http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Computational Analysis of Apolipophorin-III in Hyphantria cunea
Chandrasekar R.,Dhanalakshmi R.,Krishnan M.,Kim H. J.,Jeong H. C.,Seo S. J. Korean Society of Sericultural Science 2005 International Journal of Industrial Entomology Vol.10 No.1
Recently a cDNA clone of apoLp-III from Hyphantria cunea was isolated and subjected to computational analysis to compare with other available sequences. Multiple sequence alignments were carried out using the amino acid sequences of apoLp-III from six insects. It was found that the H. cunea apoLp-III has relatively high sequence identities to Spodoptera litura ($69.5\%$), Manduca sexta ($66.8\%$), Galleria mellonella ($65.1\%$), Bombyx mori N4 ($54.3\%$) but less identity to Locusta migratoria ($18.3\%$). The amino acid composition was compared with other insects using EXPASY tools; it shows that alanine (Ala), glutamine (Gln), leucine (Leu) and lysine (Lys) are the major amino acid components of apoLp-III in H. cunea as well as other lepidopterans. Homology modeling performed using PSI-BLAST (PDB template M. sexta) reveals that the apoLp-III molecules consist of five, long amphipathic alpha helical bundles with short loops connecting the helices and shows homology with other insects. Phylogenetic analysis shows that the orthopteran apoLp-III represented by locust was most distantly related to the lepidopteran insects.
M. Navaneetha Krishnan,S. Suresh,S. C. Vettivel,C. Emmy Prema,J. Arun,P. Thirunamakodi 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5
The different percentages of boron carbide (B4C) reinforced Magnesium metal matrix composites were processed usingPowder Metallurgy method. The characterizations are performed by Scanning Electronic Microscope (SEM), X-ray Diffractionpattern, Electron Backscattered Diffraction, and Energy Dispersive Spectrum. The texture analysis of the composites isconducted via an image processing method. Wear tests are executed in the dry sliding state under ambient room conditions. The three levels Box-Behnken design of Response Surface Methodology has been selected to create the mathematical modelsfor the three variables (weight percentage of B4C,sliding velocity, and load) to predict the responses namely specific wearrate (SWR) and coefficient of friction (COF). The developed model is validated and analyzed through the Analysis of variance(ANOVA). This model has a 95% efficient confidence to forecast the COF and SWR. The worn surface features areextracted and analyzed through an image processing technique. The roughness measurement of the worn surfaces is executedvia Atomic Force Microscopy analysis.
On a Class of γ<sup>*</sup>-pre-open Sets in Topological Spaces
Krishnan, G. Sai Sundara,Saravanakumar, D.,Ganster, M.,Ganster, M. Department of Mathematics 2014 Kyungpook mathematical journal Vol.54 No.2
In this paper, a new class of open sets, namely ${\gamma}^*$-pre-open sets was introduced and its basic properties were studied. Moreover a new type of topology ${\tau}_{{\gamma}p^*}$ was generated using ${\gamma}^*$-pre-open sets and characterized the resultant topological space (X, ${\tau}_{{\gamma}p^*}$) as ${\gamma}^*$-pre-$T_{\frac{1}{2}}$ space.
Nagaraj M. Kulkarni,Milind M. Muley,Mallikarjun S. Jaji,G. Vijaykanth,J. Raghul,Neetin Kumar D. Reddy,Santosh L. Vishwakarma,Navin B. Rajesh,Jeyamurugan Mookkan,Uma Maheswari Krishnan,Shridhar Narayan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Atorvastatin is a 3-hydroxy-3-methylglutarylcoenzyme-A reductase inhibitor used in the treatment ofatherosclerosis and dyslipidemia. Studies have evaluatedthe utility of statins in the treatment of skin inflammationbut with varied results. In the present study, we investigatedthe effect of atorvastatin on TNF-a release andkeratinocyte proliferation in vitro and in acute and chronic12-O-tetradecanoylphorbol-13-acetate (TPA) induced skininflammation in vivo. Atorvastatin significantly inhibitedlipopolysacharide induced TNF-a release in THP-1 cellsand keratinocyte proliferation in HaCaT cells. In an acutestudy, topical atorvastatin showed dose dependent reductionin TPA induced skin inflammation with highest efficacyobserved at 500 lg/ear dose. In chronic study, topicalatorvastatin significantly reduced TPA induced ear thickness,ear weight, cutaneous cytokines, MPO activity andimproved histopathological features comparable to that ofdexamethasone. Atorvastatin also inhibited TPA stimulatedNF-jB activation in mouse ear. In conclusion, our resultssuggest that atorvastatin ameliorates TPA induced skininflammation in mice at least in part, due to inhibition ofcytokine release and NF-jB activation and may be beneficialfor the treatment skin inflammation like psoriasis.
Mohiadeen Batcha M.,Sajith Ahamed A.,Ur Rahman M. Ashiq,Janarthanan S.,Krishnan M. 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.2
The present study aims to focus on the site of fat bodies involved in the differential expression of vitellogenin protein in Bombyx mori L which is not yet fully understood. Culturing fat bodies and analyzing in in vitro and in vivo approaches made it useful to study this pattern. In Bombyx mori, L. The vitellogenin protein is 200–205 kDa and resolves at two molecular weight regions that are at 180 kDa and 42 kDa. We subject dorsal perivisceral (DPV) and ventral perivisceral fat body (VPV), haemolymph for this radio labeling cell culture and incorporation experiment. Based on our in vitro and in vivo experiments of S 35 methionine fluorography, Scanning densito metric, Western blot analysis and RT-PCR expression studies had strongly proven that the ventral perivisceral fat body is the significant and exclusive site of differential vitellogenin expression in silkworm, Bombyx mori but not in dorsal peripheral fat body tissues, haemolymph by radiolabeling studies. The present paper describes an experimental set-up based on the incubation of ventral perivisceral and dorsal perivisceral fat bodies and the measurement of vitellogenin with S 35 protein labeling incorporation method. These findings from our lab were the first report proved by in vitro and in vivo labeling experiments.
M. Suriyavathana Vedanarayanan,Nandhini Krishnan 사단법인약침학회 2011 Journal of Acupuncture & Meridian Studies Vol.4 No.4
Nonalcoholic fatty liver disease (NAFLD) has emerged as a serious obesity-related disorder, and it will continue to be a major liver health issue worldwide in the coming decades. We aimed to determine the effect of Liv-Pro-08 (Nigella sativa, Entada pursaetha, and Ficus glomerata) an oral ayurvedic formulation on rats fed with highfat diet. Rats were given a high-fat diet for a period of 7 days. After this period, Liv-Pro-08 (250, 500, and 750 mg/kg.body weight was given orally for 7 days. We examined the effect of the high-fat diet on various parameters related to obesity and insulin resistance. In the experimental rats who received the extract of Liv-Pro-08, their lipoprotein profiles were significantly improved compared with those that are not receiving the extract. Also, a slight reduction was observed in serum aspartate aminotransferase,alanine aminotransferase, and alkaline phosphatase enzymes. Moreover, Liv-Pro-08significantly decreased their fasting serum glucose and fasting insulin levels. This experimental study suggests that Liv-Pro-08 can act as a therapeutic tool in preventing NAFLD progression (i.e., reducing hepatic lipid accumulation). Although further investigations and large randomized trials should be conducted, ayurvedic Liv-Pro-08 oral formulation may be a potential natural drug for NAFLD in the future.
Some reliability properties of extropy for residual and past lifetime random variables
Krishnan Aswathy S.,Sunoj S. M.,Unnikrishnan Nair N. 한국통계학회 2020 Journal of the Korean Statistical Society Vol.49 No.2
In the present paper, we study the residual extropy using distribution function and quantile function approaches. We also investigate extropy in past lifetime in both approaches. Some characterizations and ageing properties of these extropy measures are proposed. Different stochastic orders based on the residual and past lifetime extropy are also presented.
Krishnan, Sridevi,Huang, Jincui,Lee, Hyeyoung,Guerrero, Andres,Berglund, Lars,Anuurad, Erdembileg,Lebrilla, Carlito B.,Zivkovic, Angela M. American Chemical Society 2015 Journal of proteome research Vol.14 No.12
<P><B>Objectives:</B> To test whether recently developed methods for comprehensive profiling of the high-density lipoprotein (HDL) glycome combined with the HDL proteome can distinguish individuals with coronary artery disease (CAD) from those without. <B>Methods:</B> Twenty subjects at risk for CAD, who underwent diagnostic coronary arteriography, were analyzed. Ten subjects had CAD, and ten did not. HDL was extracted from fasting plasma samples by ultracentrifugation, followed by shotgun proteomic, glycomic, and ganglioside analyses using LC-MS. CAD vs non-CAD subjects’ data were compared using univariate and multivariate statistics. <B>Results:</B> Principal components analysis showed a clear separation of CAD and non-CAD subjects, confirming that combined HDL proteomic and glycomic profiles distinguished at-risk subjects with atherosclerosis from those without. CAD patients had lower HDL apolipoprotein content (specifically ApoA-I, A-II, and E, <I>p</I> < 0.05), and lower serum amyloid A2 (SAA2, p = 0.020) and SAA4 (p = 0.007) but higher sialylated glycans (<I>p</I> < 0.05). <B>Conclusion:</B> Combined proteomic and glycomic profiling of isolated HDL was tested as a novel analytical approach for developing biomarkers of disease. In this pilot study we found that HDL proteome and glycome distinguished between individuals who had CAD from those who did not within a group of individuals equally at risk for heart disease.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2015/jprobs.2015.14.issue-12/acs.jproteome.5b00730/production/images/medium/pr-2015-00730j_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr5b00730'>ACS Electronic Supporting Info</A></P>
고분자 전해질 연료전지용 Sulfonated Poly(ether sulfone)의 합성 및 특성 평가
김형준(Krishnan, N.N.),조은애(Kim, H.-J.),오인환(Prasanna, M.),홍성안(Cho, E.-A.),임태훈(Oh, I.-H.),Hong, S.-A.,Lim, T.-H. 한국신재생에너지학회 2005 한국신재생에너지학회 학술대회논문집 Vol.2005 No.06
Sulfonated poly(ether sulfone) copolymers (PESs) were synthesized using hydroquinone 2-potassium sulfonate (HPS) with other monomers (bisphenol A and 4-fluorophenyl sulfone). PESs with different mole% of hydrophilic group were prepared by changing the mole ratio of HPS in the polymerization reaction. The chemical structure and the thermal stability of these polymers were characterized by using ¹H-NMR, FT-IR and TGA techniques. The PES 60 membrane, which has 60 mole% of HPS unit in the polymer backbone, has a proton conductivity of 0.091 S/cm and good insolubility in boiling water. The TGA showed that PES 60 was stable up to 272?C with a char yield of about 29%;at;900?C;under;N₂ atmosphere. To investigate the single cell performance, the catalyst coated PES 60 membrane was used and a single cell test was carried out using H₂/O₂ gases as fuel and oxidant at various temperatures. We observed that the cell performance was enhanced by increasing the cell temperature. A current density of 1400 mA/cm² at 0.60 V was obtained at 70?C.