심근침범을 동반한 Becker형 근이영양증 환자에서 확인한 Dystrophin 유전자 Exon결실

김광일,오병희,이무용,채인호,신수,박성섭,김효수,손대원,이명묵,박영배,최윤식,이영우 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

마스낵 제조를 위한 당절임 공정의 최적화

한주영,김남우,황성희,윤광섭,신승렬 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

대부분의 마는 건조분말제품으로 가공되고 있는데, 마를 다양한 가공품으로 개발하기 위한 방법의 하나로 삼투건조라는 전처리를 행하여 건조에 의한 품질손상을 억제하고 단맛으로 기호성을 높인 건조 마 제품을 얻을 수 있는 당절임 공정의 최적화를 시도하여 최적조건을 얻고자 하였다. 침지시간을 3-7시간, 온도는 20-60℃, 당농도는 30-70%로 하는 중심합성계획법으로 실험을 설계하여 최적화하였다. 이때의 종속변수로는 침지 후 수분함량, 당도, 색도, 그리고 동결건조후의 수분함량과 재수화율로 하여 분석한 결과 동결건조 후 수분함량에 대해서는 유의성이 없었다. 세 가지의 공정변수 중 온도의 영향이 가장 적어 온도를 중심으로 고정한 후 침지시간과 당농도의 최적조건을 찾은 결과, 수분함량을 66-70%, 당도를 25-30%, L 75이상, a-2.1-2.4, b를 5이상 그리고 재수화율을 200-250을 제한 조건으로 하는 조건으로 하는 영역은 5.2-5.9시간, 56-61%로 나타났다. This study was conducted to the optimize sugaring process of yam for development of new snack product and enhancement acceptability. Three variables by five level central composite design and response surface methodology were used to determine optimum conditions for sugaring time, temperature and concentration. Optimization of the process was conducted using the combination of the moisture content, solid content, color and rehydration ratio. The regression polynomial model was suitable (P>0.05) model by Lack-of-Fit analysis with highly significant. To optimize the process, based on surface response and contour plots, superimposing the individual contour plots for the response variables. The optimum conditions for this process were 5.5 hours and 58% at 40℃ under the optimum of restricted variables as moisture content was 66 to 70, solid content was 25 to 30%, L value was above 75, a value was -2.1 to -2.4, b value was above 5 and rehydration ratio was 200 to 250.

수출용 축양품종 가지의 염절임 공정의 최적화

남학식,김남우,황성희,윤광섭,신승렬 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2003 한국식품저장유통학회지 Vol.10 No.3

가지의 수출 경쟁력 향상을 위한 한 방안으로 수출용 가지품종인 축양품종을 염가공품으로 개발하기 위하여 염절임공정을 최적화하였다. 염절임 시간, 절임온도, 염농도를 독립변수로 하고 절임 후 수분함량, 염도, 표면과 내부의 색도 등을 종속변수로 하여, 중심합성계획법으로 실험을 설계하여 최적조건을 얻고자 하였다. 수립된 이차회귀모형으로 예측식을 수립할 수 있었으며 특히 수분함량이나 염도, 표면과 내부의 L과 b 값에 대하여 높은 적합도를 보여 최적조건을 수립하기 위한 제한 변수로 선정하였다. 염농도를 중심점(30%)에서 고정시켜서 얻은 절임시간과 온도는 각각 5.5~6.5일과 13-17℃였으며, 이때의 종속변수의 제한 요건으로는 수분함량 84%이하, 염도 14%이하 표면 L값 10-20, b값 0이하, 내부 L 값은 70-75, b 값이 16-18이었다. This study was conducted to the optimize salting process of eggplant for development new product and enhancement quality for export. Three variables by five level central composite design and response surface methodology were used to determine optimum conditions for salting time, temperature and salt concentration. Optimization of the process was conducted using the combination of the moisture content, salinity and color of surface and inside of salted eggplant. The regression polynomial model was suitable (P>0.05) by Lack-of-Fit analysis with highly significant. To optimize the process, based on surface response and contour plots, the individual contour plots of the response variables were superimposed. The optimum conditions for this process were 6 days and 15℃ at 30% concentration under the optimum of restricted variables as moisture content was below 84%, salinity was below 14%, L and b value of surface were 10 to 20 and below 0, L value and b value of inside were 70 to 75 and 16 to 18.

Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model

Song, In Ho,Jeong, Mun Sik,Hong, Hyo Jeong,Shin, Jong Il,Park, Yong Serk,Woo, Sang-Keun,Moon, Byung Seok,Kim, Kwang Il,Lee, Yong Jin,Kang, Joo Hyun,Lee, Tae Sup American Association for Cancer Research 2019 Clinical Cancer Research Vol.25 No.20

<P><B>Purpose:</B></P><P>Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been known as a novel prognostic marker and therapeutic target for cholangiocarcinoma. This study aimed to evaluate the feasibility of immuno-PET imaging–based radioimmunotherapy using radiolabeled anti-L1CAM antibody in cholangiocarcinoma xenograft model.</P><P><B>Experimental Design:</B></P><P>We prepared a theranostic convergence bioradiopharmaceutical using chimeric anti-L1CAM antibody (cA10-A3) conjugated with 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) chelator and labeled with <SUP>64</SUP>Cu or <SUP>177</SUP>Lu and evaluated the immuno-PET or SPECT/CT imaging and biodistribution with <SUP>64</SUP>Cu-/<SUP>177</SUP>Lu-cA10-A3 in various cholangiocarcinoma xenograft models. Therapeutic efficacy and response monitoring were performed by <SUP>177</SUP>Lu-cA10-A3 and <SUP>18</SUP>F-FDG-PET, respectively, and immunohistochemistry was done by TUNEL and Ki-67.</P><P><B>Results:</B></P><P>Radiolabeled cA10-A3 antibodies specifically recognized L1CAM <I>in vitro</I>, clearly visualized cholangiocarcinoma tumors in immuno-PET and SPECT/CT imaging, and differentiated the L1CAM expression level in cholangiocarcinoma xenograft models. <SUP>177</SUP>Lu-cA10-A3 (12.95 MBq/100 μg) showed statistically significant reduction in tumor volumes (<I>P</I> < 0.05) and decreased glucose metabolism (<I>P</I> < 0.01). IHC analysis revealed <SUP>177</SUP>Lu-cA10-A3 treatment increased TUNEL-positive and decreased Ki-67-positive cells, compared with saline, cA10-A3, or <SUP>177</SUP>Lu-isotype.</P><P><B>Conclusions:</B></P><P>Anti-L1CAM immuno-PET imaging using <SUP>64</SUP>Cu-cA10-A3 could be translated into the clinic for characterizing the pharmacokinetics and selecting appropriate patients for radioimmunotherapy. Radioimmunotherapy using <SUP>177</SUP>Lu-cA10-A3 may provide survival benefit in L1CAM-expressing cholangiocarcinoma tumor. Theranostic convergence bioradiopharmaceutical strategy would be applied as imaging biomarker-based personalized medicine in L1CAM-expressing patients with cholangiocarcinoma.</P>

외과 의사에 의해 시행된 갑상선 결절의 악성 종양을 시사하는 초음파 소견의 분석

고건,고진철<SUP>1<,SUP>,최상용,박신희,이광찬<SUP>1<,SUP>,김진승<SUP>1<,SUP>,Gun Go,M,D,Jin Chul Koh,M,D,<SUP>1<,SUP>,Sang Yong Choi,M,D,Shin Hee Park,M,D,Kwang Chan Lee,M,D,<SUP>1<,SUP> and Chin Seung Kim,M,D,<SUP>1< 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4

Purpose: Ultrasound is most effective study for evaluating thyroid nodules. In this review, we discuss that sonographic findings to differentiate benign from malignant nodules and suggest recommendations for indications of fine needle aspiration biopsy and thyroid nodule management. Methods: Sonographic scans of 206 thyroid nodules in 164 patients were candidated for this study. We evaluated sonographic findings by shape, calcification, margin, and echogenicity, retrospectively. Sonographic findings that suggested malignancy included microcalcifications, a speculated margin, marked hypoechogenicity and a shape that was taller than wide. The final diagnosis of lesion as benign (n=180) or malignant (n=26) was confirmed by fine needle aspiration biopsy and follow-up (>6 months). We demonstrated the difference of the sensitivity, specificity, positive predictive value, negative predictive value and accuracy. Results: Of 206 thyroid nodules, 26 were malignant. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy based on our sonographic classification method were 84.6%, 73.9%, 31.9%, 97.0% and 75.2%. Conclusion: Sonography can be helpful for making the differentiation between and malignant nodules. So, when well trained surgeon find thyroid nodules on sonography, we can make correct diagnosis of malignant nodules. (Korean J Endocrine Surg 2010;10:224-228)

유기 섬유를 사용한 콘크리트의 공학적 특성

신현섭 ( Shin Hyun-sup ),김종백 ( Kim Jong-back ),김광련 ( Kim Kwang-ryeon ),한천구 ( Han Cheon-goo ) 한국구조물진단유지관리공학회 2006 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.10 No.2

This study investigates engineering properties of concrete containing nylon(NY) and cellulose(CEL) fiber. Test showed that increase of fiber adding ratio decreased fluidity, especially for CEL fiber, and it slightly increased air content satisfying target range. As for the properties of hardened concrete, most specimens containing NY or CEL fiber exhibited similar performance to control concrete in the values of compressive, tensile and flexural strength. However, even if it revised the strength considering increase of air content, those specimens adding fibers would have slightly inclined the value, compared with that of control. In addition, as for the impact strength of specimens, the NY specimen showed higher than that of CEL, especially for adding 0.6kg/m³ of NY fiber. Adding fiber did not affect length change ratio of specimens, while it showed even higher value than that of control, when added more than 0.9kg/m³ of NY fiber.

Negotiation Model for Assuring Quality in Supply Chain Using Stackelberg Game

Shin, Kwang Sup,Kwon, Back Chul Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.945 No.-

<P>Defects from various sources in the multi-layered supply chain network cause additional cost to deliver products to customers. Although a great deal of methodologies have been proposed, there exit a few research which consider the conflictual relationship between suppliers and retailers. This paper presents an economic contract model for finding optimal acceptance sampling plans between suppliers and retailers using Stackelberg game. For each players in quality control game, the payoff functions are devised by considering both cases rejecting or accepting incoming lot based on the result of acceptance sampling. Numerical studies illustrate and provide insights of the proposed approach.</P>

Adaptive Framework for Designing R&D Project Management Process Using Cloud Computing Technology

Kwang-Sup Shin(신광섭) 한국전자거래학회 2013 한국전자거래학회지 Vol.18 No.4

최근 글로벌 시장의 변화를 대표할만한 주요 키워드는 초연결(Hyper-Connection)과 지역적 세계화(Glocalization)으로 요약될 수 있다. 이러한 변화에 대응하고 경쟁 우위를 확보하기 위해서는 서비스 관리를 위한 표준화된 조직, 정책, 프로세스를 구축하는 것이 필요하다. 또한 서비스 관리 시스템은 연구개발 프로젝트 관리를 효과적으로 지원할 수 있어야만 한다. 본 연구에서는 클라우드 컴퓨팅 기술을 이용한 연구개발 프로젝트 관리 프로세스 설계를 위한 적응형 프레임워크와 시스템 구조를 제안한다. 이를 통해 전통적인 서비스 관리 기법이 가지는 한계점을 극복하고 시장의 요구에 빠르게 대응할 수 있을 것이다. 이와 함께 본 연구에서 제안하는 시스템을 통해서 국제 시장에서 경쟁우위를 확보함과 동시에 고객이 원하는 것 이상의 가치를 제공할 수 있을 것이다. Two of the most important changes in the global market can be represented with Hyper-connection and Glocalization. To cope with these changes and secure the competitive advantages, it is essential to develop the standard organization, policy, processes and criteria for service management. In addition, the service management system is required to effectively support the R&D project management. In this research, an adaptive framework and system architecture for designing R&D project management process using cloud computing has been introduced. With the proposed system, it is able to overcome the limitations of traditional service management and treat the demand from the market in agility. Moreover, it may be possible to present more value than customers want and secure the competitive advantages in the global market with the proposed system.

전체 공급망 수익성 개선을 위한 게임이론 기반의 수요 할당 메커니즘의 비교 연구

신광섭(Kwang Sup Shin) 한국전자거래학회 2014 한국전자거래학회지 Vol.19 No.1

본 연구는 공급망 운영에서 가장 기본적이고 필수적인 연구 분야인 공급자의 선정과 수요의 할당 문제를 해결하기 위한 방법으로 게임이론을 적용하였다. 특히, 가장 보편적으로 사용되고 있는 점진적 역경매 메커니즘을 비율적 형평성을 보장하는 구매 게임 방식과 공급망 전체 운영의 수익성이라는 관점에서 비교 분석하였다. 서로 다른 두 메커니즘의 정교한 비교 분석을 위한 전체 알고리즘을 제시하였으며, 구매게임을 이용한 공급자 선정 및 주문 배분의 최적해는 유전자 알고리즘을 통해 도출하였다. 전체 공급망의 수익성은 공급자와 구매자의 수익함수와 수익-비용 비율을 통해 평가하였다. 실제 현실의 공급망을 단순화한 모형을 바탕으로 본 연구에서 제안하는 방법이 전체 공급망의 수익성을 어떻게 향상시킬 수 있는 지를 간단한 실험과 통계 분석을 통해 설명하였다. 이를 통해 구매게임의 해가 역경매 방식에 비해 구매자의 수익성 감소를 통해 공급자와 구매자를 모두 포함하는 공급망 전체의 수익성을 크게 향상시킬 수 있음을 보였다. This research is an application of game theory to developing the supplier selection and demand allocation mechanism, which are the essential and major research areas of supply chain planning and operation. In this research, the most popular and widely accepted mechanism, the progressive reverse auction is analyzed and compared with the other game theoretic approach, Kalai-Smorodinsky Bargaining Solution in the viewpoint of holistic efficiency of supply chain operation. To logically and exquisitely compare the efficiencies, a heuristic algorithm based on Genetic Algorithm is devised to find the other optimal demand allocation plan. A well known metric, profit-cost ratio, as well as profit functions for both suppliers and buyer has been designed for evaluating the overall profitability of supply chain. The experimental results with synthesis data and supply chain model which were made to mimic practical supply chain are illustrated and analyzed to show how the proposed approach can enhance the profitability of supply chain planning. Based on the result, it can be said that the proposed mechanism using bargainging solution mayguarantee the better profitability for the whole supply chin including both suppliers and buyer, even though quite small portion of buyer’s profitability should be sacrified.

A Case of Acquired Mucinous Nevus in Nevus Lipomatosus Cutaneous Superficialis

( Yo Sup Shin ),( Bok Won Park ),( Ji Yun Jung ),( Eun Byul Cho ),( Eun Joo Park ),( Kwang Ho Kim ),( Kwang Joong Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.5