기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

Minicell 분리에 관한 연구

고재문,김종세,김성준,노영복 조선대학교 기초과학연구소 1989 自然科學硏究 Vol.12 No.1

Minicell은 간상 박테리아의 극단에서 변이 세포분열에 의해 생산되는 작은 비성장체이다. 그것은 protein이나 RNA를 함유하나 chromosomal DNA가 조금 있거나 거의 없고 모양은 구형이다. 본 실험을 통해 얻은 결론은 다음과 같다. A. Minicell 생산이 왕성한 x1411 균주를 12시간 배양한 후 optical density는 ML media=0.25, M9 minimal media=0.5, x1776 broth media=0.7, 3×D media=0.9, LB media=1.0으로 나타났다. B. x1411 균주와 pOX7의 형질전환율은 2×10^5개/㎍·DNA로 나타났다. C. 변형된 방법에 의해 분리되어진 minicell양은 1.8×10^4cells/㎖로 나타났다. D. Minicell의 중심부와 극단에서 생성된다는 보고와는 달리 본 실험을 통한 관찰 결과 minicell은 중심부에서는 생성되지 않고 극단에서만 생성된다. E. 전자현미경을 통한 관찰 결과 host cell과 minicell의 크기비는 10:1 정도며, 모양은 host cell은 간상이고 minicell은 구형이다. Minicells are small non-growing bodies produced by aberrant cell divisions at the polar ends of rod-shaped bacteria. They are anucleate, contain RNA and protein but little or no chromosomal DNA fragment and approximately spherical in shape. The results are summarized as follows ; A. After culturing 12 hours, cell density of typical minicell-producing χ 1411 strains appeared to 0.25 in ML media, 0.5 in M9 minimal media, 0.7 in χ 1776 broth media, 0.9 in 3XD media and 1.0 in LB meda. B. The transformation rates between χ 1411 strains and pOX7 plasmid were 2×10^5 in each ㎍. DNA. C. Isolated minicells with modified method were 1.8×10^4 in each ml. D. some papers reported that minicells are produced at the polar ends and the central part, but in this experiment minicells were only produced at the polar ends. E. The results of observation with E.M. ; the ration of cell size between the host cell and the minicell was about 10 : 1, host cell was rod type in shape and minicell spherical type.

기능성 소화불량증에서 증상에 따른 고형식의 반위배출시간의 차이

김영호,이풍렬,성인경,손희정,김재준,고광철,백승운,이종철,최규완 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

흉요추부 굴곡-신연 손상에서 척추체의 골절 양상

고영도,김종오,윤여헌,유재두,정준모 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 흉요추부 굴곡-신연 손상에 동반되는 척추체의 골절 양상을 알아 보고자 하였다. 대상 및 방법 : 흉요추부 굴곡 - 신연 손상 21례의 방사선 검사를 검토하여 골절된 척추체의 위치, 전후방 추체 높이, 손상된 분절의 후만각, 척추체 골편의 척추관내 침범 정도 및 척추체의 분쇄 정도를 관찰하였다. 결과 : 총 21례 중 압박 골절이 11례, 방출성 골절이 9례 있었다. 척추체 골절은 85%에서 굴곡-신연 손상된 분절내에서 하부 척추체에 위치하였다. 전방 추체 높이는 평균 27% 감소하였고, 압박 골절이 동반된 경우 18%, 방출성 골절이 동반된 경우 40% 감소하였다. 후방 추체 높이는 평균 1% 감소하였고, 압박 골절이 동반된 경우 1% 증가하였으며, 방출성 골절이 동반된 경우 4% 감소하였다. 손상된 분절의 후만각은 평균 19.5도이었고, 압박 골절이 동반된 경우는 15.4도, 방출성 골절이 동반된 경우는 26.8도이었다. 방출성 골절이 동반된 9례 중 골편의 척추관내 침범은 평균 27%이었으며, 척추체의 분쇄 정도는 71.4%에서 경미하였다, 결론 : 흉요추부 굴곡-신연 손상에서 척추세의 골절은 매우 흔하며 분절내 하부 척추체에 호발하였다. 가해진 힘에 비하여 전후방 추체 높이의 감소, 척추관내 침범 및 분쇄 정도가 적었으며, 이는 굴곡력이나 축성 부하의 효과가 신연력에 의해 일부 상쇄되었기 때문이다. Purpose : To evaluate the configuration of vertebral body fractures in flexion-distraction injuries of thoracolumbar spine. Materials and Method : We investigated the location of fractures, anterior or posterior vertebral body height, kyphotic angle of injured segments, canal encreachment and severity of comminution on radiologic examinations of 21 cases. Result : There were 11 compression fractures and 9 burst fractures. 85% of fractures were located in the inferior vertebrae of injured segments. Anterior vertebral height decreased by 27% on average with decrease of 18% in compression fractures and 40% in burst fractures. Posterior height decreased by 1% on average with increase of 1% in compression fractures and decrease of 4% in burst fractures. The average kyphotic angle of injured segments was 19.5˚ with 15.4˚ in compression fractures and 26.8˚ in burst fractures. The canal encreachment in 9 burst fractures was 27% on average, and the comminution of vertebral body was mild in 74%. Conclusion : The fracture of vertebral body in flexion-distraction injuries of thoracolumbar spine was very common, and located on the inferior vertebare of injured segment. The decrease of vertebral height, canal encreachment and severity of comminution was relatively less than the estimated from mechanism of injury, with offset effect of distraction force.

제주도 119구조·구급대의 활성화 및 전문화 방안

고재문,김태민,김효식,이영아 한국응급구조학회 2002 한국응급구조학회지 Vol.6 No.1

Since 1992, conventional fire fighting businesses have been converted into a metropolitan autonomous fire fighting system to be ready for a variety of disasters. However, the corresponding investment has been overlapped due to the non integration of businesses to prevent any potential disasters, and a series of collaborative systems have been not functioning so well. In the meantime, our fire fighting sector has been trying to set up its own clean and faithful position by abolishing any inconvenient system or outsourcing private sectors, and expanded its work scope from conventional fire fighting even to rescue and emergency works. While focusing on handling disaster, the fire fighting sector has been widely trusted and reliable throughout our nation. Moreover, our fire fighting sector has secured nation-wide mobile organizations, technical personnel by field, special equipments and independent communication network. In addition, the fire fighting sector has knowledges, expertise and capabilities required for managing disasters, while in charge of almost every disaster management works including fire, explosion, collapse, disaster and flood. It becomes an organization for comprehensive disaster management under an absolute national trust, which is based on the system for prevention, preparation and countermeasure against a variety of disasters. Thus, our fire fighting sector must make many efforts and try to modernize conventional education and training. The ways to facilitate rescue and emergency works may include the nurture of technical fire fighting personnel along with modernized equipments, the reinforcement of rescue and emergency education, the facilitation of operating civil defense corps, the facilitation of operating volunteer fire fighting corps, the better arrangement of 119 briefing room for public healthcare in provincial offices, the sterilization of rescue instruments and equipments, the better repair education for emergency rescue member, the establishment of regional emergency assistant system and the expansion of fire fighting personnel and equipments. In terms of reinforcing the functions and services of rescue 119 and emergency corps, we must review the following consideration: Building up security system along with operational expansion, building up a system for emergency medical treatment, building up a comprehensive information management system for rescue and emergency, constructing a provincial safety museum and so forth. For the ways to better the works of rescue 119, we can review the following considerations: Improving the education for fire fighting training corps under Jeju Provincial Fire and Disaster Mangement Department, providing rescue members with more opportunities for clinical practices, enhancing the morale of rescue members, installing a comprehensive briefing room for emergency rescue member, building up medical networks along with reasonable policies for information service, operating the consulting system for rescue 119 and so on. If these requirements are met, it is expected that the fire fighting departments in Juju province can cope with every accident and disaster a little more rapidly and quickly in compliance with local needs, so that they can keep their own position as a public fire fighting organization, which may be trusted by the public.

초등학교 과학 수업에서 팀 게임 토너먼트(TGT) 협동학습의 효과

고한중,양수경,한재영,노태희 한국초등과학교육학회 2003 초등과학교육 Vol.22 No.3

The purpose of this study was to develop a way of using Teams Games Tournaments that fits in elementary school science instruction, and to find out its effects on student's learning. Three classes (103 sixth graders) were divided into three groups; a traditional learning group, a cooperative learning group, and a teams games tournaments cooperative learning group. Students were taught about 'several kinds of gas' for nine class periods. The instructional effects upon student's achievement, science learning motivation and self-esteem toward science instruction were examined. The result of this study indicated that there was a significant interaction effect between the treatment and achievement level in the achievement test scores. The achievement test scores of the low level students were significantly higher in the teams games tournaments cooperative learning group than those in the traditional learning groups.

飮水中 銅의 水準에 따른 흰쥐 장기 내 무기질 농도에 미치는 영향 : Calcium, Phosphorus, Sodium, Potassium 및 Magnesium

高鎭福,金載營 新羅大學校 1987 論文集 Vol.24 No.-

A cereal-based diet containing 12.8mg coper/kg and drinking water were fed ad lib, to a group of rats for 4 weeks. Four other groups were given this control diet and the drinking water to which was added 25, 50, 100 and 220ppm Cu/day (as copper sulfate) respectively. After 4 weeks the rats were slaughtered and the concentrations of calcium, phosphorus, sodium, potassium and magnesium in several tissues were measured. Ca contents in toal liver of male and in total spleen or heart of female were significantly lower in Cu groups than in control group. Na concentrations in liver, kidney and heart of female and in kidney of male were decreased by the addition of Cu. Serum Na concentrations were decreased (female 65% and male 61%) at 200ppm added Cu. Spleen K concentrations of female and male were increased at 200ppm added Cu. Serum P, K and Mg concentrations of female and male were decreased by the addition of Cu but Ca concentrations were not affected.

낙동강 본류 하변의 식물상에 관한 연구

고재기,조영호 대구한의대학교 기초과학연구소 2003 基礎科學 Vol.7 No.2

본 조사에서 기록된 관속식물은 69 科 174 屬 227 種 40 變種 2 品種으로 총 269 種이 조사되었다. 생활형의 구성은 남한지역 전체와 비교할 때, 지상식물, 지중식물 및 지표식물의 비율이 낮았고, 반지중식물, 1년생식물 및 수생식물의 비율이 현저히 높게 나타났다. 본 조사 지역에서 얻어진 귀화식물은 전체 출현종의 8.55%로써 23종 이 출현하였다. 낙동강 본류의 수생식물은 총 16과 20속 31종 4변종을 총 35종류가 조사되었으며 정수성이 14종(40.0%)으로 가장 많았으며 침수성 11종(31.4%), 부엽성 7종(20.0%), 부유성 3종(8.6%)의 순으로 나타났다. 수생식물의 분포는 대구상류에 16 종, 대구 하류에 26종으로 하류로 갈수록 많이 출현하고 있으며, 침수식물인 검정말 (Hydrilla verticillata)이 우점종으로 관찰되었다. This study was undertaken to describe the riverside flora in 73 plots around the mainstream of Nak-tong River, Korea from March, 1995 to October, 1996. The field survey were carried out through the process of direct collection on actual vegetation and drying, fixation and identification of each specimen. The vascular plants around the mainstream of Nak-tong River were consisted of 269taxa; 69 families, 174 genera, 227 species, 40 varieties, 2 forms. Compared with Raunkiaer's lifeform spectrum, the percent of phanerophyte, geophyte and epiphyte were lower and hemicryptophyte, hydrophyte and therophyte were higher remarkably in spectrum of this riverside flora than spectrum of South Korea. The Korean endemic plants are 5 taxa and naturalized plants are 23 taxa. The percent of species number of naturalized plants around the mainstream of Nak-tong River per total species number of naturalized plants in South Korea is 12.8%. The hydrophytes around the mainstream of Nak-tong River were consisted of 35taxa; 16 families, 20 genera, 31 species, 4 varieties and the composition of hydrophytes by life cycle were 10 emergent hydrophytes, 5 floating-leaved hydrophytes, 13 submerged hydrophytes, 3 free-floating hydrophytes and dominant species in hydrophytes was Hydrilla verticillata And the subsidiary knowledge from this study will provide practical information on the study for biodiversity and habitat conservation.

Calcofluor White 염색법을 이용한 주폐포자충 폐렴의 조기 진단

고윤석,최정은,송재훈,김유겸,김원동,조영주,유빈,김양수,주용선 대한감염학회 1993 감염 Vol.25 No.2

To evaluate the clinical efficacy and usefulness of Calcofluor white stain in the diagnosis of Pneumocystis carinii pneumonia (PCP), we performed Calcofluor white stain in bronchoalveloar lavage fluid from 10 compromised patients with fever , dyspnea, and diffuse pulmonary infiltrates. Four of 10 cases showed positive staining for P.carinii with Calcofluor white staining. Underlying diseases were ALL, AML, AIDS, and Pinealoblastom, respectively. These patients had been treated with Bactrim for 2 or 3 weeks with complete cure. Calcofluor white stain has clear advantages over conventional staining methods such ad Gomori methenamine silver, Toluidine blue O, or Giemsa stain in terms of speed and simplicity of the technique. This method is believed to be suitable for early diagnosis of PCP. Application of this rapid diagnostic method to suspected cases with febrile pneumonitis syndrome will increase the detection rate of PCP in Korea.

민주지산(충북 영동)의 식물상

고재기,조영호 慶山大學校 基礎科學硏究所 1998 基礎科學 Vol.2 No.1

본 조사는 1997년 6월부터 11월까지 충청북도 영동군 상촌면 일대의 민주지산(1,241.7m)과 각호산(1,176m)의 북동사면을 중심으로 한 지역의 관속식물을 조사하였다. 조사된 관속식물은 92과 308속 472종 75변종 1아종 5품종으로 총 553종류로 나타났으며 이중 40종류는 이번 조사에서 추가되었다. Raunkiaer의 생활형 spectrum 분석결과는, 민주지산이 대체로 남한의 것과 비슷하나 대형지상식물, 소형지상식물 및 착생식물이 비교적 낮고, 반지중식물과 지중식물이 비교적 높게 나타났다. 지리대사초, 뻐꾹나리, 금강제비꽃, 자란초 등 17종류의 한국특산식물이 이곳에서 확인되었다. Floristic composition of Mt. Minjujisan(36。 02' 13" N, 127。 51' 06" E, 1,241.7m a.s.l.), Youngdong-gun, Chungcheongbuk-do, has investigated from June to November 1997. This study was carried out through the process of direct collection on actual vegetation, drying, fixation and identification of each specimen, The vascular plants in Mt. Minjujisan were consisted of 553taxa; 92 families, 308 genera 472 species, 1 subspecies, 75 varieties, 5 forms. Compared with Raunkiaer's lifeform spectrum, the percent of mega-mesophanerophyte nanophanerophyte and epiphyte were lower and hemicryptophyte and geophyte were higher in spectrum of Mt. Minjujisan than South Korea In this study, the endemic plants of Korea are 17 taxa Carex okamotoi, Polygonatum lasianthum var. coreanum, Tricyrtis dilatata, Salix hallaisanensis, Salix hulteni, Melandryum seoulense, Clematis trichotoma, Tholictrum rochebrunianum var. grandisepalum, Chrysosplenium barbatum, Vicia hirticalycina, Viola diamantica, Pimoinella koreana, Vaccinium koreanum, Ajuga spectabilis, Cacalia pseudo-taimingasa, Saussurea seoulensis, Serratula coronota var. insutaris. And the subsidiary knowledge from this study will provide practical information on the study for biodiversity and habitat conservation.