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Using Implementation Science to Advance Cancer Prevention in India
Krishnan, Suneeta,Sivaram, Sudha,Anderson, Benjamin O.,Basu, Partha,Belinson, Jerome L,Bhatla, Neerja,D' Cruz, Anil,Dhillon, Preet K.,Gupta, Prakash C.,Joshi, Niranjan,Jhulka, PK,Kailash, Uma,Kapambwe Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Oral, cervical and breast cancers, which are either preventable and/or amenable to early detection and treatment, are the leading causes of cancer-related morbidity and mortality in India. In this paper, we describe implementation science research priorities to catalyze the prevention and control of these cancers in India. Research priorities were organized using a framework based on the implementation science literature and the World Health Organization's definition of health systems. They addressed both community-level as well as health systems-level issues. Community-level or "pull" priorities included the need to identify effective strategies to raise public awareness and understanding of cancer prevention, monitor knowledge levels, and address fear and stigma. Health systems-level or "push" and "infrastructure" priorities included dissemination of evidence-based practices, testing of point-of-care technologies for screening and diagnosis, identification of appropriate service delivery and financing models, and assessment of strategies to enhance the health workforce. Given the extent of available evidence, it is critical that cancer prevention and treatment efforts in India are accelerated. Implementation science research can generate critical insights and evidence to inform this acceleration.
Chandrasekar, R.,Manohar, Suganthi L.,Krishnan, M. Korean Society of Applied Entomology 2007 Journal of Asia-Pacific Entomology Vol.10 No.3
In insects, the source of storage protein-1 (SP1) in ovaries has been the subject of controversy for several decades, and both extraovarian and intraovarian synthesized proteins have been implicated. Ovarian SP1 is presumed to contribute towards the chorion formation. The amino acid analysis of SP-1 of A. albistriga revealed that it consists of relatively high methionine content (10.9%) and is female-specific. The paper deals with the intraovarian synthesis and tissue distribution of SP1 in the pupal ovaries of A. albistriga. Northern hybridization analysis clearly demonstrates that the SP1 gene was expressed in the developing follicles, the maximum accumulation of its transcript at vitellogenic stage (day 4-8) during the mid pupal periods. Further, the result of EM studies regarding the localization of this protein in follicular epithelial cells is confirmed by immunogold labeling tracer techniques. A possible role for ovarian SP1 in A. albistriga and its relationship with SP1 synthesis by the fat body is discussed.
Nagaraj M. Kulkarni,Milind M. Muley,Mallikarjun S. Jaji,G. Vijaykanth,J. Raghul,Neetin Kumar D. Reddy,Santosh L. Vishwakarma,Navin B. Rajesh,Jeyamurugan Mookkan,Uma Maheswari Krishnan,Shridhar Narayan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Atorvastatin is a 3-hydroxy-3-methylglutarylcoenzyme-A reductase inhibitor used in the treatment ofatherosclerosis and dyslipidemia. Studies have evaluatedthe utility of statins in the treatment of skin inflammationbut with varied results. In the present study, we investigatedthe effect of atorvastatin on TNF-a release andkeratinocyte proliferation in vitro and in acute and chronic12-O-tetradecanoylphorbol-13-acetate (TPA) induced skininflammation in vivo. Atorvastatin significantly inhibitedlipopolysacharide induced TNF-a release in THP-1 cellsand keratinocyte proliferation in HaCaT cells. In an acutestudy, topical atorvastatin showed dose dependent reductionin TPA induced skin inflammation with highest efficacyobserved at 500 lg/ear dose. In chronic study, topicalatorvastatin significantly reduced TPA induced ear thickness,ear weight, cutaneous cytokines, MPO activity andimproved histopathological features comparable to that ofdexamethasone. Atorvastatin also inhibited TPA stimulatedNF-jB activation in mouse ear. In conclusion, our resultssuggest that atorvastatin ameliorates TPA induced skininflammation in mice at least in part, due to inhibition ofcytokine release and NF-jB activation and may be beneficialfor the treatment skin inflammation like psoriasis.