 수단선택에 대한 연구

임채문,권강훈,구경남 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.5 No.5

The growth of auto ownership which was resulted by a rapid growth of economy and population caused a terrible transportation problem. This problem will not be improved by the supply of transportation facility. These days, it is natural for every foreign country to give a priority to the public transportation. Namely, it is necessary that the policy for travellers to attract from auto to public transportation is needed. Therefore, the purpose of this study is to find a basic idea for attracting auto users to public transportation. This study is largely divided into 3 parts. First, a travel mode choice model was estimated by using which is all the sample. Second, the mode choice models were estimated with the market segmentation divided by residential and work location. Third, the policy analysis was performed by using the estimated model.

국내 5개 3차 병원의 β-lactam계 항생제 사용 실태 및 Klebsiella pneumoniae의 항생제 내성과의 상관 관계

정숙인,박경화,권기태,고관수,오원섭,정두련,백경란,염준섭,장현하,김신우,손준성,송재훈 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Background : This study was performed to evaluate the prescribing pattern of β-lactam antibiotics and the relationship between antimicrobial resistance and antimicrobial use in 5 tertiary care hospitals in Korea. Materials and Methods : Data on annual patient-days and annual consumption (defined daily dose (DDD) per 100 patient-days) of β-lactam antibiotics from 2003 to 2005 in 5 tertiary hospitals were analyzed. To determine the antimicrobial resistance in K. pneumoniae, broth microdilution test and double disk synergy were performed according to the CLSI performance standards. Spearman's correlation coeffient was used to determine the relationship between antibiotic consumption and resistance. Results : The prescription of β-lactam antibiotics in 5 tertiary hospitals markedly varied. In two hospitals, increase in consumption of β-lactam antibiotics was more than 30% during recent 3 years. The higher consumption of β-lactam antibiotics significantly correlated with the higher rate of antibiotic-resistant K. pneumoniae in 5 tertiary care hospitals. Conclusion : Continuous surveillance of antibiotic use is needed to encourage appropriate prescribing of antibiotics and to reduce antibiotic resistance. 목적 : 항생제의 오남용으로 인한 내성균의 발현 및 급속한 확산이 전세계적으로 문제시 되고 있다. 특히 병원은 항생제 내성의 중심점에 있는 것으로 여겨진다. 본 연구에서는 최근 3년간 국내 5개 3차 병원의 β-lactam계 항생제의 사용량을 조사하고, 각 병원별 항생제 사용량과 K. pneumoniae의 항생제 내성률과의 상관관계를 알아보고자 하였다. 재료 및 방법 : 국내 5개 3차 병원에서 2003년 1월부터 2005년 12월까지 병원 입원 환자를 대상으로 연도별 재원연인원수와 각 β-lactam계 항생제의 총사용량을 수집하여 DDD (defined daily dose) per 100 patient-days로 환산하여 비교하였다. 2005년 6월부터 8월까지 각 병원의 임상검체에서 동정된 K. pneumoniae를 수집하여 액체배지미량희석법으로 항생제 감수성 검사를 시행하였고 ESBL(extended-spectrum β-lactamase) 생성 여부는 double disk synergy test를 시행하였다. 항생제 사용량과 내성의 상관관계는 Spearman 상관관계 분석을 시행하였다. 결과 : 5개 병원 중 3개 병원에서는 연도별 β-lactam계 항생제 사용량이 비슷하게 유지되었으나, 2개 병원에서는 2003년에 비해 2005년에 항생제 사용량이 30% 이상 증가하였다. β-lactam계 항생제 중 제제별 비율은 각 병원마다 차이가 있었으나, 3세대 cephaosporin의 사용이 가장 많았고 2세대 ceaphlosporin, β-lactam/β-lactamase inhibitor, 1세대 cephalosporin 순이었다. 경구용 β-1actam계 항생제의 사용량(r=0.900, P<0.037)과 2세대 cephalosporin의 사용량(r=0.900, P<0.037)은 각각 K. pneumoniae의 ESBL 생성과 양의 상관관계가 있었다. Ceftazidime의 사용량은 K. pneumoniae의 ceftazidime 내성률과 양의 상관관계가 있었다(r=0.900, P<0.037). 반면 imipenem의 사용량은 piperacillin/tazobactam 내성과 음의 상관관계가 있었다(r=-0.900, P<0.037). 결론 : 최근 3개년간 항생제 사용량은 병원별로 차이가 있으나 일부 병원에서는 증가하였다. β-lactam계 항생제의 사용량은 K. pneumoniae의 항생제 내성과 상관관계가 있었다. 항생제 사용을 줄임으로써 항생제 내성을 감소시킬 수 있을 것으로 기대되며, 병원별로 항생제 사용에 대한 지속적인 감시가 필요할 것이다.