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Superconducting Tunnel Junction Detectors for Mass Spectrometry
Ohkubo, M.,Zen, N.,Kitazume, T.,Ukibe, M.,Shiki, S.,Koike, M. The Korean Superconductivity Society 2012 Progress in superconductivity Vol.14 No.2
With conventional mass spectrometry (MS), ions are separated according to mass/charge (m/z) ratios. We must speculate the z values to obtain the m values. Superconducting tunnel junction (STJ) detectors can solve this problem, and true mass spectrometry becomes possible instead of m/z spectrometry. The STJ detectors were installed in MS instruments with a variety of ion sources. As an example, we report fragmentation analysis of a non-covalent protein complex of hemoglobin.
Sasaki, Hiraku,Nonaka, Jun,Otawa, Kenichi,Kitazume, Osamu,Asano, Ryoki,Sasaki, Takako,Nakai, Yutaka Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.1
We investigated the structure of bacterial communities present in livestock manure-based composting processes and evaluated the bacterial succession during the composting processes. Compost samples were derived separately from swine manure, dairy manure and sewage sludge. The structure of the bacterial community was analyzed by polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) using universal eubacterial primers. The genus Bacillus and related genera were mainly detected following the thermophilic composting phase of swine and dairy manure composts, and the members of the phylum Bacteroidetes were mainly detected in the cattle manure waste-based and sewage sludge compost. We recovered and sequenced limited number of the bands; however, the PCR-DGGE analysis showed that predominant diversities during the composting processes were markedly changed. Although PCR-DGGE analysis revealed the presence of different phyla in the early stages of composting, the members of the phylum Firmicutes and Bacteroidetes were observed to be one of the predominant phyla after the thermophilic phase.
Superconducting Tunnel Junction Detectors for Mass Spectrometry
M. Ohkubo,N. Zen,T. Kitazume,S. Shiki,M. Ukibe,M. Koike 한국초전도학회 2012 Progress in superconductivity Vol.14 No.2
With conventional mass spectrometry (MS), ions are separated according to mass/charge (m/z) ratios. We must speculate the z values to obtain the m values. Superconducting tunnel junction (STJ) detectors can solve this problem, and true mass spectrometry becomes possible instead of m/z spectrometry. The STJ detectors were installed in MS instruments with a variety of ion sources. As an example, we report fragmentation analysis of a non-covalent protein complex of hemoglobin.
Determination of a Desirable Time Step for Quasi-Dynamic Urban Model with Sapporo Test Bed
Varameth Vichiensan, Kazuaki Miyamoto, Keiichi Kitazume 서울시립대학교 도시과학연구원 2003 International journal of urban sciences (IJUS) Vol. No.
This paper presents an application of the Sapporo GIS based Test Bed, which has been built to support urban model testing and development. It briefly describes TRANUS Sapporo model, which has been calibrated both at one time point and for a time interval. The model is quasi-dynamic, which runs its land-use and transportation submodels sequentially with time lag. In this study, Sapporo Test Bed was an efficient tool to identify the inputs and parameters that are the main cause of uncertainty of the model results. The uncertainty is accumulated by the quasi-dynamic structure, which is a usual structure of the most existing urban models. Moreover, this paper has proposed a heuristic approach to determine a desirable time step for quasi-dynamic urban model. This is achieved by a simplified Monte Carlo simulation technique. Uncertainty in the model output is evaluated from various statistical indexes. It is found that a time step of 3.3 years is most desirable by trading off between uncertainty and accuracy. However, a 3.3-year time step may not be desirable from a practical viewpoint, we evaluated that a time step of 5 years is also acceptable compared with 3.3 years based on our simulation results.
손태일,키타쯔메도모야 ( Tae Il Son,Tomoya Kitazume ) 한국공업화학회 1994 공업화학 Vol.5 No.1
시판되고 있는 4종류의 Lipase(talpase, paratase M1000L, SP398, SP435)를 이용하여, 2-[1-(1-acetoxy-2,2, 2-trifluoroethyl)]-5-trimethylsilylfuran(1)을 속도론적 광학분할에 의해서 가수분해반응을 검토했다. 그 결과 Novo Nordish사의 SP435가 속도론적 광학분할능을 가진다는 것을 확인했으며, 본 실험에서는 광학순도 92.4% enantiomeric excess(ee)를 가지는 생성물 2-[1-(2,2,2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2)를 얻었다. The hydrolysis of biochemical kinetic resolutions for 2-[1-(acetoxy-2, 2, 2-trifluoroethyl)] -5-trimethylsilylfuran(1) using four kinds of Lipase(talpase, paratase M1000L, SP398, SP435) was investigated. In the results, SP435 of Novo Nordish comp any was confirmed to show the capacity of biochemical kinetic resolutions, and 2-[1-(2, 2, 2-trifluoro-1-hydroxyethyl)]-5-trimethylsilylfuran(2) to have the optical purity expressed as 92.4% enantiomeric excess(ee) was produced in this studies.
Ami Kawamoto,Kento Takenaka,Shuji Hibiya,Yoshio Kitazume,Hiromichi Shimizu,Toshimitsu Fujii,Eiko Saito,Kazuo Ohtsuka,Ryuichi Okamoto 대한장연구학회 2024 Intestinal Research Vol.22 No.1
Background/Aims: Endoscopic activity confirmed by enteroscopy is associated with poor clinical outcome in Crohn’s disease (CD). We investigated which of the existing biomarkers best reflects endoscopic activity in CD patients including the small bowel, and whether their combined use can improve accuracy.Methods: One hundred and four consecutive patients with ileal and ileocolonic type CD who underwent balloon-assisted enteroscopy (BAE) from October 2021 to August 2022 were enrolled, with clinical and laboratory data prospectively collected and analyzed.Results: Hemoglobin, platelet count, C-reactive protein, leucine-rich alpha-2 glycoprotein (LRG), fecal calprotectin, and fecal hemoglobin all showed significant difference in those with ulcers found on BAE. LRG and fecal calprotectin showed the highest areas under the curve (0.841 and 0.853) for detecting ulcers. LRG showed a sensitivity of 78% and specificity of 80% at a cutoff value of 13 μg/mL, whereas fecal calprotectin showed a sensitivity of 91% and specificity of 67% at a cutoff value of 151 μg/g. Dual positivity for LRG and fecal calprotectin, as well as LRG and fecal hemoglobin, both predicted ulcers with an improved specificity of 92% and 100%. A positive LRG or fecal calprotectin/hemoglobin showed an improved sensitivity of 96% and 91%. Positivity for LRG and either of the fecal biomarkers was associated with increased risk of hospitalization, surgery, and relapse.Conclusions: The biomarkers LRG, fecal calprotectin, and fecal hemoglobin can serve as noninvasive and accurate tools for assessing activity in CD patients confirmed by BAE, especially when used in combination.
Magnetic resonance enterography for the evaluation of the deep small intestine in Crohn`s disease
( Kazuo Ohtsuka ),( Kento Takenaka ),( Yoshio Kitazume ),( Toshimitsu Fujii ),( Katsuyoshi Matsuoka ),( Masakazu Nagahori ),( Maiko Kimura ),( Takashi Nagaishi ),( Mamoru Watanabe ) 대한장연구학회 2016 Intestinal Research Vol.14 No.2
For the control of Crohn`s disease (CD) a thorough assessment of the small intestine is essential; several modalities may be utilized, with cross-sectional imaging being important. Magnetic resonance (MR) enterography, i.e., MRE is recommended as a modality with the highest accuracy for CD lesions. MRE and MR enteroclysis are the two methods performed following distension of the small intestine. MRE has sensitivity and specificity comparable to computed tomography enterography (CTE); although images obtained using MRE are less clear compared with CTE, MRE does not expose the patient to radiation and is superior for soft-tissue contrast. Furthermore, it can assess not only static but also dynamic and functional imaging and reveals signs of CD, such as abscess, comb sign, fat edema, fistula, lymph node enhancement, less motility, mucosal lesions, stricture, and wall enhancement. Several indices of inflammatory changes and intestinal damage have been proposed for objective evaluation. Recently, diffusion-weighted imaging has been proposed, which does not need bowel preparation and contrast enhancement. Comprehension of the characteristics of MRE and other modalities is important for better management of CD. (Intest Res 2016;14:120-126)